{"id":12704,"date":"2021-01-31T13:18:27","date_gmt":"2021-01-31T18:18:27","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetics-of-sjogrens-syndrome-lessard-2013\/"},"modified":"2021-02-20T20:29:54","modified_gmt":"2021-02-21T01:29:54","slug":"genetics-of-sjogrens-syndrome-lessard-2013","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/pt-br\/genetics-of-sjogrens-syndrome-lessard-2013\/","title":{"rendered":"S\u00edndrome de Sj\u00f6gren (Lessard, 2013)"},"content":{"rendered":"\n

T\u00cdTULO DO ESTUDO:<\/strong> Variantes em m\u00faltiplos loci implicados nas respostas imunes inatas e adaptativas est\u00e3o associadas \u00e0 s\u00edndrome de Sj\u00f6gren<\/a><\/p>\n\n

RESUMO:<\/strong> Identifica\u00e7\u00e3o de 7 regi\u00f5es gen\u00f4micas associadas ao risco de s\u00edndrome de Sj\u00f6gren. <\/p>\n\n

VIS\u00c3O GERAL:<\/strong> A s\u00edndrome de Sj\u00f6gren \u00e9 uma doen\u00e7a autoimune caracterizada por olhos e boca secos. Ocorre quando o sistema imunol\u00f3gico do corpo ataca por engano as gl\u00e2ndulas, como aquelas que produzem saliva e l\u00e1grimas. Como resultado, essas gl\u00e2ndulas ficam inflamadas e danificadas. At\u00e9 3 milh\u00f5es de pessoas s\u00f3 nos Estados Unidos podem ser afetadas pela s\u00edndrome de Sj\u00f6gren. Embora a condi\u00e7\u00e3o possa afetar indiv\u00edduos de qualquer idade, \u00e9 mais comumente diagnosticada em mulheres mais velhas. Para entender melhor a gen\u00e9tica que pode predispor uma pessoa \u00e0 doen\u00e7a, este estudo de associa\u00e7\u00e3o do genoma examinou cerca de 8.400 indiv\u00edduos de ascend\u00eancia europeia. O estudo encontrou 7 regi\u00f5es do genoma associadas \u00e0 suscetibilidade ao desenvolvimento da s\u00edndrome de Sj\u00f6gren. Os genes localizados nessas regi\u00f5es desempenham um papel no funcionamento do sistema imunol\u00f3gico, incluindo a produ\u00e7\u00e3o de prote\u00ednas interferon promotoras de inflama\u00e7\u00e3o. Juntas, as variantes identificadas podem explicar uma grande propor\u00e7\u00e3o do risco heredit\u00e1rio para a doen\u00e7a. <\/p>\n\n

VOC\u00ca SABIA?<\/strong> Como resultado da boca seca causada pela s\u00edndrome de Sj\u00f6gren, os indiv\u00edduos afetados t\u00eam um risco aumentado de desenvolver c\u00e1ries e perda de dentes. O atendimento odontol\u00f3gico regular \u00e9 altamente recomendado para pessoas que vivem com a doen\u00e7a. Beber \u00e1gua, goma de mascar e outros m\u00e9todos para estimular a produ\u00e7\u00e3o de saliva tamb\u00e9m podem ajudar. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE AMOSTRA:<\/strong> Saiba mais sobre o Nebula Research Library<\/a> . <\/p>\n\n

\"Resultados<\/a><\/figure>\n\n

VARIANTES ASSOCIADAS \u00c0 S\u00cdNDROME DE SJ\u00d6GREN:<\/strong> rs9271588, rs3757387, rs10553577, rs485497, rs2736345, rs7119038, rs6579837<\/p>\n\n

RECURSOS ADICIONAIS:<\/strong>S\u00edndrome de Sj\u00f6gren (V\u00eddeo)<\/a> <\/p>\n\n

ATUALIZA\u00c7\u00c3O SEMANAL:<\/strong> 5 de maio de 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DO ESTUDO: Variantes em m\u00faltiplos loci implicados nas respostas imunes inatas e adaptativas est\u00e3o associadas \u00e0 s\u00edndrome de Sj\u00f6gren RESUMO: Identifica\u00e7\u00e3o de 7 regi\u00f5es gen\u00f4micas associadas ao risco de s\u00edndrome de Sj\u00f6gren. VIS\u00c3O GERAL: A s\u00edndrome de Sj\u00f6gren \u00e9 …<\/p>\n

S\u00edndrome de Sj\u00f6gren (Lessard, 2013)<\/span> Leia mais \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":12705,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4999],"tags":[],"class_list":["post-12704","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports-pt-br"],"yoast_head":"\nA gen\u00e9tica da s\u00edndrome de Sj\u00f6gren (Lessard, 2013)<\/title>\n<meta name=\"description\" content=\"Carregue seus dados de DNA, explore as variantes gen\u00e9ticas ligadas \u00e0 s\u00edndrome de Sj\u00f6gren (Lessard, 2013) e descubra sua pontua\u00e7\u00e3o polig\u00eanica.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nebula.org\/blog\/pt-br\/genetics-of-sjogrens-syndrome-lessard-2013\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A gen\u00e9tica da s\u00edndrome de Sj\u00f6gren (Lessard, 2013)\" \/>\n<meta property=\"og:description\" content=\"Carregue seus dados de DNA, explore as variantes gen\u00e9ticas ligadas \u00e0 s\u00edndrome de Sj\u00f6gren (Lessard, 2013) e descubra sua pontua\u00e7\u00e3o polig\u00eanica.\" \/>\n<meta property=\"og:url\" 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