{"id":10159,"date":"2021-01-06T00:08:28","date_gmt":"2021-01-06T05:08:28","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetique-de-lvedv-pirruccello-2020\/"},"modified":"2021-02-20T20:28:50","modified_gmt":"2021-02-21T01:28:50","slug":"genetique-de-lvedv-pirruccello-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetique-de-lvedv-pirruccello-2020\/","title":{"rendered":"Volume fin-diastolique ventriculaire gauche (Pirruccello, 2020)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> L’analyse de l’imagerie par r\u00e9sonance magn\u00e9tique cardiaque chez 36000 personnes donne des informations g\u00e9n\u00e9tiques sur la cardiomyopathie dilat\u00e9e<\/a><\/p>\n\n

SOMMAIRE:<\/strong> Identification de 14 variantes g\u00e9n\u00e9tiques associ\u00e9es au volume end-diastolique ventriculaire gauche (LVEDV).<\/p>\n\n

APER\u00c7U:<\/strong> Le c\u0153ur humain est un muscle qui pompe le sang dans tout le corps. Il se compose de 4 chambres: 2 oreillettes (gauche et droite) et 2 ventricules (gauche et droite). Le sang qui a \u00e9t\u00e9 enrichi en oxyg\u00e8ne dans les poumons p\u00e9n\u00e8tre dans l’oreillette gauche puis s’\u00e9coule dans le ventricule gauche d’o\u00f9 il est pomp\u00e9 vers toutes les autres parties du corps. Le volume end-diastolique ventriculaire gauche (LVEDV) est le volume de sang dans un ventricule gauche d\u00e9tendu juste avant qu’il ne se contracte et ne pompe le sang dans le corps. La LVEDV moyenne est de 120 ml pour les femmes et de 150 ml pour les hommes et peut \u00eatre utilis\u00e9e comme mesure de la sant\u00e9 cardiaque. Cette \u00e9tude d’association pang\u00e9nomique a examin\u00e9 les g\u00e9nomes de 36 000 individus d’ascendance europ\u00e9enne pour mieux comprendre la base g\u00e9n\u00e9tique du LVEDV. L’\u00e9tude a identifi\u00e9 14 r\u00e9gions g\u00e9nomiques associ\u00e9es \u00e0 LVEDV ajust\u00e9es en fonction de la surface corporelle. L’\u00e9tude a \u00e9galement r\u00e9v\u00e9l\u00e9 une forte relation inverse entre le score polyg\u00e9nique pour un LVEDV plus grand et l’hypothyro\u00efdie. <\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> En moyenne, le c\u0153ur humain pompe environ 2 000 gallons (7 600 litres) de sang dans tout le corps chaque jour. [SOURCE]<\/a><\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> . <\/p>\n\n

\"résultats<\/a><\/figure>\n\n

VARIANTES ASSOCI\u00c9ES AU LVEDV:<\/strong> rs1873164, rs9797817, rs72967533, rs72840788, rs73028849, rs1976402, rs6458349, rs9480737, rs7502466, rs12499670, rs10850034<\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong>Le c\u0153ur (vid\u00e9o)<\/a>Comment fonctionne le c\u0153ur<\/a>Volume fin-diastolique<\/a><\/p>\n\n

VOUS POUVEZ \u00c9GALEMENT \u00caTRE INT\u00c9RESS\u00c9 PAR:<\/strong> Fraction d’\u00e9jection ventriculaire gauche (Pirruccello, 2020)<\/a>Volume end-systolique ventriculaire gauche (Pirruccello, 2020)<\/a>Volume de course (Pirruccello, 2020)<\/a>Cardiomyopathie (Meder, 2014)<\/a><\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 19 mai 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: L’analyse de l’imagerie par r\u00e9sonance magn\u00e9tique cardiaque chez 36000 personnes donne des informations g\u00e9n\u00e9tiques sur la cardiomyopathie dilat\u00e9e SOMMAIRE: Identification de 14 variantes g\u00e9n\u00e9tiques associ\u00e9es au volume end-diastolique ventriculaire gauche (LVEDV). APER\u00c7U: Le c\u0153ur humain est un …<\/p>\n

Volume fin-diastolique ventriculaire gauche (Pirruccello, 2020)<\/span> Lire la suite 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