{"id":10260,"date":"2021-01-06T00:12:30","date_gmt":"2021-01-06T05:12:30","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetique-des-tourettes-syndrome-yu-2019\/"},"modified":"2021-02-20T20:42:49","modified_gmt":"2021-02-21T01:42:49","slug":"genetique-des-tourettes-syndrome-yu-2019","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetique-des-tourettes-syndrome-yu-2019\/","title":{"rendered":"Syndrome de Tourette (Yu, 2019)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> Interroger les d\u00e9terminants g\u00e9n\u00e9tiques du syndrome de Gilles de la Tourette et d’autres tics gr\u00e2ce \u00e0 des \u00e9tudes d’association pang\u00e9nomique<\/a><\/p>\n\n

SOMMAIRE:<\/strong> D\u00e9couverte de multiples variantes g\u00e9n\u00e9tiques associ\u00e9es au syndrome de Tourette.<\/p>\n\n

APER\u00c7U:<\/strong> Le syndrome de Tourette est un trouble du syst\u00e8me nerveux caract\u00e9ris\u00e9 par des mouvements incontr\u00f4lables ou des sons appel\u00e9s tics. Elle affecte environ 1 personne sur 150 \u00e0 des degr\u00e9s divers. Le syndrome de Tourette est connu pour \u00eatre hautement h\u00e9r\u00e9ditaire, avec jusqu’\u00e0 80% du risque de maladie h\u00e9r\u00e9ditaire des parents. Cette \u00e9tude d’association \u00e0 l’\u00e9chelle du g\u00e9nome a cherch\u00e9 \u00e0 identifier des variantes g\u00e9n\u00e9tiques associ\u00e9es au syndrome de Tourette en examinant plus de 20 000 individus d’ascendance europ\u00e9enne. L’un des principaux variants est situ\u00e9 dans le g\u00e8ne FLT3, qui code pour une prot\u00e9ine r\u00e9ceptrice dont on pense qu’elle joue un r\u00f4le dans les fonctions du syst\u00e8me immunitaire. Les auteurs rapportent \u00e9galement 9 autres variantes g\u00e9n\u00e9tiques qui sont significativement associ\u00e9es au syndrome de Tourette.<\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> Le syndrome de Tourette est g\u00e9n\u00e9ralement diagnostiqu\u00e9 t\u00f4t dans la vie. Bien qu’il s’agisse d’une maladie chronique, de nombreuses personnes touch\u00e9es \u00e9prouvent un pic de sympt\u00f4mes \u00e0 l’adolescence, suivi d’une am\u00e9lioration progressive jusqu’\u00e0 l’\u00e2ge adulte. [SOURCE]<\/a><\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> . <\/p>\n\n

\"Résultats<\/a><\/figure>\n\n

VARIANTES ASSOCI\u00c9ES \u00c0 LA TOURETTE:<\/strong> rs2504235, rs191044310, rs13407215, rs2708146, rs1906252, rs12459560, rs117648881, rs6670211, rs72853320, rs73205493<\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong>Syndrome de Tourette: qu’est-ce qui fait tiquer les gens? (Vid\u00e9o)<\/a>Qu’est-ce que Tourette?<\/a><\/p>\n\n

VOUS POUVEZ \u00c9GALEMENT \u00caTRE INT\u00c9RESS\u00c9 PAR:<\/strong> Tremblements (M\u00fcller, 2016)<\/a>\u00c9pilepsie (ILAEC, 2014)<\/a><\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 11 juillet 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: Interroger les d\u00e9terminants g\u00e9n\u00e9tiques du syndrome de Gilles de la Tourette et d’autres tics gr\u00e2ce \u00e0 des \u00e9tudes d’association pang\u00e9nomique SOMMAIRE: D\u00e9couverte de multiples variantes g\u00e9n\u00e9tiques associ\u00e9es au syndrome de Tourette. APER\u00c7U: Le syndrome de Tourette est …<\/p>\n

Syndrome de Tourette (Yu, 2019)<\/span> Lire la suite 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