{"id":10167,"date":"2021-01-06T00:08:35","date_gmt":"2021-01-06T05:08:35","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetique-of-stroke-volume-pirruccello-2020\/"},"modified":"2021-02-20T20:23:49","modified_gmt":"2021-02-21T01:23:49","slug":"genetique-of-stroke-volume-pirruccello-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetique-of-stroke-volume-pirruccello-2020\/","title":{"rendered":"Volume de course (Pirruccello, 2020)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> L’analyse de l’imagerie par r\u00e9sonance magn\u00e9tique cardiaque chez 36000 personnes donne des informations g\u00e9n\u00e9tiques sur la cardiomyopathie dilat\u00e9e<\/a><\/p>\n\n

SOMMAIRE:<\/strong> Identification de 12 variantes g\u00e9n\u00e9tiques associ\u00e9es au volume systolique du c\u0153ur.<\/p>\n\n

APER\u00c7U:<\/strong> Le c\u0153ur humain est un muscle qui pompe le sang dans tout le corps. Il se compose de 4 chambres: 2 oreillettes (gauche et droite) et 2 ventricules (gauche et droite). Le sang qui a \u00e9t\u00e9 enrichi en oxyg\u00e8ne dans les poumons p\u00e9n\u00e8tre dans l’oreillette gauche puis s’\u00e9coule dans le ventricule gauche d’o\u00f9 il est pomp\u00e9 vers toutes les autres parties du corps. Le volume de course (SV) est une mesure de la quantit\u00e9 de sang pomp\u00e9e hors du ventricule gauche pendant chaque battement. La SV moyenne est de 81 ml pour les femmes et de 95 ml pour les hommes. Les mesures du volume systolique peuvent indiquer si le c\u0153ur pompe suffisamment de sang pour r\u00e9pondre aux demandes du corps. Cette \u00e9tude d’association \u00e0 l’\u00e9chelle du g\u00e9nome de plus de 36000 individus d’ascendance europ\u00e9enne a identifi\u00e9 12 variantes g\u00e9n\u00e9tiques en corr\u00e9lation avec SV, y compris des variantes proches de g\u00e8nes qui jouent un r\u00f4le dans la contraction du muscle cardiaque (MYH6) et la formation des vaisseaux sanguins (VEGFA). Ensemble, ces variantes expliquent ~ 34% de l’h\u00e9ritabilit\u00e9 du volume systolique. L’\u00e9tude a \u00e9galement r\u00e9v\u00e9l\u00e9 une forte relation inverse entre le score polyg\u00e9nique pour une SV plus grande et l’hypothyro\u00efdie.<\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> Pendant l’exercice, le corps a besoin d’un apport accru de sang pour fournir de l’oxyg\u00e8ne aux muscles. Au fil du temps, l’exercice peut entra\u00eener une augmentation de l’efficacit\u00e9 du c\u0153ur, pompant plus de sang avec moins de travail. Les activit\u00e9s a\u00e9robies telles que la course \u00e0 pied et le cyclisme sont particuli\u00e8rement efficaces pour augmenter le volume de course. [SOURCE]<\/a><\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> . <\/p>\n\n

\"résultats<\/a><\/figure>\n\n

VARIANTES ASSOCIES AUX SV:<\/strong> rs72967533, rs11065979, rs7573293, rs11066188, rs10400419, rs888690, rs422068, rs111721712, rs2891403, rs2146324, rs28391274, rs143384<\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong>Le c\u0153ur (vid\u00e9o)<\/a><\/a>Volume de course et fr\u00e9quence cardiaque (vid\u00e9o)<\/a><\/p>\n\n

VOUS POUVEZ \u00c9GALEMENT \u00caTRE INT\u00c9RESS\u00c9 PAR:<\/strong> Fraction d’\u00e9jection ventriculaire gauche (Pirruccello, 2020)<\/a> Volume fin-diastolique ventriculaire gauche (Pirruccello, 2020)<\/a>Volume end-systolique ventriculaire gauche (Pirruccello, 2020)<\/a>Insuffisance cardiaque (Shah, 2020)<\/a><\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 19 mai 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: L’analyse de l’imagerie par r\u00e9sonance magn\u00e9tique cardiaque chez 36000 personnes donne des informations g\u00e9n\u00e9tiques sur la cardiomyopathie dilat\u00e9e SOMMAIRE: Identification de 12 variantes g\u00e9n\u00e9tiques associ\u00e9es au volume systolique du c\u0153ur. APER\u00c7U: Le c\u0153ur humain est un muscle …<\/p>\n

Volume de course (Pirruccello, 2020)<\/span> Lire la suite \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6380,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4984],"tags":[],"class_list":["post-10167","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rapports"],"yoast_head":"\nLa 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