{"id":9500,"date":"2021-01-05T23:21:14","date_gmt":"2021-01-06T04:21:14","guid":{"rendered":"https:\/\/nebula.org\/blog\/sars-cov-2-susceptibilite\/"},"modified":"2021-02-20T20:46:04","modified_gmt":"2021-02-21T01:46:04","slug":"sars-cov-2-susceptibilite","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/sars-cov-2-susceptibilite\/","title":{"rendered":"COVID-19 et l’\u00e9pid\u00e9mie de SRAS de 2003"},"content":{"rendered":"\n

Introduction au SRAS<\/strong><\/h2>\n\n

Le coronavirus du syndrome respiratoire aigu s\u00e9v\u00e8re (SRAS-CoV) \u00e9merg\u00e9 en 2003<\/a> en Chine. Une \u00e9pid\u00e9mie a suivi, se propageant dans 26 pays et infectant plus de 8000 personnes avant que le virus ne soit contenu. Les sympt\u00f4mes typiques du SRAS sont similaires \u00e0 ceux de la grippe, notamment la fi\u00e8vre, les maux de t\u00eate et les sensations g\u00e9n\u00e9rales d’inconfort. Les cas graves de la maladie \u00e9taient courants, entra\u00eenant un taux de mortalit\u00e9 de pr\u00e8s de 10%. En raison de la gravit\u00e9 des sympt\u00f4mes, il \u00e9tait possible<\/a> pour identifier les personnes infect\u00e9es par le SRAS-CoV et les isoler. Mesures de sant\u00e9 publique comme distanciation sociale<\/a> ont r\u00e9ussi \u00e0 contenir l’\u00e9pid\u00e9mie. <\/p>\n\n

SRAS et pand\u00e9mie COVID-19<\/strong><\/h2>\n\n

La situation est diff\u00e9rente avec aujourd’hui Pand\u00e9mie de covid-19<\/a> . Ce nouveau coronavirus (SRAS-CoV-2) peut infecter des personnes qui restent alors largement asymptomatique<\/a> . Cela rend beaucoup plus difficile d’identifier et de contenir les personnes infect\u00e9es qui continuent de propager la maladie. Bien que le taux de mortalit\u00e9 du COVID-19 soit estim\u00e9<\/a> pour \u00eatre de 5 \u00e0 10 fois inf\u00e9rieur au SRAS, le nombre total de d\u00e9c\u00e8s a d\u00e9j\u00e0 d\u00e9pass\u00e9 l’\u00e9pid\u00e9mie de SRAS en raison de l’incapacit\u00e9 de contenir la pand\u00e9mie. <\/p>\n\n

Cependant, le SRAS-CoV et le SRAS-CoV-2 partagent \u00e9galement de nombreux similitudes<\/a> . Les deux virus sont originaires de chauves-souris et partagent 80% de leur code g\u00e9n\u00e9tique. De plus, les deux virus infectent le voies respiratoires utilisant le m\u00eame m\u00e9canisme<\/a> , et ils provoquent des sympt\u00f4mes similaires. <\/p>\n\n

Tandis que notre compr\u00e9hension du COVID-19<\/a> fait encore d\u00e9faut, de nombreuses recherches sur le SRAS ont \u00e9t\u00e9 r\u00e9alis\u00e9es dans les ann\u00e9es qui ont suivi 2003. Les chercheurs ont identifi\u00e9 des variantes g\u00e9n\u00e9tiques associ\u00e9es \u00e0 la susceptibilit\u00e9 \u00e0 l’infection par le SRAS-CoV. La question reste ouverte de savoir si les m\u00eames variantes g\u00e9n\u00e9tiques sont \u00e9galement associ\u00e9es \u00e0 une sensibilit\u00e9 \u00e0 l’infection par le SRAS-CoV-2 \u00e9tant donn\u00e9 les similitudes entre les deux coronavirus. <\/p>\n\n

Pour informer nos utilisateurs des recherches ant\u00e9rieures sur les coronavirus, nous avons ajout\u00e9 3 \u00e9tudes sur l’infection par le coronavirus du SRAS \u00e0 la Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> . Ces \u00e9tudes nous permettent de comprendre les liens entre la g\u00e9n\u00e9tique humaine et l’infection \u00e0 coronavirus.<\/p>\n\n

\"Cas
Le nombre de cas de COVID-19 a d\u00e9pass\u00e9 le nombre de cas de SRAS au d\u00e9but de f\u00e9vrier 2020. La source: statista \/ CDC<\/a> .<\/figcaption><\/figure>\n\n

<\/p>\n\n

Entr\u00e9es de la biblioth\u00e8que Nebula sur le SRAS<\/strong><\/h2>\n\n

Infection \u00e0 coronavirus du SRAS (Hamano, 2005)<\/h4>\n\n

Cette \u00e9tude a explor\u00e9 les donn\u00e9es g\u00e9n\u00e9tiques d’individus vietnamiens et identifi\u00e9 une variante g\u00e9n\u00e9tique dans le OEA-1<\/em> g\u00e8ne associ\u00e9 \u00e0 la susceptibilit\u00e9 \u00e0 l’infection par le coronavirus du SRAS.<\/p>\n\n

Infection \u00e0 coronavirus du SRAS (Ching, 2010)<\/h4>\n\n

Cette \u00e9tude a utilis\u00e9 des donn\u00e9es g\u00e9n\u00e9tiques d’individus chinois pour d\u00e9montrer qu’une variante g\u00e9n\u00e9tique est li\u00e9e \u00e0 une diminution de la sensibilit\u00e9 \u00e0 l’infection par le coronavirus du SRAS. Cette variante se trouve pr\u00e8s du MxA<\/em> g\u00e8ne, qui joue normalement un r\u00f4le dans l’inhibition de la r\u00e9plication des coronavirus du SRAS.<\/p>\n\n

Infection \u00e0 coronavirus du SRAS (Tu, 2015)<\/h4>\n\n

Cette \u00e9tude a examin\u00e9 les donn\u00e9es g\u00e9n\u00e9tiques des patients chinois atteints du SRAS pour identifier des variantes dans 2 g\u00e8nes qui conduisent \u00e0 un risque accru d’infection. Une variante est dans le CCL2<\/em> g\u00e8ne, qui joue un r\u00f4le dans l’attraction des macrophages vers un site d’infection. L’autre variante est dans le MBL<\/em> g\u00e8ne, qui aide le syst\u00e8me immunitaire \u00e0 reconna\u00eetre les sch\u00e9mas mol\u00e9culaires que l’on trouve couramment \u00e0 la surface de nombreux virus et bact\u00e9ries.<\/p>\n\n

Nouvelle recherche COVID-19<\/strong><\/h2>\n\n

D’ici peu, des \u00e9tudes sur la sensibilit\u00e9 au SRAS-CoV-2 et le r\u00f4le de la g\u00e9n\u00e9tique seront publi\u00e9es. Ici, \u00e0 Nebula, nous surveillons les recherches sur COVID-19 et fournirons \u00e0 nos utilisateurs des mises \u00e0 jour en temps opportun. Vous pouvez rester \u00e0 jour avec les derni\u00e8res d\u00e9couvertes de recherche en achetant notre s\u00e9quen\u00e7age du g\u00e9nome entier<\/a> ou t\u00e9l\u00e9charger votre existant Donn\u00e9es 23andMe ou AncestryDNA<\/a> .<\/p>\n\n

Pour des mises \u00e0 jour sur la g\u00e9n\u00e9tique du COVID-19, visitez: https:\/\/nebula.org\/blog\/category\/science\/<\/a><\/p>\n\n

Vous pouvez \u00e9galement en savoir plus sur les tests de coronavirus dans cet article de blog.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Introduction au SRAS Le coronavirus du syndrome respiratoire aigu s\u00e9v\u00e8re (SRAS-CoV) \u00e9merg\u00e9 en 2003 en Chine. Une \u00e9pid\u00e9mie a suivi, se propageant dans 26 pays et infectant plus de 8000 personnes avant que le virus ne soit contenu. Les sympt\u00f4mes …<\/p>\n

COVID-19 et l’\u00e9pid\u00e9mie de SRAS de 2003<\/span> Lire la suite \u00bb<\/a><\/p>\n","protected":false},"author":11,"featured_media":5940,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4976],"tags":[],"class_list":["post-9500","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science-fr"],"yoast_head":"\nSensibilit\u00e9 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