{"id":9712,"date":"2021-01-05T23:57:56","date_gmt":"2021-01-06T04:57:56","guid":{"rendered":"https:\/\/nebula.org\/blog\/is-als-genetic\/"},"modified":"2021-02-20T22:47:14","modified_gmt":"2021-02-21T03:47:14","slug":"is-als-genetic","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/ja\/is-als-genetic\/","title":{"rendered":"\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff08\u30cb\u30b3\u30e9\u30b9\u30012019\uff09-ALS\u306f\u907a\u4f1d\u7684\u3067\u3059\u304b\uff1f"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"h-nebula-genomics-dna-report-for-als\"><strong>ALS\u306e\u661f\u96f2\u30b2\u30ce\u30df\u30af\u30b9DNA\u30ec\u30dd\u30fc\u30c8<\/strong><\/h2>\n\n<p>ALS\u306f\u907a\u4f1d\u7684\u3067\u3059\u304b\uff1f \u3053\u306e\u8cea\u554f\u306b\u7b54\u3048\u3088\u3046\u3068\u3057\u305f\u7814\u7a76\u306b\u57fa\u3065\u3044\u3066\u3001DNA\u30ec\u30dd\u30fc\u30c8\u3092\u4f5c\u6210\u3057\u307e\u3057\u305f\u3002 \u4ee5\u4e0b\u306b\u30b5\u30f3\u30d7\u30ebDNA\u30ec\u30dd\u30fc\u30c8\u3092\u793a\u3057\u307e\u3059\u3002 \u30d1\u30fc\u30bd\u30ca\u30e9\u30a4\u30ba\u3055\u308c\u305fDNA\u30ec\u30dd\u30fc\u30c8\u3092\u5165\u624b\u3059\u308b\u306b\u306f\u3001<a href=\"https:\/\/nebula.org\/whole-genome-sequencing\/\">\u5168\u30b2\u30ce\u30e0\u30b7\u30fc\u30b1\u30f3\u30b9<\/a>\uff01<\/p>\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Nicolas-1.png\" alt=\"NebulaGenomics&#x306E;ALS&#x306B;&#x95A2;&#x3059;&#x308B;&#x30B5;&#x30F3;&#x30D7;&#x30EB;&#x30EC;&#x30DD;&#x30FC;&#x30C8;\" class=\"wp-image-7752\" width=\"577\" height=\"707\" srcset=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Nicolas-1.png 577w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Nicolas-1-245x300.png 245w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Nicolas-1-10x12.png 10w\" sizes=\"(max-width: 577px) 100vw, 577px\" \/><\/figure><\/div>\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Nicolas-2.png\" alt=\"NebulaGenomics&#x306E;ALS&#x306E;&#x907A;&#x4F1D;&#x7684;&#x5909;&#x7570;&#x306E;&#x30B5;&#x30F3;&#x30D7;&#x30EB;&#x30EC;&#x30DD;&#x30FC;&#x30C8;\" class=\"wp-image-7757\" width=\"581\" height=\"444\" srcset=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Nicolas-2.png 581w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Nicolas-2-300x229.png 300w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Nicolas-2-16x12.png 16w\" sizes=\"(max-width: 581px) 100vw, 581px\" \/><\/figure><\/div>\n\n<div class=\"wp-block-buttons aligncenter is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-vivid-cyan-blue-background-color has-background\" href=\"https:\/\/nebula.org\/whole-genome-sequencing\/\"><strong>\u30b2\u30ce\u30e0\u306e\u914d\u5217\u3092\u6c7a\u5b9a\u3057\u3001200\u3092\u8d85\u3048\u308bDNA\u30ec\u30dd\u30fc\u30c8\u306b\u30a2\u30af\u30bb\u30b9\u3057\u3066\u304f\u3060\u3055\u3044\uff01<\/strong><\/a><\/div>\n<\/div>\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<h2 class=\"wp-block-heading\" id=\"h-additional-information\"><strong>\u8ffd\u52a0\u60c5\u5831<\/strong><\/h2>\n\n<h2 class=\"wp-block-heading\" id=\"h-what-is-als-part-1-of-is-als-genetic\"><strong>ALS\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f \uff08ALS\u306f\u907a\u4f1d\u7684\u3067\u3059\u304b\uff1f\u306e\u30d1\u30fc\u30c81\uff09 <\/strong><\/h2>\n\n<p><a href=\"https:\/\/www.cdc.gov\/dotw\/als\/index.html\">\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff08ALS\uff09<\/a>\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u75be\u60a3\u306e\u30b0\u30eb\u30fc\u30d7\u306b\u5c5e\u3057\u3001\u904b\u52d5\u795e\u7d4c\u7cfb\u306e\u307e\u308c\u306a\u5909\u6027\u75be\u60a3\u3067\u3059\u3002 \u795e\u7d4c\u3084\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u306b\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u3002 \u3057\u305f\u304c\u3063\u3066\u3001\u6b69\u884c\u3001\u4f1a\u8a71\u3001\u5480\u56bc\u306a\u3069\u306e\u81ea\u767a\u7684\u306a\u7b4b\u8089\u306e\u4f7f\u7528\u3092\u5fc5\u8981\u3068\u3059\u308b\u6d3b\u52d5\u306f\u3001\u3053\u306e\u75c5\u6c17\u3067\u306f\u6642\u9593\u306e\u7d4c\u904e\u3068\u3068\u3082\u306b\u5f90\u3005\u306b\u5f31\u307e\u308a\u307e\u3059\u3002 \u3053\u308c\u306f\u65e5\u5e38\u751f\u6d3b\u52d5\u4f5c\u306e\u6f38\u9032\u7684\u306a\u5236\u9650\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002 ALS\u306e\u6cbb\u7642\u6cd5\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u75c5\u6c17\u306e\u9032\u884c\u901f\u5ea6\u3092\u9045\u304f\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n<p>\u3053\u306e\u75c5\u6c17\u306e\u4ed6\u306e\u540d\u524d\u306f\u3001\u30eb\u30fc\u30b2\u30fc\u30ea\u30c3\u30af\u75c7\u5019\u7fa4\u307e\u305f\u306f\u30b7\u30e3\u30eb\u30b3\u30c3\u30c8\u75c5\u3067\u3059\u3002 \u5f8c\u8005\u306f\u3001\u72b6\u614b\u306e\u8aac\u660e\u8005\u3001\u30b8\u30e3\u30f3\uff1d\u30de\u30eb\u30bf\u30f3\u30fb\u30b7\u30e3\u30eb\u30b3\u30c3\u30c8\u3067\u3057\u305f\u3002<a href=\"https:\/\/www.biography.com\/athlete\/lou-gehrig\">\u30eb\u30fc\u30b2\u30fc\u30ea\u30c3\u30b0<\/a>\u30cb\u30e5\u30fc\u30e8\u30fc\u30af\u30e4\u30f3\u30ad\u30fc\u30b9\u306e\u91ce\u7403\u9078\u624b\u3067\u3042\u308a\u3001ALS\u3068\u8a3a\u65ad\u3055\u308c\u305f\u5f8c\u5f15\u9000\u3057\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002 \u30b2\u30fc\u30ea\u30c3\u30af\u306e\u904b\u547d\u306f\u3001\u3053\u306e\u5e0c\u5c11\u75be\u60a3\u3092\u521d\u3081\u3066\u5927\u8846\u306b\u77e5\u3089\u3057\u3081\u307e\u3057\u305f\u3002 2014\u5e74\u306e\u6709\u540d\u306a\u30a2\u30a4\u30b9\u30d0\u30b1\u30c4\u30c1\u30e3\u30ec\u30f3\u30b8\u306f\u3001ALS\u7814\u7a76\u306b\u5411\u3051\u305f\u8cc7\u91d1\u8abf\u9054\u306b\u5f79\u7acb\u3061\u307e\u3057\u305f\uff08\u60c5\u5831\u6e90\uff1aALS\u5354\u4f1a\uff1a<a href=\"https:\/\/www.als.org\/stories-news\/ice-bucket-challenge-dramatically-accelerated-fight-against-als\">\u30a2\u30a4\u30b9\u30d0\u30b1\u30c3\u30c8\u306e\u6311\u6226<\/a>\uff09\u3002<\/p>\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Nicolas-3.png\" alt=\"&#x30A2;&#x30A4;&#x30B9;&#x30D0;&#x30B1;&#x30C4;&#x30C1;&#x30E3;&#x30EC;&#x30F3;&#x30B8;&#x53C2;&#x52A0;&#x8005;&#x3002; \" class=\"wp-image-7762\" width=\"479\" height=\"723\" srcset=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Nicolas-3.png 477w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Nicolas-3-199x300.png 199w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Nicolas-3-8x12.png 8w\" sizes=\"(max-width: 479px) 100vw, 479px\" \/><figcaption>2014\u5e74\u306e\u30a2\u30a4\u30b9\u30d0\u30b1\u30c4\u30c1\u30e3\u30ec\u30f3\u30b8\u306fALS\u306b\u5bfe\u3059\u308b\u610f\u8b58\u3092\u9ad8\u3081\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u305f\u3053\u3068\u3092\u3054\u5b58\u77e5\u3067\u3059\u304b\uff1f<a href=\"https:\/\/en.wikipedia.org\/wiki\/Ice_Bucket_Challenge#\/media\/File:Doing_the_ALS_Ice_Bucket_Challenge_(14927191426).jpg\"> Slgckgc<\/a> \u3002<a href=\"https:\/\/creativecommons.org\/licenses\/by\/2.0\"> CC BY 2.0<\/a> \u3002<\/figcaption><\/figure><\/div>\n\n<p>\u75c5\u6c17\u306e\u539f\u56e0\u3068\u6f5c\u5728\u7684\u306a\u6cbb\u7642\u6cd5\u306e\u7814\u7a76\u304c\u9032\u884c\u4e2d\u3067\u3059\u3002 \u306a\u3069\u306e\u56fd\u5bb6\u7d44\u7e54<a href=\"https:\/\/www.als.net\/als-research\/\">ALS\u30bb\u30e9\u30d4\u30fc\u958b\u767a\u7814\u7a76\u6240\uff08TDI\uff09<\/a> \u3001<a href=\"https:\/\/www.als.org\/research\/research-we-fund\/funded-grants\"> ALS\u5354\u4f1a<\/a>\u3001 \u305d\u3057\u3066\u305d\u306e<a href=\"https:\/\/www.cdc.gov\/als\/ALSResearchNotificationClinicalTrialsStudies.html\">\u75be\u75c5\u7ba1\u7406\u4e88\u9632\u30bb\u30f3\u30bf\u30fc\uff08CDC\uff09<\/a> 2020\u5e74\u306b\u5168\u54e1\u304c\u3053\u306e\u5206\u91ce\u306e\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306b\u8cc7\u91d1\u3092\u63d0\u4f9b\u3057\u307e\u3057\u305f\u3002<\/p>\n\n<h2 class=\"wp-block-heading\" id=\"h-epidemiology-part-2-of-is-als-genetic\"><strong>\u75ab\u5b66\uff08ALS\u306f\u907a\u4f1d\u7684\u3067\u3059\u304b\uff1f\uff09<\/strong><\/h2>\n\n<p>2014\u5e74\u73fe\u5728\u3001<a href=\"https:\/\/www.cdc.gov\/als\/WhatisAmyotrophiclateralsclerosis.html#:~:text=Although%20no%20one%20knows%20for,cases%20in%20the%20United%20States.\"> CDC<\/a>\u7c73\u56fd\u306716,000\u4f8b\u306eALS\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u305d\u306e\u3054\u304f\u6700\u8fd1\u306e\u7d71\u8a08\u306b\u95a2\u3059\u308b\u6b63\u78ba\u306a\u8a18\u9332\u306f\u3042\u307e\u308a\u77e5\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u3002 \u7c73\u56fd\u3067\u306f\u3001\u7d045\u301c7<a href=\"https:\/\/www.als.org\/navigating-als\/resources\/fyi-epidemiology-als-and-suspected-clusters\">\u30b1\u30fc\u30b9\u304c\u5b58\u5728\u3057\u307e\u3059<\/a>1,00,000\u4eba\u306e\u4eba\u53e3\u3054\u3068\u306b\u3002 \u75c5\u6c17\u304c\u6700\u7d42\u7684\u306b\u8a3a\u65ad\u3055\u308c\u308b\u306e\u306f55-75\u6b73\u306e\u5e74\u9f62\u7bc4\u56f2\u3067\u3059\u3002 \u305f\u3060\u3057\u3001\u3053\u306e\u72b6\u614b\u304c25\u301c35\u6b73\u306e\u82e5\u3044\u60a3\u8005\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u306f\u3081\u3063\u305f\u306b\u306a\u3044\u3053\u3068\u306b\u6ce8\u610f\u3057\u3066\u304f\u3060\u3055\u3044\u3002 \u307e\u305f\u3001\u5973\u6027\u3088\u308a\u3082\u7537\u6027\u306b\u591a\u304f\u898b\u3089\u308c\u307e\u3059\uff08\u6027\u6bd4\u306f\u7d041.5\uff1a1\u3067\u3059\uff09\u3002<\/p>\n\n<h2 class=\"wp-block-heading\" id=\"h-forms-part-3-of-is-als-genetic\"><strong>\u30d5\u30a9\u30fc\u30e0\uff08ALS\u306f\u907a\u4f1d\u7684\u3067\u3059\u304b\uff1f\u306e\u30d1\u30fc\u30c83\uff09<\/strong><\/h2>\n\n<p>\u4e3b\u306b3\u3064\u306e\u4e3b\u306a\u3082\u306e\u304c\u3042\u308a\u307e\u3059<a href=\"https:\/\/stanfordhealthcare.org\/medical-conditions\/brain-and-nerves\/amyotrophic-lateral-sclerosis\/types.html\">\u30d5\u30a9\u30fc\u30e0<\/a>ALS\u306e\u3002 <\/p>\n\n<p><em>\u6563\u767a\u6027ALS<\/em> \uff1a\u3053\u306e\u30bf\u30a4\u30d7\u306f\u3001\u8003\u3048\u3089\u308c\u308b\u539f\u56e0\u306a\u3057\u306b\u30e9\u30f3\u30c0\u30e0\u306b\u767a\u751f\u3057\u307e\u3059\u3002 ALS\u75c7\u4f8b\u306e\u5927\u90e8\u5206\uff0890\u301c95\uff05\uff09\u306f\u6563\u767a\u7684\u3067\u3059\u3002 \u7591\u308f\u3057\u3044<a href=\"https:\/\/en.wikipedia.org\/wiki\/Amyotrophic_lateral_sclerosis#cite_note-Wingo2011-17\">\u7d44\u307f\u5408\u308f\u305b<\/a>\u907a\u4f1d\u7684\u304a\u3088\u3073\u74b0\u5883\u7684\u8981\u56e0\u306e\u8cac\u4efb\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n<p><em>\u5bb6\u65cf\u6027<\/em>\uff1a\u7c73\u56fd\u3067\u306f\u3001\u5bb6\u65cf\u6027\u306e\u75c5\u6c17\u304c\u5c11\u6570\u6d3e\uff085\u301c10\uff05\uff09\u306b\u898b\u3089\u308c\u3001\u5bb6\u65cf\u304b\u3089ALS\u3092\u53d7\u3051\u7d99\u3044\u3067\u3044\u307e\u3059\u3002 \u307b\u3068\u3093\u3069\u306e\u5834\u5408\u3001\u5e38\u67d3\u8272\u4f53\u512a\u6027\u30d1\u30bf\u30fc\u30f3\u3067\u907a\u4f1d\u3057\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u5404\u7d30\u80de\u306e\u5909\u5316\u3057\u305f\u907a\u4f1d\u5b50\u306e1\u3064\u306e\u30b3\u30d4\u30fc\u3067\u969c\u5bb3\u3092\u5f15\u304d\u8d77\u3053\u3059\u306e\u306b\u5341\u5206\u3067\u3059\u3002<\/p>\n\n<p><em>\u30b0\u30a2\u30de\u30cb\u30a2\u30f3<\/em>\uff1a\u30b0\u30a2\u30e0\u306e\u4eba\u53e3\u3067\u30b0\u30a2\u30de\u30cb\u30a2\u578b\u306e\u75c5\u6c17\u304c\u89b3\u5bdf\u3055\u308c\u3066\u304a\u308a\u3001\u305d\u306e\u539f\u56e0\u306f\u507d\u306e\u30b5\u30b4\u30e4\u30b7\u3001\u30bd\u30c6\u30c4\u30df\u30af\u30ed\u30cd\u30b7\u30a2\u306e\u6d88\u8cbb\u3067\u3059\u3002<\/p>\n\n<h2 class=\"wp-block-heading\" id=\"h-pathophysiology-of-als-part-4-of-is-als-genetic\"><strong>ALS\u306e\u75c5\u614b\u751f\u7406\u5b66\uff08ALS\u306f\u907a\u4f1d\u7684\u3067\u3059\u304b\uff1f\u306e\u30d1\u30fc\u30c84\uff09<\/strong><\/h2>\n\n<p>ALS\u3067\u306f\u3001\u8133\u3068\u810a\u9ac4\u306e\u4e0a\u4f4d\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u3068\u4e0b\u4f4d\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u4e21\u65b9\u304c\u5f71\u97ff\u3092\u53d7\u3051\u307e\u3059\u3002 \u4e0a\u4f4d\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u306f\u8133\u3092\u5360\u3081\u3001\u4e0b\u4f4d\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u306f\u810a\u9ac4\u306b\u3042\u308a\u307e\u3059\u3002 ALS\u30d1\u30b9\u30a6\u30a7\u30a4\u30ba\u306e\u30a6\u30a7\u30d6\u30b5\u30a4\u30c8\u306b\u3088\u308b\u3068\u3001\u305d\u308c\u306f\u901a\u5e38\u3001\u7126\u70b9\u304b\u3089\u5e83\u304c\u308a\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u4f53\u5185\u306e\u3059\u3079\u3066\u306e\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u3092\u7834\u58ca\u3057\u3001\u6700\u7d42\u7684\u306b\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u6b7b\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002 \u305d\u3057\u3066\u3001\u8907\u6570\u306e\u8981\u56e0\u304c\u3053\u306e\u30bf\u30a4\u30d7\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u306e\u539f\u56e0\u3067\u3059\u3002 \u4ed6\u306e\u5f62\u614b\u306f\u3001\u4e0a\u4f4d\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\uff08\u539f\u767a\u6027\u5074\u7d22\u786c\u5316\u75c7\u3001PLS\uff09\u307e\u305f\u306f\u4e0b\u4f4d\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\uff08\u9032\u884c\u6027\u7b4b\u840e\u7e2e\u75c7\u3001PMA\uff09\u306b\u306e\u307f\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n<p>\u4e0a\u4f4d\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u5909\u6027\u306f\u3001\u7b4b\u7dca\u5f35\u306e\u5897\u52a0\u307e\u305f\u306f\u75d9\u6027\u9ebb\u75fa\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002 \u4e00\u65b9\u3001\u4e0b\u4f4d\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u640d\u50b7\u306f\u7b4b\u529b\u4f4e\u4e0b\u306e\u5897\u52a0\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002 \u3053\u308c\u306f\u3001\u65e5\u5e38\u306e\u6d3b\u52d5\u306e\u9069\u5207\u306a\u6a5f\u80fd\u3092\u59a8\u3052\u307e\u3059\u3002<\/p>\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large is-resized\"><img decoding=\"async\" src=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Nicolas-4.png\" alt=\"ALS&#x306B;&#x95A2;&#x9023;&#x3059;&#x308B;&#x4E0A;&#x90E8;&#x30CB;&#x30E5;&#x30FC;&#x30ED;&#x30F3;&#x3068;&#x4E0B;&#x90E8;&#x30CB;&#x30E5;&#x30FC;&#x30ED;&#x30F3;\" class=\"wp-image-7767\" width=\"624\" height=\"632\" srcset=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Nicolas-4.png 624w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Nicolas-4-296x300.png 296w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Nicolas-4-12x12.png 12w\" sizes=\"(max-width: 624px) 100vw, 624px\" \/><figcaption>\u4e0a\u4f4d\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u3068\u4e0b\u4f4d\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u56f3\uff1aALS\u306e\u5f71\u97ff\u3092\u53d7\u3051\u308b\u4e3b\u8981\u306a\u30b3\u30f3\u30dd\u30fc\u30cd\u30f3\u30c8\u3002 \u753b\u50cf\u30bd\u30fc\u30b9\uff1a<a href=\"https:\/\/en.wikipedia.org\/wiki\/Amyotrophic_lateral_sclerosis#\/media\/File:UMN_vs_LMN.png\"> Rcchang16\u3001\u30a6\u30a3\u30ad\u30e1\u30c7\u30a3\u30a2\u30b3\u30e2\u30f3\u30ba<\/a>\u3001<a href=\"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\"> CC BY-SA 4.0<\/a> \u3002<\/figcaption><\/figure><\/div>\n\n<h2 class=\"wp-block-heading\" id=\"h-causes-part-5-of-is-als-genetic\"><strong>\u539f\u56e0\uff08ALS\u306f\u907a\u4f1d\u7684\u3067\u3059\u304b\uff1f\u306e\u30d1\u30fc\u30c85\uff09<\/strong><\/h2>\n\n<p>ALS\u3067\u306f\u3001\u907a\u4f1d\u5b50\u304c\u75c5\u6c17\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u7591\u308f\u308c\u3066\u3044\u307e\u3059\u3002 \u7814\u7a76\u306f\u3001ALS\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u7684\u8981\u56e0\u3092\u5f37\u304f\u652f\u6301\u3057\u3066\u3044\u307e\u3059\u3002 \u305f\u3060\u3057\u3001\u3044\u304f\u3064\u304b\u306e\u74b0\u5883\u8981\u56e0\u306e\u5f79\u5272\u3092\u793a\u5506\u3059\u308b\u7814\u7a76\u306f\u3042\u307e\u308a\u4e00\u8cab\u3057\u3066\u3044\u307e\u305b\u3093\u3002 \u307b\u3068\u3093\u3069\u306e\u5834\u5408\u3001\u6b63\u78ba\u306a\u539f\u56e0\u306f\u4e0d\u660e\u3067\u3059\u3002 \u3057\u304b\u3057\u3001\u6b8b\u308a\u306e\u5c0f\u3055\u306a\u30b3\u30db\u30fc\u30c8\uff085-10\uff05\uff09\u3067\u306f\u3001\u907a\u4f1d\u7684\u8981\u56e0\u304c\u72b6\u614b\u3092\u8aac\u660e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u5bb6\u65cf\u6b74\u3001\u6027\u5225\u3001\u5730\u7406\u306a\u3069\u306e\u4ed6\u306e\u8981\u56e0\u3082ALS\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n<h3 class=\"wp-block-heading\" id=\"h-is-als-genetic\">ALS\u306f\u907a\u4f1d\u7684\u3067\u3059\u304b\uff1f<\/h3>\n\n<p>\u591a\u304f\u306e\u907a\u4f1d\u7684\u5909\u7570\u306fALS\u3068\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002 \u3053\u306e\u75c5\u6c17\u306b\u95a2\u9023\u3059\u308b\u7279\u5b9a\u306e\u907a\u4f1d\u5b50\u5909\u7570\u306f\u3001\u8aa4\u3063\u3066\u6298\u308a\u305f\u305f\u307e\u308c\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u75c5\u7406\u5b66\u7684\u84c4\u7a4d\u307e\u305f\u306f\u65e9\u671f\u5206\u89e3\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u6700\u7d42\u7684\u306b\u795e\u7d4c\u5909\u6027\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/p>\n\n<h4 class=\"wp-block-heading\" id=\"h-major-genetic-components-in-als\">ALS\u306e\u4e3b\u8981\u306a\u907a\u4f1d\u7684\u8981\u7d20<\/h4>\n\n<p>SOD1\u907a\u4f1d\u5b50\u306f\u3001\u30b9\u30fc\u30d1\u30fc\u30aa\u30ad\u30b7\u30c9\u30b8\u30b9\u30e0\u30bf\u30fc\u30bc\u3068\u3057\u3066\u77e5\u3089\u308c\u308b\u9175\u7d20\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002 \u3053\u306e\u9175\u7d20\u306f\u3001\u9632\u5fa1\u6a5f\u69cb\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002 SOD1\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u8aa4\u3063\u3066\u6298\u308a\u305f\u305f\u307e\u308c\u305f\u5909\u7570\u4f53\u306f\u9032\u884c\u306b\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\n\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u306f\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u8abf\u7bc0\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308bTDP-43\u3092\u30b3\u30fc\u30c9\u3057\u3066\u3044\u307e\u3059\u3002 TDP-43\u306f\u3001RNA\u30d7\u30ed\u30bb\u30c3\u30b7\u30f3\u30b0\u306e\u3055\u307e\u3056\u307e\u306a\u6bb5\u968e\u3067\u91cd\u8981\u3067\u3059\u3002 TARDBP\u306e\u3044\u304f\u3064\u304b\u306e\u512a\u6027\u907a\u4f1d\u5b50\u5909\u7570\u306f\u3001TDP-43\u306e\u6b20\u9665\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u795e\u7d4c\u5909\u6027\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002 \u3057\u305f\u304c\u3063\u3066\u3001\u3053\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5206\u5e03\u3068\u6a5f\u80fd\u306e\u5909\u5316\u306f\u3001ALS\u3068\u5f37\u3044\u95a2\u9023\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n<p>FUS\u907a\u4f1d\u5b50\u306f\u3001RNA\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e00\u7a2e\u3067\u3042\u308bFUS\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u767a\u73fe\u3057\u307e\u3059\u3002 \u305d\u306e\u6a5f\u80fd\u306e\u3044\u304f\u3064\u304b\u306f\u3001TDP-43\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u6a5f\u80fd\u3068\u985e\u4f3c\u3057\u3066\u3044\u307e\u3059\u3002 \u3057\u305f\u304c\u3063\u3066\u3001FUS\u30bf\u30f3\u30d1\u30af\u8cea\u306fRNA\u4ee3\u8b1d\u306e\u591a\u304f\u306e\u30d7\u30ed\u30bb\u30b9\u3092\u76e3\u8996\u3057\u307e\u3059\u3002 ALS\u3067\u306f\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u75c5\u539f\u6027\u591a\u69d8\u4f53\u304cFUS\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u4e0d\u9069\u5207\u306a\u6298\u308a\u7573\u307f\u3068\u5206\u5e03\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u3042\u308a\u3001\u305d\u308c\u306b\u3088\u3063\u3066\u6b63\u5e38\u306a\u7d30\u80de\u751f\u7406\u5b66\u306b\u5e72\u6e09\u3057\u307e\u3059\u3002<\/p>\n\n<p>C9ORF72\uff1a\u3053\u306e\u907a\u4f1d\u5b50\u306e\u6b63\u78ba\u306a\u5f79\u5272\u306f\u307e\u3060\u660e\u3089\u304b\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u7279\u306b\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u6d3b\u6027\u3068\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u5f62\u3067\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u8f38\u9001\u3078\u306e\u95a2\u4e0e\u3092\u793a\u3057\u305f\u5831\u544a\u306f\u307b\u3068\u3093\u3069\u3042\u308a\u307e\u305b\u3093\u3002 \u307e\u305f\u3001\u3044\u304f\u3064\u304b\u306e\u52d5\u7269\u5b9f\u9a13\u3067\u6307\u6458\u3055\u308c\u3066\u3044\u308b\u3088\u3046\u306b\u3001C9ORF72\u306e\u767a\u73fe\u4f4e\u4e0b\u306f\u75be\u60a3\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u305f\u3060\u3057\u3001\u3053\u306e\u30c0\u30a6\u30f3\u30ec\u30ae\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3060\u3051\u3067\u306fALS\u306f\u767a\u751f\u3057\u307e\u305b\u3093\u304c\u3001\u5b9f\u969b\u306b\u306f\u3001<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2017.00442\/full\">\u7e41\u96d1<\/a>\u4ed6\u306e\u3044\u304f\u3064\u304b\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u3002<\/p>\n\n<h4 class=\"wp-block-heading\">ALS\u306e\u30de\u30a4\u30ca\u30fc\u306a\u907a\u4f1d\u7684\u8981\u7d20<\/h4>\n\n<p>ALS\u306e\u4ed6\u306e\u3044\u304f\u3064\u304b\u306e\u907a\u4f1d\u5b50\u4fee\u98fe\u56e0\u5b50\u306fATXN1\u3001ATXN2\u3001UNC13A\u3067\u3059\u3002 \u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u7a81\u7136\u5909\u7570\u306f\u304a\u305d\u3089\u304f\u4eba\u3005\u3092\u4f5c\u308a\u307e\u3059<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2019.01310\/full#h4\">\u5f71\u97ff\u3092\u53d7\u3051\u3084\u3059\u3044\u3067\u3059<\/a>\u969c\u5bb3\u306b\u3002 \u3057\u304b\u3057\u3001\u305d\u308c\u3089\u306f\u3053\u306e\u75c5\u6c17\u3068\u5f37\u304f\u76f8\u95a2\u3057\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n<h2 class=\"wp-block-heading\" id=\"h-non-genetic-component-of-als-part-7-of-is-als-genetic\"><strong>ALS\u306e\u975e\u907a\u4f1d\u7684\u8981\u7d20\uff08ALS\u306f\u907a\u4f1d\u7684\u3067\u3059\u304b\uff1f\u306e\u30d1\u30fc\u30c87\uff09<\/strong><\/h2>\n\n<h3 class=\"wp-block-heading\" id=\"h-occupational-risk-factor\">\u8077\u696d\u4e0a\u306e\u5371\u967a\u56e0\u5b50<\/h3>\n\n<p>\u306e\u6570<a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/17482960902721634\">\u30ec\u30dd\u30fc\u30c8<\/a>\u6301\u3063\u3066\u308b<a href=\"https:\/\/journals.sagepub.com\/doi\/10.2466\/pms.104.4.1251-1254?url_ver=Z39.88-2003&amp;rfr_id=ori%3Arid%3Acrossref.org&amp;rfr_dat=cr_pub++0pubmed&amp;\">\u63d0\u6848<\/a>\u30d7\u30ed\u306e\u30a2\u30b9\u30ea\u30fc\u30c8\u304cALS\u3092\u767a\u75c7\u3059\u308b\u53ef\u80fd\u6027\u304c\u6700\u3082\u9ad8\u3044\u3053\u3068\u3002 \u305d\u3057\u3066\u3001\u3053\u308c\u306f\u4e3b\u306b\u91cd\u5ea6\u306e\u982d\u90e8\u5916\u50b7\u307e\u305f\u306f\u6fc0\u3057\u3044\u8eab\u4f53\u6d3b\u52d5\u304c\u539f\u56e0\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n<p>\u4ed6\u306e\u4f8b<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2737014\/\">\u8077\u5834\u3067\u306e\u66b4\u9732<\/a>\u4eba\u3005\u304c\u78c1\u5834\u307e\u305f\u306f\u6fc0\u3057\u3044\u8089\u4f53\u52b4\u50cd\u306b\u3055\u3089\u3055\u308c\u308b\u5834\u5408\u3067\u3059\u3002 \u3057\u304b\u3057\u3001\u305d\u306e\u3088\u3046\u306a\u7814\u7a76\u306f\u95a2\u9023\u6027\u306b\u57fa\u3065\u3044\u3066\u304a\u308a\u3001\u4e00\u8cab\u6027\u304c\u306a\u304f\u3001\u75c5\u56e0\u304c\u4e0d\u660e\u3067\u3059\u3002 <\/p>\n\n<h3 class=\"wp-block-heading\" id=\"h-toxic-chemicals\">\u6709\u6bd2\u5316\u5b66\u7269\u8cea<\/h3>\n\n<p>\u306e\u7d50\u679c<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27159543\/\">\u8abf\u67fb<\/a>\u30df\u30b7\u30ac\u30f3\u5927\u5b66\u30a2\u30ca\u30fc\u30d0\u30fc\u6821\uff082016\u5e745\u6708\uff09\u3067\u306f\u3001\u74b0\u5883\u6bd2\u7d20\u3078\u306e\u66dd\u9732\u304cALS\u767a\u75c7\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3044\u3046\u9577\u5e74\u306e\u7591\u60d1\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002 \u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u7814\u7a76\u8005\u3089\u306f\u3001\u969c\u5bb3\u3068\u3001\u5869\u7d20\u5316\u70ad\u5316\u6c34\u7d20\u3001\u30dd\u30ea\u5869\u5316\u30d3\u30d5\u30a7\u30cb\u30eb\u3001\u304a\u3088\u3073\u30dd\u30ea\u81ed\u5316\u30d3\u30d5\u30a7\u30cb\u30eb\u306e\u5b58\u5728\u3068\u306e\u9593\u306b\u6709\u610f\u306a\u95a2\u9023\u304c\u3042\u308b\u3053\u3068\u3092\u89b3\u5bdf\u3057\u307e\u3057\u305f\u3002 <\/p>\n\n<h3 class=\"wp-block-heading\" id=\"h-beta-methylamino-l-alanine-bmaa\">\u30d9\u30fc\u30bf\u30e1\u30c1\u30eb\u30a2\u30df\u30ceL-\u30a2\u30e9\u30cb\u30f3\uff08BMAA\uff09<\/h3>\n\n<p>BMAA\u306fALS\u306b\u95a2\u9023\u3059\u308b\u795e\u7d4c\u6bd2\u3067\u3059\u3002 \u30b0\u30a2\u30e0\u306b\u4f4f\u3080\u5148\u4f4f\u6c11\u306f\u3001\u3053\u306e\u75c5\u6c17\u306b\u304b\u304b\u308b\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u3053\u306e\u4eba\u53e3\u306e\u98df\u4e8b\u306fBMAA\u304c\u8c4a\u5bcc\u3067\u3059\u3002 \u4e00\u822c\u7684\u306b\u3001\u592a\u5e73\u6d0b\u8af8\u5cf6\u306e\u6c34\u4e2d\u306e\u30b7\u30a2\u30ce\u30d0\u30af\u30c6\u30ea\u30a2\u306fBMAA\u3092\u751f\u6210\u3057\u307e\u3059\u3002 \u305d\u3057\u3066\u30b0\u30a2\u30e0\u306e\u4eba\u3005\u304c\u30b7\u30fc\u30d5\u30fc\u30c9\u306b\u4f9d\u5b58\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u8003\u3048\u308b\u3068\u3001\u3053\u308c\u306f\u4eba\u53e3\u3092\u3088\u308a\u9ad8\u304f\u3059\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093<a href=\"https:\/\/alsnewstoday.com\/news-posts\/2019\/09\/20\/study-suggests-mechanism-als-caused-by-toxic-bmaa-compound-algae\/\">\u5371\u967a<\/a>\u3002 <\/p>\n\n<h3 class=\"wp-block-heading\" id=\"h-microbiome\">\u30df\u30af\u30ed\u30d3\u30aa\u30fc\u30e0<\/h3>\n\n<p>\u8178\u5185\u7d30\u83cc\u53e2\u306f\u3057\u3070\u3057\u3070<a href=\"https:\/\/www.neurodegenerationresearch.eu\/survey\/the-gut-microbiome-in-neurodegenerative-disease\/#:~:text=Pioneering%20research%20has%20revealed%20that,IBD%20and%20MS%20mouse%20models.\">\u5f71\u97ff<\/a>\u52d5\u7269\u5b9f\u9a13\u3067\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3088\u3046\u306b\u3001\u75c5\u6c17\u306e\u7d50\u679c\u3002 \u8178\u5185\u7d30\u83cc\u53e2<a href=\"https:\/\/www.sciencedaily.com\/releases\/2019\/07\/190722111923.htm\">\u7814\u7a76<\/a>\u30de\u30a6\u30b9\u3067\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u7d30\u83cc\u682a\u3068ALS\u306e\u9593\u306b\u91cd\u8981\u306a\u95a2\u9023\u304c\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u3055\u3089\u306b\u3001\u3053\u306e\u7814\u7a76\u3067\u306f\u3001Akkermansia muciniphila\u306e\u7cfb\u7d71\u306f\u3001\u30de\u30a6\u30b9\u306e\u75c5\u6c17\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3059\u3002 \u5225\u306e<a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2288-7\">2020\u5e74\u306e\u7814\u7a76<\/a>\u30de\u30a6\u30b9\u3067\u306f\u3001\u8178\u306e\u5fae\u751f\u7269\u7fa4\u96c6\u304c\u751f\u5b58\u306e\u7d50\u679c\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u3053\u308c\u306f\u7279\u306b\u6ce8\u76ee\u3055\u308c\u307e\u3057\u305f\u3002\u306a\u305c\u306a\u3089\u3001ALS\u611f\u53d7\u6027\u30de\u30a6\u30b9\u306f\u3001\u540c\u69d8\u306e\u907a\u4f1d\u7684\u80cc\u666f\u3092\u6301\u3063\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u5bff\u547d\u306b\u6709\u610f\u5dee\u3092\u793a\u3057\u305f\u304b\u3089\u3067\u3059\u3002 \u5fae\u751f\u7269\u7fa4\u96c6\u306e\u591a\u69d8\u6027\u30d1\u30bf\u30fc\u30f3\u306f\u8457\u3057\u304f\u7570\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u2013\u305d\u308c\u3089\u306e\u30de\u30a6\u30b9\u306e\u751f\u5b58\u671f\u9593\u306e\u9055\u3044\u306b\u8ca2\u732e\u3057\u305f\u304b\u3082\u3057\u308c\u306a\u3044\u8981\u56e0\u306e1\u3064\u3002<\/p>\n\n<h2 class=\"wp-block-heading\" id=\"h-symptoms-part-8-of-is-als-genetic\"><strong>\u75c7\u72b6\uff08ALS\u306f\u907a\u4f1d\u7684\u3067\u3059\u304b\uff1f\u306e\u30d1\u30fc\u30c88\uff09<\/strong><\/h2>\n\n<p>ALS\u306e\u7279\u5fb4\u7684\u306a\u75c7\u72b6\u306f\u3001\u4e0a\u80a2\u3068\u4e0b\u80a2\u306e\u7b4b\u8089\u306e\u52d5\u304d\u3001\u7403\u9ebb\u75fa\u306e\u7b4b\u8089\u3001\u304a\u3088\u3073\u4f53\u5e79\u306e\u7b4b\u8089\u306e\u6a5f\u80fd\u969c\u5bb3\u3067\u3059\u3002<\/p>\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"592\" height=\"720\" src=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Nicolas-5.png\" alt=\"ALS&#x306B;&#x95A2;&#x9023;&#x3059;&#x308B;&#x53EF;&#x80FD;&#x6027;&#x306E;&#x3042;&#x308B;&#x30E1;&#x30AB;&#x30CB;&#x30BA;&#x30E0;\" class=\"wp-image-7772\" srcset=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Nicolas-5.png 592w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Nicolas-5-247x300.png 247w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Nicolas-5-10x12.png 10w\" sizes=\"(max-width: 592px) 100vw, 592px\" \/><figcaption>\u591a\u304f\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u304cALS\u306b\u30ea\u30f3\u30af\u3055\u308c\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u753b\u50cf\u30bd\u30fc\u30b9\uff1a <a href=\"https:\/\/dmm.biologists.org\/content\/10\/5\/537\">\u30f4\u30a1\u30f3\u30c0\u30e0\u30892017\u5e74\u3002 \u30a6\u30a3\u30ad\u30e1\u30c7\u30a3\u30a2\u30b3\u30e2\u30f3\u30ba<\/a>\u3001<a href=\"https:\/\/creativecommons.org\/licenses\/by\/3.0\/deed.en\"> CC-BY-3.0<\/a> \u3002<\/figcaption><\/figure><\/div>\n\n<p>\u306b\u3088\u308b<a href=\"https:\/\/www.ninds.nih.gov\/Disorders\/Patient-Caregiver-Education\/Fact-Sheets\/Amyotrophic-Lateral-Sclerosis-ALS-Fact-Sheet#Symptoms\">\u56fd\u7acb\u795e\u7d4c\u75be\u60a3\u30fb\u8133\u5352\u4e2d\u7814\u7a76\u6240<\/a>\u3001\u75c7\u72b6\u306f\u5f90\u3005\u306b\u84c4\u7a4d\u3057\u307e\u3059\u3002 ALS\u306e\u521d\u671f\u75c7\u72b6\u306b\u306f\u6b21\u306e\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n<ul class=\"wp-block-list\"><li>\u8155\u3001\u811a\u3001\u80a9\u3001\u307e\u305f\u306f\u820c\u306e\u7dda\u7dad\u675f\u6027\u53ce\u7e2e\uff08\u7b4b\u8089\u306e\u3051\u3044\u308c\u3093\uff09<\/li><li>\u7b4b\u8089\u306e\u3051\u3044\u308c\u3093<\/li><li>\u7b4b\u8089\u306e\u3053\u308f\u3070\u308a\uff08\u75d9\u7e2e\uff09<\/li><li>\u8155\u3001\u811a\u3001\u9996\u3001\u6a2a\u9694\u819c\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u7b4b\u529b\u4f4e\u4e0b<\/li><li>\u4e0d\u660e\u77ad\u3067\u9f3b\u306e\u30b9\u30d4\u30fc\u30c1<\/li><li>\u5480\u56bc\u307e\u305f\u306f\u56a5\u4e0b\u306e\u56f0\u96e3<\/li><\/ul>\n\n<p>\u89b3\u5bdf\u3055\u308c\u305f\u6700\u521d\u306e\u75c7\u72b6\u306b\u5fdc\u3058\u3066\u3001\u72b6\u614b\u306f\u3055\u3089\u306b\u30b5\u30d6\u30ab\u30c6\u30b4\u30ea\u306b\u5206\u985e\u3067\u304d\u307e\u3059\u3002 \u75c7\u72b6\u304c\u6700\u521d\u306b\u8155\u307e\u305f\u306f\u811a\u3067\u59cb\u307e\u308b\u3068\u304d\u3001\u305d\u308c\u306f\u300c\u56db\u80a2\u767a\u75c7\u300dALS\u3068\u3057\u3066\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002 \u6700\u521d\u306e\u5146\u5019\u304c\u767a\u8a71\u307e\u305f\u306f\u56a5\u4e0b\u306e\u554f\u984c\u3067\u3042\u308b\u5834\u5408\u3001\u305d\u308c\u306f\u300c\u7403\u9ebb\u75fa\u767a\u75c7\u300dALS\u3068\u547c\u3070\u308c\u307e\u3059\u3002<\/p>\n\n<p>ALS\u306e\u9032\u884c\u306f\u500b\u4eba\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002 \u3057\u304b\u3057\u3001\u3059\u3079\u3066\u306e\u5834\u5408\u306b\u304a\u3044\u3066\u3001\u7b4b\u529b\u4f4e\u4e0b\u3068\u840e\u7e2e\u306f\u3001\u6a5f\u80fd\u304c\u56f0\u96e3\u306b\u306a\u308b\u307e\u3067\u4f53\u306e\u4ed6\u306e\u90e8\u5206\u306b\u5e83\u304c\u308a\u307e\u3059\u3002 \u75c5\u6c17\u306e\u9032\u884c\u3057\u305f\u6bb5\u968e\u306e\u4eba\u3005\u306f\u3001\u6700\u7d42\u7684\u306b\u306f\u7acb\u3063\u305f\u308a\u3001\u6b69\u3044\u305f\u308a\u3001\u624b\u8db3\u3092\u4f7f\u7528\u3057\u305f\u308a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u304f\u306a\u308a\u3001\u56a5\u4e0b\u3001\u4f1a\u8a71\u3001\u547c\u5438\u304c\u56f0\u96e3\u306b\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n<p>\u307b\u3068\u3093\u3069\u306e\u5834\u5408\u3001ALS\u306e\u4eba\u306f\u3001\u63a8\u8ad6\u3001\u8a18\u61b6\u3001\u7406\u89e3\u3001\u554f\u984c\u89e3\u6c7a\u306a\u3069\u306e\u3088\u308a\u9ad8\u5ea6\u306a\u7cbe\u795e\u7684\u30d7\u30ed\u30bb\u30b9\u3092\u5b9f\u884c\u3059\u308b\u80fd\u529b\u3092\u4fdd\u6301\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n<p>\u60a3\u8005\u3055\u3093\u306e\u5e73\u5747\u751f\u5b58\u671f\u9593\u306f\u767a\u75c7\u304b\u3089\u7d043\u301c5\u5e74\u3067\u3059\u304c\u3001<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3515205\/\"> 10\u301c20\u30d1\u30fc\u30bb\u30f3\u30c8<\/a>\u306e\u60a3\u8005\u306f\u3088\u308a\u9577\u3044\u671f\u9593\u751f\u304d\u6b8b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n<h2 class=\"wp-block-heading\" id=\"h-diagnosis-part-9-of-is-als-genetic\"><strong>\u8a3a\u65ad\uff08ALS\u306f\u907a\u4f1d\u7684\u3067\u3059\u304b\uff1f\u306e\u30d1\u30fc\u30c89\uff09<\/strong><\/h2>\n\n<p>\u307b\u3068\u3093\u3069\u306e\u5834\u5408\u3001\u75c7\u72b6\u306f\u4eba\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002 \u3057\u305f\u304c\u3063\u3066\u3001\u533b\u5e2b\u306f\u4ee5\u4e0b\u3092\u4f7f\u7528\u3057\u3066\u5fb9\u5e95\u7684\u306a\u691c\u67fb\u3092\u884c\u3044\u307e\u3059<a href=\"https:\/\/stanfordhealthcare.org\/medical-conditions\/brain-and-nerves\/amyotrophic-lateral-sclerosis\/diagnosis.html\">\u8907\u6570\u306e\u30c6\u30b9\u30c8<\/a>\u3002 \u73fe\u5728\u306e\u3068\u3053\u308d\u3001\u81e8\u5e8a\u306f\u3042\u308a\u307e\u305b\u3093<a href=\"http:\/\/web.alsa.org\/site\/PageServer?pagename=ALSA_Genetics_Testing#:~:text=test%20diagnose%20ALS%3F-,A.,nerve%20and%20muscle%20function%20tests.\">\u907a\u4f1d\u5b50\u691c\u67fb<\/a>ALS\u306e\u5834\u5408\u3002<\/p>\n\n<p><em><em>\u8eab\u4f53\u691c\u67fb\uff1a<\/em>\u307b\u3068\u3093\u3069\u306e\u5834\u5408\u3001\u7b4b\u529b\u4f4e\u4e0b\u3001\u7b4b\u840e\u7e2e\u3001\u3055\u3089\u306b\u306f\u7b4b\u8089\u306e\u3051\u3044\u308c\u3093\u304c\u5897\u52a0\u3059\u308b\u3068\u3001\u60a3\u8005\u306f\u521d\u3081\u3066\u533b\u5e2b\u306e\u8a3a\u5bdf\u3092\u53d7\u3051\u307e\u3059\u3002 \u7b4b\u8089\u306e\u3051\u3044\u308c\u3093\u3060\u3051\u3067\u3082\u3001\u307b\u3068\u3093\u3069\u306e\u5834\u5408\u3001\u826f\u6027\u306e\u7dda\u7dad\u675f\u6027\u53ce\u7e2e\u3092\u8868\u3059\u3053\u3068\u306b\u6ce8\u610f\u3057\u3066\u304f\u3060\u3055\u3044\u3002 \u6700\u521d\u306f\u3001\u75c7\u72b6\u306f\u4f53\u306e\u3069\u3053\u306b\u3067\u3082\u73fe\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u691c\u67fb\u4e2d\u3001\u5f1b\u7de9\u6027\u9ebb\u75fa\u3068\u75d9\u6027\u9ebb\u75fa\u306e\u5146\u5019\u304c\u540c\u6642\u306b\u73fe\u308c\u308b\u3068\u3001ALS\u306e\u8a3a\u65ad\u306e\u7591\u3044\u304c\u5f37\u307e\u308a\u307e\u3059\u3002<\/em><\/p>\n\n<p><em>\u7b4b\u96fb\u56f3\uff1a<\/em>\u8a3a\u65ad\u306b\u306f\u7b4b\u96fb\u56f3\u691c\u67fb\u3068\u7b4b\u96fb\u56f3\u691c\u67fb\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002 \u7b4b\u96fb\u56f3\u691c\u67fb\u306f\u3001\u7b4b\u8089\u306e\u96fb\u6c17\u7684\u6d3b\u52d5\u3092\u5206\u6790\u3057\u307e\u3059\u3002 \u8a3a\u65ad\u3092\u884c\u3046\u305f\u3081\u306b\u56fd\u969b\u7684\u306b\u6a19\u6e96\u5316\u3055\u308c\u305f\u57fa\u6e96\u304c\u958b\u767a\u3055\u308c\u307e\u3057\u305f\uff08\u30a8\u30eb\u30a8\u30b9\u30b3\u30ea\u30a2\u30eb\u57fa\u6e96\uff09\u3002 \u3053\u308c\u3089\u306e\u57fa\u6e96\u306b\u3088\u308b\u3068\u3001\u8a3a\u65ad\u306b\u306f\u4e0a\u4f4d\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u3068\u4e0b\u4f4d\u904b\u52d5\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u5909\u6027\u3001\u305d\u308c\u3089\u306e\u9032\u884c\u3001\u304a\u3088\u3073\u4ed6\u306e\u795e\u7d4c\u5909\u6027\u75be\u60a3\u304c\u306a\u3044\u3053\u3068\u3092\u8abf\u3079\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"624\" height=\"417\" src=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Nicolas-6.png\" alt=\"&#x7B4B;&#x96FB;&#x56F3;&#x691C;&#x67FB;\" class=\"wp-image-7777\" srcset=\"https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Nicolas-6.png 624w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Nicolas-6-300x200.png 300w, https:\/\/nebula.org\/blog\/wp-content\/uploads\/2020\/12\/Nicolas-6-16x12.png 16w\" sizes=\"(max-width: 624px) 100vw, 624px\" \/><figcaption>\u7b4b\u96fb\u56f3\u691c\u67fb\u306f\u7b4b\u8089\u306e\u96fb\u6c17\u7684\u6d3b\u52d5\u3092\u5206\u6790\u3057\u3001MS\u3092\u8a3a\u65ad\u3059\u308b\u305f\u3081\u306e\u91cd\u8981\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u3067\u3059\u3002\u30dd\u30fc\u30eb\u30a2\u30f3\u30bd\u30cb\u30fc\u30b9\u30c1\u30e5\u30ef\u30fc\u30c8\u3002 \u5e30\u5c5e-\u7d99\u627f4.0\u30a4\u30f3\u30bf\u30fc\u30ca\u30b7\u30e7\u30ca\u30eb\u3002<\/figcaption><\/figure><\/div>\n\n<p><em>\u30b9\u30d1\u30a4\u30ca\u30eb\u30bf\u30c3\u30d7\uff1a<\/em>\u533b\u5e2b\u306f\u5c11\u91cf\u306e\u8133\u810a\u9ac4\u6db2\u3092\u629c\u304d\u53d6\u308a\u3001\u708e\u75c7\u72b6\u614b\u307e\u305f\u306f\u7570\u5e38\u306a\u7d30\u80de\u306e\u5b58\u5728\u3092\u63a2\u3057\u307e\u3059\u3002 \u3053\u306e\u30c6\u30b9\u30c8\u306f\u3001\u7570\u5e38\u306a\u75c7\u72b6\u304c\u3042\u308b\u5834\u5408\u306b\u306e\u307f\u91cd\u8981\u3067\u3059\u3002 <\/p>\n\n<p><em>\u751f\u691c\uff1a<\/em>\u4e00\u822c\u7684\u306b\u3001\u5916\u79d1\u533b\u306f\u4e0a\u8155\u307e\u305f\u306f\u5927\u817f\u4e0a\u90e8\u304b\u3089\u7b4b\u8089\u306e\u4e00\u90e8\u3092\u53d6\u308a\u9664\u304d\u307e\u3059\u3002 \u6b21\u306b\u3001\u5916\u79d1\u533b\u306f\u67d3\u8272\u3068\u9855\u5fae\u93e1\u3092\u4f7f\u7528\u3057\u3066\u640d\u50b7\u3092\u63a2\u3057\u307e\u3059\u3002<\/p>\n\n<h2 class=\"wp-block-heading\" id=\"h-treatment-part-10-of-is-als-genetic\"><strong>\u6cbb\u7642\uff08ALS\u306f\u907a\u4f1d\u7684\u3067\u3059\u304b\uff1f\u306e\u30d1\u30fc\u30c810\uff09<\/strong><\/h2>\n\n<p>\u901a\u5e38\u3001\u6cbb\u7642\u306f\u85ac\u7269\u7642\u6cd5\u3068\u75c7\u5019\u6027\u6307\u5411\u7642\u6cd5\u306e\u7d44\u307f\u5408\u308f\u305b\u3067\u69cb\u6210\u3055\u308c\u307e\u3059\u3002 \u5bfe\u75c7\u7642\u6cd5\u306f\u3001\u7b4b\u529b\u4f4e\u4e0b\u306e\u5408\u4f75\u75c7\u3092\u56de\u907f\u3057\u3001\u60a3\u8005\u306e\u751f\u6d3b\u306e\u8cea\u3092\u5411\u4e0a\u3055\u305b\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u3044\u307e\u3059\u3002 \u52d5\u7269\u30e2\u30c7\u30eb\u3068\u30d2\u30c8\u5e79\u7d30\u80de\u3067\u306f\u3001<a href=\"https:\/\/medicalxpress.com\/news\/2019-05-potential-drug-als-ftd.html\">\u907a\u4f1d\u7684<\/a><a href=\"https:\/\/www.genengnews.com\/news\/als-researchers-discover-new-biomarker-and-drug-target\/\">\u7814\u7a76<\/a>\u85ac\u7269\u7642\u6cd5\u306e\u958b\u767a\u306b\u5411\u3051\u305f\u4e00\u6b69\u3068\u306a\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u6f5c\u5728\u7684\u306a\u5275\u85ac\u30bf\u30fc\u30b2\u30c3\u30c8\u3092\u7279\u5b9a\u3057\u307e\u3057\u305f\u3002<\/p>\n\n<p>\u7279\u306bALS\u306e\u5bb6\u65cf\u6b74\u304c\u3042\u308b\u5834\u5408\u306f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u53d7\u3051\u305f\u3044\u3068\u601d\u3046\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002 \u305d\u3057\u3066\u3001\u305d\u306e\u3088\u3046\u306a\u5834\u5408\u3001\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30e9\u30fc\u306f\u5bb6\u65cf\u6b74\u3060\u3051\u3067\u306a\u304f\u3001\u533b\u5b66\u7684\u80cc\u666f\u3001\u304a\u3088\u3073\u4ed6\u306e\u6f5c\u5728\u7684\u306a\u30ea\u30b9\u30af\u3092\u8a55\u4fa1\u3059\u308b\u306e\u3092\u52a9\u3051\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002 \u5bb6\u65cf\u6027ALS\u306e\u5834\u5408\u3001\u967d\u6027\u306e\u691c\u67fb\u7d50\u679c\u306f\u901a\u5e38\u3001<a href=\"https:\/\/www.als.org\/understanding-als\/who-gets-als\/genetic-testing\"> 60\u301c70\u30d1\u30fc\u30bb\u30f3\u30c8<\/a>\u30b1\u30fc\u30b9\u306e\u3002<\/p>\n\n<h3 class=\"wp-block-heading\" id=\"h-neuroprotective-therapy\">\u795e\u7d4c\u4fdd\u8b77\u7642\u6cd5<\/h3>\n\n<p>\u30ea\u30eb\u30be\u30fc\u30eb\u306f\u795e\u7d4c\u4fdd\u8b77\u7642\u6cd5\u306e\u4e00\u822c\u7684\u306a\u85ac\u3067\u3059\u3002 \u3053\u306e\u85ac\u306f\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u304b\u3089\u306e\u795e\u7d4c\u4f1d\u9054\u7269\u8cea\u30b0\u30eb\u30bf\u30e1\u30fc\u30c8\u306e\u653e\u51fa\u3092\u30d6\u30ed\u30c3\u30af\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u904b\u52d5\u795e\u7d4c\u7d30\u80de\u306e\u7834\u58ca\u3092\u6291\u5236\u3057\u307e\u3059\u3002<\/p>\n\n<p>\u30ea\u30eb\u30be\u30fc\u30eb\u306e\u6295\u4e0e\u306f\u3001\u751f\u5b58\u671f\u9593\u3092\u7d043\u304b\u6708\u5ef6\u9577\u3057\u3001ALS\u306e\u521d\u671f\u6bb5\u968e\u3092\u5ef6\u9577\u3059\u308b\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u305f\u3060\u3057\u3001\u30ea\u30eb\u30be\u30fc\u30eb\u3067\u306f\u75c5\u6c17\u306e\u9032\u884c\u3092\u5b8c\u5168\u306b\u6b62\u3081\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u3053\u3068\u306b\u6ce8\u610f\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n<p>2017\u5e74\u306e\u6642\u70b9\u3067\u3001\u7c73\u56fd\u98df\u54c1\u533b\u85ac\u54c1\u5c40\u306f\u3055\u3089\u306b\u5225\u306e\u85ac\u30a8\u30c0\u30e9\u30dc\u30f3\u306e\u627f\u8a8d\u3092\u4e0e\u3048\u3066\u3044\u307e\u3059\u3002 \u3053\u308c\u306f\u3001ALS\u306e\u767a\u75c7\u3092\u9045\u3089\u305b\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002 <\/p>\n\n<h3 class=\"wp-block-heading\" id=\"h-symptom-therapy\">\u75c7\u72b6\u7642\u6cd5<\/h3>\n\n<p>\u6b21\u306e\u75c7\u72b6\u306f\u3001\u9069\u5207\u306a\u6cbb\u7642\u6cd5\u3067\u6cbb\u7642\u3055\u308c\u308b\u3053\u3068\u304c\u3088\u304f\u3042\u308a\u307e\u3059\u3002<\/p>\n\n<ul class=\"wp-block-list\"><li>\u7b4b\u8089\u306e\u3051\u3044\u308c\u3093<\/li><li>\u56a5\u4e0b\u969c\u5bb3<\/li><li>\u553e\u6db2\u5206\u6ccc<\/li><li>\u97f3\u58f0\u969c\u5bb3\u3068\u30b3\u30df\u30e5\u30cb\u30b1\u30fc\u30b7\u30e7\u30f3<\/li><li>\u75c5\u7684\u306a\u7b11\u3044\u3068\u6ce3\u304d<\/li><li>\u547c\u5438\u5668\u75be\u60a3<\/li><li>\u3046\u3064\u75c5\u3001\u7761\u7720\u969c\u5bb3\u3001\u304a\u3088\u3073\u4e0d\u5b89<\/li><\/ul>\n\n<h3 class=\"wp-block-heading\" id=\"h-recent-news-2020\">\u6700\u8fd1\u306e\u30cb\u30e5\u30fc\u30b9\uff082020\uff09<\/h3>\n\n<p>\u30c0\u30d6\u30ea\u30f3\u306e\u30c8\u30ea\u30cb\u30c6\u30a3\u30ab\u30ec\u30c3\u30b8\u306e\u7814\u7a76\u8005\u306f\u3001<a href=\"https:\/\/www.eurekalert.org\/pub_releases\/2020-09\/tcd-tcr090220.php\">\u907a\u4f1d\u5b50\u6cbb\u7642\u306e\u7b2c1\u76f8\u81e8\u5e8a\u8a66\u9a13<\/a>\u30c0\u30d6\u30ea\u30f3\u306e\u30bb\u30f3\u30c8\u30b8\u30a7\u30fc\u30e0\u30b9\u75c5\u9662\u306e\u81e8\u5e8a\u7814\u7a76\u65bd\u8a2d\u3067\uff082020\u5e749\u67081\u65e5\u73fe\u5728\uff09\u3002 \u3053\u306e\u907a\u4f1d\u5b50\u30d9\u30fc\u30b9\u306e\u6cbb\u7642\u6cd5\u306f\u3001\u907a\u4f1d\u5b50C9ORF72\u3092\u5bfe\u8c61\u3068\u3057\u3066\u3044\u307e\u3059\u3002 \u7c73\u56fd\u306e\u88fd\u85ac\u4f1a\u793eBiogen\u306f\u3053\u306e\u81e8\u5e8a\u8a66\u9a13\u3092\u5f8c\u63f4\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n<p>\u3053\u306e\u8a18\u4e8b\u306f\u6c17\u306b\u5165\u308a\u307e\u3057\u305f\u304b\uff1f \u306e\u4ed6\u306e\u6295\u7a3f\u3092\u5fc5\u305a\u30c1\u30a7\u30c3\u30af\u3057\u3066\u304f\u3060\u3055\u3044<a href=\"https:\/\/nebula.org\/blog\/ja\/nebula-library-unlocking-genetic-research\/\">\u661f\u96f2\u7814\u7a76\u56f3\u66f8\u9928<\/a>\uff01<\/p>\n","protected":false},"excerpt":{"rendered":"<p>ALS\u306e\u661f\u96f2\u30b2\u30ce\u30df\u30af\u30b9DNA\u30ec\u30dd\u30fc\u30c8 ALS\u306f\u907a\u4f1d\u7684\u3067\u3059\u304b\uff1f \u3053\u306e\u8cea\u554f\u306b\u7b54\u3048\u3088\u3046 &hellip;<\/p>\n<p class=\"read-more\"> <a class=\"ast-button\" href=\"https:\/\/nebula.org\/blog\/ja\/is-als-genetic\/\"> <span class=\"screen-reader-text\">\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff08\u30cb\u30b3\u30e9\u30b9\u30012019\uff09-ALS\u306f\u907a\u4f1d\u7684\u3067\u3059\u304b\uff1f<\/span> Read More \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":5332,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4981],"tags":[],"class_list":["post-9712","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-4981"],"yoast_head":"<!-- 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