{"id":9962,"date":"2021-01-06T00:03:36","date_gmt":"2021-01-06T05:03:36","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetique-de-anemie-aplasique-sauvage-2020\/"},"modified":"2021-02-20T20:51:20","modified_gmt":"2021-02-21T01:51:20","slug":"genetique-de-anemie-aplasique-sauvage-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetique-de-anemie-aplasique-sauvage-2020\/","title":{"rendered":"An\u00e9mie aplasique (Savage, 2020)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> Une \u00e9tude d’association \u00e0 l’\u00e9chelle du g\u00e9nome identifie HLA-DPB1 comme un facteur de risque important d’an\u00e9mie aplasique s\u00e9v\u00e8re<\/a><\/p>\n\n

SOMMAIRE:<\/strong> Identification de 2 r\u00e9gions g\u00e9nomiques associ\u00e9es \u00e0 un risque d’an\u00e9mie aplasique s\u00e9v\u00e8re.<\/p>\n\n

APER\u00c7U:<\/strong> L’an\u00e9mie aplasique (AA) est une maladie auto-immune dans laquelle la moelle osseuse ne produit pas suffisamment de cellules sanguines. Dans les cas graves, l’AA peut mettre la vie en danger. Cette \u00e9tude d’association \u00e0 l’\u00e9chelle du g\u00e9nome visait \u00e0 identifier les variantes associ\u00e9es au risque d’an\u00e9mie aplasique s\u00e9v\u00e8re en examinant les informations g\u00e9n\u00e9tiques de pr\u00e8s de 3 000 personnes d’origine europ\u00e9enne. Les r\u00e9sultats ont indiqu\u00e9 2 r\u00e9gions g\u00e9n\u00e9tiques li\u00e9es au risque d’AA s\u00e9v\u00e8re. Les deux r\u00e9gions g\u00e9n\u00e9tiques codent pour des prot\u00e9ines du syst\u00e8me antig\u00e8ne leucocytaire humain (HLA) qui joue un r\u00f4le dans la r\u00e9gulation du syst\u00e8me immunitaire.<\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> L’exposition \u00e0 des produits chimiques toxiques comme les pesticides et les insecticides peut augmenter le risque d’an\u00e9mie aplasique. La condition peut \u00e9galement \u00eatre un effet secondaire temporaire de la radioth\u00e9rapie et de la chimioth\u00e9rapie utilis\u00e9e pour le traitement du cancer. [SOURCE]<\/a><\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> . <\/p>\n\n

\"résultats<\/a><\/figure>\n\n

<\/p>\n\n

VARIANTES ANALYS\u00c9ES:<\/strong> rs1042151, rs28367832<\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong>An\u00e9mie aplastique<\/a>An\u00e9mie aplasique (vid\u00e9o)<\/a><\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 15 f\u00e9vrier 2020<\/p>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: Une \u00e9tude d’association \u00e0 l’\u00e9chelle du g\u00e9nome identifie HLA-DPB1 comme un facteur de risque important d’an\u00e9mie aplasique s\u00e9v\u00e8re SOMMAIRE: Identification de 2 r\u00e9gions g\u00e9nomiques associ\u00e9es \u00e0 un risque d’an\u00e9mie aplasique s\u00e9v\u00e8re. APER\u00c7U: L’an\u00e9mie aplasique (AA) est une …<\/p>\n

An\u00e9mie aplasique (Savage, 2020)<\/span> Lire la suite \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":5795,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4984],"tags":[],"class_list":["post-9962","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rapports"],"yoast_head":"\nLa 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