{"id":12818,"date":"2021-01-31T13:19:34","date_gmt":"2021-01-31T18:19:34","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-of-lvedv-pirruccello-2020\/"},"modified":"2021-02-20T20:25:43","modified_gmt":"2021-02-21T01:25:43","slug":"genetica-of-lvedv-pirruccello-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/pt-br\/genetica-of-lvedv-pirruccello-2020\/","title":{"rendered":"Volume diast\u00f3lico final do ventr\u00edculo esquerdo (Pirruccello, 2020)"},"content":{"rendered":"\n

T\u00cdTULO DO ESTUDO:<\/strong> An\u00e1lise de imagens de resson\u00e2ncia magn\u00e9tica card\u00edaca em 36.000 indiv\u00edduos produz insights gen\u00e9ticos sobre cardiomiopatia dilatada<\/a><\/p>\n\n

RESUMO:<\/strong> Identifica\u00e7\u00e3o de 14 variantes gen\u00e9ticas associadas ao volume diast\u00f3lico final do ventr\u00edculo esquerdo (VDFVE).<\/p>\n\n

VIS\u00c3O GERAL:<\/strong> O cora\u00e7\u00e3o humano \u00e9 um m\u00fasculo que bombeia sangue por todo o corpo. \u00c9 composto por 4 c\u00e2maras: 2 \u00e1trios (esquerdo e direito) e 2 ventr\u00edculos (esquerdo e direito). O sangue que foi enriquecido com oxig\u00eanio nos pulm\u00f5es entra no \u00e1trio esquerdo e flui para o ventr\u00edculo esquerdo, de onde \u00e9 bombeado para todas as outras partes do corpo. O volume diast\u00f3lico final do ventr\u00edculo esquerdo (LVEDV) \u00e9 o volume de sangue em um ventr\u00edculo esquerdo relaxado imediatamente antes de se contrair e bombear o sangue para o corpo. O LVEDV m\u00e9dio \u00e9 de 120mL para mulheres e 150mL para homens e pode ser usado como uma medida da sa\u00fade card\u00edaca. Este estudo de associa\u00e7\u00e3o do genoma examinou os genomas de 36.000 indiv\u00edduos de ascend\u00eancia europeia para entender melhor a base gen\u00e9tica do LVEDV. O estudo identificou 14 regi\u00f5es gen\u00f4micas associadas ao VDFVE ajustado para a \u00e1rea de superf\u00edcie corporal. O estudo tamb\u00e9m encontrou uma forte rela\u00e7\u00e3o inversa entre a pontua\u00e7\u00e3o polig\u00eanica para maior VDFVE e hipotireoidismo. <\/p>\n\n

VOC\u00ca SABIA?<\/strong> Em m\u00e9dia, o cora\u00e7\u00e3o humano bombeia ~ 2.000 gal\u00f5es (7.600 litros) de sangue por todo o corpo todos os dias. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE AMOSTRA:<\/strong> Saiba mais sobre o Nebula Research Library<\/a> . <\/p>\n\n

\"resultados<\/a><\/figure>\n\n

VARIANTES ASSOCIADAS A LVEDV:<\/strong> rs1873164, rs9797817, rs72967533, rs72840788, rs73028849, rs1976402, rs6458349, rs9480737, rs7502466, rs12499670, rs10850034<\/p>\n\n

RECURSOS ADICIONAIS:<\/strong>O cora\u00e7\u00e3o (V\u00eddeo)<\/a>Como funciona o cora\u00e7\u00e3o<\/a>Volume diast\u00f3lico final<\/a><\/p>\n\n

VOC\u00ca TAMB\u00c9M PODE ESTAR INTERESSADO EM:<\/strong> Fra\u00e7\u00e3o de eje\u00e7\u00e3o do ventr\u00edculo esquerdo (Pirruccello, 2020)<\/a>Volume sist\u00f3lico final do ventr\u00edculo esquerdo (Pirruccello, 2020)<\/a>Volume de curso (Pirruccello, 2020)<\/a>Cardiomiopatia (Meder, 2014)<\/a><\/p>\n\n

ATUALIZA\u00c7\u00c3O SEMANAL:<\/strong> 19 de maio de 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DO ESTUDO: An\u00e1lise de imagens de resson\u00e2ncia magn\u00e9tica card\u00edaca em 36.000 indiv\u00edduos produz insights gen\u00e9ticos sobre cardiomiopatia dilatada RESUMO: Identifica\u00e7\u00e3o de 14 variantes gen\u00e9ticas associadas ao volume diast\u00f3lico final do ventr\u00edculo esquerdo (VDFVE). VIS\u00c3O GERAL: O cora\u00e7\u00e3o humano \u00e9 …<\/p>\n

Volume diast\u00f3lico final do ventr\u00edculo esquerdo (Pirruccello, 2020)<\/span> Leia mais \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":12821,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4999],"tags":[],"class_list":["post-12818","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports-pt-br"],"yoast_head":"\nA 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