{"id":10378,"date":"2021-01-06T00:27:09","date_gmt":"2021-01-06T05:27:09","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetique-de-maladie-dalzheimer-wang-2019\/"},"modified":"2021-02-20T20:43:14","modified_gmt":"2021-02-21T01:43:14","slug":"genetique-de-maladie-dalzheimer-wang-2019","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetique-de-maladie-dalzheimer-wang-2019\/","title":{"rendered":"Maladie d’Alzheimer (Wang, 2019)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> Une \u00e9tude d’association \u00e0 l’\u00e9chelle du g\u00e9nome identifie le CD1A associ\u00e9 au taux d’augmentation de la lumi\u00e8re des neurofilaments plasmatiques chez les personnes \u00e2g\u00e9es non d\u00e9mentes<\/a><\/p>\n\n

SOMMAIRE:<\/strong> Les variantes g\u00e9n\u00e9tiques du g\u00e8ne CD1A sont associ\u00e9es \u00e0 une augmentation des prot\u00e9ines NFL dans le sang et \u00e0 un risque plus \u00e9lev\u00e9 de maladie d’Alzheimer.<\/p>\n\n

LA DESCRIPTION:<\/strong> La maladie d’Alzheimer entra\u00eene un d\u00e9clin progressif de la m\u00e9moire et des capacit\u00e9s de r\u00e9flexion en endommageant les cellules nerveuses du cerveau. Les prot\u00e9ines de lumi\u00e8re neurofilamentaire (NFL) sont souvent utilis\u00e9es pour tester la pr\u00e9sence ou la progression de la maladie d’Alzheimer et d’autres troubles neurod\u00e9g\u00e9n\u00e9ratifs. La contribution g\u00e9n\u00e9tique menant \u00e0 une augmentation des taux de NFL dans le sang n’est pas bien comprise. Cette \u00e9tude a examin\u00e9 545 participants blancs non hispaniques afin de trouver des variantes g\u00e9n\u00e9tiques li\u00e9es \u00e0 une augmentation des taux sanguins de NFL et donc, \u00e0 un risque accru de maladie d’Alzheimer. Les variants g\u00e9n\u00e9tiques identifi\u00e9s ont \u00e9t\u00e9 localis\u00e9s dans le g\u00e8ne CD1A – un g\u00e8ne qui joue un r\u00f4le dans le syst\u00e8me immunitaire.<\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> Le contr\u00f4le de l’hypertension art\u00e9rielle ou des taux \u00e9lev\u00e9s de cholest\u00e9rol peut r\u00e9duire votre risque de maladie d’Alzheimer. De plus, \u00eatre physiquement et socialement actif peut aider \u00e0 pr\u00e9venir cette maladie. [ LA SOURCE<\/a> ]<\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> .<\/p>\n\n

\"Exemple<\/a><\/figure>\n\n

<\/p>\n\n

VARIANTES ASSOCI\u00c9ES \u00c0 ALZHEIMER:<\/strong> rs16840041<\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong> Polypeptide l\u00e9ger de neurofilament<\/a>Pr\u00e9sentation de la maladie d’Alzheimer<\/a><\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 26 juillet 2019<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: Une \u00e9tude d’association \u00e0 l’\u00e9chelle du g\u00e9nome identifie le CD1A associ\u00e9 au taux d’augmentation de la lumi\u00e8re des neurofilaments plasmatiques chez les personnes \u00e2g\u00e9es non d\u00e9mentes SOMMAIRE: Les variantes g\u00e9n\u00e9tiques du g\u00e8ne CD1A sont associ\u00e9es \u00e0 une …<\/p>\n

Maladie d’Alzheimer (Wang, 2019)<\/span> Lire la suite 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