{"id":12811,"date":"2021-01-31T13:19:29","date_gmt":"2021-01-31T18:19:29","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-magreza-ortofer-2020\/"},"modified":"2021-02-20T20:19:02","modified_gmt":"2021-02-21T01:19:02","slug":"genetica-magreza-ortofer-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/pt-br\/genetica-magreza-ortofer-2020\/","title":{"rendered":"Magreza (Orthofer, 2020)"},"content":{"rendered":"\n

T\u00cdTULO DO ESTUDO:<\/strong> Identifica\u00e7\u00e3o de ALK em Magreza<\/a><\/p>\n\n

RESUMO:<\/strong> Descoberta de 5 variantes gen\u00e9ticas associadas \u00e0 magreza.<\/p>\n\n

VIS\u00c3O GERAL:<\/strong> Embora a dieta e os exerc\u00edcios sejam importantes para manter o peso corporal saud\u00e1vel, os indiv\u00edduos que comem alimentos semelhantes e praticam exerc\u00edcios em quantidades semelhantes podem ter peso diferente. A maioria dos estudos que buscam variantes gen\u00e9ticas associadas ao \u00edndice de massa corporal (IMC) compara indiv\u00edduos obesos a controles saud\u00e1veis. Em vez disso, este estudo procurou associa\u00e7\u00f5es com magreza. Os pesquisadores compararam 1,9% das pessoas mais magras (6\u00ba percentil de IMC; 881 indiv\u00edduos) no biobanco da Est\u00f4nia com pessoas que tinham um peso corporal m\u00e9dio (30\u00ba – 50\u00ba percentil de IMC; 3.173 indiv\u00edduos) e encontraram 5 variantes associadas \u00e0 magreza. Uma das variantes (rs568057364) est\u00e1 dentro do gene ALK, que \u00e9 conhecido por desempenhar um papel no c\u00e2ncer. Os pesquisadores interromperam o gene ALK em camundongos e descobriram que ele resultou em resist\u00eancia \u00e0 obesidade induzida por dieta.<\/p>\n\n

VOC\u00ca SABIA?<\/strong> Pessoas com baixo peso geralmente t\u00eam defici\u00eancias nutricionais porque n\u00e3o consomem comida suficiente para receber todas as vitaminas e minerais de que seu corpo precisa. \u00c9 importante obter micronutrientes suficientes, mesmo ao limitar a ingest\u00e3o de calorias. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE AMOSTRA:<\/strong> Saiba mais sobre o Nebula Research Library<\/a> . <\/p>\n\n

\"resultados<\/a><\/figure>\n\n

VARIANTES ASSOCIADAS \u00c0 DELICADURA:<\/strong> rs6574213, rs79938778, rs61685635, rs568057364, rs4521442<\/p>\n\n

RECURSOS ADICIONAIS:<\/strong>Perda de peso e \u00edndice de massa corporal (v\u00eddeo)<\/a>Calculadora IMC<\/a><\/p>\n\n

VOC\u00ca TAMB\u00c9M PODE ESTAR INTERESSADO EM:<\/strong> Peso ao nascer e suscetibilidade a doen\u00e7as (Horikoshi, 2017)<\/a>\u00cdndice de massa corporal (Couto Alves, 2019)<\/a>\u00cdndice de massa corporal (Anderson, 2020)<\/a>Obesidade (Jiao, 2011)<\/a><\/p>\n\n

ATUALIZA\u00c7\u00c3O SEMANAL:<\/strong> 16 de junho de 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DO ESTUDO: Identifica\u00e7\u00e3o de ALK em Magreza RESUMO: Descoberta de 5 variantes gen\u00e9ticas associadas \u00e0 magreza. VIS\u00c3O GERAL: Embora a dieta e os exerc\u00edcios sejam importantes para manter o peso corporal saud\u00e1vel, os indiv\u00edduos que comem alimentos semelhantes e …<\/p>\n

Magreza (Orthofer, 2020)<\/span> Leia mais 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