{"id":10163,"date":"2021-01-06T00:08:31","date_gmt":"2021-01-06T05:08:31","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetique-de-lvesv-pirruccello-2020\/"},"modified":"2021-02-20T20:19:11","modified_gmt":"2021-02-21T01:19:11","slug":"genetique-de-lvesv-pirruccello-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetique-de-lvesv-pirruccello-2020\/","title":{"rendered":"Volume end-systolique ventriculaire gauche (Pirruccello, 2020)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> L’analyse de l’imagerie par r\u00e9sonance magn\u00e9tique cardiaque chez 36000 personnes donne des informations g\u00e9n\u00e9tiques sur la cardiomyopathie dilat\u00e9e<\/a><\/p>\n\n

SOMMAIRE:<\/strong> Identification de 28 variantes g\u00e9n\u00e9tiques associ\u00e9es au volume end-systolique ventriculaire gauche (LVESV).<\/p>\n\n

APER\u00c7U:<\/strong> Le c\u0153ur humain est un muscle qui pompe le sang dans tout le corps. Il se compose de 4 chambres: 2 oreillettes (gauche et droite) et 2 ventricules (gauche et droite). Le sang qui a \u00e9t\u00e9 enrichi en oxyg\u00e8ne dans les poumons p\u00e9n\u00e8tre dans l’oreillette gauche puis s’\u00e9coule dans le ventricule gauche d’o\u00f9 il est pomp\u00e9 vers toutes les autres parties du corps. Le volume end-systolique ventriculaire gauche (LVESV) est le volume de sang qui reste dans le ventricule gauche \u00e0 l’extr\u00e9mit\u00e9 d’une pompe. Le LVESV moyen est de 41 ml pour les femmes et de 58 ml pour les hommes et peut \u00eatre utilis\u00e9 comme mesure de la sant\u00e9 cardiaque. Cette \u00e9tude d’association pang\u00e9nomique a examin\u00e9 les g\u00e9nomes de 36 000 individus d’ascendance europ\u00e9enne pour mieux comprendre la base g\u00e9n\u00e9tique du LVESV. L’\u00e9tude a identifi\u00e9 28 r\u00e9gions g\u00e9nomiques associ\u00e9es au LVESV ajust\u00e9es pour la surface corporelle. L’\u00e9tude a \u00e9galement r\u00e9v\u00e9l\u00e9 qu’un score polyg\u00e9nique \u00e9lev\u00e9 pour le LVESV ajust\u00e9 \u00e0 la surface corporelle \u00e9tait fortement corr\u00e9l\u00e9 au risque de cardiomyopathie dilat\u00e9e. Cette condition d\u00e9crit un muscle cardiaque qui est trop \u00e9tir\u00e9 et mince et ne peut pas pomper efficacement.<\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> L’expression \u00able rire est le meilleur rem\u00e8de\u00bb a du vrai. Le rire peut \u00eatre b\u00e9n\u00e9fique pour la sant\u00e9 de votre c\u0153ur, permettant aux art\u00e8res de se d\u00e9tendre et de devenir plus flexibles, permettant une circulation sanguine plus facile. [SOURCE]<\/a><\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> . <\/p>\n\n

\"résultats<\/a><\/figure>\n\n

VARIANTES ASSOCI\u00c9ES AU LVESV:<\/strong> rs72840788, rs945425, rs2562845, rs73028849, rs5760061, rs3176326, rs10421891, rs12452367, rs34373805, rs8063213, rs79502300, rs1962104, rs11023059, rs189569984, rs9892651, rs1499813, rs2302455, rs11748963, rs10871753, rs116904997, rs190093681, rs709208, rs2886037, rs242562<\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong>Le c\u0153ur (vid\u00e9o)<\/a>Comment fonctionne le c\u0153ur<\/a><\/p>\n\n

VOUS POUVEZ \u00c9GALEMENT \u00caTRE INT\u00c9RESS\u00c9 PAR:<\/strong> Fraction d’\u00e9jection ventriculaire gauche (Pirruccello, 2020)<\/a> Volume fin-diastolique ventriculaire gauche (Pirruccello, 2020)<\/a>Volume de course (Pirruccello, 2020)<\/a>Insuffisance cardiaque (Shah, 2020)<\/a><\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 19 mai 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: L’analyse de l’imagerie par r\u00e9sonance magn\u00e9tique cardiaque chez 36000 personnes donne des informations g\u00e9n\u00e9tiques sur la cardiomyopathie dilat\u00e9e SOMMAIRE: Identification de 28 variantes g\u00e9n\u00e9tiques associ\u00e9es au volume end-systolique ventriculaire gauche (LVESV). APER\u00c7U: Le c\u0153ur humain est un …<\/p>\n

Volume end-systolique ventriculaire gauche (Pirruccello, 2020)<\/span> Lire la suite 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