{"id":12792,"date":"2021-01-31T13:19:20","date_gmt":"2021-01-31T18:19:20","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-do-volume-sistolico-pirruccello-2020\/"},"modified":"2021-02-20T20:32:04","modified_gmt":"2021-02-21T01:32:04","slug":"genetica-do-volume-sistolico-pirruccello-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/pt-br\/genetica-do-volume-sistolico-pirruccello-2020\/","title":{"rendered":"Volume de curso (Pirruccello, 2020)"},"content":{"rendered":"\n

T\u00cdTULO DO ESTUDO:<\/strong> An\u00e1lise de imagens de resson\u00e2ncia magn\u00e9tica card\u00edaca em 36.000 indiv\u00edduos produz insights gen\u00e9ticos sobre cardiomiopatia dilatada<\/a><\/p>\n\n

RESUMO:<\/strong> Identifica\u00e7\u00e3o de 12 variantes gen\u00e9ticas associadas ao volume sist\u00f3lico do cora\u00e7\u00e3o.<\/p>\n\n

VIS\u00c3O GERAL:<\/strong> O cora\u00e7\u00e3o humano \u00e9 um m\u00fasculo que bombeia sangue por todo o corpo. \u00c9 composto por 4 c\u00e2maras: 2 \u00e1trios (esquerdo e direito) e 2 ventr\u00edculos (esquerdo e direito). O sangue que foi enriquecido com oxig\u00eanio nos pulm\u00f5es entra no \u00e1trio esquerdo e flui para o ventr\u00edculo esquerdo, de onde \u00e9 bombeado para todas as outras partes do corpo. O volume sist\u00f3lico (VS) \u00e9 uma medida de quanto sangue \u00e9 bombeado para fora do ventr\u00edculo esquerdo durante cada batimento. O SV m\u00e9dio \u00e9 81mL para mulheres e 95mL para homens. As medi\u00e7\u00f5es do volume sist\u00f3lico podem indicar se o cora\u00e7\u00e3o est\u00e1 bombeando sangue suficiente para atender \u00e0s demandas do corpo. Este estudo de associa\u00e7\u00e3o do genoma de mais de 36.000 indiv\u00edduos de ascend\u00eancia europeia identificou 12 variantes gen\u00e9ticas correlacionadas com SV, incluindo variantes pr\u00f3ximas aos genes que desempenham um papel na contra\u00e7\u00e3o do m\u00fasculo card\u00edaco (MYH6) e forma\u00e7\u00e3o de vasos sangu\u00edneos (VEGFA). Juntas, essas variantes explicam ~ 34% da herdabilidade do volume sist\u00f3lico. O estudo tamb\u00e9m encontrou uma forte rela\u00e7\u00e3o inversa entre o escore polig\u00eanico para VS maior e hipotireoidismo.<\/p>\n\n

VOC\u00ca SABIA?<\/strong> Durante o exerc\u00edcio, o corpo precisa de um suprimento maior de sangue para levar oxig\u00eanio aos m\u00fasculos. Com o tempo, o exerc\u00edcio pode levar a um aumento na efici\u00eancia do cora\u00e7\u00e3o, bombeando mais sangue com menos trabalho. Atividades aer\u00f3bicas, como corrida e ciclismo, s\u00e3o particularmente eficazes para aumentar o volume sist\u00f3lico. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE AMOSTRA:<\/strong> Saiba mais sobre o Nebula Research Library<\/a> . <\/p>\n\n

\"resultados<\/a><\/figure>\n\n

VARIANTES ASSOCIADOS AO SV:<\/strong> rs72967533, rs11065979, rs7573293, rs11066188, rs10400419, rs888690, rs422068, rs111721712, rs2891403, rs2146324, rs28391274, rs143384<\/p>\n\n

RECURSOS ADICIONAIS:<\/strong>O cora\u00e7\u00e3o (V\u00eddeo)<\/a><\/a>Volume do curso e frequ\u00eancia card\u00edaca (v\u00eddeo)<\/a><\/p>\n\n

VOC\u00ca TAMB\u00c9M PODE ESTAR INTERESSADO EM:<\/strong> Fra\u00e7\u00e3o de eje\u00e7\u00e3o do ventr\u00edculo esquerdo (Pirruccello, 2020)<\/a> Volume diast\u00f3lico final do ventr\u00edculo esquerdo (Pirruccello, 2020)<\/a>Volume sist\u00f3lico final do ventr\u00edculo esquerdo (Pirruccello, 2020)<\/a>Insufici\u00eancia card\u00edaca (Shah, 2020)<\/a><\/p>\n\n

ATUALIZA\u00c7\u00c3O SEMANAL:<\/strong> 19 de maio de 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DO ESTUDO: An\u00e1lise de imagens de resson\u00e2ncia magn\u00e9tica card\u00edaca em 36.000 indiv\u00edduos produz insights gen\u00e9ticos sobre cardiomiopatia dilatada RESUMO: Identifica\u00e7\u00e3o de 12 variantes gen\u00e9ticas associadas ao volume sist\u00f3lico do cora\u00e7\u00e3o. VIS\u00c3O GERAL: O cora\u00e7\u00e3o humano \u00e9 um m\u00fasculo que …<\/p>\n

Volume de curso (Pirruccello, 2020)<\/span> Leia mais \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":12796,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4999],"tags":[],"class_list":["post-12792","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports-pt-br"],"yoast_head":"\nA gen\u00e9tica do volume sist\u00f3lico do cora\u00e7\u00e3o (Pirruccello, 2020)<\/title>\n<meta name=\"description\" content=\"Carregue seus dados de DNA, explore as variantes gen\u00e9ticas vinculadas ao volume sist\u00f3lico (Pirruccello, 2020) e descubra sua pontua\u00e7\u00e3o polig\u00eanica.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nebula.org\/blog\/pt-br\/genetica-do-volume-sistolico-pirruccello-2020\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A gen\u00e9tica do volume sist\u00f3lico do cora\u00e7\u00e3o (Pirruccello, 2020)\" \/>\n<meta property=\"og:description\" content=\"Carregue seus dados de DNA, explore as variantes gen\u00e9ticas vinculadas ao volume sist\u00f3lico (Pirruccello, 2020) e descubra sua pontua\u00e7\u00e3o polig\u00eanica.\" 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