{"id":10687,"date":"2021-01-06T00:33:26","date_gmt":"2021-01-06T05:33:26","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetique-de-colite-ulcereuse-uk-ibd-consortium-genetique-2009\/"},"modified":"2021-02-20T20:38:43","modified_gmt":"2021-02-21T01:38:43","slug":"genetique-de-colite-ulcereuse-uk-ibd-consortium-genetique-2009","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetique-de-colite-ulcereuse-uk-ibd-consortium-genetique-2009\/","title":{"rendered":"Colite ulc\u00e9reuse (UK IBD Genetics Consortium, 2009)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> Une \u00e9tude d’association pang\u00e9nomique de la colite ulc\u00e9reuse identifie trois nouveaux loci de sensibilit\u00e9, dont la r\u00e9gion HNF4A<\/a><\/p>\n\n

SOMMAIRE:<\/strong> Le risque de colite ulc\u00e9reuse peut \u00eatre influenc\u00e9 par des variantes qui jouent un r\u00f4le dans l’adh\u00e9sion cellulaire.<\/p>\n\n

LA DESCRIPTION:<\/strong> La colite ulc\u00e9reuse (CU) survient dans le gros intestin lorsque la muqueuse du c\u00f4lon devient enflamm\u00e9e, formant des ulc\u00e8res (plaies ouvertes). Pour mieux comprendre les facteurs de risque g\u00e9n\u00e9tiques qui peuvent pr\u00e9disposer une personne \u00e0 cette maladie, cette \u00e9tude d’association \u00e0 l’\u00e9chelle du g\u00e9nome a examin\u00e9 15 554 personnes d’origine europ\u00e9enne. L’\u00e9tude a trouv\u00e9 des variantes pr\u00e8s de 3 g\u00e8nes associ\u00e9s. La premi\u00e8re variante \u00e9tait proche du g\u00e8ne HNF4A, qui joue un r\u00f4le dans l’adh\u00e9sion cellulaire. La variante significative suivante, pr\u00e8s du g\u00e8ne LAMB1, aide les cellules \u00e0 rester attach\u00e9es aux parois des intestins. La troisi\u00e8me variante \u00e9tait le g\u00e8ne CDH1 qui \u00e9tait auparavant connu pour jouer un r\u00f4le dans la CU. Comme le g\u00e8ne HNF4A, il aide les cellules \u00e0 adh\u00e9rer les unes aux autres.<\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> Les changements alimentaires, tels que l’augmentation des fibres et la r\u00e9duction des produits laitiers, peuvent aider \u00e0 pr\u00e9venir certains des sympt\u00f4mes de la CU. Boire beaucoup d’eau et manger des repas plus petits et fr\u00e9quents peut \u00e9galement aider \u00e0 g\u00e9rer les sympt\u00f4mes de cette maladie. [ LA SOURCE<\/a> ]<\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> .<\/p>\n\n

\"Rapport<\/a><\/figure>\n\n

<\/p>\n\n

VARIANTES ASSOCI\u00c9ES \u00c0 L’UC:<\/strong> rs6017342, rs1728785, rs886774<\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong> Pr\u00e9sentation de la colite ulc\u00e9reuse<\/a>Adh\u00e9sion cellulaire<\/a><\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 23 juillet 2019<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: Une \u00e9tude d’association pang\u00e9nomique de la colite ulc\u00e9reuse identifie trois nouveaux loci de sensibilit\u00e9, dont la r\u00e9gion HNF4A SOMMAIRE: Le risque de colite ulc\u00e9reuse peut \u00eatre influenc\u00e9 par des variantes qui jouent un r\u00f4le dans l’adh\u00e9sion cellulaire. …<\/p>\n

Colite ulc\u00e9reuse (UK IBD Genetics Consortium, 2009)<\/span> Lire la suite \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":5700,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4984],"tags":[],"class_list":["post-10687","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rapports"],"yoast_head":"\nLa g\u00e9n\u00e9tique de la colite ulc\u00e9reuse (UK IBD Genetics Consortium, 2009)<\/title>\n<meta name=\"description\" content=\"La colite ulc\u00e9reuse survient lorsque la muqueuse du c\u00f4lon devient enflamm\u00e9e. 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