{"id":12709,"date":"2021-01-31T13:18:33","date_gmt":"2021-01-31T18:18:33","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-pulmao-adenocarcinoma-mckay-2017\/"},"modified":"2021-02-20T20:19:03","modified_gmt":"2021-02-21T01:19:03","slug":"genetica-pulmao-adenocarcinoma-mckay-2017","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/pt-br\/genetica-pulmao-adenocarcinoma-mckay-2017\/","title":{"rendered":"Adenocarcinoma pulmonar (McKay, 2017)"},"content":{"rendered":"\n

T\u00cdTULO DO ESTUDO:<\/strong> A an\u00e1lise de associa\u00e7\u00e3o em grande escala identifica novos loci de suscetibilidade ao c\u00e2ncer de pulm\u00e3o e heterogeneidade na suscetibilidade gen\u00e9tica entre subtipos histol\u00f3gicos<\/a><\/p>\n\n

RESUMO:<\/strong> Identifica\u00e7\u00e3o de 6 novas regi\u00f5es gen\u00f4micas associadas ao adenocarcinoma de pulm\u00e3o. <\/p>\n\n

VIS\u00c3O GERAL:<\/strong> O c\u00e2ncer de pulm\u00e3o \u00e9 uma condi\u00e7\u00e3o na qual as c\u00e9lulas dos pulm\u00f5es se dividem de maneira incontrol\u00e1vel. O adenocarcinoma de pulm\u00e3o \u00e9 um subtipo respons\u00e1vel por cerca de 40% de todos os c\u00e2nceres de pulm\u00e3o. \u00c9 causada por muta\u00e7\u00f5es nas c\u00e9lulas glandulares dos pulm\u00f5es, produtoras de muco. Em m\u00e9dia, o adenocarcinoma de pulm\u00e3o tende a crescer mais lentamente do que outros subtipos de c\u00e2ncer de pulm\u00e3o. Para entender melhor a base gen\u00e9tica desse c\u00e2ncer, este estudo examinou os genomas de ~ 67.000 indiv\u00edduos. Os pesquisadores identificaram 6 novas regi\u00f5es associadas ao adenocarcinoma de pulm\u00e3o. Metade dessas regi\u00f5es est\u00e1 localizada perto de genes relacionados ao comprimento dos tel\u00f4meros, que diminui com a idade. No geral, as variantes gen\u00e9ticas identificadas ajudam a explicar 6,7% da herdabilidade deste c\u00e2ncer. <\/p>\n\n

VOC\u00ca SABIA?<\/strong> O tipo mais comum de c\u00e2ncer de pulm\u00e3o em mulheres \u00e9 o adenocarcinoma. Al\u00e9m disso, o adenocarcinoma est\u00e1 menos associado ao tabagismo. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE AMOSTRA:<\/strong> Saiba mais sobre o Nebula Research Library<\/a> . <\/p>\n\n

\"resultados<\/a><\/figure>\n\n

VARIANTES ASSOCIADAS AO ADENOCARCINOMA DO PULM\u00c3O:<\/strong> rs7705526, rs77468143, rs13080835, rs115917190, rs4236709, rs1056562, rs885518, rs41309931<\/p>\n\n

RECURSOS ADICIONAIS:<\/strong>C\u00e2ncer de pulm\u00e3o (v\u00eddeo)<\/a>Tipos de c\u00e2ncer de pulm\u00e3o<\/a>Vivendo com c\u00e2ncer de pulm\u00e3o<\/a><\/p>\n\n

ATUALIZA\u00c7\u00c3O SEMANAL:<\/strong> 12 de maio de 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DO ESTUDO: A an\u00e1lise de associa\u00e7\u00e3o em grande escala identifica novos loci de suscetibilidade ao c\u00e2ncer de pulm\u00e3o e heterogeneidade na suscetibilidade gen\u00e9tica entre subtipos histol\u00f3gicos RESUMO: Identifica\u00e7\u00e3o de 6 novas regi\u00f5es gen\u00f4micas associadas ao adenocarcinoma de pulm\u00e3o. VIS\u00c3O …<\/p>\n

Adenocarcinoma pulmonar (McKay, 2017)<\/span> Leia mais \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":12711,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4999],"tags":[],"class_list":["post-12709","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports-pt-br"],"yoast_head":"\nA 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