{"id":10414,"date":"2021-01-06T00:27:47","date_gmt":"2021-01-06T05:27:47","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetique-de-lobesite-jiao-2011\/"},"modified":"2021-02-20T20:48:13","modified_gmt":"2021-02-21T01:48:13","slug":"genetique-de-lobesite-jiao-2011","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetique-de-lobesite-jiao-2011\/","title":{"rendered":"Ob\u00e9sit\u00e9 (Jiao, 2011)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> Une \u00e9tude d’association \u00e0 l’\u00e9chelle du g\u00e9nome identifie KCNMA1 contribuant \u00e0 l’ob\u00e9sit\u00e9 humaine<\/a><\/p>\n\n

SOMMAIRE:<\/strong> Un risque accru d’ob\u00e9sit\u00e9 est associ\u00e9 \u00e0 des variantes g\u00e9n\u00e9tiques dans les g\u00e8nes KCNMA1 et BDNF.<\/p>\n\n

LA DESCRIPTION:<\/strong> L’ob\u00e9sit\u00e9 est d\u00e9finie comme ayant un exc\u00e8s de graisse corporelle et est le sixi\u00e8me facteur de risque le plus important contribuant \u00e0 toutes les maladies dans le monde. Afin de mieux comprendre la composante h\u00e9r\u00e9ditaire de ce caract\u00e8re, cette \u00e9tude a r\u00e9alis\u00e9 une \u00e9tude \u00e0 l’\u00e9chelle du g\u00e9nome. En examinant 4 838 personnes ob\u00e8ses et 5 827 personnes maigres de Su\u00e8de, cette \u00e9tude a identifi\u00e9 deux nouvelles variantes g\u00e9n\u00e9tiques li\u00e9es \u00e0 un risque accru d’ob\u00e9sit\u00e9. La variante g\u00e9n\u00e9tique la plus importante a \u00e9t\u00e9 localis\u00e9e dans le g\u00e8ne KCNMA1 – qui est impliqu\u00e9 dans la contraction du muscle lisse et dans la signalisation neuronale. L’\u00e9tude a \u00e9galement confirm\u00e9 le lien entre l’ob\u00e9sit\u00e9 et le g\u00e8ne BDNF qui favorise la survie, la croissance et la diff\u00e9renciation des neurones.<\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> Vous pouvez pr\u00e9venir l’ob\u00e9sit\u00e9 \u00e0 toutes les \u00e9tapes de la vie. Plus les b\u00e9b\u00e9s sont allait\u00e9s longtemps, moins ils risquent de devenir en surpoids en vieillissant. Pour les enfants et les adultes, les moyens de pr\u00e9venir cette maladie sont assez similaires: manger des repas \u00e9quilibr\u00e9s et sains, faire de l’exercice r\u00e9guli\u00e8rement (au moins 30 minutes pour les adultes et une heure pour les enfants la plupart des jours de la semaine) et ne pas trop manger. [LA SOURCE<\/a> ]<\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> .<\/p>\n\n

\"Exemple<\/a><\/figure>\n\n

<\/p>\n\n

VARIANTES ASSOCI\u00c9ES \u00c0 L’OB\u00c9SIT\u00c9:<\/strong> rs988712, rs2116830<\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong> Le neurone<\/a>Neuroscience de 2 minutes – Le neurone<\/a> (Vid\u00e9o)<\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 23 juillet 2019<\/p>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: Une \u00e9tude d’association \u00e0 l’\u00e9chelle du g\u00e9nome identifie KCNMA1 contribuant \u00e0 l’ob\u00e9sit\u00e9 humaine SOMMAIRE: Un risque accru d’ob\u00e9sit\u00e9 est associ\u00e9 \u00e0 des variantes g\u00e9n\u00e9tiques dans les g\u00e8nes KCNMA1 et BDNF. LA DESCRIPTION: L’ob\u00e9sit\u00e9 est d\u00e9finie comme ayant …<\/p>\n

Ob\u00e9sit\u00e9 (Jiao, 2011)<\/span> Lire la suite \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":5215,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4984],"tags":[],"class_list":["post-10414","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rapports"],"yoast_head":"\nLa g\u00e9n\u00e9tique de l'ob\u00e9sit\u00e9 (Jia, 2011)<\/title>\n<meta name=\"description\" content=\"L'ob\u00e9sit\u00e9 est d\u00e9finie comme un exc\u00e8s de graisse corporelle. 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