{"id":10091,"date":"2021-01-06T00:07:17","date_gmt":"2021-01-06T05:07:17","guid":{"rendered":"https:\/\/nebula.org\/blog\/is-%e3%82%a2%e3%83%ab%e3%83%84%e3%83%8f%e3%82%a4%e3%83%9e%e3%83%bc%e7%97%85-%e9%81%ba%e4%bc%9d%e7%9a%84\/"},"modified":"2021-02-20T21:43:04","modified_gmt":"2021-02-21T02:43:04","slug":"is-%e3%82%a2%e3%83%ab%e3%83%84%e3%83%8f%e3%82%a4%e3%83%9e%e3%83%bc%e7%97%85-%e9%81%ba%e4%bc%9d%e7%9a%84","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/ja\/is-%e3%82%a2%e3%83%ab%e3%83%84%e3%83%8f%e3%82%a4%e3%83%9e%e3%83%bc%e7%97%85-%e9%81%ba%e4%bc%9d%e7%9a%84\/","title":{"rendered":"\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff08Dumitrescu\u30012020\uff09-\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306f\u907a\u4f1d\u6027\u3067\u3059\u304b\uff1f"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"h-nebula-genomics-dna-report-for-alzheimer-s-diseases\"><strong>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u661f\u96f2\u30b2\u30ce\u30df\u30af\u30b9DNA\u30ec\u30dd\u30fc\u30c8<\/strong><\/h2>\n\n<p>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306f\u907a\u4f1d\u7684\u3067\u3059\u304b\uff1f \u3053\u306e\u8cea\u554f\u306b\u7b54\u3048\u3088\u3046\u3068\u3057\u305f\u7814\u7a76\u306b\u57fa\u3065\u3044\u3066\u3001DNA\u30ec\u30dd\u30fc\u30c8\u3092\u4f5c\u6210\u3057\u307e\u3057\u305f\u3002 \u4ee5\u4e0b\u306b\u3042\u306a\u305f\u304c\u898b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059<strong>\u30b5\u30f3\u30d7\u30eb<\/strong>DNA\u30ec\u30dd\u30fc\u30c8\u3002 \u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u3055\u308c\u305fDNA\u30ec\u30dd\u30fc\u30c8\u3092\u5165\u624b\u3059\u308b\u306b\u306f\u3001<a href=\"https:\/\/nebula.org\/whole-genome-sequencing\/\">\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30b1\u30f3\u30b9<\/a>\uff01<\/p>\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><a href=\"https:\/\/nebula.org\/whole-genome-sequencing\/\"><img decoding=\"async\" width=\"1024\" height=\"1002\" src=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Screen-Shot-2020-12-04-at-8.19.29-PM-1024x1002.png\" alt=\"&#x30A2;&#x30EB;&#x30C4;&#x30CF;&#x30A4;&#x30DE;&#x30FC;&#x75C5;&#x306F;&#x907A;&#x4F1D;&#x7684;&#x3067;&#x3059;&#x304B;&#xFF1F; NebulaGenomics&#x304B;&#x3089;&#x306E;&#x30B5;&#x30F3;&#x30D7;&#x30EB;&#x30EC;&#x30DD;&#x30FC;&#x30C8;&#x3002;\" class=\"wp-image-7442\" srcset=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Screen-Shot-2020-12-04-at-8.19.29-PM-1024x1002.png 1024w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Screen-Shot-2020-12-04-at-8.19.29-PM-300x293.png 300w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Screen-Shot-2020-12-04-at-8.19.29-PM-768x751.png 768w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Screen-Shot-2020-12-04-at-8.19.29-PM-12x12.png 12w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Screen-Shot-2020-12-04-at-8.19.29-PM.png 924w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure><\/div>\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><a href=\"https:\/\/nebula.org\/whole-genome-sequencing\/\"><img decoding=\"async\" width=\"1024\" height=\"457\" src=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Screen-Shot-2020-12-04-at-8.19.37-PM-1-1024x457.png\" alt=\"&#x30A2;&#x30EB;&#x30C4;&#x30CF;&#x30A4;&#x30DE;&#x30FC;&#x75C5;&#x30B5;&#x30F3;&#x30D7;&#x30EB;&#x30EC;&#x30DD;&#x30FC;&#x30C8;&#x306E;&#x30D0;&#x30EA;&#x30A2;&#x30F3;&#x30C8;\" class=\"wp-image-7452\" srcset=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Screen-Shot-2020-12-04-at-8.19.37-PM-1-1024x457.png 1024w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Screen-Shot-2020-12-04-at-8.19.37-PM-1-300x134.png 300w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Screen-Shot-2020-12-04-at-8.19.37-PM-1-768x343.png 768w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Screen-Shot-2020-12-04-at-8.19.37-PM-1-16x7.png 16w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Screen-Shot-2020-12-04-at-8.19.37-PM-1.png 924w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure><\/div>\n\n<div class=\"wp-block-buttons aligncenter is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill\"><a class=\"wp-block-button__link has-vivid-cyan-blue-background-color has-background\" href=\"https:\/\/nebula.org\/whole-genome-sequencing\/\"><strong>\u30b2\u30ce\u30e0\u306e\u914d\u5217\u3092\u6c7a\u5b9a\u3057\u3001200\u3092\u8d85\u3048\u308bDNA\u30ec\u30dd\u30fc\u30c8\u306b\u30a2\u30af\u30bb\u30b9\u3057\u3066\u304f\u3060\u3055\u3044\uff01<\/strong><\/a><\/div>\n<\/div>\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<p>\u3067\u4ed6\u306e\u30ec\u30dd\u30fc\u30c8\u3092\u63a2\u3059<a href=\"https:\/\/nebula.org\/blog\/ja\/nebula-library-unlocking-genetic-research\/\">\u661f\u96f2\u56f3\u66f8\u9928<\/a>\uff1a<\/p>\n\n<ul class=\"wp-block-list\"><li><a target=\"_blank\" href=\"https:\/\/nebula.org\/blog\/ja\/is-%e3%82%a2%e3%83%ab%e3%83%84%e3%83%8f%e3%82%a4%e3%83%9e%e3%83%bc%e7%97%85-%e9%81%ba%e4%bc%9d%e7%9a%84-2\/\" rel=\"noreferrer noopener\">\uff08Kunkle 2019\uff09<\/a> -\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306f\u907a\u4f1d\u7684\u3067\u3059\u304b\uff1f<\/li><li><a target=\"_blank\" href=\"https:\/\/nebula.org\/blog\/ja\/is-%e8%aa%8d%e7%9f%a5%e7%97%87-%e9%81%ba%e4%bc%9d%e7%9a%84\/\" rel=\"noreferrer noopener\">\uff08\u30c7\u30df\u30f3\u30b02019\uff09<\/a> -\u8a8d\u77e5\u75c7\u306f\u907a\u4f1d\u7684\u3067\u3059\u304b\uff1f<\/li><li><a href=\"https:\/\/nebula.org\/blog\/ja\/is-%e3%81%86%e3%81%a4%e7%97%85-%e9%81%ba%e4%bc%9d%e7%9a%84\/\" target=\"_blank\" rel=\"noreferrer noopener\">\uff08\u30d1\u30ef\u30fc2017\uff09<\/a> -\u3046\u3064\u75c5\u306f\u907a\u4f1d\u7684\u3067\u3059\u304b\uff1f<\/li><li><a href=\"https:\/\/nebula.org\/blog\/is-depression-genetic-wray-2018\/\" target=\"_blank\" rel=\"noreferrer noopener\">\uff08\u30ec\u30a42018\uff09<\/a> -\u7cbe\u795e\u75be\u60a3\u306f\u907a\u4f1d\u7684\u3067\u3059\u304b\uff1f<\/li><li><a href=\"https:\/\/nebula.org\/blog\/ja\/%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa-a-1-%e3%83%ac%e3%83%99%e3%83%ab-%e3%83%aa%e3%83%81%e3%83%a3%e3%83%bc%e3%83%89%e3%82%bd%e3%83%b3-2020\/\">\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaA-1\u30ec\u30d9\u30eb\uff08\u30ea\u30c1\u30e3\u30fc\u30c9\u30bd\u30f3\u30012020\uff09<\/a><\/li><\/ul>\n\n<h2 class=\"wp-block-heading\" id=\"h-additional-information\"><strong>\u8ffd\u52a0\u60c5\u5831<\/strong><\/h2>\n\n<h2 class=\"wp-block-heading\" id=\"h-what-is-alzheimer-s-disease-part-1-of-is-alzheimer-s-disease-genetic\"><strong>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f \uff08\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306f\u907a\u4f1d\u7684\u3067\u3059\u304b\uff1f\uff09<\/strong><\/h2>\n\n<p>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306f\u9032\u884c\u6027\u3067\u4e0d\u53ef\u9006\u7684\u306a\u72b6\u614b\u3067\u3042\u308a\u3001\u5f71\u97ff\u3092\u53d7\u3051\u305f\u500b\u4eba\u306e\u8133\u3001\u5168\u4f53\u7684\u306a\u601d\u8003\u80fd\u529b\u3001\u8a18\u61b6\u3001\u793e\u4f1a\u7684\u3001\u884c\u52d5\u7684\u30b9\u30ad\u30eb\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u3002 \u6700\u7d42\u7684\u306b\u3001\u3053\u306e\u75c5\u6c17\u306f\u3001\u65e5\u5e38\u751f\u6d3b\u306e\u4e2d\u3067\u6d3b\u52d5\u3092\u884c\u3046\u4eba\u306e\u80fd\u529b\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3001\u5bb6\u65cf\u3084\u533b\u7642\u30b9\u30bf\u30c3\u30d5\u306b\u4f9d\u5b58\u3059\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002 \u8a8d\u77e5\u75c7\u306e\u30ab\u30c6\u30b4\u30ea\u30fc\u306b\u306f\u3001\u30b5\u30d6\u30ab\u30c6\u30b4\u30ea\u30fc\u3068\u3057\u3066\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u304c\u542b\u307e\u308c\u307e\u3059\u3002 <\/p>\n\n<p>\u3088\u308a\u591a\u3044<a href=\"https:\/\/www.cdc.gov\/aging\/aginginfo\/alzheimers.htm#:~:text=Who%20has%20Alzheimer's%20Disease%3F&amp;text=In%202014%2C%20as%20many%20as,but%20it%20is%20less%20common.\">500\u4e07\u4eba<\/a>\u7c73\u56fd\u3067\u306f\u73fe\u5728\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3066\u3044\u307e\u3059\u3002 \u3053\u306e\u75c5\u6c17\u306f\u3044\u3064\u3067\u3082\u500b\u4eba\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3092\u767a\u75c7\u3059\u308b\u500b\u4eba\u306e\u30ea\u30b9\u30af\u306f\u5e74\u9f62\u3068\u3068\u3082\u306b\u5897\u52a0\u3057\u307e\u3059\u3002 \u3053\u308c\u306f\u8a8d\u77e5\u75c7\u306e\u6700\u3082\u4e00\u822c\u7684\u306a\u539f\u56e0\u3067\u3042\u308a\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u304c\u3059\u3079\u3066\u306e\u8a8d\u77e5\u75c7\u75c7\u4f8b\u306e50\uff05\u4ee5\u4e0a\u3092\u5360\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002 <\/p>\n\n<p>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u7247\u3068\u30d9\u30fc\u30bf\u30a2\u30df\u30ed\u30a4\u30c9\u30d7\u30e9\u30fc\u30af\u306e\u7570\u5e38\u306a\u84c4\u7a4d\u3068\u8133\u7d30\u80de\u306e\u5468\u308a\u306e\u3082\u3064\u308c\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002 \u3053\u306e\u84c4\u7a4d\u306f\u3001\u7d44\u7e54\u306e\u640d\u50b7\u3068\u3001\u8133\u306e\u4e00\u90e8\u306e\u8133\u7d30\u80de\u306e\u6700\u7d42\u7684\u306a\u6b7b\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002 \u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u3064\u306a\u304c\u308b\u751f\u7269\u5b66\u306f\u307b\u3068\u3093\u3069\u7406\u89e3\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u500b\u4eba\u3092\u305d\u306e\u72b6\u614b\u306b\u304b\u304b\u308a\u3084\u3059\u304f\u3059\u308b\u72b6\u614b\u306b\u3064\u3044\u3066\u306f\u3042\u307e\u308a\u77e5\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u3002 \u8001\u5316\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u95a2\u9023\u3059\u308b\u6700\u3082\u4e00\u822c\u7684\u3067\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u308b\u5371\u967a\u56e0\u5b50\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u591a\u304f\u306e\u4eba\u304c\u82e5\u3044\u5e74\u9f62\u3067\u3053\u306e\u72b6\u614b\u3092\u767a\u75c7\u3057\u307e\u3059\u3002 \u72b6\u614b\u306e\u539f\u56e0\u306f\u5b8c\u5168\u306b\u306f\u7406\u89e3\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u8907\u6570<a href=\"https:\/\/nebula.org\/blog\/ja\/g-what-an-introduction-to-the-genome-wide-association-study-gwas\/\">\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u7814\u7a76\uff08GWAS\uff09<\/a>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u95a2\u3059\u308b\u7814\u7a76\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002 \u3053\u308c\u3089\u306e\u7814\u7a76\u306f\u3001\u907a\u4f1d\u5b66\u304c\u72b6\u614b\u3078\u306e\u611f\u53d7\u6027\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u8907\u6570\u306e\u907a\u4f1d\u5b50\u304c\u75c5\u6c17\u306e\u767a\u75c7\u306b\u5f79\u5272\u3092\u679c\u305f\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/www.drugwatch.com\/wp-content\/uploads\/xprogression-alzheimers-disease.png.pagespeed.ic.bSfyKjSHXt.webp\" alt=\"&#x30A2;&#x30EB;&#x30C4;&#x30CF;&#x30A4;&#x30DE;&#x30FC;&#x75C5;&#x306F;&#x907A;&#x4F1D;&#x7684;&#x3067;&#x3059;&#x304B;&#xFF1F; &#x30A4;&#x30E9;&#x30B9;&#x30C8;&#x3068;&#x3057;&#x3066;&#x793A;&#x3055;&#x308C;&#x3066;&#x3044;&#x308B;&#x30A2;&#x30EB;&#x30C4;&#x30CF;&#x30A4;&#x30DE;&#x30FC;&#x75C5;&#x306E;&#x9032;&#x884C; \"\/><figcaption><em>\u30bd\u30fc\u30b9\uff1a<\/em><a href=\"https:\/\/www.nia.nih.gov\/health\/alzheimers-disease-fact-sheet\" target=\"_blank\" rel=\"noreferrer noopener\">\u56fd\u7acb\u8001\u5316\u7814\u7a76\u6240<\/a><\/figcaption><\/figure>\n\n<h3 class=\"wp-block-heading\" id=\"h-genetics-of-alzheimer-s-disease-part-2-of-is-alzheimer-s-disease-genetic\"><strong>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u907a\u4f1d\u5b66\uff08Is\u306e\u30d1\u30fc\u30c82<mark>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u907a\u4f1d<\/mark>\uff1f\uff09<\/strong><\/h3>\n\n<p>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306f\u8907\u96d1\u306a\u969c\u5bb3\u3067\u3042\u308a\u3001\u74b0\u5883\u8981\u56e0\u3001\u5e74\u9f62\u3001\u304a\u3088\u3073\u907a\u4f1d\u7684\u69cb\u6210\u306e\u7d50\u679c\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 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\u3053\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u4fdd\u8b77\u3001\u4fee\u5fa9\u3001\u304a\u3088\u3073\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u306e\u4ef2\u4ecb\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002 APOE\u907a\u4f1d\u5b50\u5185\u306e\u7279\u5b9a\u306e\u907a\u4f1d\u7684\u5909\u7570\u306e\u5b58\u5728\u306f\u3001\u500b\u4eba\u304c\u75c5\u6c17\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002 <\/p>\n\n<p>\u305f\u3068\u3048\u3070\u3001APOE\u306e\u03b54\u5bfe\u7acb\u907a\u4f1d\u5b50\u306e\u5b58\u5728\u306f\u3001\u8133\u5185\u306e\u640d\u50b7\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u84c4\u7a4d\u306e\u5897\u52a0\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002 \u305d\u306e\u7d50\u679c\u3001APOE\u306e\u03b54\u5bfe\u7acb\u907a\u4f1d\u5b50\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u4e3b\u8981\u306a\u5371\u967a\u56e0\u5b50\u3068\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059\u304c\u3001\u969c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3059\u306e\u306b\u5341\u5206\u3067\u306f\u306a\u3044\u3088\u3046\u3067\u3059\u3002 \u4e00\u65b9\u3001\u5bfe\u7acb\u907a\u4f1d\u5b50\u03b52\u306f\u8a8d\u77e5\u75c7\u3084\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u767a\u75c7\u3092\u4e88\u9632\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002 <\/p>\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"545\" src=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/alzheimers-4-1024x545.png\" alt=\"&#x30A2;&#x30EB;&#x30C4;&#x30CF;&#x30A4;&#x30DE;&#x30FC;&#x75C5;&#x306F;&#x907A;&#x4F1D;&#x7684;&#x3067;&#x3059;&#x304B;&#xFF1F; APOE&#x306F;&#x30A2;&#x30EB;&#x30C4;&#x30CF;&#x30A4;&#x30DE;&#x30FC;&#x75C5;&#x306E;&#x907A;&#x4F1D;&#x5B66;&#x306B;&#x5BC4;&#x4E0E;&#x3059;&#x308B;&#x53EF;&#x80FD;&#x6027;&#x304C;&#x3042;&#x308A;&#x307E;&#x3059;\" class=\"wp-image-7427\" srcset=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/alzheimers-4-1024x545.png 1024w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/alzheimers-4-300x160.png 300w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/alzheimers-4-768x409.png 768w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/alzheimers-4-16x9.png 16w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/alzheimers-4.png 924w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption>\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaE4\u306e22k\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u306e\u69cb\u9020\u30e2\u30c7\u30eb\u3002<a href=\"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/deed.en\"> CC01.0\u30e6\u30cb\u30d0\u30fc\u30b5\u30eb\u30d1\u30d6\u30ea\u30c3\u30af\u30c9\u30e1\u30a4\u30f3\u306e\u732e\u8eab<\/a>\u3002<\/figcaption><\/figure><\/div>\n\n<p><strong>\u30a2\u30df\u30ed\u30a4\u30c9\u524d\u99c6\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\uff08APP\uff09\uff1a<\/strong> APP\u907a\u4f1d\u5b50\u306f\u3001\u30a2\u30df\u30ed\u30a4\u30c9\u524d\u99c6\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7523\u751f\u306b\u95a2\u3059\u308b\u6307\u793a\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002 \u591a\u304f\u306e\u81d3\u5668\u3084\u7d44\u7e54\u306b\u898b\u3089\u308c\u307e\u3059\u304c\u3001\u8133\u3084\u810a\u9ac4\u3067\u306f\u7279\u306b\u91cd\u8981\u3067\u3059\u3002 \u7814\u7a76\u8005\u305f\u3061\u306f\u3001APP\u304c\u7d30\u80de\u540c\u58eb\u306e\u63a5\u7d9a\u3092\u52a9\u3051\u308b\u3053\u3068\u3067\u6a5f\u80fd\u3059\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u63a8\u6e2c\u3057\u3066\u3044\u307e\u3059\u3002 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<\/p>\n\n<p>\u30ac\u30f3\u30de\u30bb\u30af\u30ec\u30bf\u30fc\u30bc\u8907\u5408\u4f53\u306f\u591a\u304f\u306e\u7570\u306a\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u5207\u65ad\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001APP\u306f\u8907\u5408\u4f53\u304c\u51e6\u7406\u3059\u308b\u6700\u3082\u9855\u8457\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u3053\u306e\u91cd\u8981\u306a\u5f79\u5272\u306e\u305f\u3081\u306b\u3001PSEN1\u907a\u4f1d\u5b50\u306e\u907a\u4f1d\u5b50\u5909\u7570\u306f\u3001APP\u306e\u65ad\u7247\u5316\u3092\u7570\u5e38\u306b\u51e6\u7406\u3057\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3092\u4ee3\u8868\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u84c4\u7a4d\u306b\u3064\u306a\u304c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 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<\/p>\n\n<p>\u30a2\u30df\u30ed\u30a4\u30c9\u524d\u99c6\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\uff08APP\uff09\u3001\u30d7\u30ec\u30bb\u30cb\u30ea\u30f31\uff08PSEN1\uff09\u3001\u304a\u3088\u3073\u30d7\u30ec\u30bb\u30cb\u30ea\u30f32\uff08PSEN2\uff09\u306e\u30b3\u30fc\u30c9\u5316\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u306b\u5b58\u5728\u3059\u308b\u5909\u7570\u306f\u3001\u3053\u306e\u75be\u60a3\u306e\u65e9\u671f\u767a\u75c7\u578b\u306e\u7d04\u591a\u304f\u306e\u75c7\u4f8b\u306b\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002 \u3057\u305f\u304c\u3063\u3066\u3001\u5bb6\u65cf\u6b74\u3068\u907a\u4f1d\u5b50\u691c\u67fb\u306f\u3001\u75c5\u6c17\u306e\u65e9\u671f\u767a\u75c7\u578b\u3092\u767a\u75c7\u3059\u308b\u500b\u4eba\u306e\u30ea\u30b9\u30af\u3092\u52b9\u679c\u7684\u306b\u4e88\u6e2c\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u9045\u767a\u6027\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u5834\u5408\u3001\u72b6\u6cc1\u306f\u3055\u3089\u306b\u4e0d\u900f\u660e\u306a\u307e\u307e\u3067\u3059\u3002 APOE\u907a\u4f1d\u5b50\u306b\u5b58\u5728\u3059\u308b\u5909\u7570\u306f\u3001\u9045\u767a\u578b\u306e\u72b6\u614b\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3068\u6e1b\u5c11\u306e\u4e21\u65b9\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u74b0\u5883\u8981\u56e0\u3082\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 <\/p>\n\n<p>\u6700\u5f8c\u306b\u3001\u30c0\u30a6\u30f3\u75c7\u3092\u7279\u5fb4\u4ed8\u3051\u308b21\u756a\u67d3\u8272\u4f53\u4e0a\u306e\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u306e\u7a81\u7136\u5909\u7570\u306821\u756a\u67d3\u8272\u4f53\u306e\u4f59\u5206\u306a\u30b3\u30d4\u30fc\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u306b\u5f37\u304f\u5f71\u97ff\u3059\u308b\u73cd\u3057\u3044\u907a\u4f1d\u7684\u8981\u56e0\u3067\u3059\u3002<\/p>\n\n<h3 class=\"wp-block-heading\" id=\"h-summary-part-3\">\u307e\u3068\u3081\uff08\u30d1\u30fc\u30c83\uff09<\/h3>\n\n<p>\u65e9\u671f\u767a\u75c7\u578b\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u907a\u4f1d\u7684\u30d1\u30bf\u30fc\u30f3\u306f\u7406\u89e3\u3067\u304d\u307e\u3059\u304c\u3001\u9045\u767a\u578b\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u539f\u56e0\u306f\u7406\u89e3\u3059\u308b\u306e\u304c\u5c11\u3057\u8907\u96d1\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002 \u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u9045\u767a\u578b\u306e\u75c7\u72b6\u306f\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u3084\u74b0\u5883\u3078\u306e\u5f71\u97ff\u306b\u5f71\u97ff\u3055\u308c\u307e\u3059\u304c\u3001\u907a\u4f1d\u5b66\u3082\u500b\u4eba\u306e\u30ea\u30b9\u30af\u306b\u5bc4\u4e0e\u3057\u307e\u3059\u3002 \u904e\u53bb\u6570\u5e74\u9593\u3067\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u907a\u4f1d\u5b66\u306e\u7406\u89e3\u304c\u5927\u5e45\u306b\u6539\u5584\u3055\u308c\u307e\u3057\u305f\u3002\u4eca\u5f8c\u306e\u8ffd\u52a0\u306e\u7814\u7a76\u306f\u3001\u500b\u4eba\u306e\u72b6\u614b\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u3092\u5b9a\u7fa9\u3059\u308b\u4e0a\u3067\u79c1\u305f\u3061\u306e\u907a\u4f1d\u5b50\u304c\u679c\u305f\u3059\u5f79\u5272\u3092\u5b9a\u7fa9\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002<\/p>\n\n<h2 class=\"wp-block-heading\" id=\"h-symptoms-of-alzheimer-s-part-4-of-is-alzheimer-s-disease-genetic\"><strong>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u75c7\u72b6\uff08Is\u306e\u30d1\u30fc\u30c84<mark>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u907a\u4f1d<\/mark>\uff1f\uff09<\/strong><\/h2>\n\n<p>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306f\u9032\u884c\u6027\u306e\u72b6\u614b\u3067\u3042\u308a\u3001\u500b\u4eba\u306f\u3057\u3070\u3057\u3070\u8a18\u61b6\u55aa\u5931\u3068\u8a8d\u77e5\u6a5f\u80fd\u306e\u3055\u307e\u3056\u307e\u306a\u6bb5\u968e\u3092\u7d4c\u9a13\u3057\u307e\u3059\u3002 \u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u75c5\u671f\u306b\u3088\u3063\u3066\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u4eba\u306f\u3001\u304b\u3089\u306e\u60c5\u5831\u306b\u57fa\u3065\u3044\u3066\u6b21\u306e\u75c7\u72b6\u3092\u7d4c\u9a13\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059<a href=\"https:\/\/www.nia.nih.gov\/health\/what-are-signs-alzheimers-disease\">\u56fd\u7acb\u8001\u5316\u7814\u7a76\u6240<\/a>\u3002 <\/p>\n\n<p>\u4e00\u90e8\u306e\u9ad8\u9f62\u8005\u306f\u8efd\u5ea6\u8a8d\u77e5\u969c\u5bb3\uff08MCI\uff09\u3092\u7d4c\u9a13\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 MCI\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u5c06\u6765\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3092\u767a\u75c7\u3059\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n<h4 class=\"wp-block-heading\" id=\"h-early-stage-alzheimer-s-mild\">\u521d\u671f\u6bb5\u968e\u306e\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff08\u8efd\u5ea6\uff09<\/h4>\n\n<p>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u4eba\u306f\u3001\u3053\u306e\u6bb5\u968e\u3067\u72ec\u7acb\u3057\u3066\u6a5f\u80fd\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u30aa\u30d6\u30b8\u30a7\u30af\u30c8\u306e\u7f6e\u304d\u5fd8\u308c\u3084\u306a\u3058\u307f\u306e\u3042\u308b\u5358\u8a9e\u306e\u5fd8\u308c\u306a\u3069\u3001\u30e1\u30e2\u30ea\u306e\u554f\u984c\u304c\u767a\u751f\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u75c7\u72b6\u306f\u5e83\u304f\u306f\u660e\u3089\u304b\u3067\u306f\u306a\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001\u89aa\u3057\u3044\u5bb6\u65cf\u3084\u53cb\u4eba\u304c\u6c17\u4ed8\u304f\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n<ul class=\"wp-block-list\"><li>\u8a18\u61b6\u55aa\u5931<\/li><li>\u60aa\u3044\u6c7a\u5b9a\u306b\u3064\u306a\u304c\u308b\u60aa\u3044\u5224\u65ad<\/li><li>\u81ea\u767a\u6027\u3068\u30a4\u30cb\u30b7\u30a2\u30c1\u30d6\u306e\u611f\u899a\u306e\u55aa\u5931<\/li><li>\u901a\u5e38\u306e\u65e5\u5e38\u696d\u52d9\u3092\u5b8c\u4e86\u3059\u308b\u306e\u306b\u6642\u9593\u304c\u304b\u304b\u308b<\/li><li>\u7e70\u308a\u8fd4\u3057\u8cea\u554f<\/li><li>\u304a\u91d1\u306e\u53d6\u308a\u6271\u3044\u3068\u8acb\u6c42\u66f8\u306e\u652f\u6255\u3044\u306e\u554f\u984c<\/li><li>\u3055\u307e\u3088\u3063\u3066\u8ff7\u5b50\u306b\u306a\u308b<\/li><li>\u7269\u3092\u7d1b\u5931\u3057\u305f\u308a\u3001\u5947\u5999\u306a\u5834\u6240\u306b\u7f6e\u304d\u5fd8\u308c\u305f\u308a\u3059\u308b<\/li><li>\u6c17\u5206\u3068\u6027\u683c\u306e\u5909\u5316<\/li><li>\u4e0d\u5b89\u304a\u3088\u3073\/\u307e\u305f\u306f\u653b\u6483\u6027\u306e\u5897\u52a0<\/li><\/ul>\n\n<h4 class=\"wp-block-heading\" id=\"h-middle-stage-alzheimer-s-moderate\">\u4e2d\u671f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff08\u4e2d\u7b49\u5ea6\uff09<\/h4>\n\n<p>\u3053\u306e\u6bb5\u968e\u306f\u4f55\u5e74\u3082\u7d9a\u304f\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u8a8d\u77e5\u75c7\u306e\u75c7\u72b6\u306f\u3088\u308a\u9855\u8457\u3067\u3042\u308a\u3001\u4eba\u306f\u6df7\u4e71\u3057\u305f\u308a\u3001\u6b32\u6c42\u4e0d\u6e80\u306b\u306a\u3063\u305f\u308a\u3001\u6012\u3063\u305f\u308a\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n<ul class=\"wp-block-list\"><li>\u8a18\u61b6\u55aa\u5931\u3068\u6df7\u4e71\u306e\u5897\u52a0<\/li><li>\u65b0\u3057\u3044\u3053\u3068\u3092\u5b66\u3076\u3053\u3068\u304c\u3067\u304d\u306a\u3044<\/li><li>\u8a00\u8a9e\u306e\u96e3\u3057\u3055\u3068\u6570\u5b57\u306e\u8aad\u307f\u3001\u66f8\u304d\u3001\u4f5c\u696d\u306e\u554f\u984c<\/li><li>\u601d\u8003\u3092\u6574\u7406\u3057\u3001\u8ad6\u7406\u7684\u306b\u8003\u3048\u308b\u3053\u3068\u306e\u96e3\u3057\u3055<\/li><li>\u6ce8\u610f\u529b\u306e\u77ed\u7e2e<\/li><li>\u65b0\u3057\u3044\u72b6\u6cc1\u306b\u5bfe\u51e6\u3059\u308b\u969b\u306e\u554f\u984c<\/li><li>\u670d\u3092\u7740\u308b\u306a\u3069\u306e\u591a\u6bb5\u968e\u306e\u30bf\u30b9\u30af\u3092\u5b9f\u884c\u3059\u308b\u3053\u3068\u306e\u96e3\u3057\u3055<\/li><li>\u5bb6\u65cf\u3084\u53cb\u4eba\u306e\u8a8d\u8b58\u306e\u554f\u984c<\/li><li>\u5e7b\u899a\u3001\u5984\u60f3\u3001\u5984\u60f3<\/li><li>\u4e0d\u9069\u5207\u306a\u6642\u9593\u3084\u5834\u6240\u3067\u306e\u8131\u8863\u3084\u4e0b\u54c1\u306a\u8a00\u8449\u9063\u3044\u306a\u3069\u306e\u885d\u52d5\u7684\u306a\u884c\u52d5<\/li><li>\u6012\u308a\u306e\u4e0d\u9069\u5207\u306a\u7206\u767a<\/li><li>\u843d\u3061\u7740\u304d\u306e\u306a\u3055\u3001\u8208\u596e\u3001\u4e0d\u5b89\u3001\u6d99\u3001\u653e\u6d6a-\u7279\u306b\u5348\u5f8c\u9045\u304f\u307e\u305f\u306f\u5915\u65b9\u306b<\/li><li>\u7e70\u308a\u8fd4\u3057\u306e\u767a\u8a00\u3084\u52d5\u304d\u3001\u6642\u6298\u306e\u7b4b\u8089\u306e\u3051\u3044\u308c\u3093<\/li><\/ul>\n\n<h4 class=\"wp-block-heading\" id=\"h-late-stage-alzheimer-s-disease-severe\">\u5f8c\u671f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff08\u91cd\u5ea6\uff09<\/h4>\n\n<p>\u500b\u4eba\u306f\u3001\u81ea\u5206\u306e\u74b0\u5883\u306b\u5bfe\u5fdc\u3057\u3001\u4f1a\u8a71\u3092\u884c\u3044\u3001\u6700\u7d42\u7684\u306b\u306f\u52d5\u304d\u3092\u5236\u5fa1\u3059\u308b\u80fd\u529b\u3092\u5931\u3044\u307e\u3059\u3002 \u901a\u5e38\u3001\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u306f\u56f0\u96e3\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n<ul class=\"wp-block-list\"><li>\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3\u304c\u53d6\u308c\u306a\u3044<\/li><li>\u6e1b\u91cf<\/li><li>\u767a\u4f5c<\/li><li>\u76ae\u819a\u611f\u67d3\u75c7<\/li><li>\u56a5\u4e0b\u56f0\u96e3<\/li><li>\u3046\u3081\u304d\u58f0\u3001\u3046\u3081\u304d\u58f0\u3001\u307e\u305f\u306f\u3046\u3081\u304d\u58f0<\/li><li>\u7761\u7720\u306e\u5897\u52a0<\/li><li>\u6392\u4fbf\u3068\u8180\u80f1\u306e\u5236\u5fa1\u306e\u55aa\u5931<\/li><\/ul>\n\n<h2 class=\"wp-block-heading\" id=\"h-treatment-part-5-of-is-alzheimer-s-disease-genetic\"><strong>\u6cbb\u7642\uff08Is\u306e\u30d1\u30fc\u30c85<mark>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u907a\u4f1d<\/mark>\uff1f\uff09<\/strong><\/h2>\n\n<p>\u73fe\u5728\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u6cbb\u7642\u6cd5\u306f\u3042\u308a\u307e\u305b\u3093\u3002 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