{"id":9698,"date":"2021-01-05T23:57:42","date_gmt":"2021-01-06T04:57:42","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetique-de-consommation-dalcool-evangelou-2019\/"},"modified":"2021-02-20T20:51:28","modified_gmt":"2021-02-21T01:51:28","slug":"genetique-de-consommation-dalcool-evangelou-2019","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetique-de-consommation-dalcool-evangelou-2019\/","title":{"rendered":"Consommation d’alcool (Evangelou, 2019)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> De nouveaux g\u00e8nes li\u00e9s \u00e0 l’alcool sugg\u00e8rent des m\u00e9canismes g\u00e9n\u00e9tiques partag\u00e9s avec les troubles neuropsychiatriques<\/a><\/p>\n\n

SOMMAIRE:<\/strong> D\u00e9couverte de 46 nouveaux loci associ\u00e9s \u00e0 la consommation d’alcool et liens avec des troubles neuropsychiatriques comme la schizophr\u00e9nie.<\/p>\n\n

LA DESCRIPTION:<\/strong> La consommation excessive d’alcool est l’une des principales causes de d\u00e9c\u00e8s et d’incapacit\u00e9 dans le monde avec un taux de mortalit\u00e9 allant jusqu’\u00e0 2,2% et 6,8% pour les femmes et les hommes, respectivement. C’est un trait complexe h\u00e9r\u00e9ditaire, mais seuls quelques variants g\u00e9n\u00e9tiques associ\u00e9s ont \u00e9t\u00e9 identifi\u00e9s \u00e0 ce jour. Cette association \u00e0 l’\u00e9chelle du g\u00e9nome a examin\u00e9 480 842 individus d’ascendance europ\u00e9enne et d\u00e9couvert 46 nouvelles variantes g\u00e9n\u00e9tiques associ\u00e9es \u00e0 la consommation d’alcool. L’\u00e9tude a \u00e9galement estim\u00e9 que ces variantes expliquent environ 9% de l’h\u00e9ritabilit\u00e9 de la consommation d’alcool. En outre, il a \u00e9t\u00e9 d\u00e9montr\u00e9 que de multiples variantes affectent l’activit\u00e9 des g\u00e8nes dans le cerveau et beaucoup ont \u00e9t\u00e9 pr\u00e9c\u00e9demment associ\u00e9es \u00e0 des conditions neuropsychiatriques telles que la schizophr\u00e9nie, la maladie de Parkinson et la d\u00e9mence. L’\u00e9tude arrive \u00e0 la conclusion que la consommation d’alcool et les troubles neuropsychiatriques partagent un m\u00e9canisme g\u00e9n\u00e9tique.<\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> Vous pourrez peut-\u00eatre r\u00e9duire votre consommation d’alcool en vous fixant une limite de consommation stricte, en ne gardant pas d’alcool l\u00e0 o\u00f9 vous vivez, en vous occupant et en demandant de l’aide. [ LA SOURCE<\/a> ]<\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> .<\/p>\n\n

\"Exemple<\/a><\/figure>\n\n

<\/p>\n\n

VARIANTES LI\u00c9ES \u00c0 LA CONSOMMATION D’ALCOOL: <\/strong>rs145452708, rs11940694, rs1260326, rs1991556, rs9841829, rs1004787, rs13107325, rs838145, rs1104608, rs2071305, rs7121986, rs6969458, rs74424378, rs13024996, rs34060476, rs61873510, rs1421085, rs11648570, rs2277499, rs2310752, rs112635299, rs780569, rs10496076, rs71414193, rs16854020, rs485425, rs113443718, rs57281063, rs72768626, rs227179, rs9320010, rs2726034, rs13390019, rs7517344, rs4916723, rs10249167, rs7640, rs4794015, rs1053651, rs7698119, rs12312693, rs7958704, rs11114787, rs2356369, rs12031875, rs12646808, rs10078588, rs748919, rs785293, rs988748<\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong> Examen de la consommation d’alcool en hausse<\/a>Les raisons les plus courantes de l’alcoolisme<\/a><\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 9 ao\u00fbt 2019<\/p>\n\n

<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: De nouveaux g\u00e8nes li\u00e9s \u00e0 l’alcool sugg\u00e8rent des m\u00e9canismes g\u00e9n\u00e9tiques partag\u00e9s avec les troubles neuropsychiatriques SOMMAIRE: D\u00e9couverte de 46 nouveaux loci associ\u00e9s \u00e0 la consommation d’alcool et liens avec des troubles neuropsychiatriques comme la schizophr\u00e9nie. LA DESCRIPTION: …<\/p>\n

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