{"id":12784,"date":"2021-01-31T13:19:17","date_gmt":"2021-01-31T18:19:17","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-de-lvesv-pirruccello-2020\/"},"modified":"2021-02-20T20:21:52","modified_gmt":"2021-02-21T01:21:52","slug":"genetica-de-lvesv-pirruccello-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/pt-br\/genetica-de-lvesv-pirruccello-2020\/","title":{"rendered":"Volume sist\u00f3lico final do ventr\u00edculo esquerdo (Pirruccello, 2020)"},"content":{"rendered":"\n

T\u00cdTULO DO ESTUDO:<\/strong> An\u00e1lise de imagens de resson\u00e2ncia magn\u00e9tica card\u00edaca em 36.000 indiv\u00edduos produz insights gen\u00e9ticos sobre cardiomiopatia dilatada<\/a><\/p>\n\n

RESUMO:<\/strong> Identifica\u00e7\u00e3o de 28 variantes gen\u00e9ticas associadas ao volume sist\u00f3lico final do ventr\u00edculo esquerdo (LVESV).<\/p>\n\n

VIS\u00c3O GERAL:<\/strong> O cora\u00e7\u00e3o humano \u00e9 um m\u00fasculo que bombeia sangue por todo o corpo. \u00c9 composto por 4 c\u00e2maras: 2 \u00e1trios (esquerdo e direito) e 2 ventr\u00edculos (esquerdo e direito). O sangue que foi enriquecido com oxig\u00eanio nos pulm\u00f5es entra no \u00e1trio esquerdo e flui para o ventr\u00edculo esquerdo, de onde \u00e9 bombeado para todas as outras partes do corpo. O volume sist\u00f3lico final do ventr\u00edculo esquerdo (LVESV) \u00e9 o volume de sangue que permanece no ventr\u00edculo esquerdo no final de uma bomba. O LVESV m\u00e9dio \u00e9 de 41mL para mulheres e 58mL para homens e pode ser usado como uma medida da sa\u00fade card\u00edaca. Este estudo de associa\u00e7\u00e3o do genoma examinou os genomas de 36.000 indiv\u00edduos de ascend\u00eancia europeia para compreender melhor a base gen\u00e9tica do LVESV. O estudo identificou 28 regi\u00f5es gen\u00f4micas associadas a LVESV ajustadas para \u00e1rea de superf\u00edcie corporal. O estudo tamb\u00e9m descobriu que uma alta pontua\u00e7\u00e3o polig\u00eanica para a LVESV ajustada \u00e0 superf\u00edcie corporal estava fortemente correlacionada com o risco de cardiomiopatia dilatada. Essa condi\u00e7\u00e3o descreve um m\u00fasculo card\u00edaco que est\u00e1 muito alongado e fino e n\u00e3o consegue bombear com efici\u00eancia.<\/p>\n\n

VOC\u00ca SABIA?<\/strong> A express\u00e3o \u201crir \u00e9 o melhor rem\u00e9dio\u201d tem alguma verdade. O riso pode ser ben\u00e9fico para a sa\u00fade do cora\u00e7\u00e3o, permitindo que as art\u00e9rias relaxem e se tornem mais flex\u00edveis, facilitando o fluxo sangu\u00edneo. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE AMOSTRA:<\/strong> Saiba mais sobre o Nebula Research Library<\/a> . <\/p>\n\n

\"resultados<\/a><\/figure>\n\n

VARIANTES ASSOCIADOS A LVESV:<\/strong> rs72840788, rs945425, rs2562845, rs73028849, rs5760061, rs3176326, rs10421891, rs12452367, rs34373805, rs8063213, rs79502300, rs1962104, rs11023059, rs189569984, rs9892651, rs1499813, rs2302455, rs11748963, rs10871753, rs116904997, rs190093681, rs709208, rs2886037, rs242562<\/p>\n\n

RECURSOS ADICIONAIS:<\/strong>O cora\u00e7\u00e3o (V\u00eddeo)<\/a>Como funciona o cora\u00e7\u00e3o<\/a><\/p>\n\n

VOC\u00ca TAMB\u00c9M PODE ESTAR INTERESSADO EM:<\/strong> Fra\u00e7\u00e3o de eje\u00e7\u00e3o do ventr\u00edculo esquerdo (Pirruccello, 2020)<\/a> Volume diast\u00f3lico final do ventr\u00edculo esquerdo (Pirruccello, 2020)<\/a>Volume de curso (Pirruccello, 2020)<\/a>Insufici\u00eancia card\u00edaca (Shah, 2020)<\/a><\/p>\n\n

ATUALIZA\u00c7\u00c3O SEMANAL:<\/strong> 19 de maio de 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DO ESTUDO: An\u00e1lise de imagens de resson\u00e2ncia magn\u00e9tica card\u00edaca em 36.000 indiv\u00edduos produz insights gen\u00e9ticos sobre cardiomiopatia dilatada RESUMO: Identifica\u00e7\u00e3o de 28 variantes gen\u00e9ticas associadas ao volume sist\u00f3lico final do ventr\u00edculo esquerdo (LVESV). VIS\u00c3O GERAL: O cora\u00e7\u00e3o humano \u00e9 …<\/p>\n

Volume sist\u00f3lico final do ventr\u00edculo esquerdo (Pirruccello, 2020)<\/span> Leia mais \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":12788,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4999],"tags":[],"class_list":["post-12784","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports-pt-br"],"yoast_head":"\nA 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