{"id":10277,"date":"2021-01-06T00:21:44","date_gmt":"2021-01-06T05:21:44","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetique-de-longevite-timmers-2020\/"},"modified":"2021-02-20T20:20:55","modified_gmt":"2021-02-21T01:20:55","slug":"genetique-de-longevite-timmers-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetique-de-longevite-timmers-2020\/","title":{"rendered":"Long\u00e9vit\u00e9 (Timmers, 2020)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> L’analyse g\u00e9nomique multivari\u00e9e implique de nouveaux loci et le m\u00e9tabolisme de l’h\u00e8me dans le vieillissement humain<\/a><\/p>\n\n

SOMMAIRE:<\/strong> Identification de 10 variantes g\u00e9n\u00e9tiques associ\u00e9es \u00e0 la long\u00e9vit\u00e9.<\/p>\n\n

APER\u00c7U:<\/strong> La long\u00e9vit\u00e9 est un trait d\u00e9fini comme ayant une dur\u00e9e de vie plus longue que la plupart des gens. Cette \u00e9tude d\u00e9finit sp\u00e9cifiquement la long\u00e9vit\u00e9 comme une vie plus longue que 90% des personnes. Bien que des facteurs tels que l’alimentation et l’acc\u00e8s aux soins de sant\u00e9 influencent la dur\u00e9e de vie d’un individu, la g\u00e9n\u00e9tique joue \u00e9galement un r\u00f4le dans la long\u00e9vit\u00e9. Cette \u00e9tude d’association pang\u00e9nomique a examin\u00e9 plus de 36 000 individus d’ascendance europ\u00e9enne pour d\u00e9terminer les facteurs g\u00e9n\u00e9tiques associ\u00e9s \u00e0 la long\u00e9vit\u00e9. L’\u00e9tude a trouv\u00e9 10 variantes g\u00e9n\u00e9tiques li\u00e9es au trait, mais aussi \u00e0 la dur\u00e9e de vie et \u00e0 la sant\u00e9 des parents. Le variant avec l’association la plus forte (rs429358) est dans le g\u00e8ne APOE et est li\u00e9 \u00e0 la maladie d’Alzheimer. Cette variante \u00e0 elle seule conf\u00e8re environ 1,7 plus de chances de vivre plus longtemps que 90% des personnes.<\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> Les \u00abzones bleues\u00bb sont des endroits dans le monde o\u00f9 les individus ont tendance \u00e0 vivre beaucoup plus longtemps que la moyenne. Okinawa (Japon) et Ikaria (Gr\u00e8ce) sont deux de ces localit\u00e9s, o\u00f9 un pourcentage \u00e9lev\u00e9 d’habitants vivent jusqu’\u00e0 90 ans. Une alimentation riche en plantes et de solides liens familiaux sont des traits communs dans de nombreuses \u00abzones bleues\u00bb. [SOURCE]<\/a><\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> . <\/p>\n\n

\"résultats<\/a><\/figure>\n\n

VARIANTES ASSOCI\u00c9ES \u00c0 LA LONG\u00c9VIT\u00c9:<\/strong> rs429358, rs10455872, rs7859727, rs61905747, rs6511720, rs12830425, rs1159806, rs4783780, rs2643826, rs17499404<\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong><\/a>La science du vieillissement (vid\u00e9o)<\/a>La long\u00e9vit\u00e9 est-elle d\u00e9termin\u00e9e par la g\u00e9n\u00e9tique?<\/a><\/p>\n\n

VOUS POUVEZ \u00c9GALEMENT \u00caTRE INT\u00c9RESS\u00c9 PAR:<\/strong> Long\u00e9vit\u00e9 (Deelen, 2019)<\/a><\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 28 juillet 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: L’analyse g\u00e9nomique multivari\u00e9e implique de nouveaux loci et le m\u00e9tabolisme de l’h\u00e8me dans le vieillissement humain SOMMAIRE: Identification de 10 variantes g\u00e9n\u00e9tiques associ\u00e9es \u00e0 la long\u00e9vit\u00e9. APER\u00c7U: La long\u00e9vit\u00e9 est un trait d\u00e9fini comme ayant une dur\u00e9e …<\/p>\n

Long\u00e9vit\u00e9 (Timmers, 2020)<\/span> Lire la suite \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6665,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4984],"tags":[],"class_list":["post-10277","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rapports"],"yoast_head":"\nLa g\u00e9n\u00e9tique de la long\u00e9vit\u00e9 (Timmers, 2020)<\/title>\n<meta name=\"description\" content=\"T\u00e9l\u00e9chargez vos donn\u00e9es ADN, explorez les variantes g\u00e9n\u00e9tiques li\u00e9es \u00e0 la long\u00e9vit\u00e9 (Timmers, 2020) et d\u00e9couvrez votre score polyg\u00e9nique.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nebula.org\/blog\/fr\/genetique-de-longevite-timmers-2020\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La g\u00e9n\u00e9tique de la long\u00e9vit\u00e9 (Timmers, 2020)\" \/>\n<meta property=\"og:description\" content=\"T\u00e9l\u00e9chargez vos donn\u00e9es ADN, explorez les variantes g\u00e9n\u00e9tiques li\u00e9es \u00e0 la long\u00e9vit\u00e9 (Timmers, 2020) et d\u00e9couvrez votre score polyg\u00e9nique.\" \/>\n<meta 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