{"id":10792,"date":"2021-01-06T00:35:21","date_gmt":"2021-01-06T05:35:21","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetique-of-sars-coronavirus-infection-tu-2015\/"},"modified":"2021-02-20T20:51:57","modified_gmt":"2021-02-21T01:51:57","slug":"genetique-of-sars-coronavirus-infection-tu-2015","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetique-of-sars-coronavirus-infection-tu-2015\/","title":{"rendered":"Infection \u00e0 coronavirus du SRAS (Tu, 2015)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> Polymorphismes fonctionnels du CCL2<\/em> et MBL<\/em> les g\u00e8nes augmentent de mani\u00e8re cumulative la sensibilit\u00e9 \u00e0 l’infection \u00e0 coronavirus du syndrome respiratoire aigu s\u00e9v\u00e8re<\/a><\/p>\n\n

SOMMAIRE:<\/strong> Identification de 2 variantes g\u00e9n\u00e9tiques associ\u00e9es \u00e0 un risque accru de syndrome respiratoire aigu s\u00e9v\u00e8re (SRAS) coronavirus<\/em> infection.<\/p>\n\n

APER\u00c7U:<\/strong> Syndrome respiratoire aigu s\u00e9v\u00e8re (SRAS) coronavirus<\/em> a \u00e9merg\u00e9 en 2003 en Chine. Au cours de cette ann\u00e9e, plus de 8 000 infections dans 26 pays ont \u00e9t\u00e9 signal\u00e9es. Les sympt\u00f4mes du SRAS ressemblent \u00e0 ceux de la grippe et comprennent de la fi\u00e8vre et une toux s\u00e8che. Les cas graves sont courants et entra\u00eenent un taux de mortalit\u00e9 d’environ 10%. Cette \u00e9tude a examin\u00e9 les donn\u00e9es g\u00e9n\u00e9tiques de pr\u00e8s de 1000 personnes d’ascendance chinoise qui ont re\u00e7u un diagnostic de SRAS. L’\u00e9tude a identifi\u00e9 2 variantes associ\u00e9es \u00e0 une sensibilit\u00e9 \u00e0 l’infection par le SRAS coronavirus<\/em> . Une variante est dans le g\u00e8ne CCL2, qui joue un r\u00f4le dans l’attraction macrophages<\/em> \u00e0 un site d’infection. L’autre variante est dans le g\u00e8ne MBL, qui aide le syst\u00e8me immunitaire \u00e0 reconna\u00eetre les mod\u00e8les mol\u00e9culaires que l’on trouve couramment \u00e0 la surface de nombreux virus et bact\u00e9ries. (Remarque: cette \u00e9tude n’est pas une \u00e9tude d’association \u00e0 l’\u00e9chelle du g\u00e9nome. Seules quelques variantes ont \u00e9t\u00e9 g\u00e9notyp\u00e9es de mani\u00e8re s\u00e9lective.)<\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> Le coronavirus du SRAS est apparu \u00e0 la suite d’une transmission d’animal \u00e0 humain. On pense que l’h\u00f4te d’origine \u00e9tait une chauve-souris ou une civette, un animal ressemblant \u00e0 un chat trouv\u00e9 en Asie tropicale. [SOURCE]<\/a><\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> . <\/p>\n\n

\"Exemple<\/a><\/figure>\n\n

<\/p>\n\n

VARIANTES ASSOCI\u00c9ES AU RISQUE D’INFECTION \u00c0 CORONAVIRUS DU SRAS:<\/strong> rs1024611, rs1800450<\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong>Syndrome respiratoire aigu s\u00e9v\u00e8re (SRAS)<\/a>Coronavirus du SRAS (vid\u00e9o)<\/a><\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 23 mars 2020<\/p>\n\n

Pour des mises \u00e0 jour sur la g\u00e9n\u00e9tique du COVID-19, visitez: https:\/\/nebula.org\/blog\/category\/science\/<\/a><\/p>\n\n

Vous pouvez en savoir plus sur tests de coronavirus \u00e0 domicile<\/a> dans notre revue!<\/p>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: Polymorphismes fonctionnels du CCL2 et MBL les g\u00e8nes augmentent de mani\u00e8re cumulative la sensibilit\u00e9 \u00e0 l’infection \u00e0 coronavirus du syndrome respiratoire aigu s\u00e9v\u00e8re SOMMAIRE: Identification de 2 variantes g\u00e9n\u00e9tiques associ\u00e9es \u00e0 un risque accru de syndrome respiratoire …<\/p>\n

Infection \u00e0 coronavirus du SRAS (Tu, 2015)<\/span> Lire la suite 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