{"id":9600,"date":"2021-01-05T23:23:37","date_gmt":"2021-01-06T04:23:37","guid":{"rendered":"https:\/\/nebula.org\/blog\/dna-%e3%82%b7%e3%83%bc%e3%82%b1%e3%83%b3%e3%82%b9\/"},"modified":"2021-02-20T20:27:33","modified_gmt":"2021-02-21T01:27:33","slug":"dna-%e3%82%b7%e3%83%bc%e3%82%b1%e3%83%b3%e3%82%b9","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/ja\/dna-%e3%82%b7%e3%83%bc%e3%82%b1%e3%83%b3%e3%82%b9\/","title":{"rendered":"DNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0-\u751f\u547d\u306e\u30b3\u30fc\u30c9\u3092\u8aad\u307f\u53d6\u308b\u6280\u8853"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"h-what-is-dna-sequencing\">DNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f<\/h2>\n\n<p>DNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u306f\u3001\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306e\u9806\u5e8f\u3092\u6c7a\u5b9a\u3059\u308b\u65b9\u6cd5\u3067\u3059\u3002<a href=\"https:\/\/nebula.org\/blog\/ja\/dna-%e3%83%87%e3%82%aa%e3%82%ad%e3%82%b7%e3%83%aa%e3%83%9c%e6%a0%b8%e9%85%b8\/\"> DNA<\/a>\u5206\u5b50\u3002 DNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u306f\u30b2\u30ce\u30df\u30af\u30b9\u306b\u9769\u547d\u3092\u3082\u305f\u3089\u3057\u307e\u3057\u305f\u3002 1995\u5e74\u4ee5\u6765\u3001DNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u306b\u3088\u308a\u300150,000\u3092\u8d85\u3048\u308b\uff082020\u5e74\u73fe\u5728\uff09\u3055\u307e\u3056\u307e\u306a\u751f\u7269\u306e\u30b2\u30ce\u30e0\u3092\u5206\u6790\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3057\u305f\u3002 <\/p>\n\n<p>\u3053\u306e\u624b\u6cd5\u306f\u3001\u4ed6\u306eDNA\u5206\u6790\u624b\u6cd5\u3068\u3068\u3082\u306b\u3001\u3068\u308a\u308f\u3051\u907a\u4f1d\u75c5\u306e\u8abf\u67fb\u306b\u3082\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002 \u3055\u3089\u306b\u3001\u5206\u5b50\u30af\u30ed\u30fc\u30cb\u30f3\u30b0\u306e\u6587\u8108\u3067\u306f\u3001DNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u306f\u5206\u5b50\u751f\u7269\u5b66\u304a\u3088\u3073\u907a\u4f1d\u5b50\u5de5\u5b66\u306e\u5b9f\u9a13\u5ba4\u3067\u4e0d\u53ef\u6b20\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n<figure class=\"wp-block-table\"><table class=\"has-subtle-pale-pink-background-color has-background\"><tbody><tr><td><a href=\"https:\/\/nebula.org\/whole-genome-sequencing\/\"><strong>DNA\u3092100\uff05\u30c7\u30b3\u30fc\u30c9\u3059\u308b\u3053\u3068\u306b\u8208\u5473\u304c\u3042\u308a\u307e\u3059\u304b\uff1f Nebula Genomics\u306f\u3001\u6700\u3082\u624b\u9803\u306a\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30b1\u30f3\u30b9\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002 \u30b2\u30ce\u30e0\u30c7\u30fc\u30bf\u3078\u306e\u30d5\u30eb\u30a2\u30af\u30bb\u30b9\u3001\u6700\u65b0\u306e\u79d1\u5b66\u7684\u767a\u898b\u306b\u57fa\u3065\u304f\u6bce\u9031\u306e\u66f4\u65b0\u3001\u9ad8\u5ea6\u306a\u7956\u5148\u5206\u6790\u3001\u304a\u3088\u3073\u5f37\u529b\u306a\u30b2\u30ce\u30e0\u63a2\u7d22\u30c4\u30fc\u30eb\u3092\u4f7f\u7528\u3057\u3066\u3001\u4e00\u751f\u306e\u767a\u898b\u3092\u958b\u59cb\u3057\u307e\u3059\u3002 \u8a73\u7d30\u306b\u3064\u3044\u3066\u306f\u3001\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/strong><\/a><\/td><\/tr><\/tbody><\/table><\/figure>\n\n<p><em>Christina Swords\u3001Ph.D\u3002\u304c\u7de8\u96c6<\/em><\/p>\n\n<h2 class=\"wp-block-heading\" id=\"h-the-challenges-of-dna-sequencing\"><strong>DNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u306e\u8ab2\u984c<\/strong><\/h2>\n\n<p>\u751f\u5316\u5b66\u7684\u307e\u305f\u306f\u5206\u5b50\u7684\u65b9\u6cd5\u304c\u958b\u767a\u3055\u308c\u305f1970\u5e74\u4ee3\u534a\u3070\u307e\u3067\u3001\u751f\u7269\u5b66\u7684\u914d\u5217\u306e\u6c7a\u5b9a\u306f\u4f55\u5341\u5e74\u3082\u306e\u9593\u672a\u89e3\u6c7a\u306e\u554f\u984c\u3067\u3057\u305f\u3002 \u4eca\u65e5\u3067\u306f\u3001\u30b2\u30ce\u30e0\u5168\u4f53\u306e\u5927\u898f\u6a21\u306a\u30b7\u30fc\u30b1\u30f3\u30b9\u3067\u3055\u3048\u3001\u6bd4\u8f03\u7684\u9ad8\u901f\u3067\u7c21\u5358\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002 <\/p>\n\n<p>\u305f\u3060\u3057\u3001\u30b2\u30ce\u30e0\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u306e\u8ab2\u984c\u306f\u3001\u6838\u9178\u914d\u5217\u3092\u76f4\u63a5\u8aad\u307f\u53d6\u308b\u3053\u3068\u3060\u3051\u306b\u9650\u5b9a\u3055\u308c\u307e\u305b\u3093\u3002 \u6280\u8853\u7684\u306a\u5236\u9650\u306b\u3088\u308a\u3001\u500b\u3005\u306e\u30b7\u30fc\u30b1\u30f3\u30b9\u53cd\u5fdc\u3067\u306f\u3001\u6700\u59271000\u5869\u57fa\u5bfe\u306e\u77ed\u3044DNA\u30bb\u30af\u30b7\u30e7\u30f3\uff08\u8aad\u307f\u53d6\u308a\uff09\u306e\u307f\u304c\u8aad\u307f\u53d6\u3089\u308c\u307e\u3059\u3002 DNA\u306e\u9577\u3044\u9396\u306b\u3064\u3044\u3066\u306f\u3001\u30d7\u30e9\u30a4\u30de\u30fc\u30a6\u30a9\u30fc\u30ad\u30f3\u30b0\u3068\u3057\u3066\u77e5\u3089\u308c\u308b\u65b9\u6cd5\u304c1979\u5e74\u306b\u6700\u521d\u306b\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\u3002 \u3053\u306e\u624b\u9806\u3067\u306f\u3001\u30b7\u30fc\u30b1\u30f3\u30b9\u30921\u3064\u305a\u3064\u8aad\u307f\u53d6\u308a\u307e\u3057\u305f\u3002<\/p>\n\n<p>\u5927\u898f\u6a21\u306a\u30b7\u30fc\u30b1\u30f3\u30b9\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3067\u306f\u3001<a href=\"https:\/\/www.genome.gov\/human-genome-project\">\u30d2\u30c8\u30b2\u30ce\u30e0\u30d7\u30ed\u30b8\u30a7\u30af\u30c8<\/a>\u3001\u6570\u5341\u5104\u306e\u5869\u57fa\u5bfe\u304c\u30b7\u30fc\u30b1\u30f3\u30b9\u3055\u308c\u307e\u3057\u305f\u3002 \u3053\u308c\u306f\u3001\u30b7\u30e7\u30c3\u30c8\u30ac\u30f3\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u3068\u3057\u3066\u77e5\u3089\u308c\u308b\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u3088\u3063\u3066\u884c\u308f\u308c\u307e\u3057\u305f\u3002 \u4eca\u65e5\u3001\u79c1\u305f\u3061\u306f\u75c5\u6c17\u3001\u5275\u85ac\u30bf\u30fc\u30b2\u30c3\u30c8\u3001DNA\u30d9\u30fc\u30b9\u306e\u540c\u5b9a\u306a\u3069\u3092\u7814\u7a76\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 \u8d85\u4e26\u5217DNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u306e\u304a\u304b\u3052\u3067\u3059\u3002<\/p>\n\n<p>\u30b7\u30e7\u30c3\u30c8\u30ac\u30f3\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u3067\u306f\u3001DNA\u9396\u306f\u6700\u521d\u306b\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306e\u5c0f\u3055\u306a\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u306b\u5206\u89e3\u3055\u308c\u3001\u6b21\u306b\u5869\u57fa\u3054\u3068\u306b\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u3055\u308c\u307e\u3059\u3002 \u6b21\u306b\u3001\u500b\u3005\u306e\u77ed\u3044\u30bb\u30b0\u30e1\u30f3\u30c8\u306e\u914d\u5217\u60c5\u5831\u306f\u3001\u30d0\u30a4\u30aa\u30a4\u30f3\u30d5\u30a9\u30de\u30c6\u30a3\u30af\u30b9\u30c4\u30fc\u30eb\u3092\u4f7f\u7528\u3057\u3066\u5b8c\u5168\u306a\u30b2\u30ce\u30e0\u306b\u518d\u69cb\u7bc9\u3055\u308c\u307e\u3059\u3002<\/p>\n\n<p>\u751f\u7269\u5b66\u7684\u306b\u95a2\u9023\u3059\u308b\u60c5\u5831\u3092\u53d6\u5f97\u3059\u308b\u305f\u3081\u306b\u3001\u751f\u30c7\u30fc\u30bf\u30b7\u30fc\u30b1\u30f3\u30b9\u304c\u5206\u6790\u3055\u308c\u307e\u3059\u3002 \u305d\u308c\u304c\u306a\u3051\u308c\u3070\u3001\u914d\u5217\u60c5\u5831\u306f\u79d1\u5b66\u7684\u4fa1\u5024\u304c\u306a\u3044\u307e\u307e\u3067\u3059\u3002<\/p>\n\n<h2 class=\"wp-block-heading\" id=\"h-sequencing-methods\"><strong>\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u65b9\u6cd5<\/strong><\/h2>\n\n<p>\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u30de\u30b7\u30f3\u3092\u4f7f\u7528\u3057\u3066DNA\u914d\u5217\u60c5\u5831\u3092\u8aad\u307f\u53d6\u308b\u305f\u3081\u306b\u3001\u4eca\u65e5\u3044\u304f\u3064\u304b\u306e\u65b9\u6cd5\u304c\u5229\u7528\u53ef\u80fd\u3067\u3059\u3002 \u9577\u3044\u9593\u3001\u30b7\u30fc\u30b1\u30f3\u30b9\u624b\u6cd5\u306e\u958b\u767a\u306f\u30b5\u30f3\u30ac\u30fc\u30b7\u30fc\u30b1\u30f3\u30b9\u306b\u57fa\u3065\u3044\u3066\u69cb\u7bc9\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002 \u6700\u65b0\u306e\u65b9\u6cd5\u306f\u3001\u9ad8\u5ea6\u306b\u4e26\u5217\u5316\u3055\u308c\u305f\u30b7\u30fc\u30b1\u30f3\u30b9\u3092\u901a\u3058\u3066\u9ad8\u901f\u30b7\u30fc\u30b1\u30f3\u30b9\u306e\u53ef\u80fd\u6027\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002 \u65b0\u3057\u3044\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u65b9\u6cd5\u306f\u3001\u3057\u3070\u3057\u3070\u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u3068\u547c\u3070\u308c\u307e\u3059\u3002<\/p>\n\n<h3 class=\"wp-block-heading\" id=\"h-classical-methods\"><strong>\u53e4\u5178\u7684\u306a\u65b9\u6cd5<\/strong><\/h3>\n\n<h4 class=\"wp-block-heading\" id=\"h-method-of-maxam-and-gilbert\"><strong>\u30de\u30af\u30b5\u30e0\u3068\u30ae\u30eb\u30d0\u30fc\u30c8\u306e\u65b9\u6cd5<\/strong><\/h4>\n\n<p>\u3053\u306e\u65b9\u6cd5\u306f\u30011977\u5e74\u306bAllanMaxam\u3068WalterGilbert\u306b\u3088\u3063\u3066\u958b\u767a\u3055\u308c\u307e\u3057\u305f\u3002 \u3053\u308c\u306f2\u3064\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u57fa\u3065\u3044\u3066\u3044\u307e\u3059\u3002 DNA\u306e\u5869\u57fa\u7279\u7570\u7684\u306a\u5316\u5b66\u7684\u5207\u65ad\u3068\u305d\u308c\u306b\u7d9a\u304f\u5909\u6027\u30dd\u30ea\u30a2\u30af\u30ea\u30eb\u30a2\u30df\u30c9\u30b2\u30eb\u96fb\u6c17\u6cf3\u52d5\u306b\u3088\u308b\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u306e\u5206\u96e2\u3002 <\/p>\n\n<p>DNA\u306f\u3001\u6700\u521d\u306b5 &#8216;\u307e\u305f\u306f3&#8217;\u672b\u7aef\u3067\u653e\u5c04\u6027\u30ea\u30f3\u9178\u5869\u307e\u305f\u306f\u975e\u653e\u5c04\u6027\u7269\u8cea\uff08\u30d3\u30aa\u30c1\u30f3\u3001\u30d5\u30eb\u30aa\u30ec\u30bb\u30a4\u30f3\uff09\u3067\u6a19\u8b58\u3055\u308c\u307e\u3059\u3002 \u6b21\u306b\u30014\u3064\u306e\u5225\u3005\u306e\u8abf\u88fd\u7269\u3067\u3001DNA\u306e\u7cd6\u30ea\u30f3\u9178\u9aa8\u683c\u304b\u3089\u306e\u7279\u5b9a\u306e\u5869\u57fa\u304c\u90e8\u5206\u7684\u306b\uff08\u9650\u5b9a\u7684\u306b\uff09\u4fee\u98fe\u3055\u308c\u3001\u5207\u65ad\u3055\u308c\u307e\u3059\u3002 \u305f\u3068\u3048\u3070\u3001\u5869\u57fa\u6027\u30b0\u30a2\u30cb\u30f3\uff08G\uff09\u306f\u3001\u8a66\u85ac\u306e\u786b\u9178\u30b8\u30e1\u30c1\u30eb\u306b\u3088\u3063\u3066\u30e1\u30c1\u30eb\u5316\u3055\u308c\u3001\u30d4\u30da\u30ea\u30b8\u30f3\u306b\u3088\u308b\u30a2\u30eb\u30ab\u30ea\u51e6\u7406\u306b\u3088\u3063\u3066\u9664\u53bb\u3055\u308c\u307e\u3059\u3002<\/p>\n\n<p>\u305d\u306e\u5f8c\u3001DNA\u9396\u306f\u5b8c\u5168\u306b\u5207\u65ad\u3055\u308c\u307e\u3059\u3002 \u5404\u8abf\u88fd\u7269\u3067\u306f\u3001\u7570\u306a\u308b\u9577\u3055\u306e\u65ad\u7247\u304c\u5f62\u6210\u3055\u308c\u3001\u305d\u306e3 &#8216;\u672b\u7aef\u306f\u5e38\u306b\u7279\u5b9a\u306e\u5869\u57fa\u3067\u5207\u65ad\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u5909\u6027\u30dd\u30ea\u30a2\u30af\u30ea\u30eb\u30a2\u30df\u30c9\u30b2\u30eb\u96fb\u6c17\u6cf3\u52d5\u306f\u3001\u9577\u3055\u306b\u5f93\u3063\u3066\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u3092\u5206\u96e2\u3057\u3001\u9577\u3055\u306e\u9055\u3044\u306f1\u5869\u57fa\u3067\u89e3\u6c7a\u3055\u308c\u307e\u3059\u3002 \u30b2\u30eb\u4e0a\u306e4\u3064\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u6bd4\u8f03\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001DNA\u306e\u914d\u5217\u3092\u8aad\u307f\u53d6\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 <\/p>\n\n<p>\u3053\u306e\u65b9\u6cd5\u306b\u3088\u308a\u3001\u767a\u660e\u8005\u306f\u7d30\u83cc\u30b2\u30ce\u30e0\u306e\u30aa\u30da\u30ed\u30f3\u914d\u5217\u3092\u6c7a\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002 \u4eca\u65e5\u3001\u3053\u306e\u65b9\u6cd5\u306f\u6709\u6bd2\u306a\u8a66\u85ac\u3092\u5fc5\u8981\u3068\u3059\u308b\u305f\u3081\u3001\u307b\u3068\u3093\u3069\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002 \u3055\u3089\u306b\u3001\u540c\u6642\u306b\u958b\u767a\u3055\u308c\u305f\u30b5\u30f3\u30ac\u30fc\u30b8\u30c7\u30aa\u30ad\u30b7\u6cd5\u3088\u308a\u3082\u81ea\u52d5\u5316\u304c\u56f0\u96e3\u3067\u3059\u3002<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh4.googleusercontent.com\/uCg6Zgm2uOGHpyiUDS7Igrzb7G31oM5J0SUj4ogs32EHCEZK0jzoR1bxDYGf8cWtBwTjD25wqKCx3nIWN-gGmCkn66FZweUaOL4pJM9tYA08z9h3NArwrpZ-aqK66bZ11LY5k6Sm\" alt=\"MaxamGilbert&#x30B7;&#x30FC;&#x30B1;&#x30F3;&#x30B9;&#x30A2;&#x30D7;&#x30ED;&#x30FC;&#x30C1;&#x3002;\" title=\"MaxamGilbert&#x30B7;&#x30FC;&#x30B1;&#x30F3;&#x30B9; \"\/><figcaption>MaxamGilbert\u30b7\u30fc\u30b1\u30f3\u30b9\u30a2\u30d7\u30ed\u30fc\u30c1\u3002 \u753b\u50cf\u30bd\u30fc\u30b9\uff1aJHCaufield\u3001\u30a6\u30a3\u30ad\u30e1\u30c7\u30a3\u30a2\u30b3\u30e2\u30f3\u30ba<br\/><\/figcaption><\/figure>\n\n<h4 class=\"wp-block-heading\" id=\"h-dideoxy-method-sanger-sequencing\"><strong>\u30b8\u30c7\u30aa\u30ad\u30b7\u6cd5\uff08\u30b5\u30f3\u30ac\u30fc<\/strong><strong>\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0<\/strong>\uff09<\/h4>\n\n<p>\u30b5\u30f3\u30ac\u30fc\u30b8\u30c7\u30aa\u30ad\u30b7\u6cd5\u306f\u3001\u9023\u9396\u505c\u6b62\u5408\u6210\u3068\u3082\u547c\u3070\u308c\u307e\u3059\u3002 \u9175\u7d20\u6cd5\u3067\u3059\u3002 1975\u5e74\u9803\u306bSangerandCoulson\u306b\u3088\u3063\u3066\u958b\u767a\u3055\u308c\u307e\u3057\u305f\u3002 1977\u5e74\u306b\u3001\u30b2\u30ce\u30e0\u306e\u6700\u521d\u306e\u5b8c\u5168\u306a\u914d\u5217\uff08\u30d0\u30af\u30c6\u30ea\u30aa\u30d5\u30a1\u30fc\u30b8\u03c6X174\uff09\u3068\u3068\u3082\u306b\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n<p>\u30b5\u30f3\u30ac\u30fc\u306f\u3001DNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u306e\u7814\u7a76\u30671980\u5e74\u306b\u30ce\u30fc\u30d9\u30eb\u5316\u5b66\u8cde\u3092\u53d7\u8cde\u3057\u307e\u3057\u305f\u3002 \u5f7c\u306f\u30a6\u30a9\u30eb\u30bf\u30fc\u30ae\u30eb\u30d0\u30fc\u30c8\u3068\u30dd\u30fc\u30eb\u30d0\u30fc\u30b0\u3068\u4e00\u7dd2\u306b\u8cde\u3092\u53d7\u8cde\u3057\u307e\u3057\u305f\u3002<\/p>\n\n<p>\u9175\u7d20<a href=\"https:\/\/nebula.org\/blog\/ja\/dna-%e3%83%9d%e3%83%aa%e3%83%a1%e3%83%a9%e3%83%bc%e3%82%bc\/\">DNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc<\/a>2\u3064\u306e\u76f8\u88dc\u7684DNA\u9396\u306e1\u3064\u3092\u9577\u304f\u3059\u308b\u305f\u3081\u306b\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002 DNA\u4e8c\u91cd\u3089\u305b\u3093\u306f\u52a0\u71b1\u306b\u3088\u308a\u5909\u6027\u3057\u3001\u305d\u306e\u5f8c\u4e00\u672c\u9396\u3092\u3055\u3089\u306b\u51e6\u7406\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 <\/p>\n\n<p>\u4ed6\u306e\u70b9\u3067\u306f\u540c\u4e00\u306e4\u3064\u306e\u8abf\u88fd\u7269\u3067\u306f\u30014\u3064\u306e\u5869\u57fa\u306e\u305d\u308c\u305e\u308c\u306e1\u3064\u304c\u30b8\u30c7\u30aa\u30ad\u30b7\u30cc\u30af\u30ec\u30aa\u30b7\u30c9\u4e09\u30ea\u30f3\u9178\uff08ddNTP\uff09\u3068\u3057\u3066\u6dfb\u52a0\u3055\u308c\u307e\u3059\u3002 \u3053\u308c\u3089\u306e\u9396\u672b\u7aefddNTP\u306b\u306f\u3001\u6b21\u306e\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306e\u30ea\u30f3\u9178\u57fa\u3092\u7d50\u5408\u3059\u308b\u305f\u3081\u306e3&#8242;-\u30d2\u30c9\u30ed\u30ad\u30b7\u57fa\u304c\u3042\u308a\u307e\u305b\u3093\u3002 \u65b0\u3057\u304f\u5408\u6210\u3055\u308c\u305f\u9396\u3078\u306e\u305d\u308c\u3089\u306e\u4ed8\u52a0\u306f\u3001OH\u57fa\u304c\u6b20\u843d\u3057\u3066\u3044\u308b\u305f\u3081\u3001DNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u306b\u3088\u308bDNA\u4f38\u9577\u3092\u505c\u6b62\u3057\u307e\u3059\u3002<\/p>\n\n<p> \u305d\u306e\u7d50\u679c\u3001\u7570\u306a\u308b\u9577\u3055\u306eDNA\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u304c\u751f\u6210\u3055\u308c\u3001\u500b\u3005\u306e\u30d0\u30c3\u30c1\u3067\u5e38\u306b\u540c\u3058ddNTP\u3067\u7d42\u308f\u308a\u307e\u3059\u3002 <\/p>\n\n<p>\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u53cd\u5fdc\u5f8c\u3001\u3059\u3079\u3066\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u304b\u3089\u306e\u6a19\u8b58\u3055\u308c\u305f\u30d6\u30ec\u30fc\u30af\u30aa\u30d5\u7523\u7269\u306f\u3001\u30dd\u30ea\u30a2\u30af\u30ea\u30eb\u30a2\u30df\u30c9\u30b2\u30eb\u96fb\u6c17\u6cf3\u52d5\u306b\u3088\u3063\u3066\u7e26\u65b9\u5411\u306b\u5206\u96e2\u3055\u308c\u307e\u3059\u3002 <\/p>\n\n<p>\u653e\u5c04\u6027\u30b2\u30eb\u306e\u9732\u5149\u5f8c\u3001\u30b7\u30fc\u30b1\u30f3\u30b9\u3092\u5199\u771f\u30d5\u30a3\u30eb\u30e0\uff08X\u7dda\u30d5\u30a3\u30eb\u30e0\uff09\u3067\u8aad\u307f\u53d6\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 \u5bfe\u5fdc\u3059\u308b\u76f8\u88dc\u914d\u5217\u306f\u3001\u4f7f\u7528\u3055\u308c\u308b\u4e00\u672c\u9396DNA\u30c6\u30f3\u30d7\u30ec\u30fc\u30c8\u306e\u914d\u5217\u3067\u3059\u3002 \u4eca\u65e5\u3067\u306f\u3001\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u9023\u9396\u53cd\u5fdc\uff08PCR\uff09\u306e\u30d0\u30ea\u30a8\u30fc\u30b7\u30e7\u30f3\u304c\u30b7\u30fc\u30b1\u30f3\u30b9\u53cd\u5fdc\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002 <\/p>\n\n<p>PCR\u3068\u306f\u7570\u306a\u308a\u3001\u30d7\u30e9\u30a4\u30de\u30fc\u306f1\u3064\u3057\u304b\u4f7f\u7528\u3055\u308c\u306a\u3044\u305f\u3081\u3001DNA\u306f\u76f4\u7dda\u7684\u306b\u306e\u307f\u5897\u5e45\u3055\u308c\u307e\u3059\u3002<\/p>\n\n<p>1980\u5e74\u4ee3\u521d\u982d\u3001\u30d5\u30ea\u30c3\u30c4M.\u30dd\u30fc\u30eb\u3068\u5f7c\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306fDNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u306e\u305f\u3081\u306e\u653e\u5c04\u6027\u6cd5\u3092\u958b\u767a\u3057\u307e\u3057\u305f\u3002 \u3053\u306e\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u6280\u8853\u3067\u306f\u3001DNA\u5206\u5b50\u306f\u96fb\u6c17\u6cf3\u52d5\u5206\u96e2\u4e2d\u306b\u30ad\u30e3\u30ea\u30a2\u306b\u8ee2\u9001\u3055\u308c\u307e\u3059\u3002 <\/p>\n\n<p>\u300c\u30c0\u30a4\u30ec\u30af\u30c8\u30d6\u30ed\u30c3\u30c6\u30a3\u30f3\u30b0\u96fb\u6c17\u6cf3\u52d5\u30b7\u30b9\u30c6\u30e0GATC1500\u300d\u306f\u3001\u30b3\u30f3\u30b9\u30bf\u30f3\u30c4\u3092\u62e0\u70b9\u3068\u3059\u308b\u4f01\u696dGATCBiotech\u306b\u3088\u3063\u3066\u8ca9\u58f2\u3055\u308c\u307e\u3057\u305f\u3002 DNA\u30b7\u30fc\u30b1\u30f3\u30b5\u30fc\u306f\u3001\u305f\u3068\u3048\u3070\u3001\u9175\u6bcd\u306e2\u756a\u67d3\u8272\u4f53\u3092\u914d\u5217\u6c7a\u5b9a\u3059\u308b\u305f\u3081\u306e\u30e8\u30fc\u30ed\u30c3\u30d1\u306e\u30b2\u30ce\u30e0\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3067\u4f7f\u7528\u3055\u308c\u307e\u3057\u305f\u3002<em> Saccharomyces cerevisiae<\/em> \u3002<\/p>\n\n<p>1990\u5e74\u4ee3\u521d\u982d\u4ee5\u6765\u3001\u86cd\u5149\u8272\u7d20\u3067\u6a19\u8b58\u3055\u308c\u305f\u30b8\u30c7\u30aa\u30ad\u30b7\u30cc\u30af\u30ec\u30aa\u30b7\u30c9\u4e09\u30ea\u30f3\u9178\u304c\u7279\u306b\u4f7f\u7528\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002 4\u3064\u306eddNTP\u306f\u3001\u305d\u308c\u305e\u308c\u7570\u306a\u308b\u8272\u7d20\u3068\u7d50\u5408\u3057\u3066\u3044\u307e\u3059\u3002 \u3053\u306e\u5909\u66f4\u306b\u3088\u308a\u30014\u3064\u306eddNTP\u3059\u3079\u3066\u30921\u3064\u306e\u53cd\u5fdc\u5bb9\u5668\u306b\u8ffd\u52a0\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002 <\/p>\n\n<p>\u5225\u3005\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306b\u5206\u5272\u3057\u3066\u653e\u5c04\u6027\u540c\u4f4d\u5143\u7d20\u3092\u51e6\u7406\u3059\u308b\u5fc5\u8981\u306f\u3082\u3046\u3042\u308a\u307e\u305b\u3093\u3002 \u5f97\u3089\u308c\u305f\u9023\u9396\u505c\u6b62\u751f\u6210\u7269\u306f\u3001\u30ad\u30e3\u30d4\u30e9\u30ea\u30fc\u96fb\u6c17\u6cf3\u52d5\u306b\u3088\u3063\u3066\u5206\u96e2\u3055\u308c\u3001\u30ec\u30fc\u30b6\u30fc\u306b\u3088\u3063\u3066\u86cd\u5149\u3092\u767a\u3059\u308b\u3088\u3046\u306b\u52b1\u8d77\u3055\u308c\u307e\u3059\u3002<\/p>\n\n<p>\u3057\u305f\u304c\u3063\u3066\u3001\u5404DNA\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u306e\u6700\u5f8c\u306b\u3042\u308bddNTP\u306f\u3001\u7570\u306a\u308b\u8272\u306e\u86cd\u5149\u3092\u793a\u3057\u307e\u3059\u3002 \u3053\u306e\u86cd\u5149\u306f\u3001\u691c\u51fa\u5668\u3067\u691c\u51fa\u3067\u304d\u307e\u3059\u3002 \u30a8\u30ec\u30af\u30c8\u30ed\u30d5\u30a7\u30ed\u30b0\u30e9\u30e0\u306f\u3001\u914d\u5217\u6c7a\u5b9a\u3055\u308c\u305fDNA\u9396\u306e\u5869\u57fa\u914d\u5217\u3092\u76f4\u63a5\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh5.googleusercontent.com\/yyZ_LR_fZ-94euUL4t6vX5lCWQ1W4uw1VoHq1jMUzzQVpDVHUUNHY9Hj5n_C7-cYtYgBEvwimFWHcva6WeuZNDXQ3OL6S0p62PoS2mO33PGJW-VV4DREdi5hmplZlVvpjkeqtHcW\" alt=\"&#x30B5;&#x30F3;&#x30AC;&#x30FC;&#x30B7;&#x30FC;&#x30B1;&#x30F3;&#x30B7;&#x30F3;&#x30B0;&#x306E;&#x5178;&#x578B;&#x7684;&#x306A;&#x30EF;&#x30FC;&#x30AF;&#x30D5;&#x30ED;&#x30FC;&#x3002; \" title=\"&#x30B5;&#x30F3;&#x30AC;&#x30FC;&#x30B7;&#x30FC;&#x30B1;&#x30F3;&#x30B7;&#x30F3;&#x30B0;\"\/><figcaption>\u30b5\u30f3\u30ac\u30fc\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u306e\u5178\u578b\u7684\u306a\u30ef\u30fc\u30af\u30d5\u30ed\u30fc\u3002 \u753b\u50cf\u30bd\u30fc\u30b9\uff1aEstevezj\u3001\u30a6\u30a3\u30ad\u30e1\u30c7\u30a3\u30a2\u30b3\u30e2\u30f3\u30ba<\/figcaption><\/figure>\n\n<h3 class=\"wp-block-heading\" id=\"h-modern-approaches\"><strong>\u73fe\u4ee3\u306e\u30a2\u30d7\u30ed\u30fc\u30c1<\/strong><\/h3>\n\n<p>\u7814\u7a76\u304a\u3088\u3073\u8a3a\u65ad\u306b\u304a\u3051\u308bDNA\u914d\u5217\u6c7a\u5b9a\u306e\u91cd\u8981\u6027\u304c\u5897\u3059\u306b\u3064\u308c\u3066\u3001\u30b9\u30eb\u30fc\u30d7\u30c3\u30c8\u306e\u5411\u4e0a\u3092\u53ef\u80fd\u306b\u3059\u308b\u65b9\u6cd5\u304c\u958b\u767a\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002 \u73fe\u5728\u3001\u7d048\u65e5\u3067\u5b8c\u5168\u306a\u30d2\u30c8\u30b2\u30ce\u30e0\u306e\u914d\u5217\u3092\u6c7a\u5b9a\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3059\u3002 \u5bfe\u5fdc\u3059\u308b\u65b9\u6cd5\u306f\u3001\u7b2c2\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b9\u3068\u547c\u3070\u308c\u307e\u3059\u3002<\/p>\n\n<p> \u3055\u307e\u3056\u307e\u306a\u4f01\u696d\u304c\u3001\u3055\u307e\u3056\u307e\u306a\u9577\u6240\u3068\u77ed\u6240\u3092\u6301\u3064\u65b9\u6cd5\u3092\u958b\u767a\u3057\u3066\u3044\u307e\u3059\u3002 \u3053\u3053\u306b\u30ea\u30b9\u30c8\u3055\u308c\u3066\u3044\u308b\u3082\u306e\u3068\u306f\u5225\u306b\u3001\u4ed6\u306e\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002 \u7b2c2\u4e16\u4ee3\u306eDNA\u30b7\u30fc\u30b1\u30f3\u30b9\u306f\u3001\u30b8\u30e3\u30fc\u30ca\u30ebNatureMethods\u306b\u3088\u3063\u3066\u300c2007\u5e74\u306e\u30e1\u30bd\u30c3\u30c9\u300d\u306b\u9078\u3070\u308c\u307e\u3057\u305f\u3002<\/p>\n\n<h4 class=\"wp-block-heading\" id=\"h-dna-sequencing-using-pyrosequencing\"><strong>\u30d1\u30a4\u30ed\u30b7\u30fc\u30b1\u30f3\u30b9\u3092\u4f7f\u7528\u3057\u305fDNA\u30b7\u30fc\u30b1\u30f3\u30b9<\/strong><\/h4>\n\n<p>\u30d1\u30a4\u30ed\u30b7\u30fc\u30b1\u30f3\u30b9\u3067\u306f\u3001DNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u3092\u4f7f\u7528\u3057\u3066\u3001DNA\u30ab\u30a6\u30f3\u30bf\u30fc\u9396\u3092\u5408\u6210\u3057\u307e\u3059\u304c\u3001DNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u306e\u7a2e\u985e\u306f\u3055\u307e\u3056\u307e\u3067\u3059\u3002 <\/p>\n\n<p>DNA\u6df7\u5408\u7269\u3092DNA\u30a2\u30c0\u30d7\u30bf\u30fc\u3068\u30e9\u30a4\u30b2\u30fc\u30b7\u30e7\u30f3\u3057\u3001\u76f8\u88dc\u7684\u306a\u30a2\u30c0\u30d7\u30bf\u30fc\u914d\u5217\u3092\u4ecb\u3057\u3066\u30d3\u30fc\u30ba\u306b\u7d50\u5408\u3057\u307e\u3059\u3002 DNA\u3092\u30ed\u30fc\u30c9\u3057\u305f\u30d3\u30fc\u30ba\u306f\u3001\u7d30\u5b54\u306e\u3042\u308b\u30d7\u30ec\u30fc\u30c8\u306b\u914d\u7f6e\u3055\u308c\u307e\u3059\u3002 \u691c\u51fa\u306f\u5149\u691c\u51fa\u5668\u306b\u4f9d\u5b58\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n<p>DNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u306f\u3001\u65b0\u3057\u304f\u5408\u6210\u3055\u308c\u305fDNA\u9396\u306b\u500b\u3005\u306e\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u3092\u9023\u7d9a\u7684\u306b\u7d50\u5408\u3059\u308b\u305f\u3081\u3001\u300c\u52d5\u4f5c\u4e2d\u300d\u306b\u89b3\u5bdf\u3055\u308c\u307e\u3059\u3002 \u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306e\u633f\u5165\u304c\u6210\u529f\u3059\u308b\u3068\u3001\u691c\u51fa\u5668\u306b\u3088\u3063\u3066\u691c\u51fa\u3055\u308c\u308b\u5149\u4fe1\u53f7\u306b\u5909\u63db\u3055\u308c\u307e\u3059\u3002 \u30b7\u30fc\u30b1\u30f3\u30b9\u3055\u308c\u308bDNA\u306f\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u9396\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3001\u4e00\u672c\u9396\u306e\u5f62\u3067\u5229\u7528\u3067\u304d\u307e\u3059\u3002 <\/p>\n\n<p>DNA\u9396\u306e\u4f38\u9577\u306f\u30014\u7a2e\u985e\u306e\u30c7\u30aa\u30ad\u30b7\u30cc\u30af\u30ec\u30aa\u30b7\u30c9\u4e09\u30ea\u30f3\u9178\uff08dNTP\uff09\u306e1\u3064\u3092\u88dc\u5b8c\u7684\u306b\u52a0\u3048\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u884c\u308f\u308c\u307e\u3059\u3002 \u9069\u5207\u306a\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u304c\u8ffd\u52a0\u3055\u308c\u308b\u3068\u3001\u30b7\u30b0\u30ca\u30eb\u304c\u5f97\u3089\u308c\u307e\u3059\u3002 \u4e0d\u9069\u5207\u306aNTP\u3092\u8ffd\u52a0\u3057\u3066\u3082\u3001\u691c\u51fa\u53ef\u80fd\u306a\u4fe1\u53f7\u306f\u767a\u751f\u3057\u307e\u305b\u3093\u3002 \u6b21\u306b\u3001\u65e2\u5b58\u306eNTP\u304c\u7834\u68c4\u3055\u308c\u3001\u5225\u306e\u30bf\u30a4\u30d7\u304c\u8ffd\u52a0\u3055\u308c\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u53cd\u5fdc\u304c\u518d\u3073\u793a\u3055\u308c\u308b\u307e\u3067\u7d9a\u304d\u307e\u3059\u3002<\/p>\n\n<p>\u3053\u308c\u306f\u30eb\u30b7\u30d5\u30a7\u30e9\u30fc\u30bc\u9175\u7d20\u3092\u4ecb\u3057\u305f\u53cd\u5fdc\u3067\u3059\u3002 \u76f8\u88dc\u7684\u306a\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u304cDNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u306b\u3088\u3063\u3066\u7d44\u307f\u8fbc\u307e\u308c\u308b\u3068\u3001\u30d4\u30ed\u30ea\u30f3\u9178\uff08PPi\uff09\u304c\u653e\u51fa\u3055\u308c\u307e\u3059\u3002 \u30d4\u30ed\u30ea\u30f3\u9178\u306fATP\u30b9\u30eb\u30d5\u30ea\u30e9\u30fc\u30bc\u306b\u3088\u3063\u3066\u30a2\u30c7\u30ce\u30b7\u30f3\u4e09\u30ea\u30f3\u9178\uff08ATP\uff09\u306b\u5909\u63db\u3055\u308c\u307e\u3059\u3002 <\/p>\n\n<p>ATP\u306f\u3001\u30eb\u30b7\u30d5\u30a7\u30ea\u30f3\u3092\u30aa\u30ad\u30b7\u30eb\u30b7\u30d5\u30a7\u30ea\u30f3\u306b\u5909\u63db\u3059\u308b\u30eb\u30b7\u30d5\u30a7\u30e9\u30fc\u30bc\u53cd\u5fdc\u3092\u4fc3\u9032\u3057\u307e\u3059\u3002 \u3053\u308c\u306b\u3088\u308a\u3001\u691c\u51fa\u53ef\u80fd\u306a\u5149\u4fe1\u53f7\u304c\u751f\u6210\u3055\u308c\u307e\u3059\u3002\u305d\u306e\u5f37\u5ea6\u306f\u3001\u6d88\u8cbb\u3055\u308c\u305fATP\u306b\u6bd4\u4f8b\u3057\u307e\u3059\u3002<\/p>\n\n<p>\u30d1\u30a4\u30ed\u30b7\u30fc\u30b1\u30f3\u30b9\u306f\u3001\u7279\u5b9a\u306e\u983b\u5ea6\u3092\u6c7a\u5b9a\u3059\u308b\u305f\u3081\u306b\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059<a href=\"https:\/\/nebula.org\/blog\/ja\/%e9%81%ba%e4%bc%9d%e5%ad%90\/\">\u907a\u4f1d\u5b50<\/a>\u7a81\u7136\u5909\u7570\u3001\u4f8b\u3048\u3070\u907a\u4f1d\u75c5\u306e\u8abf\u67fb\u3002 \u30d1\u30a4\u30ed\u30b7\u30fc\u30b1\u30f3\u30b9\u306f\u7c21\u5358\u306b\u81ea\u52d5\u5316\u3067\u304d\u3001DNA\u30b5\u30f3\u30d7\u30eb\u306e\u9ad8\u5ea6\u306a\u4e26\u5217\u5206\u6790\u306b\u9069\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh3.googleusercontent.com\/wIPpCnxtXE4qvkT4LYJyd0oKdFQwW55iw5ugmZsNTPidcqH39LRzxQZF63dXHox445puAPaxXoRhOSUchzeXNYySxAeriLYE4Hy7WZklh2n8Xu8VghRYLEXjEyryLddCM0_w8Fsr\" alt=\"&#x30D1;&#x30A4;&#x30ED;&#x30B7;&#x30FC;&#x30B1;&#x30F3;&#x30B9;&#x3002;\" title=\"&#x30D1;&#x30A4;&#x30ED;&#x30B7;&#x30FC;&#x30B1;&#x30F3;&#x30B9;\"\/><figcaption>\u30d1\u30a4\u30ed\u30b7\u30fc\u30b1\u30f3\u30b9\u3002 \u753b\u50cf\u30bd\u30fc\u30b9\uff1aThisisjp\u3001\u30a6\u30a3\u30ad\u30e1\u30c7\u30a3\u30a2\u30b3\u30e2\u30f3\u30ba<\/figcaption><\/figure>\n\n<h4 class=\"wp-block-heading\" id=\"h-sequencing-by-hybridization\"><strong>\u30cf\u30a4\u30d6\u30ea\u30c0\u30a4\u30bc\u30fc\u30b7\u30e7\u30f3\u306b\u3088\u308b\u914d\u5217\u6c7a\u5b9a<\/strong><\/h4>\n\n<p>\u3053\u306e\u76ee\u7684\u306e\u305f\u3081\u306b\u3001\u77ed\u3044DNA\u30bb\u30af\u30b7\u30e7\u30f3\uff08\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff09\u306f\u3001\u30ac\u30e9\u30b9\u30ad\u30e3\u30ea\u30a2\uff08DNA\u30c1\u30c3\u30d7\u307e\u305f\u306f\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4\uff09\u4e0a\u3067\u884c\u3068\u5217\u306b\u56fa\u5b9a\u3055\u308c\u307e\u3059\u3002 <\/p>\n\n<p>\u914d\u5217\u6c7a\u5b9a\u3055\u308c\u308bDNA\u306e\u65ad\u7247\u306f\u8272\u7d20\u3067\u6a19\u8b58\u3055\u308c\u3001\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u30de\u30c8\u30ea\u30c3\u30af\u30b9\u306b\u9069\u7528\u3055\u308c\u307e\u3059\u3002 \u3053\u308c\u306b\u3088\u308a\u3001\u76f8\u88dc\u7684\u306a\u56fa\u5b9a\u304a\u3088\u3073\u904a\u96e2DNA\u30bb\u30af\u30b7\u30e7\u30f3\u304c\u4e92\u3044\u306b\u30cf\u30a4\u30d6\u30ea\u30c0\u30a4\u30ba\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 \u7d50\u5408\u3057\u3066\u3044\u306a\u3044\u30d5\u30e9\u30b0\u30e1\u30f3\u30c8\u3092\u6d17\u3044\u6d41\u3057\u305f\u5f8c\u3001\u30cf\u30a4\u30d6\u30ea\u30c0\u30a4\u30bc\u30fc\u30b7\u30e7\u30f3\u30d1\u30bf\u30fc\u30f3\u3092\u30ab\u30e9\u30fc\u30e9\u30d9\u30eb\u3068\u305d\u306e\u5f37\u5ea6\u304b\u3089\u8aad\u307f\u53d6\u308a\u307e\u3059\u3002 <\/p>\n\n<p>\u56fa\u5b9a\u30aa\u30ea\u30b4\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306e\u914d\u5217\u304a\u3088\u3073\u305d\u308c\u3089\u306e\u91cd\u8907\u9818\u57df\u306f\u65e2\u77e5\u3067\u3042\u308b\u3002 \u3057\u305f\u304c\u3063\u3066\u3001\u30ab\u30e9\u30fc\u30d1\u30bf\u30fc\u30f3\u306f\u3001\u6700\u7d42\u7684\u306b\u306f\u672a\u77e5\u306eDNA\u306e\u57fa\u790e\u3068\u306a\u308b\u5168\u4f53\u7684\u306a\u30b7\u30fc\u30b1\u30f3\u30b9\u3092\u63a8\u6e2c\u3059\u308b\u305f\u3081\u306b\u4f7f\u7528\u3067\u304d\u307e\u3059\u3002<\/p>\n\n<h4 class=\"wp-block-heading\" id=\"h-ion-semiconductor-dna-sequencing-system\"><strong>\u30a4\u30aa\u30f3\u534a\u5c0e\u4f53DNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u30b7\u30b9\u30c6\u30e0<\/strong><\/h4>\n\n<p>\u30b6\u30fb<a href=\"https:\/\/www.thermofisher.com\/nl\/en\/home\/brands\/ion-torrent.html\">\u30a4\u30aa\u30f3\u30c8\u30ec\u30f3\u30c8<\/a>\u30e1\u30bd\u30c3\u30c9\u306f\u3001\u534a\u5c0e\u4f53\u30c1\u30c3\u30d7\u6280\u8853\u3092\u4f7f\u7528\u3057\u3066\u3001\u96c6\u7a4d\u56de\u8def\u3092\u4f7f\u7528\u3057\u3066\u76f4\u63a5\u975e\u5149\u5b66\u30b2\u30ce\u30e0\u30b7\u30fc\u30b1\u30f3\u30b9\u3092\u5b9f\u884c\u3057\u307e\u3059\u3002 <\/p>\n\n<p>\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u30c7\u30fc\u30bf\u306f\u3001\u30c6\u30f3\u30d7\u30ec\u30fc\u30c8\u4f9d\u5b58\u306eDNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u306b\u3088\u3063\u3066\u751f\u6210\u3055\u308c\u305f\u30a4\u30aa\u30f3\u306e\u691c\u51fa\u304b\u3089\u76f4\u63a5\u53d6\u5f97\u3055\u308c\u307e\u3059\u3002 \u3053\u306e\u65b9\u6cd5\u3067\u4f7f\u7528\u3055\u308c\u308b\u534a\u5c0e\u4f53\u30c1\u30c3\u30d7\u306f\u3001\u30a4\u30aa\u30f3\u611f\u5fdc\u6027\u96fb\u754c\u52b9\u679c\u30c8\u30e9\u30f3\u30b8\u30b9\u30bf\u3092\u5099\u3048\u3066\u3044\u307e\u3059\u3002 \u305d\u306e\u30bb\u30f3\u30b5\u30fc\u306f\u3001\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u53cd\u5fdc\u304c\u884c\u308f\u308c\u308b120\u4e07\u30a6\u30a7\u30eb\u306e\u30b0\u30ea\u30c3\u30c9\u306b\u914d\u7f6e\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u3053\u306e\u30b0\u30ea\u30c3\u30c9\u306b\u3088\u308a\u3001\u72ec\u7acb\u3057\u305f\u30b7\u30fc\u30b1\u30f3\u30b9\u53cd\u5fdc\u3092\u4e26\u884c\u3057\u3066\u540c\u6642\u306b\u691c\u51fa\u3067\u304d\u307e\u3059\u3002<\/p>\n\n<p>\u76f8\u88dc\u578b\u91d1\u5c5e\u9178\u5316\u819c\u534a\u5c0e\u4f53\uff08CMOS\uff09\u6280\u8853\u304c\u4f7f\u7528\u3055\u308c\u3066\u304a\u308a\u3001\u9ad8\u3044\u6e2c\u5b9a\u70b9\u5bc6\u5ea6\u3067\u8cbb\u7528\u52b9\u679c\u306e\u9ad8\u3044\u53cd\u5fdc\u304c\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n<figure class=\"wp-block-image is-resized\"><img decoding=\"async\" src=\"https:\/\/lh3.googleusercontent.com\/B5hrNL3q3yWRNkdCVqleutJQGyZQEmuxbKnFM8O5V4kw6OACKVSRhy16Y_xBacwQujfdPgROoem63z0NRuo6IA1u3z4yV66pWlrd5zQmXv_NGn0lAwm4FaDpn4jtYnvQPk1xfG7A\" alt=\"&#x30A4;&#x30AA;&#x30F3;&#x534A;&#x5C0E;&#x4F53;&#x30B7;&#x30FC;&#x30B1;&#x30F3;&#x30B7;&#x30F3;&#x30B0;&#x6280;&#x8853;&#x3001;&#x51FA;&#x5178;&#xFF1A;Konrad Foerstner&#x3001;&#x30A6;&#x30A3;&#x30AD;&#x30E1;&#x30C7;&#x30A3;&#x30A2;&#x30B3;&#x30E2;&#x30F3;&#x30BA;\" width=\"400\" height=\"300\" title=\"&#x534A;&#x5C0E;&#x4F53;&#x30B7;&#x30FC;&#x30B1;&#x30F3;&#x30B5;&#x30FC;\"\/><figcaption>\u30a4\u30aa\u30f3\u534a\u5c0e\u4f53\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u6280\u8853\u3001\u51fa\u5178\uff1aKonrad Foerstner\u3001\u30a6\u30a3\u30ad\u30e1\u30c7\u30a3\u30a2\u30b3\u30e2\u30f3\u30ba<\/figcaption><\/figure>\n\n<h4 class=\"wp-block-heading\" id=\"h-sequencing-with-bridge-synthesis\"><strong>\u30d6\u30ea\u30c3\u30b8\u5408\u6210\u306b\u3088\u308b\u30b7\u30fc\u30b1\u30f3\u30b9<\/strong><\/h4>\n\n<p>\u3053\u306e\u30b7\u30fc\u30b1\u30f3\u30b9\u6280\u8853\u306f\u3001Solexa \/ Illumina\u306e\u30d6\u30ea\u30c3\u30b8\u5408\u6210\u306b\u3088\u308b\u30b7\u30fc\u30b1\u30f3\u30b9\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002 \u914d\u5217\u6c7a\u5b9a\u3055\u308c\u308b\u4e8c\u672c\u9396DNA\u306f\u3001\u4e21\u7aef\u304c\u7570\u306a\u308b\u30a2\u30c0\u30d7\u30bf\u30fc\u914d\u5217\u3067\u4e21\u7aef\u304c\u30e9\u30a4\u30b2\u30fc\u30b7\u30e7\u30f3\u3055\u308c\u3066\u3044\u307e\u3059\u3002 <\/p>\n\n<p>\u6b21\u306b\u3001DNA\u3092\u5909\u6027\u3055\u305b\u3001\u5e0c\u91c8\u5f8c\u306b\u4e00\u672c\u9396\u306e\u5f62\u3067\u30ad\u30e3\u30ea\u30a2\u30d7\u30ec\u30fc\u30c8\u306b\u30e9\u30a4\u30b2\u30fc\u30b7\u30e7\u30f3\u3057\u307e\u3059\u3002 \u305d\u3057\u3066\u3001\u30d6\u30ea\u30c3\u30b8\u5897\u5e45\u306b\u3088\u3063\u3066\u305d\u306e\u5834\u3067\u3055\u3089\u306b\u5897\u5e45\u3055\u308c\u307e\u3059\u3002 \u3053\u308c\u306b\u3088\u308a\u3001\u30ad\u30e3\u30ea\u30a2\u30d7\u30ec\u30fc\u30c8\u4e0a\u306b\u5897\u5e45\u3055\u308c\u305fDNA\u306e\u500b\u3005\u306e\u9818\u57df\uff08\u30af\u30e9\u30b9\u30bf\u30fc\uff09\u304c\u4f5c\u6210\u3055\u308c\u3001\u30af\u30e9\u30b9\u30bf\u30fc\u5185\u3067\u540c\u3058\u914d\u5217\u306b\u306a\u308a\u307e\u3059\u3002 <\/p>\n\n<p>PCR\u53cd\u5fdc\u306f\u30014\u3064\u306e\u7570\u306a\u308b\u8272\u306e\u86cd\u5149\u9396\u7d42\u7d50\u57fa\u8cea\u3092\u4f7f\u7528\u3057\u307e\u3059\u3002 \u30b5\u30a4\u30af\u30eb\u3054\u3068\u306b\u7d44\u307f\u8fbc\u307e\u308c\u308b\u305d\u308c\u305e\u308c\u306e\u5869\u57fa\u306f\u3001\u30af\u30e9\u30b9\u30bf\u30fc\u5185\u3067\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u306b\u6c7a\u5b9a\u3055\u308c\u307e\u3059\u3002<\/p>\n\n<h4 class=\"wp-block-heading\" id=\"h-two-base-encoding\"><strong>2\u30d9\u30fc\u30b9\u30a8\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0<\/strong><\/h4>\n\n<p>\u30aa\u30ea\u30b4\u30e9\u30a4\u30b2\u30fc\u30b7\u30e7\u30f3\u691c\u51fa\u306b\u3088\u308b\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\uff08<a href=\"https:\/\/www.thermofisher.com\/nl\/en\/home\/life-science\/sequencing\/next-generation-sequencing\/solid-next-generation-sequencing\/solid-next-generation-sequencing-systems-reagents-accessories\/solid-next-generation-sequencing-chemistry.html\">\u56fa\u4f53<\/a>\uff09Applied Biosystems\u306f\u3001Sequencing byLigation\u306e\u30d0\u30ea\u30a8\u30fc\u30b7\u30e7\u30f3\u3067\u3059\u3002 <\/p>\n\n<p>DNA\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u306f\u5e0c\u91c8\u3055\u308c\u3001DNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u3067\u30de\u30a4\u30af\u30ed\u30d3\u30fc\u30ba\u306b\u7d50\u5408\u3055\u308c\u307e\u3059\u3002 \u6b21\u306b\u3001DNA\u306f\u30a8\u30de\u30eb\u30b8\u30e7\u30f3PCR\u3067\u5897\u5e45\u3055\u308c\u307e\u3059\u3002 \u3057\u305f\u304c\u3063\u3066\u3001\u5404\u30de\u30a4\u30af\u30ed\u30d3\u30fc\u30ba\u306b\u306f\u3001\u5358\u4e00\u306eDNA\u914d\u5217\u306e\u8907\u6570\u306e\u30b3\u30d4\u30fc\u304c\u542b\u307e\u308c\u3066\u3044\u307e\u3059\u3002 \u30de\u30a4\u30af\u30ed\u30d3\u30fc\u30ba\u306f3 &#8216;\u672b\u7aef\u304c\u4fee\u98fe\u3055\u308c\u3066\u3044\u308b\u305f\u3081\u3001\u30ad\u30e3\u30ea\u30a2\u30d7\u30ec\u30fc\u30c8\u306b\u500b\u5225\u306b\u53d6\u308a\u4ed8\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n<p> \u30d7\u30e9\u30a4\u30de\u30fc\u7d50\u5408\u5f8c\u30014\u3064\u306e\u7570\u306a\u308b\u5207\u65ad\u53ef\u80fd\u306a\u30d7\u30ed\u30fc\u30d6\u304c\u8ffd\u52a0\u3055\u308c\u3001\u305d\u308c\u305e\u308c\u304c\u7570\u306a\u308b\u86cd\u5149\u8272\u3067\u30de\u30fc\u30af\u3055\u308c\u307e\u3059\u3002 \u305d\u308c\u3089\u306f\u6700\u521d\u306e2\u3064\u306e\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\uff08CA\u3001CT\u3001GG\u3001GC\uff09\u306b\u3088\u3063\u3066DNA\u30c6\u30f3\u30d7\u30ec\u30fc\u30c8\u306b\u7d50\u5408\u3057\u307e\u3059\u3002 \u6b21\u306b\u3001\u30de\u30a4\u30af\u30ed\u30d3\u30fc\u30ba\u3092DNA\u30ea\u30ac\u30fc\u30bc\u3067\u30e9\u30a4\u30b2\u30fc\u30b7\u30e7\u30f3\u3057\u307e\u3059\u3002 \u6b21\u306b\u3001\u30d7\u30ed\u30fc\u30d6\u304c\u5207\u65ad\u3055\u308c\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u30e9\u30d9\u30eb\u304c\u89e3\u653e\u3055\u308c\u307e\u3059\u3002 <\/p>\n\n<p>\u6700\u59275\u3064\u306e\u30d7\u30e9\u30a4\u30de\u30fc\u3092\u4f7f\u7528\u3057\u3066\u3001DNA\u914d\u5217\u306e\u5404\u5869\u57fa\u304c\u5c11\u306a\u304f\u3068\u30822\u3064\u306e\u7570\u306a\u308b\u30e9\u30a4\u30b2\u30fc\u30b7\u30e7\u30f3\u53cd\u5fdc\u3067\u6c7a\u5b9a\u3055\u308c\u307e\u3059\u3002<\/p>\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/lh4.googleusercontent.com\/-Ea1y8V90klItxRKEcwj3mBlVP3piFANgADdvOBiHBUZWHl6KTORTtpSbhxtefq2Smnrj-jpvbB3i0-jTVHpg-zp6GAweftqJ1ZHbKfraabzfNPZ-0fMZfB8lWdx3IZ7zzt8Ojwr\" alt=\"SOLiD&#x30D7;&#x30E9;&#x30C3;&#x30C8;&#x30D5;&#x30A9;&#x30FC;&#x30E0;&#x3002;\" title=\"SOLiD&#x30D7;&#x30E9;&#x30C3;&#x30C8;&#x30D5;&#x30A9;&#x30FC;&#x30E0;\"\/><figcaption>SOLiD\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3001\u753b\u50cf\u30bd\u30fc\u30b9\uff1aPhilippe Hupe\u3001\u30a6\u30a3\u30ad\u30e1\u30c7\u30a3\u30a2\u30b3\u30e2\u30f3\u30ba<\/figcaption><\/figure>\n\n<h4 class=\"wp-block-heading\" id=\"h-dna-sequencing-with-paired-ends\"><strong>\u30da\u30a2\u30a8\u30f3\u30c9\u30bf\u30b0\u306b\u3088\u308bDNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0<\/strong><\/h4>\n\n<p>DNA\u914d\u5217\u306e\u672b\u7aef\u304b\u3089\u77ed\u3044DNA\u65ad\u7247\u3092\u751f\u6210\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u660e\u78ba\u306b\u8b58\u5225\u53ef\u80fd\u306a\u30b7\u30b0\u30ca\u30eb\u3092\u5f97\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 \u3053\u306eDNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u6cd5\u306f\u30da\u30a2\u30a8\u30f3\u30c9\u30bf\u30b0\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u3001PETS\u3068\u3057\u3066\u3082\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n<h3 class=\"wp-block-heading\" id=\"h-third-generation-dna-sequencing\"><strong>\u7b2c3\u4e16\u4ee3\u306eDNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0<\/strong><\/h3>\n\n<p>\u521d\u3081\u3066\u3001\u7b2c3\u4e16\u4ee3\u306e\u30b7\u30fc\u30b1\u30f3\u30b9\u3067\u306f\u3001\u5358\u4e00\u5206\u5b50\u306e\u5b9f\u9a13\u3068\u3057\u3066\u5358\u4e00\u5206\u5b50\u306e\u53cd\u5fdc\u3092\u6e2c\u5b9a\u3057\u307e\u3059\u3002 <\/p>\n\n<p>\u3053\u308c\u306b\u3088\u308a\u3001\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u306e\u524d\u306bPCR\u3067\u5897\u5e45\u3059\u308b\u5fc5\u8981\u304c\u306a\u304f\u306a\u308a\u307e\u3059\u3002 \u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u306f\u3001\u3044\u304f\u3064\u304b\u306eDNA\u914d\u5217\u306b\u7d50\u5408\u3059\u308b\u305f\u3081\u306e\u30d0\u30a4\u30a2\u30b9\u3092\u793a\u3057\u307e\u3059\u3002 \u3057\u305f\u304c\u3063\u3066\u3001\u3053\u308c\u306f\u71b1\u5b89\u5b9a\u6027DNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u306b\u3088\u308b\u4e0d\u5747\u4e00\u306a\u5897\u5e45\u3092\u56de\u907f\u3057\u307e\u3059\u3002 <\/p>\n\n<p>\u3057\u305f\u304c\u3063\u3066\u3001\u4e00\u90e8\u306e\u30b7\u30fc\u30b1\u30f3\u30b9\u306f\u898b\u843d\u3068\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u3055\u3089\u306b\u3001\u500b\u3005\u306e\u7d30\u80de\u306e\u30b2\u30ce\u30e0\u3092\u8abf\u3079\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 <\/p>\n\n<p>\u89e3\u653e\u3055\u308c\u305f\u4fe1\u53f7\u306f\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u3067\u8a18\u9332\u3055\u308c\u307e\u3059\u3002 \u7b2c3\u4e16\u4ee3\u306eDNA\u30b7\u30fc\u30b1\u30f3\u30b9\u3067\u306f\u3001\u4f7f\u7528\u3059\u308b\u65b9\u6cd5\u306b\u5fdc\u3058\u30662\u3064\u306e\u7570\u306a\u308b\u4fe1\u53f7\u304c\u8a18\u9332\u3055\u308c\u307e\u3059\u3002 \u305d\u308c\u3089\u306f\u653e\u51fa\u3055\u308c\u305f\u30d7\u30ed\u30c8\u30f3\u307e\u305f\u306f\u30d5\u30eb\u30aa\u30ed\u30d5\u30a9\u30a2\u3067\u3059\u3002 \u500b\u3005\u306e\u7d30\u80de\u306eDNA\u304a\u3088\u3073RNA\u30b7\u30fc\u30b1\u30f3\u30b9\u306f\u3001\u30b8\u30e3\u30fc\u30ca\u30ebNatureMethods\u306b\u3088\u3063\u3066\u300c2013\u5e74\u306e\u30e1\u30bd\u30c3\u30c9\u300d\u306b\u9078\u3070\u308c\u307e\u3057\u305f\u3002<\/p>\n\n<figure class=\"wp-block-image is-resized\"><img decoding=\"async\" src=\"https:\/\/lh5.googleusercontent.com\/tTTe7UKvVeAuNV0RVKrh5tbuFfIeC1Uo10tAEqRz-UmkBpp_ejizHvA71b1rtLYy0oEqoikepDYGs16q-t-OGbdVrIeAybSxgPjCwHgbrPWGlBl_piOO4MbRhgwwdPp04Aq_kj9O\" alt=\"&#x7B2C;3&#x4E16;&#x4EE3;&#x306E;&#x30B7;&#x30FC;&#x30B1;&#x30F3;&#x30B9;&#x6280;&#x8853;&#x3002; &#x753B;&#x50CF;&#x30BD;&#x30FC;&#x30B9;&#xFF1A;Chandra Shekhar Pareek&#x3001;Rafal Smoczynski&#x3001;Andrej Tretyn&#x3001;&#x30A6;&#x30A3;&#x30AD;&#x30E1;&#x30C7;&#x30A3;&#x30A2;&#x30B3;&#x30E2;&#x30F3;&#x30BA;\" width=\"563\" height=\"386\" title=\"&#x7B2C;3&#x4E16;&#x4EE3;&#x306E;&#x30B7;&#x30FC;&#x30B1;&#x30F3;&#x30B9;\"\/><figcaption>\u7b2c3\u4e16\u4ee3\u306e\u30b7\u30fc\u30b1\u30f3\u30b9\u6280\u8853\u3002 \u753b\u50cf\u30bd\u30fc\u30b9\uff1aChandra Shekhar Pareek\u3001Rafal Smoczynski\u3001Andrej Tretyn\u3001\u30a6\u30a3\u30ad\u30e1\u30c7\u30a3\u30a2\u30b3\u30e2\u30f3\u30ba<\/figcaption><\/figure>\n\n<h4 class=\"wp-block-heading\" id=\"h-nanopore-sequencing\"><strong>\u30ca\u30ce\u30dd\u30a2\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0<\/strong><\/h4>\n\n<p><a href=\"https:\/\/nanoporetech.com\/applications\/dna-nanopore-sequencing\">\u30ca\u30ce\u30dd\u30a2\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0<\/a>\u4eba\u5de5\u7684\u306b\u4f5c\u6210\u3055\u308c\u305f\u819c\u306b\u57cb\u3081\u8fbc\u307e\u308c\u305f\u30ca\u30ce\u30dd\u30a2\u3092\u901a\u308b\u30a4\u30aa\u30f3\u306e\u6d41\u308c\u306e\u5909\u5316\u306b\u57fa\u3065\u3044\u3066\u3044\u307e\u3059\u3002 \u30ca\u30ce\u30dd\u30a2\u306f\u3001\u751f\u7269\u5b66\u7684\u307e\u305f\u306f\u5408\u6210\u306e\u30dd\u30a2\u3001\u3042\u308b\u3044\u306f\u534a\u5408\u6210\u306e\u30dd\u30a2\u3067\u3059\u3002 \u30ca\u30ce\u30dd\u30a2\u306f\u3001\u7279\u306b\u9ad8\u3044\u96fb\u6c17\u62b5\u6297\u3092\u6301\u3064\u4eba\u5de5\u819c\u306b\u57cb\u3081\u8fbc\u307e\u308c\u3066\u3044\u307e\u3059\u3002 <\/p>\n\n<p>\u901a\u5e38\u306e\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30eb\u3068\u306f\u5bfe\u7167\u7684\u306b\u3001\u7d30\u5b54\u306f\u6052\u4e45\u7684\u306b\u958b\u3044\u3066\u3044\u307e\u3059\u3002 \u3053\u308c\u306b\u3088\u308a\u3001\u96fb\u4f4d\u3092\u5370\u52a0\u3057\u305f\u5f8c\u3001\u819c\u3092\u901a\u308b\u30a4\u30aa\u30f3\u306e\u4e00\u5b9a\u306e\u6d41\u308c\u304c\u53ef\u80fd\u306b\u306a\u308a\u307e\u3059\u3002 \u7d30\u5b54\u3092\u901a\u904e\u3059\u308bDNA\u5206\u5b50\u306f\u3001\u96fb\u6d41\u306e\u6e1b\u5c11\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002 \u3053\u306e\u96fb\u6d41\u6e1b\u5c11\u306b\u306f\u3001\u5404\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306b\u56fa\u6709\u306e\u632f\u5e45\u304c\u3042\u308a\u3001\u6e2c\u5b9a\u3057\u3066\u5bfe\u5fdc\u3059\u308b\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306b\u5272\u308a\u5f53\u3066\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 <\/p>\n\n<p>\u4e00\u672c\u9396\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u3067\u306f\u3001\u4e8c\u672c\u9396DNA\u9396\u304c\u30d8\u30ea\u30ab\u30fc\u30bc\u306b\u3088\u3063\u3066\u5206\u96e2\u3055\u308c\u3001\u30ca\u30ce\u30dd\u30a2\u306b\u5c0e\u5165\u3055\u308c\u307e\u3059\u3002 <\/p>\n\n<p>MspA\u7d30\u5b54\u306e\u5834\u5408\u3001DNA\u306e4\u3064\u306e\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u304c\u540c\u6642\u306b\u7d30\u5b54\u5185\u306b\u914d\u7f6e\u3055\u308c\u307e\u3059\u3002 \u901a\u904e\u901f\u5ea6\u306f\u3001\u3068\u308a\u308f\u3051\u3001\u819c\u5168\u4f53\u306epH\u5024\u306e\u5dee\u306b\u4f9d\u5b58\u3057\u307e\u3059\u3002 4\u3064\u306e\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306e\u305d\u308c\u305e\u308c\u306e\u7279\u5b9a\u306e\u30a4\u30aa\u30f3\u96fb\u6d41\u306e\u5909\u5316\u306b\u3088\u308a\u3001\u914d\u5217\u3092\u8aad\u307f\u53d6\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 <\/p>\n\n<p>\u8a55\u4fa1\u306f\u3001\u305f\u3068\u3048\u3070\u3001Poretools\u30bd\u30d5\u30c8\u30a6\u30a7\u30a2\u3092\u4f7f\u7528\u3057\u3066\u5b9f\u884c\u3055\u308c\u307e\u3059\u3002 \u3053\u306e\u65b9\u6cd5\u306e\u5229\u70b9\u306f\u3001\u9577\u3044DNA\u9396\u3067\u3082\u4e00\u5b9a\u306e\u7cbe\u5ea6\u304c\u3042\u308b\u3053\u3068\u3067\u3059\u3002 \u30e1\u30bd\u30c3\u30c9\u306e\u30d0\u30ea\u30a8\u30fc\u30b7\u30e7\u30f3\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30b7\u30fc\u30b1\u30f3\u30b9\u306b\u4f7f\u7528\u3055\u308c\u307e\u3059\u3002<\/p>\n\n<p>\u30ca\u30ce\u30dd\u30a2\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u6280\u8853\u306f\u3001\u82f1\u56fd\u306e\u4f1a\u793eOxford NanoporeTechnologies\u306b\u3088\u3063\u3066\u9032\u6b69\u3057\u3066\u3044\u307e\u3059\u3002 \u5f7c\u3089\u306e\u300cMinION\u300d\u30b7\u30fc\u30b1\u30f3\u30b5\u30fc\u306f\u5f53\u521d\u3001\u300c\u65e9\u671f\u30a2\u30af\u30bb\u30b9\u30d7\u30ed\u30b0\u30e9\u30e0\u300d\u3092\u901a\u3058\u3066\u306e\u307f\u5229\u7528\u53ef\u80fd\u3067\u3057\u305f\u3002 \u3057\u304b\u3057\u30012015\u5e74\u304b\u3089\u5f93\u6765\u306e\u6d41\u901a\u30c1\u30e3\u30cd\u30eb\u3092\u901a\u3058\u3066\u5229\u7528\u53ef\u80fd\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n<p>\u51fa\u767a\u3059\u308b\u524d\u306b\u3001\u6b21\u4e16\u4ee3\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u30d9\u30fc\u30b9\u3092\u30c1\u30a7\u30c3\u30af\u3057\u3066\u304f\u3060\u3055\u3044<a href=\"https:\/\/nebula.org\/whole-genome-sequencing\/\">\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30b1\u30f3\u30b9<\/a>\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"<p>DNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f DNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u306f\u3001\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u306e\u9806\u5e8f\u3092 &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"ast-button\" href=\"https:\/\/nebula.org\/blog\/ja\/dna-%e3%82%b7%e3%83%bc%e3%82%b1%e3%83%b3%e3%82%b9\/\"> <span class=\"screen-reader-text\">DNA\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0-\u751f\u547d\u306e\u30b3\u30fc\u30c9\u3092\u8aad\u307f\u53d6\u308b\u6280\u8853<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":18,"featured_media":36531,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4977],"tags":[],"class_list":["post-9600","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-4977"],"yoast_head":"<!-- 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