{"id":10405,"date":"2021-01-06T00:27:36","date_gmt":"2021-01-06T05:27:36","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetique-de-la-maladie-dalzheimer-seshadri-2010\/"},"modified":"2021-02-20T20:46:21","modified_gmt":"2021-02-21T01:46:21","slug":"genetique-de-la-maladie-dalzheimer-seshadri-2010","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetique-de-la-maladie-dalzheimer-seshadri-2010\/","title":{"rendered":"Maladie d&rsquo;Alzheimer (Seshadri, 2010)"},"content":{"rendered":"\n<p><strong>TITRE DE L&rsquo;\u00c9TUDE:<\/strong><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/185849\"> Analyse \u00e0 l&rsquo;\u00e9chelle du g\u00e9nome des locus g\u00e9n\u00e9tiques associ\u00e9s \u00e0 la maladie d&rsquo;Alzheimer<\/a><\/p>\n\n<p><strong>SOMMAIRE:<\/strong> Identification de nouveaux variants (dont l&rsquo;un \u00e9tait dans le g\u00e8ne BIN1) associ\u00e9s \u00e0 la maladie d&rsquo;Alzheimer.<\/p>\n\n<p><strong>LA DESCRIPTION:<\/strong> La maladie d&rsquo;Alzheimer est un trouble c\u00e9r\u00e9bral progressif qui diminue lentement la m\u00e9moire et les capacit\u00e9s cognitives. C&rsquo;est la forme la plus courante de d\u00e9mence chez les personnes \u00e2g\u00e9es et on sait qu&rsquo;elle est une maladie hautement h\u00e9r\u00e9ditaire. Cette \u00e9tude a identifi\u00e9 de nouvelles variantes g\u00e9n\u00e9tiques et confirm\u00e9 des variantes pr\u00e9c\u00e9demment d\u00e9couvertes associ\u00e9es \u00e0 la maladie d&rsquo;Alzheimer dans une cohorte de plus de 35 000 personnes. L&rsquo;un des nouveaux variants les plus significatifs trouv\u00e9s \u00e9tait pr\u00e8s du g\u00e8ne BIN1, qui joue un r\u00f4le important dans la formation et la r\u00e9gulation de la membrane cellulaire.<\/p>\n\n<p><strong>LE SAVIEZ-VOUS?<\/strong> Bien que vos chances de d\u00e9velopper la maladie d&rsquo;Alzheimer d\u00e9pendent principalement de votre \u00e2ge et de votre g\u00e9n\u00e9tique, des habitudes saines peuvent aider \u00e0 retarder l&rsquo;apparition et la progression de la maladie. L&rsquo;exercice, un r\u00e9gime m\u00e9diterran\u00e9en et le sommeil sont les moyens les plus probables de conjurer la maladie. [<a href=\"https:\/\/www.health.harvard.edu\/alzheimers-and-dementia\/what-can-you-do-to-avoid-alzheimers-disease\"> LA SOURCE<\/a> ]<\/p>\n\n<p><strong>EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur<a href=\"https:\/\/nebula.org\/blog\/fr\/recherche-genetique-deblocage-bibliotheque-nebuleuse\/\"> Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> .<\/p>\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/nebula.org\/free-dna-upload-analysis\/\"><img decoding=\"async\" src=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/01\/Nebula-personalized-results-genomics-1024x375.png\" alt=\"R&#xE9;sultats des &#xE9;chantillons d'Alzheimer.\"\/><\/a><\/figure>\n\n<p><\/p>\n\n<p><strong>ASSOCI\u00c9 \u00c0 ALZHEIMER<\/strong><strong> VARIANTES ANALYS\u00c9ES:<\/strong> rs2075650, rs11136000, rs3851179, rs744373, rs597668<\/p>\n\n<p><strong>RESSOURCES ADDITIONNELLES:<\/strong> <br\/><a rel=\"noreferrer noopener\" href=\"https:\/\/www.alz.org\/alzheimers-dementia\/what-is-alzheimers\" target=\"_blank\">Pr\u00e9sentation de la maladie d&rsquo;Alzheimer<\/a><br\/><a rel=\"noreferrer noopener\" href=\"https:\/\/en.wikipedia.org\/wiki\/Cell_membrane\" target=\"_blank\">Membrane cellulaire<\/a><\/p>\n\n<p><strong>MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 23 juillet 2019<\/p>\n\n<p><\/p>\n\n<p><br\/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>TITRE DE L&rsquo;\u00c9TUDE: Analyse \u00e0 l&rsquo;\u00e9chelle du g\u00e9nome des locus g\u00e9n\u00e9tiques associ\u00e9s \u00e0 la maladie d&rsquo;Alzheimer SOMMAIRE: Identification de nouveaux variants (dont l&rsquo;un \u00e9tait dans le g\u00e8ne BIN1) associ\u00e9s \u00e0 la maladie d&rsquo;Alzheimer. LA DESCRIPTION: La maladie d&rsquo;Alzheimer est un &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"ast-button\" href=\"https:\/\/nebula.org\/blog\/fr\/genetique-de-la-maladie-dalzheimer-seshadri-2010\/\"> <span class=\"screen-reader-text\">Maladie d&rsquo;Alzheimer (Seshadri, 2010)<\/span> Lire la suite \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":5185,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4984],"tags":[],"class_list":["post-10405","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rapports"],"yoast_head":"<!-- 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