{"id":10781,"date":"2021-01-06T00:35:12","date_gmt":"2021-01-06T05:35:12","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetique-de-alopecie-areata-petukhova-2010\/"},"modified":"2021-02-20T20:41:41","modified_gmt":"2021-02-21T01:41:41","slug":"genetique-de-alopecie-areata-petukhova-2010","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetique-de-alopecie-areata-petukhova-2010\/","title":{"rendered":"Alop\u00e9cie areata (Petukhova, 2010)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> Une \u00e9tude d’association pang\u00e9nomique dans l’alop\u00e9cie areata implique une immunit\u00e9 inn\u00e9e et adaptative<\/a><\/p>\n\n

SOMMAIRE:<\/strong> Identification de 16 r\u00e9gions g\u00e9nomiques associ\u00e9es \u00e0 l’alop\u00e9cie areata, un auto-immune<\/em> maladie qui provoque la perte de cheveux.<\/p>\n\n

APER\u00c7U:<\/strong> L’alop\u00e9cie areata survient lorsque le syst\u00e8me immunitaire attaque follicules pileux<\/em> , entra\u00eenant une perte de cheveux. L’alop\u00e9cie touche plus de 6,8 millions de personnes aux \u00c9tats-Unis. La base g\u00e9n\u00e9tique de la maladie reste largement inconnue. En examinant les g\u00e9nomes de 4 332 individus, cette \u00e9tude a identifi\u00e9 16 variantes g\u00e9n\u00e9tiques ind\u00e9pendantes associ\u00e9es \u00e0 l’alop\u00e9cie. La plupart de ces variantes g\u00e9n\u00e9tiques se trouvent \u00e0 l’int\u00e9rieur ou \u00e0 proximit\u00e9 de g\u00e8nes qui jouent un r\u00f4le dans le syst\u00e8me immunitaire. Fait int\u00e9ressant, cette \u00e9tude impliquait des g\u00e8nes ULBP, qui codent cellule tueuse naturelle<\/em> r\u00e9cepteur<\/em> ligands<\/em> , qui n’ont pas \u00e9t\u00e9 pr\u00e9c\u00e9demment li\u00e9s \u00e0 ceci ou \u00e0 d’autres auto-immune<\/em> maladies. Celles-ci cellule tueuse naturelle<\/em> r\u00e9cepteur<\/em> ligands<\/em> agissent comme des \u00absignaux de danger\u00bb pour le syst\u00e8me immunitaire.<\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> Les options de traitement courantes pour l’alop\u00e9cie areata comprennent les injections de st\u00e9ro\u00efdes ou les irritants topiques. Cependant, r\u00e9cemment, le traitement des patients par Xeljanz, qui est utilis\u00e9 pour traiter la polyarthrite rhumato\u00efde, a connu un succ\u00e8s. De nombreux patients voient la croissance des cheveux apr\u00e8s 2 ou 3 mois. [SOURCE]<\/a><\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> . <\/p>\n\n

\"Résultats<\/a><\/figure>\n\n

<\/p>\n\n

VARIANTES ASSOCI\u00c9ES \u00c0 L’ALOP\u00c9CIE:<\/strong> rs9275572, rs16898264, rs9479482, rs3130320, rs2009345, rs3763312, rs6910071, rs1024161, rs3118470, rs4147359, rs1701704, rs3096851, rs7682241<\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong>Maladies auto-immunes<\/a>Fondation nationale de l’alop\u00e9cie areata<\/a><\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 16 mars 2020<\/p>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: Une \u00e9tude d’association pang\u00e9nomique dans l’alop\u00e9cie areata implique une immunit\u00e9 inn\u00e9e et adaptative SOMMAIRE: Identification de 16 r\u00e9gions g\u00e9nomiques associ\u00e9es \u00e0 l’alop\u00e9cie areata, un auto-immune maladie qui provoque la perte de cheveux. APER\u00c7U: L’alop\u00e9cie areata survient lorsque …<\/p>\n

Alop\u00e9cie areata (Petukhova, 2010)<\/span> Lire la suite \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":5900,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4984],"tags":[],"class_list":["post-10781","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rapports"],"yoast_head":"\nLa 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