{"id":12745,"date":"2021-01-31T13:18:46","date_gmt":"2021-01-31T18:18:46","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-melanoma-landi-2020\/"},"modified":"2021-02-20T20:20:15","modified_gmt":"2021-02-21T01:20:15","slug":"genetica-melanoma-landi-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/pt-br\/genetica-melanoma-landi-2020\/","title":{"rendered":"Melanoma (Landi, 2020)"},"content":{"rendered":"\n

T\u00cdTULO DO ESTUDO:<\/strong> Meta-an\u00e1lises de associa\u00e7\u00e3o de todo o genoma combinando m\u00faltiplos fen\u00f3tipos de risco fornecem insights sobre a arquitetura gen\u00e9tica da suscetibilidade ao melanoma cut\u00e2neo<\/a><\/p>\n\n

RESUMO:<\/strong> Identifica\u00e7\u00e3o de 54 regi\u00f5es gen\u00f4micas associadas ao risco de melanoma. <\/p>\n\n

VIS\u00c3O GERAL:<\/strong> O melanoma \u00e9 o tipo mais grave de c\u00e2ncer de pele. Este estudo comparou ~ 36.000 pacientes com melanoma com ~ 375.000 indiv\u00edduos saud\u00e1veis de ascend\u00eancia europeia e identificou 68 variantes gen\u00e9ticas em 54 regi\u00f5es gen\u00f4micas diferentes. O estudo tamb\u00e9m encontrou associa\u00e7\u00f5es entre o risco de c\u00e2ncer e a cor da pele mais clara, bem como um maior n\u00famero de manchas no corpo. Uma das regi\u00f5es associadas ao melanoma e \u00e0s toupeiras est\u00e1 perto do gene PARP1, um gene de reparo de DNA que ajuda a controlar o gene causador do melanoma MITF. Outra variante foi associada \u00e0 regi\u00e3o HLA, o que sugere um papel da imunidade no desenvolvimento do c\u00e2ncer de pele. Outros genes estavam envolvidos na manuten\u00e7\u00e3o do tel\u00f4mero. As regi\u00f5es gen\u00f4micas descobertas neste estudo explicam coletivamente ~ 8,5% da herdabilidade de risco desta condi\u00e7\u00e3o. <\/p>\n\n

VOC\u00ca SABIA?<\/strong> Existem muitos sinais de alerta para determinar se uma mancha \u00e9 apenas uma toupeira ou realmente \u00e9 um melanoma. A verifica\u00e7\u00e3o mais f\u00e1cil \u00e9 chamada de teste \u201cPatinho Feio\u201d – se uma toupeira parecer diferente das outras verrugas em seu corpo, como o patinho feio parecia diferente de seus irm\u00e3os, vale a pena dar uma olhada! Os melanomas geralmente s\u00e3o assim\u00e9tricos, t\u00eam bordas incomuns, t\u00eam cores diferentes, s\u00e3o grandes em di\u00e2metro ou mudam com o tempo. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE AMOSTRA:<\/strong> Saiba mais sobre o Nebula Research Library<\/a> . <\/p>\n\n

\"resultados<\/a><\/figure>\n\n

VARIANTES ASSOCIADAS AO ESTUDO:<\/strong> rs1805007, rs6059655, rs1126809, rs408825, rs16891982, rs7902587, rs871024, rs132941, rs1801516, rs117132860, rs4354713, rs1339759, rs6914598, rs10739220, rs2695237, rs13178866, rs32578, rs4731207, rs76798800, rs1800440, rs8444, rs4420522, rs149617956, rs143190905, rs72834823, rs10960710, rs12913832, rs1278768, rs117648907, rs3950296, rs10859996, rs78378222, rs12984831, rs113469387, rs4237963, rs7941496, rs5766565, rs2967383, rs1056927, rs6908626, rs6994183, rs12473635, rs12215602, rs79966207, rs7778378, rs670318, rs2369633, rs28986343, rs12539524, rs3780269, rs10931936, rs12290699, rs13263376, rs12523094<\/p>\n\n

RECURSOS ADICIONAIS:<\/strong>ABCDE’s para detec\u00e7\u00e3o de melanoma (v\u00eddeo)<\/a>De onde vem o melanoma, como detect\u00e1-lo e como evit\u00e1-lo (V\u00eddeo)<\/a><\/p>\n\n

ATUALIZA\u00c7\u00c3O SEMANAL:<\/strong> 12 de maio de 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DO ESTUDO: Meta-an\u00e1lises de associa\u00e7\u00e3o de todo o genoma combinando m\u00faltiplos fen\u00f3tipos de risco fornecem insights sobre a arquitetura gen\u00e9tica da suscetibilidade ao melanoma cut\u00e2neo RESUMO: Identifica\u00e7\u00e3o de 54 regi\u00f5es gen\u00f4micas associadas ao risco de melanoma. VIS\u00c3O GERAL: O …<\/p>\n

Melanoma (Landi, 2020)<\/span> Leia mais \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":12753,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4999],"tags":[],"class_list":["post-12745","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports-pt-br"],"yoast_head":"\nA 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