{"id":9901,"date":"2021-01-06T00:02:46","date_gmt":"2021-01-06T05:02:46","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetique-du-glaucome-macgregor-2018\/"},"modified":"2021-02-20T20:40:28","modified_gmt":"2021-02-21T01:40:28","slug":"genetique-du-glaucome-macgregor-2018","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetique-du-glaucome-macgregor-2018\/","title":{"rendered":"Glaucome (MacGregor, 2018)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> Une \u00e9tude d’association pang\u00e9nomique de la pression intraoculaire r\u00e9v\u00e8le de nouvelles voies vers le glaucome<\/a><\/p>\n\n

SOMMAIRE:<\/strong> Identification de plus de 24 variantes g\u00e9n\u00e9tiques en corr\u00e9lation avec le d\u00e9veloppement du glaucome.<\/p>\n\n

LA DESCRIPTION:<\/strong> Le glaucome est l’une des principales causes de c\u00e9cit\u00e9 chez les personnes \u00e2g\u00e9es, bien qu’il puisse survenir \u00e0 tout \u00e2ge. Il se d\u00e9veloppe lorsque le nerf optique qui relie l’\u0153il au cerveau est endommag\u00e9, souvent en raison d’une pression accrue dans l’\u0153il. Une m\u00e9thode pour arr\u00eater la progression du glaucome consiste \u00e0 diminuer cette pression. Cette \u00e9tude d’association \u00e0 l’\u00e9chelle du g\u00e9nome de plus de 130 000 participants d’origine europ\u00e9enne a identifi\u00e9 24 variantes g\u00e9n\u00e9tiques associ\u00e9es \u00e0 une augmentation de la pression intraoculaire et au risque de d\u00e9velopper cette maladie. Deux des variantes sont situ\u00e9es \u00e0 proximit\u00e9 de g\u00e8nes qui jouent un r\u00f4le dans le d\u00e9veloppement et la fonction du nerf optique (CDKN2B et SIX6).<\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> Bien que les dommages caus\u00e9s par cette maladie ne puissent \u00eatre invers\u00e9s, une d\u00e9tection pr\u00e9coce peut aider \u00e0 ralentir la progression de la perte de vision. Des examens oculaires r\u00e9guliers peuvent d\u00e9tecter une augmentation de la pression intraoculaire avant que la vision ne devienne alt\u00e9r\u00e9e. [ LA SOURCE<\/a> ]<\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> .<\/p>\n\n

\"Exemple<\/a><\/figure>\n\n

VARIANTES ASSOCIES AU GLAUCOME:<\/strong> rs7518099, rs944801, rs2472493, rs2093210, rs9913911, rs28795989, rs945686, rs2745572, rs9284802, rs58073046, rs12699251, rs10505100, rs2024211, rs9853115, rs61394862, rs2935057, rs2073006, rs61861119, rs8141433, rs4141671, rs73174345, rs1013278, rs7924522, rs11710139<\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong> Pression intraoculaire (oculaire)<\/a><\/a>Quelle est cette maladie?<\/a><\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 24 octobre 2019<\/p>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: Une \u00e9tude d’association pang\u00e9nomique de la pression intraoculaire r\u00e9v\u00e8le de nouvelles voies vers le glaucome SOMMAIRE: Identification de plus de 24 variantes g\u00e9n\u00e9tiques en corr\u00e9lation avec le d\u00e9veloppement du glaucome. LA DESCRIPTION: Le glaucome est l’une des …<\/p>\n

Glaucome (MacGregor, 2018)<\/span> Lire la suite 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