{"id":9610,"date":"2021-01-05T23:23:50","date_gmt":"2021-01-06T04:23:50","guid":{"rendered":"https:\/\/nebula.org\/blog\/population-genomique\/"},"modified":"2021-02-20T20:48:13","modified_gmt":"2021-02-21T01:48:13","slug":"population-genomique","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/population-genomique\/","title":{"rendered":"De un \u00e0 des millions – l’\u00e8re de la g\u00e9nomique des populations"},"content":{"rendered":"\n

Il y a plus de 15 ans, le Projet du g\u00e9nome humain<\/a> produit un seul g\u00e9nome humain pour un co\u00fbt de plus de 3 milliards de dollars. Depuis, des co\u00fbts en baisse exponentielle ont permis aux chercheurs de s\u00e9quencer les g\u00e9nomes de centaines de milliers de personnes. Aujourd’hui, les gouvernements nationaux du monde entier lancent des projets de g\u00e9nomique des populations \u00e0 grande \u00e9chelle pour obtenir des informations susceptibles de contribuer \u00e0 am\u00e9liorer les soins de sant\u00e9. <\/p>\n\n

Aux \u00c9tats-Unis, le National Institute of Health Programme de recherche All Of Us<\/a> recueille des donn\u00e9es sur au moins un million d’Am\u00e9ricains afin de cr\u00e9er une base de donn\u00e9es unique pour la m\u00e9decine de pr\u00e9cision et la recherche en g\u00e9nomique. De l’autre c\u00f4t\u00e9 de l’\u00e9tang, le UK BioBank<\/a> a recrut\u00e9 500 000 personnes pour \u00e9tudier des maladies graves combinant dossiers m\u00e9dicaux, donn\u00e9es d’imagerie et g\u00e9n\u00e9tique.<\/p>\n\n

Douzaine de autres exemples<\/a> existent \u00e0 diff\u00e9rentes \u00e9chelles, y compris en Finlande \u00c9tude FinnGen<\/a> , le GenomeAsia 100K consortium<\/a> qui se concentre sur la m\u00e9decine de pr\u00e9cision dans la population asiatique, et le Mission Genomics Health Futures<\/a> investissement dans la recherche australienne en g\u00e9nomique. <\/p>\n\n

D\u00e9passer les attentes <\/h2>\n\n

La valeur de ces initiatives s’av\u00e8re extraordinaire. Les chercheurs ont d\u00e9j\u00e0 fait beaucoup en utilisant la UK Biobank – le nombre de publications scientifiques utilisant la ressource augmente rapidement d’ann\u00e9e en ann\u00e9e (figure 1).<\/p>\n\n

\"\"
Figure 1. Le nombre de publications par an ayant utilis\u00e9 la ressource UK Biobank en juin 2019. <\/figcaption><\/figure>\n\n

Par exemple, plus t\u00f4t cette ann\u00e9e, des chercheurs utilisant des donn\u00e9es de la biobanque britannique ont d\u00e9montr\u00e9 une association entre un mode de vie sain et un risque plus faible de d\u00e9mence<\/a> – un aper\u00e7u qui pourrait \u00eatre utilis\u00e9 pour lutter contre l’incidence croissante de la d\u00e9mence dans notre soci\u00e9t\u00e9 vieillissante.<\/p>\n\n

Avec la myriade de projets de g\u00e9nomique et de s\u00e9quen\u00e7age des populations en cours dans le monde entier, la biobanque britannique n’est que la pointe de l’iceberg. La diminution des co\u00fbts et l’am\u00e9lioration de la technologie stimulent la recherche en g\u00e9nomique, permettant une meilleure compr\u00e9hension des maladies et permettant de plus en plus la pr\u00e9vention.<\/p>\n\n

Le meilleur des deux mondes <\/h2>\n\n

La ventilation ci-dessus ne consid\u00e8re na\u00efvement que les initiatives gouvernementales – des soci\u00e9t\u00e9s de tests g\u00e9n\u00e9tiques directement aux consommateurs 23andMe<\/a> et AncestryDNA<\/a> avoir des bases de donn\u00e9es beaucoup plus volumineuses que tout projet de recherche existant Et au moment de la r\u00e9daction de cet article, ces chiffres sont stup\u00e9fiants – AncestryDNA r\u00e9clamations<\/a> faire tester l’ADN de plus de 15 millions de personnes, tandis que 23andMe cite<\/a> plus de 10 millions de clients.<\/p>\n\n

Les projets gouvernementaux entra\u00eenent des d\u00e9penses importantes – des op\u00e9rations administratives compliqu\u00e9es, des processus co\u00fbteux et une inefficacit\u00e9 g\u00e9n\u00e9rale. Les tests g\u00e9n\u00e9tiques directs aux consommateurs r\u00e9duisent en grande partie ce probl\u00e8me en fournissant un acc\u00e8s facile et abordable aux technologies de tests g\u00e9n\u00e9tiques qui permettent une croissance rapide des bases de donn\u00e9es d’informations g\u00e9n\u00e9tiques. <\/p>\n\n

Chez Nebula Genomics, nous cherchons \u00e0 combiner les meilleurs aspects des initiatives de g\u00e9nomique de population parrain\u00e9es par le gouvernement avec les avantages des tests g\u00e9n\u00e9tiques destin\u00e9s directement aux consommateurs. Contrairement \u00e0 la plupart des soci\u00e9t\u00e9s de g\u00e9nomique personnelles, nous ne cherchons pas \u00e0 mon\u00e9tiser les donn\u00e9es de nos clients. Au lieu, nous sommes hyper concentr\u00e9s sur la protection de la vie priv\u00e9e<\/a> de leurs informations g\u00e9n\u00e9tiques et leur permettant de contr\u00f4ler la mani\u00e8re dont leurs donn\u00e9es sont partag\u00e9es avec les chercheurs. Comme la plupart des projets de g\u00e9nomique des populations, nous utilisons technologie de s\u00e9quen\u00e7age d’ADN de nouvelle g\u00e9n\u00e9ration<\/a> qui g\u00e9n\u00e8re des ordres de grandeur plus de donn\u00e9es que les technologies utilis\u00e9es par la plupart des soci\u00e9t\u00e9s de tests g\u00e9n\u00e9tiques destin\u00e9s directement aux consommateurs. Combinez cela avec l’efficacit\u00e9 d’une start-up, et le r\u00e9sultat est une base de donn\u00e9es g\u00e9nomique qui \u00e9tablit un \u00e9quilibre id\u00e9al entre des projets \u00e0 but non lucratif financ\u00e9s par le gouvernement et une base de donn\u00e9es g\u00e9nomique commerciale qui se d\u00e9veloppe \u00e0 un rythme effr\u00e9n\u00e9. <\/p>\n\n

Les consommateurs d’abord, les chercheurs ensuite <\/h2>\n\n

Notre objectif est de cr\u00e9er une ressource pour les chercheurs qui peut contribuer \u00e0 faire progresser la m\u00e9decine. Cependant, pour nous, il est encore plus important de permettre \u00e0 nos utilisateurs de b\u00e9n\u00e9ficier de la g\u00e9nomique personnelle. Nebula est l\u00e0 pour vous aider \u00e0 comprendre votre g\u00e9nome. Nous donnons \u00e0 nos utilisateurs l’acc\u00e8s aux derni\u00e8res technologies de test g\u00e9n\u00e9tique et d\u00e9couvertes g\u00e9n\u00e9tiques de pointe<\/a> tout en garantissant l’abordabilit\u00e9 et l’intimit\u00e9. Vous pouvez t\u00e9l\u00e9charger votre fichiers 23andMe ou AncestryDNA existants<\/a> aujourd’hui, ou commandez notre s\u00e9quen\u00e7age du g\u00e9nome entier<\/a> et commencez \u00e0 explorer vos propres plans. <\/p>\n","protected":false},"excerpt":{"rendered":"

Il y a plus de 15 ans, le Projet du g\u00e9nome humain produit un seul g\u00e9nome humain pour un co\u00fbt de plus de 3 milliards de dollars. Depuis, des co\u00fbts en baisse exponentielle ont permis aux chercheurs de s\u00e9quencer les …<\/p>\n

De un \u00e0 des millions – l’\u00e8re de la g\u00e9nomique des populations<\/span> Lire la suite \u00bb<\/a><\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4976],"tags":[],"class_list":["post-9610","post","type-post","status-publish","format-standard","hentry","category-science-fr"],"yoast_head":"\nDe un \u00e0 des millions - 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