{"id":10374,"date":"2021-01-06T00:27:05","date_gmt":"2021-01-06T05:27:05","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetique-de-lacne-navarini-2019\/"},"modified":"2021-02-20T20:35:04","modified_gmt":"2021-02-21T01:35:04","slug":"genetique-de-lacne-navarini-2019","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetique-de-lacne-navarini-2019\/","title":{"rendered":"Acn\u00e9 (Navarini, 2019)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> Une \u00e9tude d’association \u00e0 l’\u00e9chelle du g\u00e9nome identifie trois nouveaux loci de sensibilit\u00e9 \u00e0 l’acn\u00e9 vulgaire s\u00e9v\u00e8re<\/a><\/p>\n\n

SOMMAIRE:<\/strong> Une d\u00e9r\u00e9gulation de la voie de signalisation du TGF\u03b2 peut augmenter la sensibilit\u00e9 \u00e0 l’acn\u00e9.<\/p>\n\n

LA DESCRIPTION:<\/strong> L’acn\u00e9 est une maladie inflammatoire de la peau dans laquelle les follicules pileux sont obstru\u00e9s par de l’huile et des cellules mortes de la peau. Il est h\u00e9r\u00e9ditaire \u00e0 environ 80%. Cette \u00e9tude d’association pang\u00e9nomique a inclus 1 893 patients atteints de cette affection cutan\u00e9e et 5 132 individus en bonne sant\u00e9 du Royaume-Uni. L’\u00e9tude a identifi\u00e9 3 variants g\u00e9n\u00e9tiques li\u00e9s aux g\u00e8nes OVOL1, FST et TGF\u03b22, tous associ\u00e9s \u00e0 la voie de signalisation des cellules TGF\u03b2. La voie de signalisation du TGF\u03b2 (transforming growth factor beta) est impliqu\u00e9e dans de nombreux processus chez les adultes et les embryons. Certains de ces processus comprennent la croissance cellulaire, le maintien de conditions cellulaires normales et l’apoptose (mort cellulaire programm\u00e9e).<\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> En plus des m\u00e9dicaments ou des produits de soin de la peau, vous pouvez aider \u00e0 pr\u00e9venir cette affection cutan\u00e9e en vous lavant le visage deux fois par jour, en gardant vos cheveux propres, en \u00e9vitant de faire sauter ou de cueillir des boutons et en portant un \u00e9cran solaire lorsque vous sortez. [ LA SOURCE<\/a> ]<\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> .<\/p>\n\n

\"Rapport<\/a><\/figure>\n\n

<\/p>\n\n

VARIANTES ASSOCI\u00c9ES \u00c0 L’ACN\u00c9:<\/strong> rs478304, rs38055, rs1159268<\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong>Voie de signalisation TGF\u03b2<\/a>Apoptose<\/a>Pr\u00e9sentation de l’acn\u00e9<\/a>Acn\u00e9 en mouvement<\/a><\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 23 juillet 2019<\/p>\n\n

Jetez \u00e9galement un \u0153il \u00e0 notre Revue de curologie<\/a> !<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: Une \u00e9tude d’association \u00e0 l’\u00e9chelle du g\u00e9nome identifie trois nouveaux loci de sensibilit\u00e9 \u00e0 l’acn\u00e9 vulgaire s\u00e9v\u00e8re SOMMAIRE: Une d\u00e9r\u00e9gulation de la voie de signalisation du TGF\u03b2 peut augmenter la sensibilit\u00e9 \u00e0 l’acn\u00e9. LA DESCRIPTION: L’acn\u00e9 est …<\/p>\n

Acn\u00e9 (Navarini, 2019)<\/span> Lire la suite 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