{"id":9879,"date":"2021-01-06T00:02:29","date_gmt":"2021-01-06T05:02:29","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetique-de-mosaique-perte-de-chromosome-y-terao-2019\/"},"modified":"2021-02-20T20:42:00","modified_gmt":"2021-02-21T01:42:00","slug":"genetique-de-mosaique-perte-de-chromosome-y-terao-2019","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetique-de-mosaique-perte-de-chromosome-y-terao-2019\/","title":{"rendered":"Perte de mosa\u00efque du chromosome Y (Terao, 2019)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> Le GWAS de la perte de mosa\u00efque du chromosome Y met en \u00e9vidence les effets g\u00e9n\u00e9tiques sur la diff\u00e9renciation des cellules sanguines<\/a><\/p>\n\n

SOMMAIRE:<\/strong> Identification de 46 variantes g\u00e9n\u00e9tiques associ\u00e9es \u00e0 la perte en mosa\u00efque du chromosome Y (mLOY).<\/p>\n\n

LA DESCRIPTION:<\/strong> Les cellules du corps humain stockent des informations g\u00e9n\u00e9tiques dans 23 paires de chromosomes. mLOY est une affection sp\u00e9cifique \u00e0 l’homme caract\u00e9ris\u00e9e par la perte du chromosome Y par certaines cellules. mLOY a \u00e9t\u00e9 li\u00e9 \u00e0 diverses conditions m\u00e9dicales, y compris le cancer, et est le plus souvent observ\u00e9 dans les globules blancs des hommes vieillissants. Cette \u00e9tude d’association \u00e0 l’\u00e9chelle du g\u00e9nome a analys\u00e9 les donn\u00e9es g\u00e9n\u00e9tiques de 95 380 hommes japonais pour mieux comprendre les facteurs g\u00e9n\u00e9tiques qui contribuent \u00e0 cette condition. L’\u00e9tude a d\u00e9couvert 46 variantes g\u00e9n\u00e9tiques dont 35 sont nouvelles, et collectivement ces variantes expliquent environ 9% de l’h\u00e9ritabilit\u00e9 de mLOY. Bon nombre des variantes g\u00e9n\u00e9tiques identifi\u00e9es sont proches de g\u00e8nes actifs dans les cellules souches sanguines.<\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> Des \u00e9tudes ont montr\u00e9 que le tabagisme peut augmenter consid\u00e9rablement le risque de perte de mosa\u00efque du chromosome Y. Il y a de bonnes nouvelles pour les fumeurs qui cherchent \u00e0 arr\u00eater – la m\u00eame recherche a montr\u00e9 que les fumeurs pr\u00e9c\u00e9dents n’\u00e9taient pas plus susceptibles d’avoir une perte de chromosome Y que les non-fumeurs. [ LA SOURCE<\/a> ]<\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> .<\/p>\n\n

\"Exemple<\/a><\/figure>\n\n

VARIANTES MULTI-ASSOCI\u00c9ES:<\/strong> rs56116444, rs80277818, rs2842873, rs72698721, rs59543286, rs4709819, rs227079, rs4721217, rs2237896, rs78997619, rs55727837, rs34324, rs11769630, rs4681200, rs4683900, rs10849448, rs728739, rs871134, rs35355140, rs138423884, rs34468831, rs10948011, rs9921295, rs17049722, rs11251, rs77406149, rs2646425, rs2811487, rs1859259, rs12668837, rs34778241, rs2853677, rs9299129, rs527504, rs77874075, rs10692222, rs548509555, rs117587217, rs201753350, rs12225799, rs79058858, rs74843651, rs189309686, rs2804301, rs2979469<\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong> Chromosomes sexuels<\/a>Cellule souche h\u00e9matopo\u00ef\u00e9tique<\/a><\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 24 octobre 2019<\/p>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: Le GWAS de la perte de mosa\u00efque du chromosome Y met en \u00e9vidence les effets g\u00e9n\u00e9tiques sur la diff\u00e9renciation des cellules sanguines SOMMAIRE: Identification de 46 variantes g\u00e9n\u00e9tiques associ\u00e9es \u00e0 la perte en mosa\u00efque du chromosome Y …<\/p>\n

Perte de mosa\u00efque du chromosome Y (Terao, 2019)<\/span> Lire la suite \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":5750,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4984],"tags":[],"class_list":["post-9879","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rapports"],"yoast_head":"\nLa 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