{"id":9984,"date":"2021-01-06T00:03:53","date_gmt":"2021-01-06T05:03:53","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetique-de-telomere-longueur-codd-2013\/"},"modified":"2021-02-20T20:54:37","modified_gmt":"2021-02-21T01:54:37","slug":"genetique-de-telomere-longueur-codd-2013","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/fr\/genetique-de-telomere-longueur-codd-2013\/","title":{"rendered":"Longueur des t\u00e9lom\u00e8res (Codd, 2013)"},"content":{"rendered":"\n

TITRE DE L’\u00c9TUDE:<\/strong> Identification de sept loci affectant la longueur moyenne des t\u00e9lom\u00e8res et leur association avec la maladie<\/a><\/p>\n\n

SOMMAIRE:<\/strong> Identification de 5 nouvelles r\u00e9gions g\u00e9n\u00e9tiques li\u00e9es \u00e0 la longueur des t\u00e9lom\u00e8res.<\/p>\n\n

APER\u00c7U:<\/strong> L’ADN de nos cellules est \u00e9troitement emball\u00e9 dans des structures appel\u00e9es chromosomes. Les s\u00e9quences aux extr\u00e9mit\u00e9s des chromosomes forment des coiffes appel\u00e9es t\u00e9lom\u00e8res. Ces structures aident \u00e0 prot\u00e9ger nos chromosomes, tout comme les pointes en plastique des lacets prot\u00e8gent les extr\u00e9mit\u00e9s de l’effilochage. Au cours de nombreuses divisions cellulaires, au cours desquelles l’ADN entier d’une cellule est copi\u00e9, les t\u00e9lom\u00e8res se raccourcissent progressivement jusqu’\u00e0 ce que l’ADN soit endommag\u00e9 et que les cellules finissent par mourir. On estime que jusqu’\u00e0 80% de la longueur des t\u00e9lom\u00e8res d’un individu est h\u00e9r\u00e9ditaire. Les t\u00e9lom\u00e8res courts ont \u00e9t\u00e9 associ\u00e9s \u00e0 un risque accru de plusieurs maladies li\u00e9es \u00e0 l’\u00e2ge. La longueur des t\u00e9lom\u00e8res a \u00e9galement \u00e9t\u00e9 li\u00e9e au cancer, mais la directionnalit\u00e9 des effets de cette association est moins claire. Cette \u00e9tude a examin\u00e9 les donn\u00e9es g\u00e9n\u00e9tiques de pr\u00e8s de 50 000 individus d’origine europ\u00e9enne et identifi\u00e9 7 r\u00e9gions g\u00e9n\u00e9tiques associ\u00e9es \u00e0 la longueur des t\u00e9lom\u00e8res, dont 5 sont nouvelles. La variation g\u00e9n\u00e9tique dans ces r\u00e9gions explique collectivement plus de 1% de la variance de la longueur des t\u00e9lom\u00e8res.<\/p>\n\n

LE SAVIEZ-VOUS?<\/strong> Alors que nos t\u00e9lom\u00e8res raccourcissent naturellement tout au long de notre vie, certains choix de style de vie sont connus pour acc\u00e9l\u00e9rer ce processus! En particulier, le tabagisme et l’exposition aux UV peuvent acc\u00e9l\u00e9rer le raccourcissement des t\u00e9lom\u00e8res et augmenter la sensibilit\u00e9 \u00e0 diverses maladies. [SOURCE]<\/a><\/p>\n\n

EXEMPLE DE R\u00c9SULTATS:<\/strong> En savoir plus sur Biblioth\u00e8que de recherche sur la n\u00e9buleuse<\/a> . <\/p>\n\n

\"résultats<\/a><\/figure>\n\n

<\/p>\n\n

VARIANTES ANALYS\u00c9ES:<\/strong> rs10936599, rs2736100, rs7675998, rs9420907, rs8105767, rs755017, rs11125529<\/p>\n\n

RESSOURCES ADDITIONNELLES:<\/strong>T\u00e9lom\u00e8res<\/a>La science des cellules qui ne vieillissent jamais (vid\u00e9o)<\/a><\/p>\n\n

MISE \u00c0 JOUR HEBDOMADAIRE:<\/strong> 15 f\u00e9vrier 2020<\/p>\n\n

Vous souhaitez en savoir plus sur la longueur de vos t\u00e9lom\u00e8res? Vous aimerez peut-\u00eatre notre TeloYears<\/a> la revue.<\/p>\n","protected":false},"excerpt":{"rendered":"

TITRE DE L’\u00c9TUDE: Identification de sept loci affectant la longueur moyenne des t\u00e9lom\u00e8res et leur association avec la maladie SOMMAIRE: Identification de 5 nouvelles r\u00e9gions g\u00e9n\u00e9tiques li\u00e9es \u00e0 la longueur des t\u00e9lom\u00e8res. APER\u00c7U: L’ADN de nos cellules est \u00e9troitement emball\u00e9 …<\/p>\n

Longueur des t\u00e9lom\u00e8res (Codd, 2013)<\/span> Lire la suite \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":5800,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4984],"tags":[],"class_list":["post-9984","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-rapports"],"yoast_head":"\nLa 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