{"id":9601,"date":"2021-01-05T23:23:37","date_gmt":"2021-01-06T04:23:37","guid":{"rendered":"https:\/\/nebula.org\/blog\/%e3%82%a8%e3%83%94%e3%82%b8%e3%82%a7%e3%83%8d%e3%83%86%e3%82%a3%e3%82%af%e3%82%b9\/"},"modified":"2021-02-20T20:19:17","modified_gmt":"2021-02-21T01:19:17","slug":"%e3%82%a8%e3%83%94%e3%82%b8%e3%82%a7%e3%83%8d%e3%83%86%e3%82%a3%e3%82%af%e3%82%b9","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/ja\/%e3%82%a8%e3%83%94%e3%82%b8%e3%82%a7%e3%83%8d%e3%83%86%e3%82%a3%e3%82%af%e3%82%b9\/","title":{"rendered":"\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9-\u907a\u4f1d\u6697\u53f7\u3092\u8d85\u3048\u305f\u60c5\u5831"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"h-what-is-epigenetics\"><strong>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f<\/strong><\/h2>\n\n<p>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306f\u3001\u306e\u6d3b\u52d5\u3092\u6c7a\u5b9a\u3059\u308b\u8981\u56e0\u306e\u7814\u7a76\u3067\u3059<a href=\"https:\/\/nebula.org\/blog\/ja\/%e9%81%ba%e4%bc%9d%e5%ad%90\/\">\u907a\u4f1d\u5b50<\/a>\u4eba\u9593\u306e\u4e2d\u3067<a href=\"https:\/\/nebula.org\/blog\/ja\/%e3%82%b2%e3%83%8e%e3%83%a0\/\">\u30b2\u30ce\u30e0<\/a>\u3002 \u305d\u308c\u306f\u3001\u306e\u5909\u5316\u306b\u57fa\u3065\u304b\u306a\u3044\u907a\u4f1d\u5b50\u6a5f\u80fd\u306e\u5909\u5316\u3092\u4f34\u3044\u307e\u3059<a href=\"https:\/\/nebula.org\/blog\/ja\/dna-%e3%83%87%e3%82%aa%e3%82%ad%e3%82%b7%e3%83%aa%e3%83%9c%e6%a0%b8%e9%85%b8\/\">DNA<\/a>\u30b7\u30fc\u30b1\u30f3\u30b9\u304c\u5a18\u7d30\u80de\u306b\u6e21\u3055\u308c\u307e\u3059\u3002<\/p>\n\n<p>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306e\u57fa\u790e\u306f\u3001\u30af\u30ed\u30de\u30c1\u30f3\u306e\u5316\u5b66\u5909\u5316\u3067\u3059\u3002 DNA\u306b\u7d50\u5408\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3084DNA\u81ea\u4f53\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u3053\u308c\u3089\u306e\u5909\u5316\u306f\u3001\u30bb\u30af\u30b7\u30e7\u30f3\u307e\u305f\u306f\u67d3\u8272\u4f53\u5168\u4f53\u306e\u6d3b\u52d5\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u3053\u308c\u306f\u3001\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5909\u5316\u307e\u305f\u306f\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5237\u308a\u8fbc\u307f\u3068\u3082\u547c\u3070\u308c\u307e\u3059\u3002 <\/p>\n\n<p>DNA\u914d\u5217\u306f\u5909\u66f4\u3055\u308c\u3066\u3044\u306a\u3044\u305f\u3081\u3001DNA\u914d\u5217\u304b\u3089\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u4fee\u98fe\u3092\u691c\u51fa\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002 \u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u30d7\u30ed\u30bb\u30b9\u306e\u7a2e\u985e\u306b\u306f\u3001X\u67d3\u8272\u4f53\u306e\u4e0d\u6d3b\u6027\u5316\u3001\u907a\u4f1d\u5b50\u306e\u5237\u308a\u8fbc\u307f\u3001\u307e\u305f\u306f\u7d30\u80de\u306e\u8ee2\u5199\u8a18\u61b6\u306e\u4fdd\u5b58\u304c\u542b\u307e\u308c\u307e\u3059\u3002<\/p>\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"614\" src=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/epigenetics1-1024x614.jpg\" alt=\"\" class=\"wp-image-3067\" title=\"&#x4E3B;&#x306A;&#x30A8;&#x30D4;&#x30B8;&#x30A7;&#x30CD;&#x30C6;&#x30A3;&#x30C3;&#x30AF;&#x306A;&#x5909;&#x5316;&#x306E;&#x6982;&#x7565;&#x56F3;&#xFF1A;DNA&#x3068;&#x30D2;&#x30B9;&#x30C8;&#x30F3;&#x306E;&#x30E1;&#x30C1;&#x30EB;&#x5316;\" srcset=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/epigenetics1-1024x614.jpg 1024w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/epigenetics1-300x180.jpg 300w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/epigenetics1-768x460.jpg 768w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/epigenetics1-1536x921.jpg 1536w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/epigenetics1-16x10.jpg 16w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/epigenetics1.jpg 924w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption>DNA\u307e\u305f\u306fDNA\u914d\u5217\u306b\u7d50\u5408\u3059\u308b\u30d2\u30b9\u30c8\u30f3\u306e\u76f4\u63a5\u30e1\u30c1\u30eb\u5316\u3092\u793a\u3059\u3001\u67d3\u8272\u4f53\u5185\u306e\u5f8c\u6210\u7684\u5909\u5316\u306e\u4f4d\u7f6e\u3002 \u30bd\u30fc\u30b9\uff1a<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Epigenetic_mechanisms.jpg\">\u56fd\u7acb\u885b\u751f\u7814\u7a76\u6240\/\u30d1\u30d6\u30ea\u30c3\u30af\u30c9\u30e1\u30a4\u30f3<\/a><\/figcaption><\/figure>\n\n<figure class=\"wp-block-table\"><table class=\"has-subtle-pale-pink-background-color has-background\"><tbody><tr><td><a href=\"https:\/\/nebula.org\/whole-genome-sequencing\/\"><strong>DNA\u3092100\uff05\u30c7\u30b3\u30fc\u30c9\u3059\u308b\u3053\u3068\u306b\u8208\u5473\u304c\u3042\u308a\u307e\u3059\u304b\uff1f Nebula Genomics\u306f\u3001\u6700\u3082\u624b\u9803\u306a\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30b1\u30f3\u30b9\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002 \u30b2\u30ce\u30e0\u30c7\u30fc\u30bf\u3078\u306e\u30d5\u30eb\u30a2\u30af\u30bb\u30b9\u3001\u6700\u65b0\u306e\u79d1\u5b66\u7684\u767a\u898b\u306b\u57fa\u3065\u304f\u6bce\u9031\u306e\u66f4\u65b0\u3001\u9ad8\u5ea6\u306a\u7956\u5148\u5206\u6790\u3001\u304a\u3088\u3073\u5f37\u529b\u306a\u30b2\u30ce\u30e0\u63a2\u7d22\u30c4\u30fc\u30eb\u3092\u4f7f\u7528\u3057\u3066\u3001\u4e00\u751f\u306e\u767a\u898b\u3092\u958b\u59cb\u3057\u307e\u3059\u3002 \u8a73\u7d30\u306b\u3064\u3044\u3066\u306f\u3001\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/strong><\/a><\/td><\/tr><\/tbody><\/table><\/figure>\n\n<p><em>Christina Swords\u3001Ph.D\u3002\u304c\u7de8\u96c6<\/em><\/p>\n\n<h2 class=\"wp-block-heading\" id=\"h-epigenetics-basics\"><strong>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306e\u57fa\u790e<\/strong><\/h2>\n\n<p>\u53d7\u7cbe\u5f8c\u3001\u5375\u7d30\u80de\u306f\u5206\u88c2\u3057\u307e\u3059\u3002 8\u30bb\u30eb\u306e\u6bb5\u968e\u307e\u3067\u3001\u3059\u3079\u3066\u306e\u5a18\u30bb\u30eb\u306f\u540c\u3058\u3067\u3059\u3002 \u305d\u308c\u3089\u306f\u305d\u308c\u305e\u308c\u304c\u305d\u308c\u81ea\u4f53\u3067\u5b8c\u5168\u306a\u751f\u7269\u3092\u751f\u7523\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u306e\u3067\u3001\u5168\u80fd\u6027\u3068\u547c\u3070\u308c\u307e\u3059\u3002 <\/p>\n\n<p>\u3053\u306e\u6bb5\u968e\u306e\u5f8c\u3001\u7570\u306a\u308b\u5185\u90e8\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u6301\u3064\u30bb\u30eb\u304c\u3042\u308a\u307e\u3059\u3002 \u3053\u308c\u3089\u306e\u7d30\u80de\u306f\u3001\u307e\u3059\u307e\u3059\u7279\u6b8a\u5316\u3059\u308b\u306b\u3064\u308c\u3066\u3001\u958b\u767a\u306e\u53ef\u80fd\u6027\u304c\u5236\u9650\u3055\u308c\u307e\u3059\u3002 <\/p>\n\n<p>\u4f53\u304c\u5b8c\u5168\u306b\u5f62\u6210\u3055\u308c\u308b\u3068\u3001\u307b\u3068\u3093\u3069\u306e\u4f53\u7d30\u80de\u306f\u3001\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u57fa\u3065\u3044\u3066\u6a5f\u80fd\u3059\u308b\u3088\u3046\u306b\u3057\u3063\u304b\u308a\u3068\u30d7\u30ed\u30b0\u30e9\u30e0\u3055\u308c\u307e\u3059\u3002 DNA\u306e\u5869\u57fa\u307e\u305f\u306fDNA\u3092\u30d1\u30c3\u30b1\u30fc\u30b8\u30f3\u30b0\u3059\u308b\u30d2\u30b9\u30c8\u30f3\u3001\u3042\u308b\u3044\u306f\u305d\u306e\u4e21\u65b9\u306e\u751f\u5316\u5b66\u7684\u4fee\u98fe\u306b\u3088\u308a\u3001\u6a5f\u80fd\u304c\u4fee\u6b63\u3055\u308c\u307e\u3057\u305f\u3002 \u907a\u4f1d\u7269\u8cea\u306e\u914d\u5217\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u30e9\u30f3\u30c0\u30e0\u306a\u7a81\u7136\u5909\u7570\u3092\u9664\u3044\u3066\u5909\u66f4\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n<p>\u3053\u306e\u3088\u3046\u306a\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u4fee\u98fe\u306b\u3088\u308a\u3001\u30b2\u30ce\u30e0\u306e\u7279\u5b9a\u306e\u9818\u57df\u304c\u300c\u30b5\u30a4\u30ec\u30f3\u30b7\u30f3\u30b0\u300d\u3055\u308c\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u7c21\u5358\u306b\u8ee2\u5199\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u305b\u3093\u3002<a href=\"https:\/\/nebula.org\/blog\/ja\/mrna-%e3%83%a1%e3%83%83%e3%82%bb%e3%83%b3%e3%82%b8%e3%83%a3%e3%83%bc-rna\/\"> RNA<\/a>\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u7528\u3002 \u3053\u308c\u3089\u306e\u4fee\u98fe\u306f\u3001\u4f53\u7d30\u80de\u3067\u306f\u5e79\u7d30\u80de\u3084\u751f\u6b96\u7d30\u80de\u3068\u306f\u304b\u306a\u308a\u7570\u306a\u3063\u3066\u898b\u3048\u307e\u3059\u3002 \u6700\u3082\u91cd\u8981\u306a\u4fee\u98fe\u306f\u3001\u30b7\u30c8\u30b7\u30f3\u5869\u57fa\u306e\u30e1\u30c1\u30eb\u5316\u3068\u3001\u30d2\u30b9\u30c8\u30f3\u306e\u5074\u9396\u30e1\u30c1\u30eb\u5316\u304a\u3088\u3073\u30a2\u30bb\u30c1\u30eb\u5316\u3067\u3059\u3002<\/p>\n\n<p>\u30e1\u30c1\u30eb\u5316\u306b\u52a0\u3048\u3066\u3001\u30c6\u30ed\u30e1\u30a2\u306f\u91cd\u8981\u306a\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u3002 \u30c6\u30ed\u30e1\u30a2\u306f\u67d3\u8272\u4f53\u306e\u672b\u7aef\u3092\u5206\u89e3\u304b\u3089\u4fdd\u8b77\u3057\u307e\u3059<a href=\"https:\/\/nebula.org\/blog\/ja\/%e6%9c%89%e7%b3%b8%e5%88%86%e8%a3%82-%e7%b4%b0%e8%83%9e%e5%88%86%e8%a3%82\/\">\u7d30\u80de\u5206\u88c2<\/a>\u3002 \u9175\u7d20\u30c6\u30ed\u30e1\u30e9\u30fc\u30bc\u306f\u3001\u67d3\u8272\u4f53\u304c\u7121\u50b7\u306e\u307e\u307e\u3067\u3042\u308b\u3053\u3068\u3092\u4fdd\u8a3c\u3057\u307e\u3059\u3002 \u7cbe\u795e\u7684\u30b9\u30c8\u30ec\u30b9\u306f\u3053\u306e\u9175\u7d20\u306e\u6d3b\u6027\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u6700\u7d42\u7684\u306b\u306f\u8001\u5316\u904e\u7a0b\u3067\u30c6\u30ed\u30e1\u30a2\u306e\u77ed\u7e2e\u304c\u52a0\u901f\u3057\u307e\u3059\u3002<\/p>\n\n<h2 class=\"wp-block-heading\" id=\"h-comparison-to-genetics\"><strong>C<\/strong> omparison<strong>\u907a\u4f1d\u5b66\u3078<\/strong><\/h2>\n\n<p>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u3068\u3044\u3046\u7528\u8a9e\u306f\u3001\u7d99\u627f\u306e\u30d7\u30ed\u30bb\u30b9\u3092\u8003\u3048\u308b\u3068\u7406\u89e3\u3067\u304d\u307e\u3059\u3002<\/p>\n\n<ul class=\"wp-block-list\"><li>\u7d30\u80de\u304c\u5206\u88c2\u3059\u308b\u524d\u306b\u3001\u907a\u4f1d\u7269\u8cea\u306f2\u500d\u306b\u306a\u308a\u307e\u3059\u3002 \u6b21\u306b\u3001\u8907\u88fd\u3055\u308c\u305f\u30b2\u30ce\u30e0\u306e\u534a\u5206\u304c2\u3064\u306e\u5a18\u7d30\u80de\u306e1\u3064\u306b\u79fb\u3055\u308c\u307e\u3059\u3002 \u6bcd\u4f53\u306e\u907a\u4f1d\u7269\u8cea\u306e\u534a\u5206\u306f\u5375\u7d30\u80de\u306b\u3088\u3063\u3066\u904b\u3070\u308c\u3001\u7236\u65b9\u306e\u534a\u5206\u306f\u7cbe\u5b50\u7d30\u80de\u306b\u3088\u3063\u3066\u904b\u3070\u308c\u307e\u3059\u3002<\/li><li>\u5206\u5b50\u907a\u4f1d\u5b66\u306f\u3001\u907a\u4f1d\u7269\u8cea\u30922\u3064\u306e\u30c7\u30aa\u30ad\u30b7\u30ea\u30dc\u6838\u9178\u9396\u306e\u4e8c\u91cd\u3089\u305b\u3093\u3068\u3057\u3066\u8aac\u660e\u3057\u307e\u3059\u3002 \u30b9\u30c8\u30e9\u30f3\u30c9\u306f\u3001\u30d0\u30c3\u30af\u30dc\u30fc\u30f3\u3068\u3057\u3066\u30ea\u30f3\u9178-\u30c7\u30aa\u30ad\u30b7\u30ea\u30dc\u30fc\u30b9\u7cd6\u30dd\u30ea\u30de\u30fc\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002 \u907a\u4f1d\u60c5\u5831\u306f\u3001\u30c7\u30aa\u30ad\u30b7\u30ea\u30dc\u30fc\u30b9\u7cd6\u9aa8\u683c\u306b\u7d50\u5408\u3057\u3066\u3044\u308b4\u3064\u306e\u5869\u57fa\u306e\u914d\u5217\u306b\u7531\u6765\u3057\u307e\u3059\u3002 \u305d\u308c\u3089\u306f\u3001\u30a2\u30c7\u30cb\u30f3\uff08A\uff09\u3001\u30b7\u30c8\u30b7\u30f3\uff08C\uff09\u3001\u30b0\u30a2\u30cb\u30f3\uff08G\uff09\u3001\u304a\u3088\u3073\u30c1\u30df\u30f3\uff08T\uff09\u3067\u3059\u3002<\/li><li>1\u3064\u306e\u30b9\u30c8\u30e9\u30f3\u30c9\u306e\u5869\u57fa\u306f\u3001\u307b\u3068\u3093\u3069\u306e\u5834\u5408\u30012\u756a\u76ee\u306e\u30b9\u30c8\u30e9\u30f3\u30c9\u306e\u4e00\u81f4\u3059\u308b\u5869\u57fa\u3068\u30da\u30a2\u306b\u306a\u308a\u307e\u3059\u3002 \u30a2\u30c7\u30cb\u30f3\u306f\u30c1\u30df\u30f3\u3068\u30da\u30a2\u306b\u306a\u308a\u3001\u30b7\u30c8\u30b7\u30f3\u306f\u30b0\u30a2\u30cb\u30f3\u3068\u30da\u30a2\u306b\u306a\u308a\u307e\u3059\u3002<\/li><li>\u907a\u4f1d\u60c5\u5831\u306f\u3001\u30d3\u30eb\u30c7\u30a3\u30f3\u30b0\u30d6\u30ed\u30c3\u30afA\u3001C\u3001G\u3001T\uff08\u5869\u57fa\u914d\u5217\uff09\u306e\u9806\u5e8f\u3067\u56fa\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/li><\/ul>\n\n<p>\u907a\u4f1d\u306e\u3044\u304f\u3064\u304b\u306e\u73fe\u8c61\u306f\u3001\u4eca\u8aac\u660e\u3057\u305fDNA\u30e2\u30c7\u30eb\u3067\u306f\u8aac\u660e\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n<ul class=\"wp-block-list\"><li>\u7d30\u80de\u5206\u5316\u306e\u904e\u7a0b\u3067\u3001\u7570\u306a\u308b\u6a5f\u80fd\u3092\u6301\u3064\u5a18\u7d30\u80de\u304c\u5f62\u6210\u3055\u308c\u307e\u3059\u3002 \u7d30\u80de\u5206\u5316\u5f8c\u3082\u3001\u7570\u306a\u308b\u7d30\u80de\u30bf\u30a4\u30d7\u306f\u540c\u69d8\u306eDNA\u914d\u5217\u3092\u4fdd\u6301\u3057\u307e\u3059\u3002 \u7d30\u80de\u306e\u6a5f\u80fd\u7684\u540c\u4e00\u6027\u306e\u6c7a\u5b9a\u306f\u3001\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306e\u30c8\u30d4\u30c3\u30af\u3067\u3059\u3002<\/li><li>\u7236\u89aa\u307e\u305f\u306f\u6bcd\u89aa\u304b\u3089\u306e\u307f\u300c\u53d7\u3051\u7d99\u304c\u308c\u300d\u3001DNA\u3068\u306f\u95a2\u4fc2\u306e\u306a\u3044\u5f62\u8cea\u304c\u3042\u308a\u307e\u3059\u3002 \u3053\u306e\u72b6\u614b\u306e\u4e71\u308c\u306f\u6df1\u523b\u306a\u75c5\u6c17\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/li><li>\u5206\u5316\u3057\u305f\u7d30\u80de\u304c\u5e79\u7d30\u80de\u306b\u623b\u3055\u308c\u308b\u3068\u304d\u3001\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u30d1\u30bf\u30fc\u30f3\u3092\u53d6\u308a\u9664\u304f\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002 \u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u56fa\u5b9a\u304c\u89e3\u9664\u3055\u308c\u308b\u3068\u3001\u7d30\u80de\u306f\u518d\u3073\u3059\u3079\u3066\u307e\u305f\u306f\u591a\u304f\u306e\u6a5f\u80fd\u3092\u7372\u5f97\u3057\u3066\u7d99\u627f\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/li><\/ul>\n\n<h2 class=\"wp-block-heading\" id=\"h-histones-and-their-role-in-epigenetic-fixation\"><strong>\u30d2\u30b9\u30c8\u30f3\u3068\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u56fa\u5b9a\u306b\u304a\u3051\u308b\u305d\u308c\u3089\u306e\u5f79\u5272<\/strong><\/h2>\n\n<p>DNA\u306f\u7d30\u80de\u6838\u306b\u88f8\u3067\u5b58\u5728\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u30d2\u30b9\u30c8\u30f3\u306b\u7d50\u5408\u3057\u3066\u3044\u307e\u3059\u3002 8\u3064\u306e\u7570\u306a\u308b\u30d2\u30b9\u30c8\u30f3\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u306e\u6838\u3092\u5f62\u6210\u3057\u3001\u305d\u306e\u4e0a\u306b146\u5869\u57fa\u5bfe\u306eDNA\u9396\u304c\u5dfb\u304b\u308c\u3066\u3044\u307e\u3059\u3002 \u30d2\u30b9\u30c8\u30f3\u9396\u306e\u672b\u7aef\u306f\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u304b\u3089\u7a81\u304d\u51fa\u3066\u304a\u308a\u3001\u30d2\u30b9\u30c8\u30f3\u4fee\u98fe\u9175\u7d20\u306e\u6a19\u7684\u3067\u3059\u3002 <\/p>\n\n<p>\u30d2\u30b9\u30c8\u30f3\u4fee\u98fe\u306f\u3001\u4e3b\u306b\u30ea\u30b8\u30f3\u3001\u30d2\u30b9\u30c1\u30b8\u30f3\u3001\u307e\u305f\u306f\u30a2\u30eb\u30ae\u30cb\u30f3\u306e\u30e1\u30c1\u30eb\u5316\u3068\u30a2\u30bb\u30c1\u30eb\u5316\u3001\u304a\u3088\u3073\u30bb\u30ea\u30f3\u306e\u30ea\u30f3\u9178\u5316\u3067\u3059\u3002 \u307e\u305f\u3001\u30ea\u30b8\u30f3\u5074\u9396\u304c1\u3064\u30012\u3064\u3001\u307e\u305f\u306f3\u3064\u306e\u30e1\u30c1\u30eb\u57fa\u3067\u5360\u3081\u3089\u308c\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u306b\u3082\u5f71\u97ff\u3057\u307e\u3059\u3002 \u4e00\u7a2e\u306e\u300c\u30d2\u30b9\u30c8\u30f3\u30b3\u30fc\u30c9\u300d\u306f\u3001\u30d2\u30b9\u30c8\u30f3\u306b\u3088\u3063\u3066\u7d50\u5408\u3055\u308c\u305f\u907a\u4f1d\u5b50\u306e\u6d3b\u52d5\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"725\" height=\"561\" src=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/epigenetics2.png\" alt=\"\" class=\"wp-image-8067\" title=\"&#x30D2;&#x30B9;&#x30C8;&#x30F3;&#x306E;&#x30E1;&#x30C1;&#x30EB;&#x5316;&#x3068;&#x30A2;&#x30BB;&#x30C1;&#x30EB;&#x5316;\" srcset=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/epigenetics2.png 725w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/epigenetics2-300x232.png 300w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/epigenetics2-16x12.png 16w\" sizes=\"(max-width: 725px) 100vw, 725px\" \/><figcaption>\u30d2\u30b9\u30c8\u30f3\u306e\u30e1\u30c1\u30eb\u5316\uff08\u4e0a\uff09\u3068\u30a2\u30bb\u30c1\u30eb\u5316\uff08\u4e0b\uff09\u306f\u3001DNA\u9396\u306e\u30d1\u30c3\u30ad\u30f3\u30b0\u3068\u30a2\u30f3\u30d1\u30c3\u30ad\u30f3\u30b0\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002 \u30bd\u30fc\u30b9\uff1a<a href=\"https:\/\/commons.wikimedia.org\/wiki\/File:Figure_16_03_02.png\"> CNX OpenStax \/ CC-BY 4.0<\/a><\/figcaption><\/figure>\n\n<h3 class=\"wp-block-heading\" id=\"h-influence-of-methylation-and-acetylation-on-the-conformation-of-chromatin\"><strong>\u30af\u30ed\u30de\u30c1\u30f3\u306e\u30b3\u30f3\u30d5\u30a9\u30e1\u30fc\u30b7\u30e7\u30f3\u306b\u5bfe\u3059\u308b\u30e1\u30c1\u30eb\u5316\u3068\u30a2\u30bb\u30c1\u30eb\u5316\u306e\u5f71\u97ff<\/strong><\/h3>\n\n<p>\u30d2\u30b9\u30c8\u30f3\u5074\u9396\u306e\u5909\u5316\u306f\u3001\u907a\u4f1d\u5b50\u30bb\u30b0\u30e1\u30f3\u30c8\u306e\u4f53\u7a4d\u3092\u5909\u5316\u3055\u305b\u307e\u3059\u3002 \u67d3\u8272\u4f53\u306e\u51dd\u7e2e\u3068\u907a\u4f1d\u5b50\u306e\u4e0d\u6d3b\u6027\u5316\u306b\u52a0\u3048\u3066\u3001\u9589\u3058\u305f\u30b3\u30f3\u30d5\u30a9\u30e1\u30fc\u30b7\u30e7\u30f3\u306e\u907a\u4f1d\u5b50\u30bb\u30b0\u30e1\u30f3\u30c8\u306e\u91cf\u304c\u5c11\u306a\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002 \u907a\u4f1d\u5b50\u6d3b\u6027\u3068\u3068\u3082\u306b\u3001\u3088\u308a\u5927\u91cf\u306e\u907a\u4f1d\u5b50\u30bb\u30b0\u30e1\u30f3\u30c8\u304c\u30aa\u30fc\u30d7\u30f3\u30b3\u30f3\u30d5\u30a9\u30e1\u30fc\u30b7\u30e7\u30f3\u3067\u89b3\u5bdf\u3055\u308c\u307e\u3059\u3002 2\u3064\u306e\u72b6\u614b\u9593\u306e\u9077\u79fb\u306f\u3001\u30e1\u30c1\u30eb\u57fa\u306e\u30b7\u30c8\u30b7\u30f3\u5869\u57fa\u3078\u306e\u7d50\u5408\u3068\u5207\u65ad\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u307e\u3059\u3002<\/p>\n\n<p>\u4e00\u822c\u306b\u3001\u30a2\u30bb\u30c1\u30eb\u57fa\u304c\u30d2\u30b9\u30c8\u30f3\u306b\u7d50\u5408\u3059\u308b\u3068\u3001\u30cc\u30af\u30ec\u30aa\u30bd\u30fc\u30e0\u306e\u30b3\u30f3\u30d5\u30a9\u30e1\u30fc\u30b7\u30e7\u30f3\u304c\u958b\u304d\u307e\u3059\u3002 \u3053\u306e\u958b\u53e3\u90e8\u306b\u3088\u308a\u3001\u907a\u4f1d\u5b50\u306fRNA\u30dd\u30ea\u30e1\u30e9\u30fc\u30bc\u306b\u3088\u308b\u8ee2\u5199\u306b\u5229\u7528\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002 \u30e1\u30c1\u30eb\u57fa\u304c\u30ea\u30b8\u30f3\u5074\u9396\u306b\u7d50\u5408\u3059\u308b\u3068\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u30e1\u30c1\u30eb\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8ceaMeCB\u304c\u7d50\u5408\u3057\u307e\u3059\u3002 \u3053\u308c\u3089\u306e\u30ea\u30d7\u30ec\u30c3\u30b5\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u30d2\u30b9\u30c8\u30f3\u306e\u30b3\u30f3\u30d5\u30a9\u30e1\u30fc\u30b7\u30e7\u30f3\u3092\u9589\u3058\u3001\u8ee2\u5199\u3092\u9632\u304e\u307e\u3059\u3002<\/p>\n\n<h2 class=\"wp-block-heading\" id=\"h-epigenetic-changes-in-the-life-course\"><strong>\u30e9\u30a4\u30d5\u30b3\u30fc\u30b9\u306b\u304a\u3051\u308b\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u5909\u5316<\/strong><\/h2>\n\n<p>\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306f\u907a\u4f1d\u306e\u5834\u5408\u306b\u9650\u5b9a\u3055\u308c\u307e\u305b\u3093\u3002 \u30e9\u30a4\u30d5\u30b3\u30fc\u30b9\u306e\u7d99\u7d9a\u7684\u306a\u5909\u5316\u3068\u75c5\u6c17\u306e\u767a\u75c7\u3068\u306e\u95a2\u4fc2\u306b\u307e\u3059\u307e\u3059\u6ce8\u76ee\u304c\u96c6\u307e\u3063\u3066\u3044\u307e\u3059\u3002 \u305f\u3068\u3048\u3070\u3001\u4e00\u5375\u6027\u53cc\u751f\u5150\u306f3\u6b73\u3067\u9ad8\u5ea6\u306a\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u306a\u985e\u4f3c\u6027\u3092\u793a\u3057\u307e\u3059\u304c\u300150\u6b73\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002 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<\/p>\n\n<p>\u81ea\u6bba\u5019\u88dc\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7814\u7a76\u3067\u306f\u3001\u5f71\u97ff\u3092\u53d7\u3051\u305f\u4eba\u30922\u3064\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u5206\u3051\u307e\u3057\u305f\u3002\u5b50\u4f9b\u6642\u4ee3\u306e\u8650\u5f85\u306e\u7d4c\u9a13\u304c\u3042\u308b\u4eba\u3068\u306a\u3044\u4eba\u3067\u3059\u3002 \u8650\u5f85\u306e\u6b74\u53f2\u3092\u6301\u3064\u5019\u88dc\u8005\u3060\u3051\u304c\u3001\u30e1\u30c1\u30eb\u5316\u306b\u3088\u3063\u3066\u53d7\u5bb9\u4f53\u907a\u4f1d\u5b50\u304c\u30d6\u30ed\u30c3\u30af\u3055\u308c\u307e\u3057\u305f\u3002 <\/p>\n\n<p>\u598a\u5a20\u4e2d\u306b\u6bcd\u89aa\u304c\u7d4c\u9a13\u3057\u305f\u30c8\u30e9\u30a6\u30de\u306f\u3001\u598a\u5a20\u4e2d\u306e\u5b50\u4f9b\u306b\u4f55\u5341\u5e74\u3082\u7d9a\u304f\u6c38\u7d9a\u7684\u306a\u7d50\u679c\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u3055\u3048\u3042\u308a\u307e\u3059\u3002 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<\/p>\n\n<p>\u3057\u304b\u3057\u3001\u7fd2\u5f97\u3057\u305f\u80fd\u529b\u304c\u751f\u6b96\u7d30\u80de\u3092\u4ecb\u3057\u3066\u53d7\u3051\u7d99\u304c\u308c\u308b\u3068\u3044\u3046\u8a3c\u62e0\u306f\u307b\u3068\u3093\u3069\u3042\u308a\u307e\u305b\u3093\u3002 \u7372\u5f97\u3057\u305f\u80fd\u529b\u3092\u6b21\u306e\u4e16\u4ee3\u306b\u5f15\u304d\u7d99\u3050\u3053\u3068\u306f\u3001\u307e\u3060\u907a\u4f1d\u7684\u75c7\u72b6\u306e\u8a3c\u62e0\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002 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