{"id":10685,"date":"2021-01-06T00:33:24","date_gmt":"2021-01-06T05:33:24","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetique-de-colite-ulcereuse-anderson-2011\/"},"modified":"2021-02-20T20:53:19","modified_gmt":"2021-02-21T01:53:19","slug":"genetique-de-colite-ulcereuse-anderson-2011","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetique-de-colite-ulcereuse-anderson-2011\/","title":{"rendered":"Colite ulc\u00e9reuse (Anderson, 2011)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> La m\u00e9ta-analyse identifie 29 loci de risque suppl\u00e9mentaires de colite ulc\u00e9reuse, portant le nombre d’associations confirm\u00e9es \u00e0 47<\/a><\/p>\n\n

SOMMAIRE:<\/strong> Les variantes g\u00e9n\u00e9tiques li\u00e9es \u00e0 l’inflammation et \u00e0 la mort cellulaire programm\u00e9e peuvent affecter le risque de colite ulc\u00e9reuse.<\/p>\n\n

LA DESCRIPTION:<\/strong> La colite ulc\u00e9reuse (CU) est une maladie inflammatoire de l’intestin qui survient lorsque des plaies se d\u00e9veloppent dans le c\u00f4lon en raison d’une inflammation continue. Les sympt\u00f4mes tels que la diarrh\u00e9e, les douleurs abdominales et la fatigue se d\u00e9veloppent g\u00e9n\u00e9ralement avec le temps. La CU est \u00e9galement connue pour \u00eatre h\u00e9r\u00e9ditaire, mais les facteurs g\u00e9n\u00e9tiques sous-jacents ne sont pas bien compris. Cette \u00e9tude a examin\u00e9 plus de 40 000 individus d’ascendance europ\u00e9enne et d\u00e9couvert 29 nouvelles variantes g\u00e9n\u00e9tiques associ\u00e9es \u00e0 la CU. Beaucoup de ces variantes \u00e9taient auparavant li\u00e9es \u00e0 la mort cellulaire programm\u00e9e et au syst\u00e8me immunitaire, en particulier \u00e0 l’inflammation. On estime que les nouvelles variantes expliquent 16% de l’h\u00e9ritabilit\u00e9 de la CU, toutes les variantes significatives expliquant 28% de son h\u00e9ritabilit\u00e9.<\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> Pour r\u00e9duire les sympt\u00f4mes de la colite ulc\u00e9reuse, buvez beaucoup d’eau, limitez les produits laitiers et faites de l’exercice r\u00e9guli\u00e8rement. [ LA SOURCE<\/a> ]<\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> .<\/p>\n\n

\"Rapport<\/a><\/figure>\n\n

VARIANTES ASSOCI\u00c9ES \u00c0 L’UC:<\/strong> rs9268853, rs6426833, rs11209026, rs10758669, rs2836878, rs6871626, rs6584283, rs6017342, rs1801274, rs10781499, rs16940202, rs9822268, rs3024505, rs6920220, rs17085007, rs7134599, rs4510766, rs2155219, rs798502, rs7608910, rs678170, rs7524102, rs7554511, rs1297265, rs2310173, rs941823, rs4246905, rs267939, rs2872507, rs2838519, rs4676406, rs11676348, rs907611, rs2297441, rs943072, rs12261843, rs254560, rs6451493 *, rs514560, rs6451493 *, rs5114560, rs6451493 *, rs7114990<\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong> Colite ulc\u00e9reuse – Sympt\u00f4mes et causes<\/a>Mort cellulaire programm\u00e9e (vid\u00e9o)<\/a><\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 30 ao\u00fbt 2019<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: La m\u00e9ta-analyse identifie 29 loci de risque suppl\u00e9mentaires de colite ulc\u00e9reuse, portant le nombre d’associations confirm\u00e9es \u00e0 47 SOMMAIRE: Les variantes g\u00e9n\u00e9tiques li\u00e9es \u00e0 l’inflammation et \u00e0 la mort cellulaire programm\u00e9e peuvent affecter le risque de colite …<\/p>\n

Colite ulc\u00e9reuse (Anderson, 2011)<\/span> Lire la suite 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