{"id":10245,"date":"2021-01-06T00:12:10","date_gmt":"2021-01-06T05:12:10","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetique-des-lesions-cerebrales-armstrong-2020\/"},"modified":"2021-02-20T20:48:06","modified_gmt":"2021-02-21T01:48:06","slug":"genetique-des-lesions-cerebrales-armstrong-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetique-des-lesions-cerebrales-armstrong-2020\/","title":{"rendered":"L\u00e9sions c\u00e9r\u00e9brales (Armstrong, 2020)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> Une variation g\u00e9n\u00e9tique commune indique des causes distinctes d’hyperintensit\u00e9s p\u00e9riventriculaire et de mati\u00e8re blanche profonde<\/a><\/p>\n\n

SOMMAIRE:<\/strong> D\u00e9couverte de 11 r\u00e9gions g\u00e9nomiques associ\u00e9es \u00e0 des hyperintensit\u00e9s de la substance blanche p\u00e9riventriculaire qui indiquent des l\u00e9sions c\u00e9r\u00e9brales.<\/p>\n\n

APER\u00c7U:<\/strong> Le cerveau est un organe d\u00e9licat qui n\u00e9cessite un flux sanguin constant. Les accidents vasculaires c\u00e9r\u00e9braux surviennent lorsqu’une grande partie du cerveau n’est plus aliment\u00e9e en sang en raison d’un caillot majeur ou d’un saignement – cela entra\u00eene des l\u00e9sions c\u00e9r\u00e9brales \u00e9videntes. Cependant, des caillots ou des saignements plus petits peuvent tuer ou endommager les cellules c\u00e9r\u00e9brales, ce qui peut entra\u00eener une d\u00e9mence ou des probl\u00e8mes de mouvement. Ceux-ci peuvent ne pas \u00eatre d\u00e9tect\u00e9s jusqu’\u00e0 ce que le patient subisse un scanner c\u00e9r\u00e9bral: les dommages se manifestent par une tache blanche plus brillante, appel\u00e9e hyperintensit\u00e9. Cette \u00e9tude a recherch\u00e9 ces taches blanches dans les scans c\u00e9r\u00e9braux pr\u00e8s des sacs de liquide au centre du cerveau, appel\u00e9s ventricules. Ces l\u00e9sions c\u00e9r\u00e9brales sont appel\u00e9es hyperintensit\u00e9s de la substance blanche p\u00e9riventriculaire. En examinant les scintigraphies c\u00e9r\u00e9brales de plus de 26 000 personnes, les auteurs ont identifi\u00e9 11 r\u00e9gions g\u00e9nomiques associ\u00e9es aux hyperintensit\u00e9s p\u00e9riventriculaires de la substance blanche. La pr\u00e9sence de ces l\u00e9sions \u00e9tait associ\u00e9e \u00e0 un risque accru d’accident vasculaire c\u00e9r\u00e9bral, mais n’\u00e9tait pas associ\u00e9e \u00e0 un risque accru de d\u00e9mence.<\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> Il existe des preuves que les l\u00e9sions de la substance blanche peuvent \u00eatre \u00e9vit\u00e9es en ne fumant pas et en pr\u00e9venant l’hypertension, le diab\u00e8te de type 2 et l’ob\u00e9sit\u00e9. [SOURCE]<\/a><\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> . <\/p>\n\n

\"résultats<\/a><\/figure>\n\n

VARIANTES ASSOCIES AUX L\u00c9SIONS C\u00c9R\u00c9BRALES:<\/strong> rs3744020, rs3758575, rs12928520, rs275350, rs7596872, rs72934583, rs57242328, rs7213273, rs1993484, rs11838776, rs1799983 <\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong>Qu’est-ce que la maladie de la substance blanche? (Vid\u00e9o)<\/a>Maladie de la mati\u00e8re blanche<\/a><\/p>\n\n

VOUS POUVEZ \u00c9GALEMENT \u00caTRE INT\u00c9RESS\u00c9 PAR:<\/strong> AVC (Malik, 2018)<\/a>\u00c9paisseur du cortex c\u00e9r\u00e9bral (Grasby, 2020)<\/a>Volume c\u00e9r\u00e9bral total (Zhao, 2019)<\/a><\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 25 juin 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: Une variation g\u00e9n\u00e9tique commune indique des causes distinctes d’hyperintensit\u00e9s p\u00e9riventriculaire et de mati\u00e8re blanche profonde SOMMAIRE: D\u00e9couverte de 11 r\u00e9gions g\u00e9nomiques associ\u00e9es \u00e0 des hyperintensit\u00e9s de la substance blanche p\u00e9riventriculaire qui indiquent des l\u00e9sions c\u00e9r\u00e9brales. APER\u00c7U: Le …<\/p>\n

L\u00e9sions c\u00e9r\u00e9brales (Armstrong, 2020)<\/span> Lire la suite \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6565,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4984],"tags":[],"class_list":["post-10245","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rapports"],"yoast_head":"\nLa 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