{"id":12772,"date":"2021-01-31T13:19:08","date_gmt":"2021-01-31T18:19:08","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetics-her2-like-breast-cancer-zhang-2020\/"},"modified":"2021-02-20T20:25:48","modified_gmt":"2021-02-21T01:25:48","slug":"genetics-her2-like-breast-cancer-zhang-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/pt-br\/genetics-her2-like-breast-cancer-zhang-2020\/","title":{"rendered":"C\u00e2ncer de mama semelhante a HER2-enriquecido (Zhang, 2020)"},"content":{"rendered":"\n

T\u00cdTULO DO ESTUDO:<\/strong> Estudo de associa\u00e7\u00e3o de todo o genoma identifica 32 novos loci de suscetibilidade ao c\u00e2ncer de mama a partir de an\u00e1lises gerais e espec\u00edficas de subtipo<\/a><\/p>\n\n

RESUMO:<\/strong> Descoberta de novas variantes gen\u00e9ticas associadas ao c\u00e2ncer de mama semelhante ao enriquecido com HER2.<\/p>\n\n

VIS\u00c3O GERAL:<\/strong> Os seios s\u00e3o estruturas complexas com v\u00e1rios tipos de c\u00e9lulas que podem dar origem a v\u00e1rios tipos de c\u00e2ncer. Os c\u00e2nceres de mama s\u00e3o classificados por quais receptores<\/em> c\u00e9lulas cancerosas t\u00eam do lado de fora. Esta classifica\u00e7\u00e3o \u00e9 \u00fatil para prever resultados e tratamentos eficazes. Os c\u00e2nceres de mama que usam o receptor do fator de crescimento epid\u00e9rmico humano 2 (HER2 +) representam 15-30% de todos os c\u00e2nceres de mama. Os c\u00e2nceres de mama HER2 + s\u00e3o historicamente associados a um progn\u00f3stico ruim e a um aumento da recorr\u00eancia, mas agora existem novos medicamentos que visam especificamente o receptor HER2 e melhoram a sobrevida. C\u00e2nceres do tipo enriquecido com HER2 t\u00eam o receptor HER2, mas n\u00e3o t\u00eam outro horm\u00f4nio receptores<\/em> gostar receptores<\/em> para estrog\u00eanio ou progesterona. Este estudo de associa\u00e7\u00e3o de todo o genoma examinou cerca de 266.000 indiv\u00edduos de ascend\u00eancia europeia para identificar variantes gen\u00e9ticas associadas a diferentes tipos de c\u00e2ncer de mama, incluindo c\u00e2nceres semelhantes a HER2. No total, os pesquisadores identificaram 330 regi\u00f5es gen\u00f4micas associadas a tipos de c\u00e2ncer de mama e as usaram para calcular pontua\u00e7\u00f5es polig\u00eanicas.<\/p>\n\n

VOC\u00ca SABIA?<\/strong> As terapias modernas s\u00e3o capazes de atingir especificamente as c\u00e9lulas que expressam HER2. Isso aumentou drasticamente a taxa de sobreviv\u00eancia de pacientes com c\u00e2ncer de mama HER2 +. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE AMOSTRA:<\/strong> Saiba mais sobre o Nebula Research Library<\/a> . <\/p>\n\n

\"resultados<\/a><\/figure>\n\n

VARIANTES ASSOCIADAS AO C\u00c2NCER DE MAMA ENRIQUECIDO HER2:<\/strong> rs9712235, rs4602255, rs188092014, rs13256025, rs13277568, rs11652463, rs495367, rs7924772, rs78378222, rs206435, rs17215231, rs612683, rs616488, rs7513707, rs12406858, rs637868, rs11249433, rs111458676, rs11205303, rs12091730, rs2992756, rs35383942, rs6686987, rs7514172, rs2785646, rs2576261, rs11118563, rs72755295, rs4233486, rs114282204, rs707475, rs2151842, rs78425380, rs6746250, rs17625845, rs10164550, rs10179592, rs17726078, rs1550622, rs2356656, rs6743383, rs10197246, rs4442975, rs11693806, rs3791977, rs4676356, rs6725517, rs12472404, rs4322799, rs1036759, rs9882792, rs552647, rs112476261, rs17838698, rs56387622, rs6762558, rs2886671, rs9825432, rs13066793, rs639355, rs62331150, rs56039025, rs13147907, rs10012017, rs17014016, rs17157372, rs335160, rs1428387, rs10069690, rs6860806, rs62329727, rs1432679, rs17611291, rs10074269, rs6864691, rs4868701, rs116095464, rs187108781, rs4613718, rs10941679, rs17343002, rs889310, rs16886165, rs76250845, rs11949391, rs113778879, rs3010266, r s157557, rs418053, rs2121348, rs6913578, rs60954078, rs851984, rs6904031, rs910416, rs3819405, rs9364472, rs6940159, rs12211970, rs9358466, rs34196306, rs111342015, rs73754909, rs71559437, rs7800548, rs12706954, rs68056147, rs62485509, rs7971, rs289997, rs74765302, rs13244925, rs17268829, rs4439053, rs111963714, rs62517052, rs12546444, rs13267382, rs62526620, rs35542655, rs12541094, rs7842619, rs12550713, rs10096351, rs1016578, rs7830152, rs66823261, rs1028016, rs310295, rs9693444, rs13365225, rs1511243, rs72658084, rs1533366, rs10816625, rs13294895, rs7848334, rs630965, rs1895062, rs3861871, rs17694493, rs4880038, rs10975870, rs10120432, rs10885405, rs12250948, rs45631580, rs45631563, rs10796139, rs7072776, rs10764337, rs2384736, rs10995201, rs6479868, rs111833376, rs719338, rs4980029, rs7125780, rs610437, rs625145, rs7121616, rs7939702, rs11822830, rs10832963, rs4980386, rs4472923, rs7394715, rs10838267, rs77047825, rs12287832, rs10896047, rs35039974, rs661204, rs78540526, rs6597981 rs2454399, rs12422552, rs788458, rs7297051, rs2277339, rs17356907, rs56404467, rs11571833, rs9315973, rs12870942, rs2181965, rs4983544, rs34914085, rs2253012, rs2588809, rs11624333, rs941764, rs78440108, rs144767203, rs187010898, rs4774565, rs8042593, rs35874463, rs8035987, rs2290202, rs34872983, rs75753503, rs11076805, rs35668161, rs4784227, rs55872725, rs6499648, rs7184573, rs28539243, rs12709163, rs7500067, rs9931038, rs12449271, rs79461387, rs150537328, rs11296, rs17881320, rs149370081, rs2787486, rs745570, rs16976596, rs11665269, rs1111207, rs527616, rs8092192, rs72931898, rs9954058, rs9952980, rs117922601, rs56069439, rs10164323, rs56681946, rs4399645, rs1172821, rs1154723, rs6030585, rs13039563, rs16991615, rs2822999, rs2823130, rs2403907, rs4818836, rs9798754, rs17879961, rs5997390, rs34134147, rs132289, rs5750715, rs9611990, rs112855987, rs28512361<\/p>\n\n

RECURSOS ADICIONAIS:<\/strong>C\u00e2ncer de mama HER2 positivo: tudo o que voc\u00ea deve saber (V\u00eddeo)<\/a>Status HER2<\/a><\/p>\n\n

VOC\u00ca TAMB\u00c9M PODE ESTAR INTERESSADO EM:<\/strong> C\u00e2ncer de mama tipo A Luminal (Zhang, 2020)<\/a>C\u00e2ncer de mama tipo B \/ HER2 negativo luminal (Zhang, 2020)<\/a>C\u00e2ncer de mama tipo B luminal (Zhang, 2020)<\/a>C\u00e2ncer de mama triplo-negativo (Zhang, 2020)<\/a>C\u00e2ncer de mama (Shu, 2020)<\/a><\/p>\n\n

ATUALIZA\u00c7\u00c3O SEMANAL:<\/strong> 2 de junho de 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DO ESTUDO: Estudo de associa\u00e7\u00e3o de todo o genoma identifica 32 novos loci de suscetibilidade ao c\u00e2ncer de mama a partir de an\u00e1lises gerais e espec\u00edficas de subtipo RESUMO: Descoberta de novas variantes gen\u00e9ticas associadas ao c\u00e2ncer de mama …<\/p>\n

C\u00e2ncer de mama semelhante a HER2-enriquecido (Zhang, 2020)<\/span> Leia mais \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":12773,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4999],"tags":[],"class_list":["post-12772","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports-pt-br"],"yoast_head":"\nA gen\u00e9tica do c\u00e2ncer de mama semelhante ao enriquecido com HER2 (Zhang, 2020)<\/title>\n<meta name=\"description\" content=\"Fa\u00e7a upload de seus dados de DNA, explore as variantes gen\u00e9ticas vinculadas ao c\u00e2ncer de mama semelhante ao enriquecido com HER2 (Zhang, 2020) e descubra sua pontua\u00e7\u00e3o polig\u00eanica.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nebula.org\/blog\/pt-br\/genetics-her2-like-breast-cancer-zhang-2020\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A gen\u00e9tica do c\u00e2ncer de mama semelhante ao enriquecido com HER2 (Zhang, 2020)\" \/>\n<meta property=\"og:description\" content=\"Fa\u00e7a upload de seus dados de DNA, explore as variantes gen\u00e9ticas vinculadas ao c\u00e2ncer de mama semelhante ao enriquecido 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He earned an M.S. and is currently a Ph.D. Candidate in the Biological and Biomedical Sciences (BBS) Ph.D. program at Harvard University.\u00a0He has experience in science policy as an intern at the Science and Innovation Network where he assisted in the science diplomacy functions of the British Consulate-General and as a research associate at TScan Therapeutics. He is also interested in science communication and writing. You can read more about Garrett's experience and publications on LinkedIn and ORCID.","sameAs":["https:\/\/nebula.org\/whole-genome-sequencing\/"],"url":"https:\/\/nebula.org\/blog\/pt-br\/author\/garrett-dunlap\/"}]}},"_links":{"self":[{"href":"https:\/\/nebula.org\/blog\/pt-br\/wp-json\/wp\/v2\/posts\/12772","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nebula.org\/blog\/pt-br\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nebula.org\/blog\/pt-br\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/pt-br\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/pt-br\/wp-json\/wp\/v2\/comments?post=12772"}],"version-history":[{"count":0,"href":"https:\/\/nebula.org\/blog\/pt-br\/wp-json\/wp\/v2\/posts\/12772\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nebula.org\/blog\/pt-br\/wp-json\/wp\/v2\/media\/12773"}],"wp:attachment":[{"href":"https:\/\/nebula.org\/blog\/pt-br\/wp-json\/wp\/v2\/media?parent=12772"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nebula.org\/blog\/pt-br\/wp-json\/wp\/v2\/categories?post=12772"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nebula.org\/blog\/pt-br\/wp-json\/wp\/v2\/tags?post=12772"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}