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<br\/><\/p>\n\n<p>\u3053\u306e\u554f\u984c\u306f\u3001\u307b\u3068\u3093\u3069\u306e\u30b2\u30ce\u30e0\u30c7\u30fc\u30bf\u304c\u3069\u3053\u304b\u3089\u6765\u3066\u3044\u308b\u306e\u304b\u3001\u3088\u308a\u5177\u4f53\u7684\u306b\u306f\u8ab0\u304b\u3089\u6765\u3066\u3044\u308b\u306e\u304b\u3092\u8003\u3048\u308b\u3068\u7279\u306b\u660e\u767d\u3067\u3059\u3002 \u30e8\u30fc\u30ed\u30c3\u30d1\u306e\u7956\u5148\u306e\u4eba\u3005\u306f\u4e16\u754c\u4eba\u53e3\u306e25\uff05\u672a\u6e80\u3092\u5360\u3081\u3066\u3044\u307e\u3059\u304c\u3001\u5f7c\u3089\u306f\u907a\u4f1d\u5b50\u7814\u7a76\u3001\u7279\u306b\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u7814\u7a76\uff08\u307e\u305f\u306fGWAS\uff09\u306e\u53c2\u52a0\u8005\u306e\u5927\u90e8\u5206\u3092\u5360\u3081\u3066\u3044\u307e\u3059\u3002 \u3053\u306e\u30e6\u30fc\u30ed\u4e2d\u5fc3\u306e\u898b\u65b9\u306b\u306f\u3001\u72ec\u81ea\u306e\u591a\u69d8\u6027\u306e\u554f\u984c\u3082\u3042\u308a\u307e\u3059\u3002 2005\u5e74\u304b\u30892018\u5e74\u306b\u304b\u3051\u3066\u3001GWAS\u53c2\u52a0\u8005\u306e\u5927\u591a\u6570\u306b\u8ca2\u732e\u3057\u305f\u306e\u306f\u3001\u7c73\u56fd\u3001\u82f1\u56fd\u3001\u30a2\u30a4\u30b9\u30e9\u30f3\u30c9\u306e3\u304b\u56fd\u306e\u307f\u3067\u3057\u305f\u3002<\/p>\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter is-resized\"><img decoding=\"async\" src=\"https:\/\/lh5.googleusercontent.com\/tMUlv-WEc4sn3gQzxG76QxyyLULZUj79mJW0DgTvdEeFzRfFYfRn-6WPvZCpZRiWvDhp7Fkm29woG_SdC0-spbqnO1r964e1lazALxwnNYJF4ZL6iCpGwGXIWhR2AX4CTi2Vvdb0\" alt=\"\" width=\"553\" height=\"472\"\/><figcaption> \u56f31\u3002 \u30b2\u30ce\u30e0\u30c7\u30fc\u30bf\u30bb\u30c3\u30c8\u306b\u304a\u3051\u308b\u3055\u307e\u3056\u307e\u306a\u6c11\u65cf\u30b0\u30eb\u30fc\u30d7\u306e\u8868\u73fe\u3002 \u30e2\u30e9\u30ec\u30b9\u304b\u3089<em>etal\u3002<\/em><a href=\"https:\/\/genomebiology.biomedcentral.com\/articles\/10.1186\/s13059-018-1396-2\"> NHGRI-EBI GWAS\u30ab\u30bf\u30ed\u30b0\u3078\u306e\u9069\u7528\u3092\u4f34\u3046\u3001\u30b2\u30ce\u30df\u30af\u30b9\u7814\u7a76\u306b\u304a\u3051\u308b\u7956\u5148\u30c7\u30fc\u30bf\u306e\u8868\u73fe\u306e\u305f\u3081\u306e\u6a19\u6e96\u5316\u3055\u308c\u305f\u30d5\u30ec\u30fc\u30e0\u30ef\u30fc\u30af<\/a>\u3002 <\/figcaption><\/figure><\/div>\n\n<p>\u305d\u306e\u7d50\u679c\u3001\u4ed6\u306e\u6c11\u65cf\u306f\u30b2\u30ce\u30e0\u7814\u7a76\u3067\u975e\u5e38\u306b\u904e\u5c0f\u8a55\u4fa1\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u305f\u3068\u3048\u3070\u3001\u30a2\u30b8\u30a2\u4eba\u306f\u4e16\u754c\u306e\u4eba\u53e3\u306e60\uff05\u3092\u5360\u3081\u3066\u3044\u307e\u3059\u304c\u3001GWAS\u53c2\u52a0\u8005\u306e11\uff05\u306b\u3059\u304e\u307e\u305b\u3093\u3002 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href=\"https:\/\/www.atsjournals.org\/doi\/full\/10.1164\/rccm.201712-2529OC\">\u6700\u8fd1\u306e\u7814\u7a76<\/a>\u3053\u308c\u3089\u306e\u96c6\u56e3\u3067\u3001\u5438\u5165\u5668\u3067\u4e00\u822c\u7684\u306b\u898b\u3089\u308c\u308b\u85ac\u5264\u3067\u3042\u308b\u30a2\u30eb\u30d6\u30c6\u30ed\u30fc\u30eb\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\u306e\u4f4e\u4e0b\u306b\u5bfe\u5fdc\u3059\u308b\u907a\u4f1d\u7684\u5909\u7570\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u3053\u308c\u3089\u306e\u96c6\u56e3\u306b\u304a\u3051\u308b\u75be\u60a3\u306e\u7570\u5e38\u306a\u91cd\u75c7\u5ea6\u3092\u8aac\u660e\u3059\u308b\u306e\u306b\u5f79\u7acb\u3064\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<br\/><\/p>\n\n<p>\u540c\u6642\u306b\u3001\u7814\u7a76\u8005\u306f\u3001\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u7279\u5b9a\u306e\u30b0\u30eb\u30fc\u30d7\u3060\u3051\u3067\u306a\u304f\u3001\u3059\u3079\u3066\u306e\u4eba\u3092\u52a9\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u767a\u898b\u3092\u898b\u9003\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 PCSK9\u963b\u5bb3\u5264\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u308b\u307e\u3063\u305f\u304f\u65b0\u3057\u3044\u30af\u30e9\u30b9\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b\u85ac\u3092\u8003\u3048\u3066\u307f\u307e\u3057\u3087\u3046\u3002 \u3053\u308c\u3089\u306e\u85ac\u306f\u3001<a 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href=\"https:\/\/nebula.org\/whole-genome-sequencing\/\">\u30b7\u30fc\u30b1\u30f3\u30b7\u30f3\u30b0\u30ad\u30c3\u30c8\u3092\u6ce8\u6587\u3059\u308b<\/a>\u4eca\u65e5\u3001\u3042\u306a\u305f\u306e\u907a\u4f1d\u5b50\u3068\u305d\u308c\u3089\u304c\u4e0e\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u6d1e\u5bdf\u306b\u3064\u3044\u3066\u3082\u3063\u3068\u5b66\u3076\u3042\u306a\u305f\u306e\u65c5\u3092\u59cb\u3081\u307e\u3057\u3087\u3046\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u79c1\u305f\u3061\u306f\u3001\u30c7\u30fc\u30bf\u304c\u5897\u3048\u7d9a\u3051\u308b\u6642\u4ee3\u306b\u751f\u304d\u3066\u3044\u307e\u3059\u3002 \u8003\u3048\u3089\u308c\u308b\u307b\u307c\u3059\u3079\u3066\u306e\u5206\u91ce\u3067\u3001 &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"ast-button\" href=\"https:\/\/nebula.org\/blog\/ja\/%e3%82%b2%e3%83%8e%e3%83%a0%e7%a0%94%e7%a9%b6%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e5%a4%9a%e6%a7%98%e6%80%a7%e3%81%ae%e5%a2%97%e5%a4%a7\/\"> <span 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