{"id":9546,"date":"2021-01-05T23:22:39","date_gmt":"2021-01-06T04:22:39","guid":{"rendered":"https:\/\/nebula.org\/blog\/%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa-e-apoe\/"},"modified":"2021-02-20T20:22:18","modified_gmt":"2021-02-21T01:22:18","slug":"%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa-e-apoe","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/ja\/%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa-e-apoe\/","title":{"rendered":"APOE-\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u306b\u3064\u3044\u3066\u4f55\u304c\u308f\u304b\u308a\u307e\u3059\u304b\uff1f [JULY 2020]"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea-\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u300c\u8ca8\u7269\u8239\u300d<\/h2>\n\n<p>\u3053\u306e\u30d6\u30ed\u30b0\u6295\u7a3f\u3067\u306f\u3001APOE\uff08\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaE\uff09\u3068\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u304a\u3051\u308b\u305d\u306e\u5f79\u5272\u306b\u3064\u3044\u3066\u8aac\u660e\u3057\u307e\u3059\u3002<\/p>\n\n<p>\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u8102\u80aa\u306f\u591a\u304f\u306e\u60aa\u3044\u5ba3\u4f1d\u3092\u53d7\u3051\u307e\u3059\u3002 \u591a\u304f\u306e\u4eba\u304c\u79c1\u305f\u3061\u306e\u4f53\u306e\u4e2d\u3067\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u77e5\u3063\u3066\u9a5a\u3044\u3066\u3044\u307e\u3059\uff01 \u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306f\u3001\u4f53\u5185\u3067\u5316\u5b66\u4f1d\u9054\u7269\u8cea\u3068\u3057\u3066\u4f5c\u7528\u3059\u308b\u30db\u30eb\u30e2\u30f3\u3092\u751f\u6210\u3059\u308b\u305f\u3081\u306b\u91cd\u8981\u3067\u3059\u3002 \u307e\u305f\u3001\u80c6\u6c41\u306e\u4e3b\u6210\u5206\u3067\u3042\u308a\u3001\u6d88\u5316\u3092\u52a9\u3051\u308b\u50cd\u304d\u3092\u3057\u307e\u3059\u3002 \u8102\u80aa\u306f\u4f53\u5185\u306e\u7d30\u80de\u306e\u6210\u9577\u306b\u4e0d\u53ef\u6b20\u3067\u3042\u308a\u3001\u91cd\u8981\u306a\u81d3\u5668\u3092\u53d6\u308a\u56f2\u307f\u4fdd\u8b77\u3059\u308b\u306e\u306b\u3082\u5f79\u7acb\u3061\u307e\u3059\u3002 <\/p>\n\n<p>\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u8102\u80aa\u306f\u4f53\u306b\u4e0d\u53ef\u6b20\u3067\u3059\u304c\u3001\u305d\u308c\u3089\u306f\u81ea\u5206\u3067\u4f53\u306e\u4e2d\u3092\u79fb\u52d5\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002 \u4ee3\u308f\u308a\u306b\u3001\u8ca8\u7269\u8239\u306e\u3088\u3046\u306b\u6a5f\u80fd\u3059\u308b\u300c\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u300d\u3068\u547c\u3070\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u4f9d\u5b58\u3057\u3066\u3044\u307e\u3059\u3002 \u3053\u308c\u3089\u306e\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u8102\u80aa\u3092\u30d1\u30c3\u30b1\u30fc\u30b8\u5316\u3057\u3001\u8840\u6db2\u3092\u4ecb\u3057\u3066\u4f53\u306e\u3055\u307e\u3056\u307e\u306a\u90e8\u5206\u306b\u8f38\u9001\u3057\u307e\u3059\u3002 <\/p>\n\n<p>\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u300c\u8ca8\u7269\u8239\u300d\u306f\u3001\u4f53\u306e\u4e2d\u3092\u79fb\u52d5\u3059\u308b\u3068\u304d\u306b\u3001\u3055\u307e\u3056\u307e\u306a\u7a2e\u985e\u306e\u7d30\u80de\u306e\u8868\u9762\u306b\u3042\u308b\u53d7\u5bb9\u4f53\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u4ed8\u7740\u3057\u307e\u3059\u3002 \u3053\u308c\u3089\u306e\u53d7\u5bb9\u4f53\u306f\u3001\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u3064\u304b\u3093\u3067\u7d30\u80de\u306b\u904b\u3076\u30d5\u30c3\u30af\u306e\u3088\u3046\u306b\u6a5f\u80fd\u3057\u307e\u3059\u3002 \u7d30\u80de\u5185\u306b\u5165\u308b\u3068\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u8102\u80aa\u3092\u4f7f\u7528\u3057\u3066\u7d30\u80de\u306e\u91cd\u8981\u306a\u6a5f\u80fd\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<br\/><\/p>\n\n<figure class=\"wp-block-image size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/04\/image-4-985x1024.png\" alt=\"&#x30A2;&#x30DD;&#x30EA;&#x30DD;&#x30BF;&#x30F3;&#x30D1;&#x30AF;&#x8CEA;&#x306F;&#x3001;&#x30B3;&#x30EC;&#x30B9;&#x30C6;&#x30ED;&#x30FC;&#x30EB;&#x3092;&#x8F38;&#x9001;&#x3059;&#x308B;&#x5C0F;&#x80DE;&#x306E;&#x5F62;&#x6210;&#x3092;&#x52A9;&#x3051;&#x307E;&#x3059;&#x3002; &#x30A2;&#x30DD;&#x30EA;&#x30DD;&#x30BF;&#x30F3;&#x30D1;&#x30AF;&#x8CEA;E&#xFF08;APOE&#xFF09;&#x306F;&#x3001;&#x30B3;&#x30EC;&#x30B9;&#x30C6;&#x30ED;&#x30FC;&#x30EB;&#x3092;&#x8133;&#x7D30;&#x80DE;&#x306B;&#x8F38;&#x9001;&#x3059;&#x308B;&#x306E;&#x306B;&#x5F79;&#x7ACB;&#x3061;&#x307E;&#x3059;&#x3002; \" class=\"wp-image-1827\" width=\"300\"\/><figcaption>\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u8102\u8cea\u8f38\u9001\u3092\u52a9\u3051\u308b\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u7c92\u5b50\u306e\u5f62\u6210\u3092\u52a9\u3051\u307e\u3059\u3002 \u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaE\uff08APOE\uff09\u306f\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u8133\u7d30\u80de\u306b\u8f38\u9001\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002 <\/figcaption><\/figure>\n\n<p>\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3001\u8102\u80aa\u306f\u3059\u3079\u3066\u79c1\u305f\u3061\u306e\u4f53\u306b\u5fc5\u8981\u3067\u3059\u304c\u3001\u305d\u308c\u3089\u306e\u30ec\u30d9\u30eb\u306f\u9069\u5207\u306b\u76e3\u8996\u304a\u3088\u3073\u5236\u5fa1\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002 \u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306b\u3064\u3044\u3066\u306f\u3001<a href=\"https:\/\/www.health.harvard.edu\/blog\/understanding-cholesterol-hdl-vs-ldl-2018041213608\"> 2\u7a2e\u985e\u3042\u308a\u307e\u3059<\/a>-HDL\uff08\u9ad8\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08\u3088\u308a\u4e00\u822c\u7684\u306b\u306f\u300c\u5584\u7389\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u300d\u3068\u547c\u3070\u308c\u308b\uff09\u3001\u304a\u3088\u3073LDL\uff08\u4f4e\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\uff08\u3057\u3070\u3057\u3070\u300c\u60aa\u7389\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u300d\u3068\u547c\u3070\u308c\u308b\uff09\u3002 HDL\u306f\u9ad8\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u53d7\u5bb9\u4f53\u306b\u7d50\u5408\u3057\u3001LDL\u306f\u4f4e\u5bc6\u5ea6\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u53d7\u5bb9\u4f53\u306b\u7d50\u5408\u3057\u307e\u3059\u3002 \u6700\u9069\u306a\u5065\u5eb7\u306e\u305f\u3081\u306b\u306f\u30012\u3064\u306e\u30bf\u30a4\u30d7\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u91cd\u8981\u3067\u3059\u3002 HDL\u306e\u30ec\u30d9\u30eb\u306e\u4f4e\u4e0b\u307e\u305f\u306fLDL\u306e\u30ec\u30d9\u30eb\u306e\u4e0a\u6607\u306f\u3001\u591a\u304f\u306e\u75c5\u6c17\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u3053\u308c\u306f\u3001\u51a0\u72b6\u52d5\u8108\u6027\u5fc3\u81d3\u75c5\u3001\u8133\u5352\u4e2d\u3001\u9ad8\u8840\u5727\u306a\u3069\u306e\u5fc3\u8840\u7ba1\u75be\u60a3\u306b\u7279\u306b\u5f53\u3066\u306f\u307e\u308a\u307e\u3059\u3002 <br\/><\/p>\n\n<figure class=\"wp-block-table is-style-regular\"><table class=\"has-subtle-pale-pink-background-color has-background\"><tbody><tr><td><strong><a href=\"https:\/\/nebula.org\/whole-genome-sequencing\/\">DNA\u3092100\uff05\u30c7\u30b3\u30fc\u30c9\u3057\u3001\u3059\u3079\u3066\u306e\u5909\u7570\u3092\u7279\u5b9a\u3059\u308bDNA\u691c\u67fb\u3092\u304a\u63a2\u3057\u3067\u3059\u304b\uff1f Nebula Genomics\u3067\u306f\u3001\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30b1\u30f3\u30b9\u3092\u305f\u3063\u305f299\u30c9\u30eb\u3067\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002 \u3053\u308c\u306f\u3001APOE\u304a\u3088\u3073\u305d\u306e\u4ed6\u306e\u907a\u4f1d\u5b50\u306e\u3059\u3079\u3066\u306e\u5909\u7570\u4f53\u3092\u7279\u5b9a\u3067\u304d\u308b\u6700\u3082\u5b8c\u5168\u306aDNA\u691c\u67fb\u3067\u3059\u3002 \u8a73\u7d30\u306f\u3053\u3061\u3089\u3092\u30af\u30ea\u30c3\u30af\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/a><\/strong><\/td><\/tr><\/tbody><\/table><\/figure>\n\n<h2 class=\"wp-block-heading\">\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaE\uff08APOE\uff09-CNS\u30b9\u30da\u30b7\u30e3\u30ea\u30b9\u30c8<\/h2>\n\n<p>\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30b0\u30eb\u30fc\u30d7\u3067\u3059\u3002 \u7570\u306a\u308b\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u3001\u7570\u306a\u308b\u30bf\u30a4\u30d7\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3068\u512a\u5148\u7684\u306b\u76f8\u4e92\u4f5c\u7528\u3057\u307e\u3059\u3002 19\u756a\u67d3\u8272\u4f53\u4e0a\u306b\u3042\u308b\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaE\uff08APOE\uff09\u306f\u3001\u4e3b\u306bLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u30d1\u30c3\u30b1\u30fc\u30b8\u5316\u3057\u3066\u8f38\u9001\u3059\u308b\u30b0\u30eb\u30fc\u30d7\u306e\u30e1\u30f3\u30d0\u30fc\u3067\u3059\u3002 APOE\u306f\u5168\u8eab\u306b\u898b\u3089\u308c\u307e\u3059\u304c\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u4e3b\u8981\u306a\u8f38\u9001\u4f53\u3068\u3057\u3066\u7279\u5225\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002<a href=\"https:\/\/www.youtube.com\/watch?v=q8NtmDrb_qo\">\u4e2d\u67a2\u795e\u7d4c\u7cfb\uff08CNS\uff09<\/a> \u3001\u8133\u3068\u810a\u9ac4\u3067\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u3053\u3053\u3067\u3001APOE\u306f\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u3092\u30cb\u30e5\u30fc\u30ed\u30f3\u306b\u904b\u3076\u50cd\u304d\u3092\u3059\u308b\u524d\u306b\u3001\u661f\u72b6\u7d30\u80de\u3068\u547c\u3070\u308c\u308bCNS\u7d30\u80de\u306b\u3088\u3063\u3066\u4f5c\u3089\u308c\u307e\u3059\u3002 \u30cb\u30e5\u30fc\u30ed\u30f3\u306f\u3001\u795e\u7d4c\u7cfb\u5168\u4f53\u3067\u60c5\u5831\u3092\u53d6\u5f97\u304a\u3088\u3073\u9001\u4fe1\u3059\u308b\u7d30\u80de\u3067\u3042\u308a\u3001\u611f\u899a\u60c5\u5831\u3092\u53d7\u4fe1\u3057\u3066\u5fdc\u7b54\u3059\u308b\u3053\u3068\u3092\u53ef\u80fd\u306b\u3057\u307e\u3059\u3002<\/p>\n\n<p>APOE\u907a\u4f1d\u5b50\u306b\u306f\u3001E2\u3001E3\u3001\u304a\u3088\u3073E4\u306e3\u3064\u306e\u4e3b\u8981\u306a\u5bfe\u7acb\u907a\u4f1d\u5b50\u307e\u305f\u306f\u30d0\u30fc\u30b8\u30e7\u30f3\u304c\u3042\u308a\u307e\u3059\u3002 \u3053\u308c\u3089\u306e\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaE\u306e\u591a\u578b\u306f\u3001DNA\u306e\u7a81\u7136\u5909\u7570\u306b\u3088\u3063\u3066\u751f\u3058\u3066\u3044\u307e\u3059\u3002 \u5bfe\u7acb\u907a\u4f1d\u5b50\u306f\u901a\u5e38\u3001\u907a\u4f1d\u5b50\u306e\u5358\u4e00\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u307e\u305f\u306f\u6587\u5b57\u306e\u7a81\u7136\u5909\u7570\u306e\u7d50\u679c\u3067\u3059\u3002 \u3053\u308c\u3089\u306e\u7a81\u7136\u5909\u7570\u306f\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059<a href=\"https:\/\/ghr.nlm.nih.gov\/primer\/genomicresearch\/snp\">\u4e00\u5869\u57fa\u591a\u578b\uff08SNP\uff09<\/a> \u3002 \u30d2\u30c8\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaE\u907a\u4f1d\u5b50\u306e3\u3064\u306e\u5bfe\u7acb\u907a\u4f1d\u5b50\u306f\u3001rs7412\u3068rs429358\u306e2\u3064\u306eSNP\u304b\u3089\u751f\u3058\u307e\u3059\u3002<\/p>\n\n<p>\u907a\u4f1d\u5b50\u306e2\u6587\u5b57\u3092\u5909\u66f4\u3059\u308b\u3060\u3051\u3067\u306f\u305d\u308c\u307b\u3069\u9055\u3044\u306f\u306a\u3044\u3088\u3046\u306b\u601d\u308f\u308c\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001APOE\u5bfe\u7acb\u907a\u4f1d\u5b50\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u304b\u3089\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u3001\u30de\u30e9\u30ea\u30a2\u306b\u81f3\u308b\u307e\u3067\u3001\u591a\u304f\u306e\u75c5\u6c17\u306e\u30ea\u30b9\u30af\u306b\u9a5a\u304f\u307b\u3069\u5927\u304d\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u3002 \u305f\u3068\u3048\u3070\u3001APOE\u5bfe\u7acb\u907a\u4f1d\u5b50\u306e\u72b6\u614b\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u306e\u4e3b\u8981\u306a\u907a\u4f1d\u7684\u6c7a\u5b9a\u8981\u56e0\u3067\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002 \u5b9f\u969b\u3001APOE\u5bfe\u7acb\u907a\u4f1d\u5b50\u306e\u9055\u3044\u306f\u3001\u30ea\u30b9\u30af\u306e\u4f4e\u4e0b\u3068\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u767a\u75c7\u306e\u5e73\u5747\u3088\u308a\u308220\u500d\u9ad8\u3044\u30ea\u30b9\u30af\u3068\u306e\u9055\u3044\u3092\u610f\u5473\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n<p>\u3042\u306a\u305f\u306e\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaE\u907a\u4f1d\u5b50\u578b\u306f\u3042\u306a\u305f\u306b\u3064\u3044\u3066\u4f55\u3068\u8a00\u3046\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n\n<h3 class=\"wp-block-heading\">\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaE2\uff08APOE 2\uff09 <\/h3>\n\n<p>E2\uff08\u30a4\u30d7\u30b7\u30ed\u30f32\u307e\u305f\u306f\u03b52\uff09\u5bfe\u7acb\u907a\u4f1d\u5b50\u3092\u6301\u3064\u500b\u4f53\u306f\u3001\u4e21\u65b9\u306eSNP\u306b\u300cT\u300d\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002 \u4eba\u53e3\u306e\u7d048.4\uff05\u304c\u3053\u306e\u5bfe\u7acb\u907a\u4f1d\u5b50\u3092\u6301\u3063\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002 \u4ee5\u524d\u306e\u7814\u7a76\u306f\u3001E2\u5bfe\u7acb\u907a\u4f1d\u5b50\u304c\u500b\u4eba\u306b\u5e73\u5747\u3088\u308a\u4f4e\u3044\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u30ea\u30b9\u30af\u3092\u4e0e\u3048\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002 <\/p>\n\n<p>\u7814\u7a76\u306f\u307e\u305f\u3001APOE2\u5bfe\u7acb\u907a\u4f1d\u5b50\u3068\u52d5\u8108\u306e\u75c5\u6c17\u3067\u3042\u308b\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u3068\u306e\u95a2\u4fc2\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002 E2\u5bfe\u7acb\u907a\u4f1d\u5b50\u306f\u307e\u305f\u3001\u767a\u75c7\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059<a href=\"https:\/\/rarediseases.info.nih.gov\/diseases\/6703\/hyperlipidemia-type-3\">III\u578b\u9ad8\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8840\u75c7<\/a>\u3001\u7dcf\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u304c\u9ad8\u304f\u3001HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\u304c\u4f4e\u3044\u3053\u3068\u3092\u7279\u5fb4\u3068\u3059\u308b\u969c\u5bb3\u3002<\/p>\n\n<h3 class=\"wp-block-heading\">\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaE3\uff08APOE 3\uff09<\/h3>\n\n<p>E3\uff08\u30a4\u30d7\u30b7\u30ed\u30f33\u307e\u305f\u306f\u03b53\uff09\u5bfe\u7acb\u907a\u4f1d\u5b50\u306f\u6700\u3082\u4e00\u822c\u7684\u306a\u5bfe\u7acb\u907a\u4f1d\u5b50\u3067\u3042\u308a\u3001\u4eba\u53e3\u306e\u63a8\u5b9a77.9\uff05\u304cAPOE\u907a\u4f1d\u5b50\u306e\u3053\u306e\u5909\u7570\u4f53\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002 \u3053\u306eAPOE\u907a\u4f1d\u5b50\u578b\u306f\u3001rs7412SNP\u306e\u300cC\u300d\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u3068rs429358SNP\u306e\u300cT\u300d\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306e\u7d50\u679c\u3067\u3059\u3002 \u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u306b\u3064\u3044\u3066\u306f\u3001E3\u5bfe\u7acb\u907a\u4f1d\u5b50\u306f\u300c\u4e2d\u7acb\u300d\u3068\u898b\u306a\u3055\u308c\u307e\u3059\u3002 \u4ed6\u306e\u7814\u7a76\u3067\u306f\u3001E3\u5bfe\u7acb\u907a\u4f1d\u5b50\u3092\u6301\u3064\u500b\u4eba\u306f\u91cd\u5ea6\u306e\u30de\u30e9\u30ea\u30a2\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\u3002 <\/p>\n\n<h3 class=\"wp-block-heading\">\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaE4\uff08APOE 4\uff09<\/h3>\n\n<p>E4\u5bfe\u7acb\u907a\u4f1d\u5b50\uff08\u30a4\u30d7\u30b7\u30ed\u30f34\u5bfe\u7acb\u907a\u4f1d\u5b50\u307e\u305f\u306fAPOE\u03b54\uff09\u306f\u3001rs7412\u304a\u3088\u3073rs429358SNP\u306e\u4e21\u65b9\u306b\u3042\u308b\u300cC\u300d\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306b\u3088\u3063\u3066\u7279\u5fb4\u4ed8\u3051\u3089\u308c\u307e\u3059\u3002 \u4eba\u53e3\u306e\u7d0414\uff05\u306b\u3057\u304b\u5b58\u5728\u3057\u307e\u305b\u3093\u304c\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u306e\u307b\u307c40\uff05\u304c\u3053\u306e\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaE\u5bfe\u7acb\u907a\u4f1d\u5b50\u306e\u30b3\u30d4\u30fc\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002 \u4e21\u65b9\u306e\u89aa\u304b\u3089APOE4\u5bfe\u7acb\u907a\u4f1d\u5b50\u3092\u53d7\u3051\u7d99\u3050\u500b\u4eba\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u304c20\u500d\u9ad8\u3044\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u3055\u3089\u306b\u3001\u3053\u306e\u5bfe\u7acb\u907a\u4f1d\u5b50\u3092\u6301\u3064\u500b\u4eba\u306f\u3001\u591a\u304f\u306e\u5834\u5408\u3001Alazheiemr\u306e\u65e9\u671f\u767a\u75c7\u578b\u5bb6\u65cf\u3068\u3057\u3066\u7279\u5fb4\u4ed8\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u5bb6\u65cf\u306e\u4e00\u90e8\u3067\u3059\u3002 <\/p>\n\n<p>\u5b8c\u5168\u306b\u306f\u7406\u89e3\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u3053\u306e\u30ea\u30b9\u30af\u306e\u4e0a\u6607\u306f\u3001\u5909\u7570\u4f53\u304c\u30a2\u30df\u30ed\u30a4\u30c9\u6591\u3092\u5206\u89e3\u3067\u304d\u306a\u3044\u3053\u3068\u306b\u8d77\u56e0\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u3053\u308c\u3089\u306e\u30d7\u30e9\u30fc\u30af\u306f\u3001\u8133\u306e\u6a5f\u80fd\u3092\u7834\u58ca\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u84c4\u7a4d\u3067\u3059\u3002 \u305d\u308c\u3089\u306f\u3001APOE\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u7d30\u80de\u8868\u9762\u306e\u30d8\u30d1\u30e9\u30f3\u786b\u9178\u30d7\u30ed\u30c6\u30aa\u30b0\u30ea\u30ab\u30f3\uff08HSPG\uff09\u306b\u7d50\u5408\u3059\u308b\u3068\u304d\u306b\u3057\u3070\u3057\u3070\u5f62\u6210\u3055\u308c\u307e\u3059\u3002<\/p>\n\n<p>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u52a0\u3048\u3066\u3001E4\u5bfe\u7acb\u907a\u4f1d\u5b50\u306f\u4ed6\u306e\u591a\u304f\u306e\u75c5\u6c17\u306e\u30ea\u30b9\u30af\u3082\u9ad8\u3081\u307e\u3059\u3002 \u3053\u308c\u3089\u306e\u4e2d\u306b\u306f\u3001\u30a2\u30c6\u30ed\u30fc\u30e0\u6027\u52d5\u8108\u786c\u5316\u75c7\u3001HIV\u3001\u7761\u7720\u6642\u7121\u547c\u5438\u3001\u91cd\u5ea6\u306e\u30de\u30e9\u30ea\u30a2\u3001\u304a\u3088\u3073\u591a\u767a\u6027\u786c\u5316\u75c7\u306e\u9032\u884c\u304c\u3042\u308a\u307e\u3059\u3002 APOE4\u5bfe\u7acb\u907a\u4f1d\u5b50\u3082\u30b9\u30d4\u30fc\u30c9\u30a2\u30c3\u30d7\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3059<a href=\"https:\/\/www.verywellhealth.com\/telomere-shortening-the-secret-to-aging-2224346\">\u30c6\u30ed\u30e1\u30a2\u77ed\u7e2e<\/a>\u3001\u8001\u5316\u304a\u3088\u3073\u8001\u5316\u95a2\u9023\u75be\u60a3\u306b\u95a2\u9023\u3059\u308b\u30d7\u30ed\u30bb\u30b9\u3002<br\/><\/p>\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><br\/><\/td><td><strong>APOE 2 <\/strong><\/td><td><strong>APOE 3 <\/strong><\/td><td><strong>APOE 4<\/strong><\/td><\/tr><tr><td>rs7412 <\/td><td>T<\/td><td>C<\/td><td>C<\/td><\/tr><tr><td>rs429358<\/td><td>T<\/td><td>T<\/td><td>C<\/td><\/tr><tr><td>\u4eba\u53e3\u983b\u5ea6<\/td><td>8.4%<\/td><td>77.9%<\/td><td>13.7%<\/td><\/tr><tr><td>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u306e\u983b\u5ea6<\/td><td>3.9%<\/td><td>59.4%<\/td><td>36.7%<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<h2 class=\"wp-block-heading\">APOE\u5bfe\u7acb\u907a\u4f1d\u5b50\u3092\u8d85\u3048\u3066<\/h2>\n\n<p>\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaE4\u5bfe\u7acb\u907a\u4f1d\u5b50\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u500b\u4eba\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3092\u767a\u75c7\u3059\u308b\u304b\u3069\u3046\u304b\u306f\u5b9a\u304b\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002 \u305f\u3068\u3048\u3070\u3001APOE\u5bfe\u7acb\u907a\u4f1d\u5b50\u3068\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u3068\u306e\u76f8\u95a2\u95a2\u4fc2\u306f\u3001\u3059\u3079\u3066\u306e\u96c6\u56e3\u306b\u5f53\u3066\u306f\u307e\u308b\u3068\u306f\u9650\u308a\u307e\u305b\u3093\u3002 \u30ca\u30a4\u30b8\u30a7\u30ea\u30a2\u306fE4\u5bfe\u7acb\u907a\u4f1d\u5b50\u306e\u983b\u5ea6\u304c\u6700\u3082\u9ad8\u3044\u3067\u3059\u304c\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306f\u6b8b\u3063\u3066\u3044\u307e\u3059<a href=\"https:\/\/www.statnews.com\/2017\/08\/22\/alzheimers-apoe4-risk\/\">\u304b\u306a\u308a\u73cd\u3057\u3044<\/a>\u56fd\u3067\u3002<\/p>\n\n<p>\u4ed6\u306e\u591a\u304f\u306e\u72b6\u614b\u3068\u540c\u69d8\u306b\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306f\u5358\u4e00\u306e\u907a\u4f1d\u5b50\u307e\u305f\u306f\u907a\u4f1d\u7684\u5909\u7570\u306e\u7d50\u679c\u3067\u306f\u306a\u304f\u3001\u591a\u304f\u306e\u907a\u4f1d\u5b50\u304c\u5354\u8abf\u3057\u3066\u6a5f\u80fd\u3059\u308b\u7d50\u679c\u3067\u3059\u3002 APP\u3084SORL1\u306a\u3069\u3001\u4ed6\u306e\u591a\u304f\u306e\u907a\u4f1d\u5b50\u304c\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u3069\u3061\u3089\u3082\u4e2d\u67a2\u795e\u7d4c\u7cfb\u3067\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002 \u6700\u8fd1<a href=\"https:\/\/nebula.org\/blog\/ja\/g-what-an-introduction-to-the-genome-wide-association-study-gwas\/\">\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u7814\u7a76<\/a>TREM2\u907a\u4f1d\u5b50\u3067\u7279\u5b9a\u3055\u308c\u305fSNP\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u304c3\u301c5\u500d\u9ad8\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n<h2 class=\"wp-block-heading\">\u3042\u306a\u305f\u306e\u30ea\u30b9\u30af\u3092\u6e1b\u3089\u3059\u305f\u3081\u306b\u884c\u52d5\u3092\u8d77\u3053\u3059<\/h2>\n\n<p>\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u3092\u6c7a\u5b9a\u3059\u308b\u8981\u56e0\u306f\u907a\u4f1d\u5b66\u3060\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002 \u74b0\u5883\u3001\u7279\u306b\u30e9\u30a4\u30d5\u30b9\u30bf\u30a4\u30eb\u306e\u9078\u629e\u306f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3084\u305d\u306e\u4ed6\u306e\u75c5\u6c17\u3067\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002 \u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u5834\u5408\u3001\u77e5\u7684\u523a\u6fc0\u6d3b\u52d5\u306f\u30ea\u30b9\u30af\u3092\u8efd\u6e1b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u30af\u30ed\u30b9\u30ef\u30fc\u30c9\u30d1\u30ba\u30eb\u3092\u3059\u308b\u3053\u3068\u3001\u65b0\u3057\u3044\u8a00\u8a9e\u3092\u5b66\u3076\u3053\u3068\u3001\u305d\u3057\u3066\u793e\u4f1a\u7684\u76f8\u4e92\u4f5c\u7528\u306f\u3059\u3079\u3066\u3001\u75c5\u6c17\u306e\u30ea\u30b9\u30af\u306e\u6e1b\u5c11\u3068\u76f8\u95a2\u3059\u308b\u6d3b\u52d5\u3067\u3059\u3002<\/p>\n\n<p>\u98df\u4e8b\u306e\u9078\u629e\u3082\u3001\u500b\u4eba\u306e\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u98fd\u548c\u8102\u80aa\u306e\u591a\u3044\u98df\u54c1\u3092\u6442\u53d6\u3059\u308b\u3068\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3068\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u4e21\u65b9\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u3053\u308c\u306b\u306f\u3001\u63da\u3052\u7269\u3001\u30d4\u30b6\u3001\u4e73\u88fd\u54c1\u3001\u8102\u80aa\u306e\u591a\u3044\u8089\u304c\u542b\u307e\u308c\u307e\u3059\u3002 \u4e00\u65b9\u3001\u5730\u4e2d\u6d77\u3068\u65e5\u672c\u306e\u98df\u4e8b\u306f\u4eba\u306e\u75c5\u6c17\u306e\u30ea\u30b9\u30af\u3092\u6e1b\u3089\u3059\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002 \u3069\u3061\u3089\u306e\u98df\u4e8b\u3082\u9b5a\u3001\u91ce\u83dc\u3001\u5168\u7c92\u7a40\u7269\u304c\u8c4a\u5bcc\u3067\u3059\u3002 <\/p>\n\n<h2 class=\"wp-block-heading\">\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30b1\u30f3\u30b9<\/h2>\n\n<p>Nebula Genomics\u3067\u306f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u304b\u3089\u53d7\u3051\u53d6\u3063\u305f\u30c7\u30fc\u30bf\u3092\u63a2\u7d22\u3067\u304d\u308b\u3088\u3046\u306b\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002 \u30b2\u30ce\u30e0\u306b\u7c21\u5358\u306b\u30a2\u30af\u30bb\u30b9\u3067\u304d\u308b\u3088\u3046\u306b\u8a2d\u8a08\u3055\u308c\u305f\u30c4\u30fc\u30eb\u3092\u591a\u6570\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002 <\/p>\n\n<p>DNA\u306b\u3064\u3044\u3066\u306e\u8cea\u554f\u306b\u7b54\u3048\u3089\u308c\u308b\u3088\u3046\u306b\u3001\u30b2\u30ce\u30e0\u63a2\u7d22\u30c4\u30fc\u30eb\u3092\u69cb\u7bc9\u3057\u307e\u3057\u305f\u3002 \u95a2\u5fc3\u306e\u3042\u308b\u907a\u4f1d\u5b50\u3092\u7c21\u5358\u306b\u8abf\u3079\u3066\u3001\u8a73\u7d30\u3092\u8abf\u3079\u3001\u6f5c\u5728\u7684\u306a\u5909\u7570\u3092\u7279\u5b9a\u3067\u304d\u307e\u3059\u3002 \u307e\u305f\u306f\u3001\u30b2\u30ce\u30e0\u30d6\u30e9\u30a6\u30b6\u30fc\u3092\u4f7f\u7528\u3057\u3066\u3001\u30b7\u30fc\u30b1\u30f3\u30b9\u30c7\u30fc\u30bf\u3092\u76f4\u63a5\u78ba\u8a8d\u3059\u308b\u3053\u3068\u3082\u3067\u304d\u307e\u3059\u3002 \u3055\u3089\u306b\u3001FASTQ\u3001BAM\u3001VCF\u30d5\u30a1\u30a4\u30eb\u306a\u3069\u306e\u751f\u306eDNA\u30c7\u30fc\u30bf\u3092\u3044\u3064\u3067\u3082\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3067\u304d\u307e\u3059\u3002 <br\/><\/p>\n\n<p>\u3042\u306a\u305f\u306e\u6ce8\u6587<a href=\"https:\/\/nebula.org\/whole-genome-sequencing\/\">30x\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30b1\u30f3\u30b9\u30ad\u30c3\u30c8<\/a>\u4eca\u65e5\u304b\u3089\u65c5\u3092\u59cb\u3081\u307e\u3057\u3087\u3046\uff01<\/p>\n\n<p>\u3053\u306e\u8a18\u4e8b\u306f\u6c17\u306b\u5165\u308a\u307e\u3057\u305f\u304b\uff1f \u3082\u3057\u305d\u3046\u306a\u3089\u3001\u3042\u306a\u305f\u306f\u79c1\u305f\u3061\u306e\u30d6\u30ed\u30b0\u6295\u7a3f\u3082\u597d\u304d\u304b\u3082\u3057\u308c\u307e\u305b\u3093<a href=\"https:\/\/nebula.org\/blog\/ja\/mthfr\/\">MTHFR<\/a> \uff01<\/p>\n\n<p>\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u306e\u7a81\u7136\u5909\u7570\u3092\u7279\u5b9a\u3059\u308b\u3053\u3068\u306b\u8208\u5473\u304c\u3042\u308b\u5834\u5408\u306f\u3001\u6b21\u306eDNA\u30a2\u30c3\u30d7\u30ed\u30fc\u30c9\u30b5\u30a4\u30c8\u304c\u5f79\u7acb\u3064\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n<ul class=\"wp-block-list\"><li><a href=\"https:\/\/nebula.org\/whole-genome-sequencing\/\">\u661f\u96f2\u30b2\u30ce\u30df\u30af\u30b9<\/a><\/li><li><a href=\"https:\/\/nebula.org\/blog\/ja\/promethease-%e3%83%ac%e3%83%93%e3%83%a5%e3%83%bc\/\">\u30d7\u30ed\u30e1\u30c6\u30fc\u30bc<\/a><\/li><li><a href=\"https:\/\/nebula.org\/blog\/ja\/%e9%81%ba%e4%bc%9d%e5%ad%90-%e9%ad%94%e7%a5%9e-%e3%83%ac%e3%83%93%e3%83%a5%e3%83%bc\/\">\u907a\u4f1d\u306e\u9b54\u795e<\/a><\/li><li><a href=\"https:\/\/nebula.org\/blog\/ja\/%e8%87%aa%e5%b7%b1%e3%83%87%e3%82%b3%e3%83%bc%e3%83%89-%e3%83%ac%e3%83%93%e3%83%a5%e3%83%bc\/\">SelfDecode<\/a><\/li><li><a href=\"https:\/\/nebula.org\/blog\/ja\/xcode-life-review\/\">Xcode Life<\/a><\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8cea-\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u300c\u8ca8\u7269\u8239\u300d \u3053\u306e\u30d6\u30ed\u30b0\u6295\u7a3f\u3067\u306f\u3001APOE\uff08\u30a2\u30dd &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"ast-button\" href=\"https:\/\/nebula.org\/blog\/ja\/%e3%82%a2%e3%83%9d%e3%83%aa%e3%83%9d%e3%82%bf%e3%83%b3%e3%83%91%e3%82%af%e8%b3%aa-e-apoe\/\"> <span class=\"screen-reader-text\">APOE-\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30ea\u30b9\u30af\u306b\u3064\u3044\u3066\u4f55\u304c\u308f\u304b\u308a\u307e\u3059\u304b\uff1f [JULY 2020]<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":6252,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4977],"tags":[],"class_list":["post-9546","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-4977"],"yoast_head":"<!-- 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You can read more about Garrett's experience and publications on LinkedIn and ORCID.","sameAs":["https:\/\/nebula.org\/whole-genome-sequencing\/"],"url":"https:\/\/nebula.org\/blog\/ja\/author\/garrett-dunlap\/"}]}},"_links":{"self":[{"href":"https:\/\/nebula.org\/blog\/ja\/wp-json\/wp\/v2\/posts\/9546","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nebula.org\/blog\/ja\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nebula.org\/blog\/ja\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/ja\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/ja\/wp-json\/wp\/v2\/comments?post=9546"}],"version-history":[{"count":0,"href":"https:\/\/nebula.org\/blog\/ja\/wp-json\/wp\/v2\/posts\/9546\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/ja\/wp-json\/wp\/v2\/media\/6252"}],"wp:attachment":[{"href":"https:\/\/nebula.org\/blog\/ja\/wp-json\/wp\/v2\/media?parent=9546"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nebula.org\/blog\/ja\/wp-json\/wp\/v2\/categories?post=9546"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nebula.org\/blog\/ja\/wp-json\/wp\/v2\/tags?post=9546"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}