{"id":9578,"date":"2021-01-05T23:23:13","date_gmt":"2021-01-06T04:23:13","guid":{"rendered":"https:\/\/nebula.org\/blog\/mthfr\/"},"modified":"2021-02-20T20:21:23","modified_gmt":"2021-02-21T01:21:23","slug":"mthfr","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/ja\/mthfr\/","title":{"rendered":"MTHFR \u2013\u306a\u305c\u3053\u306e\u907a\u4f1d\u5b50\u306b\u305d\u308c\u307b\u3069\u95a2\u5fc3\u304c\u3042\u308b\u306e\u3067\u3059\u304b\uff1f"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">\u524d\u66f8\u304d<\/h2>\n\n<p>\u907a\u4f1d\u5b505,10-\u30e1\u30c1\u30ec\u30f3\u30c6\u30c8\u30e9\u30d2\u30c9\u30ed\u8449\u9178\u30ec\u30c0\u30af\u30bf\u30fc\u30bc\u306b\u3064\u3044\u3066\u306e\u8a71\u984c\u306b\u3064\u3044\u3066\u805e\u3044\u305f\u3053\u3068\u304c\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3001\u307e\u305f\u306f<em>MTHFR<\/em>\u7565\u3057\u3066<em>\u3002<\/em>\u3053\u306e\u907a\u4f1d\u5b50\u306e\u907a\u4f1d\u7684\u5909\u7570\u307e\u305f\u306f\u7a81\u7136\u5909\u7570\u3092\u30ea\u30f3\u30af\u3059\u308b\u4f55\u5343\u3082\u306e\u7814\u7a76\u304c\u767a\u8868\u3055\u308c\u3066\u3044\u307e\u3059\u3001<em> <\/em>\u4f55\u767e\u3082\u306e\u75c5\u72b6\u306b\u3002 \u3053\u308c\u3089\u306e\u75c5\u72b6\u306b\u306f\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u3001\u8840\u6db2\u51dd\u56fa\u306e\u554f\u984c\u3001\u7cbe\u795e\u969c\u5bb3\u3001\u767a\u9054\u969c\u5bb3\u3001\u598a\u5a20\u5408\u4f75\u75c7\u3001\u304a\u3088\u3073\u764c\u304c\u542b\u307e\u308c\u307e\u3059\u3002 \u305f\u3060\u3057\u3001\u65e2\u5b58\u306e\u79d1\u5b66\u30c7\u30fc\u30bf\u306f\u3001\u305d\u306e\u3088\u3046\u306a\u95a2\u9023\u306b\u3064\u3044\u3066\u306a\u3055\u308c\u305f\u4e3b\u5f35\u306e\u307b\u3068\u3093\u3069\u3092\u30b5\u30dd\u30fc\u30c8\u3057\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n<p>\u3053\u306e\u30d6\u30ed\u30b0\u6295\u7a3f\u3067\u306f\u3001\u79d1\u5b66\u6587\u732e\u3092\u5206\u6790\u3057\u3066\u3001\u79c1\u305f\u3061\u304c\u77e5\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u8aac\u660e\u3057\u307e\u3059\u3002<em> MTHFR\u3001<\/em>\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u4f53\u3092\u30c6\u30b9\u30c8\u3059\u308b\u5fc5\u8981\u304c\u306a\u3044\u7406\u7531\u3068\u3001\u8aa4\u3063\u305f\u60c5\u5831\u3092\u5e83\u3081\u3001\u305d\u308c\u304b\u3089\u5229\u76ca\u3092\u5f97\u3066\u3044\u308b\u4ee3\u66ff\u533b\u7642\u3084\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u4f1a\u793e\u306b\u6ce8\u610f\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u7406\u7531\u3002 <\/p>\n\n<figure class=\"wp-block-table is-style-regular\"><table class=\"has-subtle-pale-pink-background-color has-background\"><tbody><tr><td><a href=\"https:\/\/nebula.org\/whole-genome-sequencing\/\"><strong>DNA\u3092100\uff05\u30c7\u30b3\u30fc\u30c9\u3057\u3001\u3059\u3079\u3066\u306e\u5909\u7570\u3092\u7279\u5b9a\u3059\u308bDNA\u691c\u67fb\u3092\u304a\u63a2\u3057\u3067\u3059\u304b\uff1f Nebula Genomics\u3067\u306f\u3001\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30b1\u30f3\u30b9\u3092\u305f\u3063\u305f299\u30c9\u30eb\u3067\u63d0\u4f9b\u3057\u3066\u3044\u307e\u3059\u3002 \u3053\u308c\u306f\u3001MTHFR\u304a\u3088\u3073\u305d\u306e\u4ed6\u306e\u907a\u4f1d\u5b50\u306e\u3059\u3079\u3066\u306e\u5909\u7570\u4f53\u3092\u7279\u5b9a\u3067\u304d\u308b\u6700\u3082\u5b8c\u5168\u306aDNA\u691c\u67fb\u3067\u3059\u3002 \u8a73\u7d30\u306f\u3053\u3061\u3089\u3092\u30af\u30ea\u30c3\u30af\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/strong><\/a><\/td><\/tr><\/tbody><\/table><\/figure>\n\n<h2 class=\"wp-block-heading\"><strong>\u80cc\u5f8c\u306b\u3042\u308b\u79d1\u5b66<\/strong><strong><em>MTHFR<\/em><\/strong><\/h2>\n\n<h3 class=\"wp-block-heading\"><strong>\u3068\u306f<\/strong><strong><em>MTHFR<\/em><\/strong><strong> \uff1f<\/strong><\/h3>\n\n<figure class=\"wp-block-image is-resized\"><img decoding=\"async\" src=\"https:\/\/lh4.googleusercontent.com\/u5yRgvwc8nlRoJTTj5aJxV_MD-vv4msq2agoLPFkvWr0hVBKF_0wZ8UrHSGEz14z3xDGGeDqIzCKd_fIRDX3UKLpd8fme8l1-8lVRViFUS_ZMSM5kDEU06PpVDCGFEHedM9DxMV4\" alt=\"MTHFR&#x306F;&#x3001;&#x8449;&#x9178;&#x306E;&#x4E3B;&#x8981;&#x306A;&#x751F;&#x7269;&#x5B66;&#x7684;&#x6D3B;&#x6027;&#x578B;&#x3067;&#x3042;&#x308B;5-MTHF&#x3092;&#x751F;&#x6210;&#x3057;&#x307E;&#x3059;&#x3002;\" width=\"800\" height=\"476\"\/><figcaption>MTHFR\u306f\u3001\u8449\u9178\u306e\u4e3b\u8981\u306a\u751f\u7269\u5b66\u7684\u6d3b\u6027\u578b\u3067\u3042\u308b5-MTHF\u3092\u751f\u6210\u3057\u307e\u3059\u3002<\/figcaption><\/figure>\n\n<p><em>MTHFR<\/em>\u9175\u7d205,10-\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3059<strong>m<\/strong>\u30a8\u30c1\u30ec\u30f3\u30c6<strong>t<\/strong> ra<strong> h<\/strong> ydrofolate<strong> r<\/strong>\u30a8\u30c0\u30af\u30bf\u30fc\u30bc\u3002 \u9175\u7d20\u306f\u3001\u4f53\u5185\u306e\u5316\u5b66\u53cd\u5fdc\u3092\u52a0\u901f\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002 MTHFR\u9175\u7d20\u306f\u3001\u3042\u308b\u5f62\u614b\u306e\u8449\u9178\uff085,10-\u30e1\u30c1\u30ec\u30f3\u30c6\u30c8\u30e9\u30d2\u30c9\u30ed\u8449\u9178\uff09\u3092\u7570\u306a\u308b\u5f62\u614b\u306e\u8449\u9178\uff085-\u30e1\u30c1\u30eb\u30c6\u30c8\u30e9\u30d2\u30c9\u30ed\u8449\u9178\uff09\u306b\u5909\u63db\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002\u5f8c\u8005\u306f\u3001\u8449\u9178\u306e\u4e3b\u8981\u306a\u751f\u7269\u5b66\u7684\u6d3b\u6027\u578b\u3067\u3059\u3002 \u305d\u308c\u306f\u3001\u30a2\u30df\u30ce\u9178\u3068\u3057\u3066\u3082\u77e5\u3089\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30d3\u30eb\u30c7\u30a3\u30f3\u30b0\u30d6\u30ed\u30c3\u30af\u3092\u5408\u6210\u3059\u308b\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002 \u5177\u4f53\u7684\u306b\u306f\u3001\u3053\u306e\u5f62\u614b\u306e\u8449\u9178\u306f\u30db\u30e2\u30b7\u30b9\u30c6\u30a4\u30f3\u3092\u30e1\u30c1\u30aa\u30cb\u30f3\u306b\u5909\u63db\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u3002 \u307e\u305f\u3001DNA\u640d\u50b7\u5fdc\u7b54\u3084\u795e\u7d4c\u7cfb\u306e\u6a5f\u80fd\u306b\u3082\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n<h3 class=\"wp-block-heading\"><strong>\u306e\u4e00\u822c\u7684\u306a\u30d0\u30ea\u30a2\u30f3\u30c8<\/strong><strong><em>MTHFR<\/em><\/strong><\/h3>\n\n<p>\u3044\u304f\u3064\u304b\u306e\u4e00\u822c\u7684\u306a\u3082\u306e\u304c\u3042\u308a\u307e\u3059<em>MTHFR<\/em>\u907a\u4f1d\u5b50\u5909\u7570\u4f53<em> <\/em>\u9175\u7d20\u306e\u6d3b\u6027\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u5b9f\u969b\u306b\u306f\u3001<a href=\"https:\/\/link.springer.com\/article\/10.1007\/s10897-016-9956-7#CR39\">\u4e00\u822c\u4eba\u53e3\u306e40\uff05\u306e\u500b\u4eba<\/a>\u3053\u308c\u3089\u306e2\u3064\u306e\u4e00\u822c\u7684\u306a\u30d0\u30ea\u30a2\u30f3\u30c8\u306e\u3044\u305a\u308c\u304b\u304c\u3042\u308a\u307e\u3059<em>\u3001<\/em> C677T\u304a\u3088\u3073A1298C\u3002 C677T\u5909\u7570\u4f53\u306f\u3001\u7279\u306b\u30a2\u30e9\u30cb\u30f3\u304b\u3089\u30d0\u30ea\u30f3\u3078\u306e\u30a2\u30df\u30ce\u9178\u306e\u5909\u5316\u306b\u3088\u308a\u9175\u7d20\u5168\u4f53\u304c\u3088\u308a\u591a\u304f\u306a\u308b\u3068\u3044\u3046\u4e8b\u5b9f\u306e\u305f\u3081\u306b\u3001\u9175\u7d20\u6d3b\u6027\u304c30\u301c70\uff05\u4f4e\u4e0b\u3057\u307e\u3059\u3002<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC64948\/\">\u71b1\u306b\u5f31\u3044<\/a>\u3002 \u5bfe\u7167\u7684\u306b\u3001A1298C\u306f<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9719624\">\u9175\u7d20\u306e\u5c0f\u3055\u306a\u6e1b\u5c11<\/a>\u672a\u77e5\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u308b\u6d3b\u52d5\u3002<\/p>\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>SNP ID<\/td><td>\u30e1\u30b8\u30e3\u30fc\u30a2\u30ec\u30eb<\/td><td>\u30de\u30a4\u30ca\u30fc\u30a2\u30ec\u30eb<\/td><td>\u30de\u30a4\u30ca\u30fc\u30a2\u30ec\u30eb\u96c6\u56e3\u983b\u5ea6*<\/td><td>\u30a2\u30df\u30ce\u9178\u306e\u5909\u5316<\/td><\/tr><tr><td>rs1801133\uff08C677T\uff09<\/td><td>C<\/td><td>T<\/td><td>34%<\/td><td>C\uff08\u30a2\u30e9\u30cb\u30f3\uff09&gt; T\uff08\u30d0\u30ea\u30f3\uff09<\/td><\/tr><tr><td>rs1801131\uff08A1298C\uff09<\/td><td>A<\/td><td>C<\/td><td>31%<\/td><td>A\uff08\u30b0\u30eb\u30bf\u30df\u30f3\uff09&gt; C\uff08\u30a2\u30e9\u30cb\u30f3\uff09<\/td><\/tr><\/tbody><\/table><\/figure>\n\n<p>*<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/snp\/docs\/gsr\/alfa\/\">\u30a2\u30ec\u30eb\u5468\u6ce2\u6570\u30a2\u30b0\u30ea\u30b2\u30fc\u30bf\u30fc\uff08ALFA\uff09\u30d7\u30ed\u30b8\u30a7\u30af\u30c8<\/a><\/p>\n\n<p>\u3059\u3079\u3066\u3067\u306f\u306a\u3044\u3053\u3068\u306b\u6ce8\u610f\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059<em>\u4e00\u822c<\/em>\u907a\u4f1d\u7684\u5909\u7570\u306f\u3001\u7279\u306b\u305d\u308c\u3089\u304c\u4eba\u9593\u306e\u96c6\u56e3\u3067\u4fe1\u3058\u3089\u308c\u306a\u3044\u307b\u3069\u4e00\u822c\u7684\u3067\u3042\u308b\u5834\u5408\u3001\u75c5\u6c17\u306e\u539f\u56e0\u3068\u306a\u308a\u307e\u3059\u3002<strong> <\/strong>\u500b\u3005\u306eC677T\u304a\u3088\u3073A1298C\u5909\u7570\u4f53\u306f\u9175\u7d20\u6d3b\u6027\u3092\u4f4e\u4e0b\u3055\u305b\u307e\u3059\u304c\u3001\u4e00\u822c\u7684\u306b\u5065\u5eb7\u4e0a\u306e\u554f\u984c\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u305b\u3093\u3002 MTHFR\u3067\u3042\u3063\u3066\u3082\u3001\u307b\u3068\u3093\u3069\u306e\u4eba\u306f\u5065\u5eb7\u4e0a\u306e\u554f\u984c\u306f\u3042\u308a\u307e\u305b\u3093\uff08\u3064\u307e\u308a\u3001\u30db\u30e2\u30b7\u30b9\u30c6\u30a4\u30f3\u3092\u30e1\u30c1\u30aa\u30cb\u30f3\u306b\u5909\u63db\u3057\u307e\u3059\uff09<em> <\/em>\u6700\u9069\u306b\u6a5f\u80fd\u3057\u3066\u3044\u307e\u305b\u3093\u3002 \u5b9f\u969b\u3001\u5358\u4e00\u306e\u5909\u7570\u4f53\u3092\u6301\u3064\u307b\u3068\u3093\u3069\u306e\u500b\u4eba\u306f\u3001\u6b63\u5e38\u306a\u3001\u307e\u305f\u306f\u4e0a\u6607\u3057\u3066\u3044\u306a\u3044\u30db\u30e2\u30b7\u30b9\u30c6\u30a4\u30f3\u30ec\u30d9\u30eb\u3092\u6301\u3063\u3066\u3044\u308b\u3088\u3046\u306b\u898b\u3048\u307e\u3059\u3002<\/p>\n\n<p>\u305f\u3060\u3057\u3001\u5834\u5408\u306b\u3088\u3063\u3066\u306f\u3001MTHFR\u6d3b\u6027\u304c\u975e\u5e38\u306b\u4f4e\u3044\u30ec\u30d9\u30eb\u306b\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001MTHFR\u907a\u4f1d\u5b50C677T\u5909\u7570\u4f53\u306e\u30b3\u30d4\u30fc\u304c2\u3064\u3042\u308b\u500b\u4eba\u3067\u767a\u751f\u3059\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002 \u3053\u308c\u306b\u3088\u308a\u3001\u30db\u30e2\u30b7\u30b9\u30c6\u30a4\u30f3\u30ec\u30d9\u30eb\u304c\u9ad8\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u30db\u30e2\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\u3068\u3057\u3066\u3082\u77e5\u3089\u308c\u308b\u8840\u6db2\u4e2d\u306e\u30db\u30e2\u30b7\u30b9\u30c6\u30a4\u30f3\u306e\u4e0a\u6607\u306f\u3001\u6cbb\u7642\u305b\u305a\u306b\u653e\u7f6e\u3059\u308b\u3068\u3001\u7570\u5e38\u306a\u8840\u6db2\u51dd\u56fa\u3001\u9aa8\u306e\u3082\u308d\u3055\u3001\u8fd1\u8996\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u795e\u7d4c\u7ba1\u6b20\u640d\u75c7\uff08\u4e8c\u5206\u810a\u690e\uff09\u306e\u5b50\u4f9b\u3092\u7523\u3080\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u305d\u308c\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001<a href=\"https:\/\/ghr.nlm.nih.gov\/condition\/homocystinuria#statistics\">\u30db\u30e2\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\u306f\u307e\u308c\u3067\u3059<\/a>\u3001\u4e16\u754c\u4e2d\u306720\u4e07\u4eba\u304b\u308933\u4e075000\u4eba\u306b1\u4eba\u304c\u7f79\u60a3\u3057\u3066\u3044\u307e\u3059\u3002 \u3055\u3089\u306b\u3001\u30db\u30e2\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\u306f\u3001\u6b21\u306e\u3088\u3046\u306a\u4ed6\u306e\u907a\u4f1d\u5b50\u306e\u907a\u4f1d\u5b50\u5909\u7570\u306b\u8d77\u56e0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<a href=\"https:\/\/ghr.nlm.nih.gov\/gene\/CBS\">\u30b7\u30b9\u30bf\u30c1\u30aa\u30cb\u30f3-\u30d9\u30fc\u30bf-\u30b7\u30f3\u30bf\u30fc\u30bc\uff08CBS\uff09<\/a> \u3002 \u6700\u5f8c\u306b\u3001\u30db\u30e2\u30b7\u30b9\u30c1\u30f3\u5c3f\u75c7\u306f\u3001\u75c7\u72b6\u306b\u767a\u4f5c\u3084\u767a\u9054\u9045\u5ef6\u304c\u542b\u307e\u308c\u308b\u305f\u3081\u3001\u7c21\u5358\u306b\u691c\u51fa\u3067\u304d\u307e\u3059\u3002 \u3057\u305f\u304c\u3063\u3066\u3001\u3053\u306e\u72b6\u614b\u306f\u4e3b\u306b\u4eba\u751f\u306e\u65e9\u3044\u6bb5\u968e\u3067\u8a3a\u65ad\u3055\u308c\u3001\u6642\u306b\u306f\u5148\u5929\u6027\u6b20\u640d\u75c7\u3068\u3057\u3066\u3082\u8a3a\u65ad\u3055\u308c\u307e\u3059\u3002<\/p>\n\n<h2 class=\"wp-block-heading\"><strong>\u30c6\u30b9\u30c8\u3059\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u306a\u3044\u7406\u7531<\/strong><strong><em>MTHFR<\/em><\/strong><strong>\u7a81\u7136\u5909\u7570<\/strong><\/h2>\n\n<p>\u306b\u591a\u304f\u306e\u95a2\u5fc3\u304c\u3042\u308a\u307e\u3059<em>MTHFR<\/em>\u6d88\u8cbb\u8005\u306b\u76f4\u63a5\u907a\u4f1d\u5b50\u691c\u67fb\u30b5\u30fc\u30d3\u30b9\u3092\u5229\u7528\u3057\u305f\u4eba\u3005\u306e\u9593\u306e\u907a\u4f1d\u5b50\u3002 \u3053\u308c\u306f\u3042\u306a\u305f\u304c\u30c6\u30b9\u30c8\u3092\u53d7\u3051\u308b\u5fc5\u8981\u304c\u3042\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u304b<em> <\/em>\u3053\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u4f53\uff1f<\/p>\n\n<p>\u524d\u306b\u8ff0\u3079\u305f\u3088\u3046\u306b\u3001\u30ea\u30f3\u30af\u3057\u3066\u3044\u308b\u4f55\u5343\u3082\u306e\u7814\u7a76\u8a18\u4e8b\u306b\u3082\u304b\u304b\u308f\u3089\u305a<em>MTHFR<\/em>\u4f55\u767e\u3082\u306e\u5065\u5eb7\u72b6\u614b\u306e\u5909\u7a2e\u3067\u3042\u308a\u3001\u8a3c\u62e0\u306e\u307b\u3068\u3093\u3069\u306f\u77db\u76fe\u3057\u3066\u3044\u308b\u304b\u3001\u6c7a\u5b9a\u7684\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002 \u305f\u3068\u3048\u3070\u3001\u3044\u304f\u3064\u304b<a href=\"https:\/\/jamanetwork.com\/journals\/jama\/article-abstract\/195434\">\u521d\u671f\u306e\u7814\u7a76<\/a>C677T\u304a\u3088\u3073A1298C\u5909\u7570\u3092\u6301\u3064\u500b\u4eba\u306f\u3001\u5fc3\u81d3\u75c5\u3092\u767a\u75c7\u3059\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002 \u3057\u304b\u3057\u3001\u3082\u3063\u3068<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3283559\/\">\u6700\u8fd1\u306e\u7814\u7a76<\/a>\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u304c\u5927\u304d\u3044\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u306f\u3001\u305d\u306e\u9006\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002 \u6ce8\u610f\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002 \u3055\u3089\u306b\u3001\u5358\u4e00\u306e\u4e00\u822c\u7684\u306a\u907a\u4f1d\u7684\u5909\u7570\u304c\u4f55\u767e\u3082\u306e\u7121\u95a2\u4fc2\u306a\u5065\u5eb7\u554f\u984c\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3044\u3046\u8003\u3048\u306f\u4fe1\u3058\u304c\u305f\u3044\u3082\u306e\u3067\u3059\u3002 \u6700\u7d42\u7684\u306b\u306f\u3001\u30b5\u30f3\u30d7\u30eb\u30b5\u30a4\u30ba\u304c\u5927\u304d\u3044\u5834\u5408\u306f\u3001\u3088\u308a\u591a\u304f\u306e\u8abf\u67fb\u7814\u7a76\u3092\u5b9f\u65bd\u3057\u3066\u304b\u3089\u3067\u306a\u3044\u3068\u3001<em> MTHFR<\/em>\u75c5\u6c17\u306e\u5909\u7a2e\u3002<\/p>\n\n<p>\u73fe\u5728\u3001<a href=\"https:\/\/www.acog.org\/\"> American College of Obstetricians and Gynecologists<\/a>\u306e\u30c6\u30b9\u30c8\u306f\u304a\u52e7\u3081\u3057\u307e\u305b\u3093<em>MTHFR<\/em>\u30d0\u30ea\u30a2\u30f3\u30c8\u3002 \u30db\u30e2\u30b7\u30b9\u30c6\u30a4\u30f3\u30ec\u30d9\u30eb\u306f\u4ee3\u308f\u308a\u306b\u7c21\u5358\u306a\u8840\u6db2\u691c\u67fb\u3067\u76f4\u63a5\u6e2c\u5b9a\u3067\u304d\u308b\u305f\u3081\u3001\u4e00\u822c\u7684\u306b\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u5fc5\u8981\u304c\u306a\u3044\u3053\u3068\u306b\u6ce8\u610f\u3059\u308b\u3053\u3068\u3082\u91cd\u8981\u3067\u3059\u3002 \u30db\u30e2\u30b7\u30b9\u30c6\u30a4\u30f3\u30ec\u30d9\u30eb\u304c\u7570\u5e38\u306b\u9ad8\u3044\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u5834\u5408\u3001\u6cbb\u7642\u306f\u7c21\u5358\u3067\u3059\u3002 \u8449\u9178\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u306f\u53ef\u80fd\u3067\u3059\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u4f53\u306f\u9175\u7d20\u306e\u5fc5\u8981\u6027\u3092\u56de\u907f\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 \u3044\u305a\u308c\u306b\u305b\u3088\u3001\u3042\u306a\u305f\u306f\u8a8d\u53ef\u3055\u308c\u305f\u533b\u5e2b\u306e\u533b\u5b66\u7684\u30a2\u30c9\u30d0\u30a4\u30b9\u306b\u5f93\u3046\u3079\u304d\u3067\u3059\u3002<\/p>\n\n<h2 class=\"wp-block-heading\"><strong>\u4ee3\u66ff\u533b\u7642\u306e\u30a6\u30a7\u30d6\u30b5\u30a4\u30c8\u304c\u8a00\u3046\u3053\u3068\u306b\u6ce8\u610f\u3057\u3066\u304f\u3060\u3055\u3044<\/strong><\/h2>\n\n<p>\u81ea\u7136\u7642\u6cd5\u533b\u306b\u3088\u3063\u3066\u904b\u55b6\u3055\u308c\u3066\u3044\u308b\u30a6\u30a7\u30d6\u30b5\u30a4\u30c8\u306e\u6570\u306f\u3001<em> MTHFR<\/em>\u3055\u307e\u3056\u307e\u306a\u75c5\u6c17\u306e\u5371\u967a\u56e0\u5b50\u3068\u3057\u3066\u306e\u5909\u7570\u4f53\u3002 \u305f\u3068\u3048\u3070\u3001\u30d9\u30f3\u30ea\u30f3\u30c1\u535a\u58eb\u304c\u904b\u55b6\u3059\u308bMTHFR.Net\u306f\u3001\u8a3a\u65ad\u7528\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u3068\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u8ca9\u58f2\u3057\u3066\u3044\u307e\u3059\u3002<em> <\/em>\u30d0\u30ea\u30a2\u30f3\u30c8\u3068\u60f3\u5b9a\u3055\u308c\u308b\u6b20\u9665\u3092\u6271\u3044\u307e\u3059\u3002 \u3082\u30461\u3064\u306e\u4f8b\u306f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u30ad\u30c3\u30c8\u3092150\u30c9\u30eb\u3067\u8ca9\u58f2\u3057\u3066\u3044\u308bMy HomeMTHFR\u3067\u3059\u3002 \u4ed6\u306e\u30a6\u30a7\u30d6\u30b5\u30a4\u30c8\u306f\u30015-MTHF\u306e\u3088\u3046\u306a\u9ad8\u5024\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u8ca9\u58f2\u3057\u3066\u304a\u308a\u3001\u300c\u4e0d\u598a\u75c7\u3001\u4e0d\u5b89\u795e\u7d4c\u75c7\u3001\u3046\u3064\u75c5\u3001\u708e\u75c7\u300d\u306a\u3069\u306e\u6cbb\u7642\u306b\u5f79\u7acb\u3064\u3068\u4e3b\u5f35\u3057\u3066\u3044\u307e\u3059\u3002 \u8aa4\u3063\u305f\u60c5\u5831\u306b\u6ce8\u610f\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n<h2 class=\"wp-block-heading\"><strong>\u3042\u306a\u305f\u81ea\u8eab\u306b\u3064\u3044\u3066\u3082\u3063\u3068\u77e5\u308a\u305f\u3044\u3067\u3059\u304b\uff1f<\/strong><\/h2>\n\n<p>\u5065\u5eb7\u72b6\u614b\u306e\u591a\u304f<em>MTHFR<\/em>\u95a2\u9023\u4ed8\u3051\u3089\u308c\u3066\u3044\u308b\u5834\u5408\u3068\u95a2\u9023\u4ed8\u3051\u3089\u308c\u3066\u3044\u306a\u3044\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u5358\u4e00\u306e\u907a\u4f1d\u5b50\u307e\u305f\u306f\u305d\u306e\u907a\u4f1d\u5b50\u5185\u306e\u907a\u4f1d\u7684\u5909\u7570\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u53ef\u80fd\u6027\u306f\u4f4e\u3044\u3067\u3059\u3002 \u3080\u3057\u308d\u3001\u3053\u308c\u3089\u306e\u5065\u5eb7\u72b6\u614b\u306e\u307b\u3068\u3093\u3069\u306f<em>\u7e41\u96d1\u3001<\/em>\u305d\u3057\u3066\u304a\u305d\u3089\u304f\u591a\u304f\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u4f53\u306e\u5f71\u97ff\u306e\u7d50\u679c\u3067\u3059\u3002 \u305f\u3068\u3048\u3070\u3001<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26950853\/?from_single_result=26950853&amp;expanded_search_query=26950853\">\u51a0\u72b6\u52d5\u8108\u6027\u5fc3\u81d3\u75c5\u306b\u95a2\u3059\u308b\u6700\u8fd1\u306e\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u7814\u7a76<\/a>\u3092\u542b\u3080\u4ed6\u306e\u907a\u4f1d\u5b50\u306e\u8fd1\u304f\u306e\u907a\u4f1d\u7684\u5909\u7570\u306e\u5f79\u5272\u3092\u5f37\u8abf\u3057\u305f<em>QKI\u3002<\/em><\/p>\n\n<h3 class=\"wp-block-heading\"><strong>\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30b1\u30f3\u30b9<\/strong><\/h3>\n\n<p>Nebula Genomics\u306e\u76ee\u6a19\u306f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u30c7\u30fc\u30bf\u3092\u63a2\u7d22\u3067\u304d\u308b\u3088\u3046\u306b\u3059\u308b\u3053\u3068\u3067\u3059\u3002 DNA\u306b\u3064\u3044\u3066\u306e\u8cea\u554f\u306b\u7b54\u3048\u308b\u305f\u3081\u306e\u30c4\u30fc\u30eb\u3092\u591a\u6570\u3054\u7528\u610f\u3057\u3066\u3044\u307e\u3059\u3002 \u95a2\u5fc3\u306e\u3042\u308b\u907a\u4f1d\u5b50\u3092\u7c21\u5358\u306b\u8abf\u3079\u3066\u8a73\u7d30\u3092\u78ba\u8a8d\u3057\u305f\u308a\u3001\u30b2\u30ce\u30e0\u30d6\u30e9\u30a6\u30b6\u30fc\u3092\u4f7f\u7528\u3057\u3066\u30c7\u30fc\u30bf\u3092\u76f4\u63a5\u8abf\u3079\u305f\u308a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 MTHFR\u907a\u4f1d\u5b50\u306e\u907a\u4f1d\u7684\u5909\u7570\u3092\u8abf\u3079\u308b\u3053\u3068\u3082\u3067\u304d\u307e\u3059\u3002 \u3042\u306a\u305f\u306e\u6ce8\u6587<a href=\"https:\/\/nebula.org\/whole-genome-sequencing\/\">30x\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30b1\u30f3\u30b9\u30ad\u30c3\u30c8<\/a>\u4eca\u65e5\u304b\u3089\u3042\u306a\u305f\u306e\u30b2\u30ce\u30e0\u306e\u63a2\u7d22\u3092\u59cb\u3081\u307e\u3057\u3087\u3046\uff01<\/p>\n\n<p>\u3053\u306e\u8a18\u4e8b\u306f\u6c17\u306b\u5165\u308a\u307e\u3057\u305f\u304b\uff1f 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href=\"https:\/\/nebula.org\/whole-genome-sequencing\/\">\u661f\u96f2\u30b2\u30ce\u30df\u30af\u30b9<\/a><\/li><li><a href=\"https:\/\/nebula.org\/blog\/ja\/promethease-%e3%83%ac%e3%83%93%e3%83%a5%e3%83%bc\/\">\u30d7\u30ed\u30e1\u30c6\u30fc\u30bc<\/a><\/li><li><a href=\"https:\/\/nebula.org\/blog\/ja\/%e9%81%ba%e4%bc%9d%e5%ad%90-%e9%ad%94%e7%a5%9e-%e3%83%ac%e3%83%93%e3%83%a5%e3%83%bc\/\">\u907a\u4f1d\u306e\u9b54\u795e<\/a><\/li><li><a href=\"https:\/\/nebula.org\/blog\/ja\/vitagene-%e3%83%ac%e3%83%93%e3%83%a5%e3%83%bc\/\">Vitagene<\/a><\/li><li><a href=\"https:\/\/nebula.org\/blog\/ja\/%e8%87%aa%e5%b7%b1%e3%83%87%e3%82%b3%e3%83%bc%e3%83%89-%e3%83%ac%e3%83%93%e3%83%a5%e3%83%bc\/\">SelfDecode<\/a><\/li><li><a href=\"https:\/\/nebula.org\/blog\/ja\/xcode-life-review\/\">Xcode Life<\/a><\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u524d\u66f8\u304d \u907a\u4f1d\u5b505,10-\u30e1\u30c1\u30ec\u30f3\u30c6\u30c8\u30e9\u30d2\u30c9\u30ed\u8449\u9178\u30ec\u30c0\u30af\u30bf\u30fc\u30bc\u306b\u3064\u3044\u3066\u306e\u8a71\u984c\u306b\u3064\u3044 &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"ast-button\" href=\"https:\/\/nebula.org\/blog\/ja\/mthfr\/\"> <span class=\"screen-reader-text\">MTHFR \u2013\u306a\u305c\u3053\u306e\u907a\u4f1d\u5b50\u306b\u305d\u308c\u307b\u3069\u95a2\u5fc3\u304c\u3042\u308b\u306e\u3067\u3059\u304b\uff1f<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":13,"featured_media":6387,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4977],"tags":[],"class_list":["post-9578","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-4977"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.13 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>MTHFR \u2013\u306a\u305c\u3053\u306e\u907a\u4f1d\u5b50\u306b\u305d\u308c\u307b\u3069\u95a2\u5fc3\u304c\u3042\u308b\u306e\u3067\u3059\u304b\uff1f [JULY 2020]<\/title>\n<meta name=\"description\" content=\"DNA\u691c\u67fb\u30b5\u30fc\u30d3\u30b9\u306e\u30e6\u30fc\u30b6\u30fc\u306e\u9593\u3067MTHFR\u907a\u4f1d\u5b50\u306b\u591a\u304f\u306e\u95a2\u5fc3\u304c\u3042\u308a\u307e\u3059\u3002 \u3057\u304b\u3057\u3001MTHFR\u306f\u672c\u5f53\u306b\u591a\u304f\u306e\u75c5\u6c17\u3067\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u304b\uff1f\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nebula.org\/blog\/ja\/mthfr\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta 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content=\"2021-02-21T01:21:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/05\/2880px-MTHFR_reaction.svg.png\" \/>\n\t<meta property=\"og:image:width\" content=\"924\" \/>\n\t<meta property=\"og:image:height\" content=\"527\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Ankeeta Shah, B.A.\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@nebulagenomics\" \/>\n<meta name=\"twitter:site\" content=\"@nebulagenomics\" \/>\n<meta name=\"twitter:label1\" content=\"\u57f7\u7b46\u8005\" \/>\n\t<meta name=\"twitter:data1\" content=\"Ankeeta Shah, B.A.\" \/>\n<script type=\"application\/ld+json\" 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