{"id":10865,"date":"2021-01-06T00:36:46","date_gmt":"2021-01-06T05:36:46","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetique-de-nephropathie-membraneuse-xie-2020\/"},"modified":"2021-02-20T20:19:46","modified_gmt":"2021-02-21T01:19:46","slug":"genetique-de-nephropathie-membraneuse-xie-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetique-de-nephropathie-membraneuse-xie-2020\/","title":{"rendered":"N\u00e9phropathie membraneuse (Xie, 2020)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> L’architecture g\u00e9n\u00e9tique de la n\u00e9phropathie membraneuse et son potentiel pour am\u00e9liorer le diagnostic non invasif<\/a><\/p>\n\n

SOMMAIRE:<\/strong> Identification de 4 r\u00e9gions g\u00e9nomiques associ\u00e9es \u00e0 la n\u00e9phropathie membraneuse, une auto-immune<\/em> maladie des reins. <\/p>\n\n

APER\u00c7U:<\/strong> Les reins sont des organes qui \u00e9liminent les d\u00e9chets et l’exc\u00e8s d’eau du sang, qui finit par se transformer en urine. La n\u00e9phropathie membraneuse (MN) est un auto-immune<\/em> maladie qui conduit \u00e0 une insuffisance r\u00e9nale. Cette \u00e9tude d’association \u00e0 l’\u00e9chelle du g\u00e9nome a tent\u00e9 d’identifier des variantes g\u00e9n\u00e9tiques associ\u00e9es \u00e0 un risque accru de n\u00e9phropathie membraneuse. En examinant les donn\u00e9es g\u00e9n\u00e9tiques de plus de 12 000 individus d’origine asiatique et europ\u00e9enne, 4 r\u00e9gions du g\u00e9nome \u00e9taient corr\u00e9l\u00e9es \u00e0 un risque accru de MN. Tous les variants identifi\u00e9s sont proches de g\u00e8nes li\u00e9s \u00e0 la fonction du syst\u00e8me immunitaire, soulignant que la n\u00e9phropathie membraneuse est une auto-immune<\/em> maladie. En outre, les variantes ont d\u00e9j\u00e0 \u00e9t\u00e9 li\u00e9es \u00e0 une maladie inflammatoire de l’intestin, un autre auto-immune<\/em> \u00e9tat. <\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> Les traitements de la n\u00e9phropathie membraneuse comprennent des m\u00e9dicaments qui poussent les patients \u00e0 uriner davantage et un r\u00e9gime pauvre en sel. Des m\u00e9dicaments qui aident \u00e0 garder le syst\u00e8me immunitaire sous contr\u00f4le sont \u00e9galement utilis\u00e9s. [SOURCE]<\/a><\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> . <\/p>\n\n

\"résultats<\/a><\/figure>\n\n

VARIANTES ASSOCIES AU MN:<\/strong> rs9271573, rs17831251, rs9405192, rs230540 <\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong>Vos reins et leur fonctionnement<\/a> Neuropathie membraneuse (vid\u00e9o)<\/a><\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 21 avril 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: L’architecture g\u00e9n\u00e9tique de la n\u00e9phropathie membraneuse et son potentiel pour am\u00e9liorer le diagnostic non invasif SOMMAIRE: Identification de 4 r\u00e9gions g\u00e9nomiques associ\u00e9es \u00e0 la n\u00e9phropathie membraneuse, une auto-immune maladie des reins. APER\u00c7U: Les reins sont des organes …<\/p>\n

N\u00e9phropathie membraneuse (Xie, 2020)<\/span> Lire la suite \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6230,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4984],"tags":[],"class_list":["post-10865","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rapports"],"yoast_head":"\nLa 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