{"id":12834,"date":"2021-01-31T13:19:43","date_gmt":"2021-01-31T18:19:43","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-de-lesoes-cerebrais-armstrong-2020\/"},"modified":"2021-02-20T20:35:48","modified_gmt":"2021-02-21T01:35:48","slug":"genetica-de-lesoes-cerebrais-armstrong-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/pt-br\/genetica-de-lesoes-cerebrais-armstrong-2020\/","title":{"rendered":"Les\u00f5es cerebrais (Armstrong, 2020)"},"content":{"rendered":"\n

T\u00cdTULO DO ESTUDO:<\/strong> Varia\u00e7\u00e3o gen\u00e9tica comum indica causas distintas para hiperintensidades periventricular e de subst\u00e2ncia branca profunda<\/a><\/p>\n\n

RESUMO:<\/strong> Descoberta de 11 regi\u00f5es gen\u00f4micas associadas a hiperintensidades da subst\u00e2ncia branca periventricular que indicam les\u00f5es cerebrais.<\/p>\n\n

VIS\u00c3O GERAL:<\/strong> O c\u00e9rebro \u00e9 um \u00f3rg\u00e3o delicado que requer fluxo sangu\u00edneo constante. O derrame ocorre quando uma grande parte do c\u00e9rebro n\u00e3o recebe mais sangue devido a um grande co\u00e1gulo ou sangramento – isso leva a danos cerebrais \u00f3bvios. No entanto, co\u00e1gulos ou sangramentos menores podem matar ou danificar as c\u00e9lulas cerebrais, possivelmente causando dem\u00eancia ou problemas de movimento. Eles podem passar despercebidos at\u00e9 que o paciente fa\u00e7a uma varredura cerebral: o dano aparece como uma mancha branca mais brilhante, chamada de hiperintensidade. Este estudo procurou por esses pontos brancos em varreduras cerebrais perto dos sacos de fluido no centro do c\u00e9rebro, chamados ventr\u00edculos. Essas les\u00f5es cerebrais s\u00e3o chamadas de hiperintensidades da subst\u00e2ncia branca periventricular. Observando imagens do c\u00e9rebro de mais de 26.000 pessoas, os autores identificaram 11 regi\u00f5es gen\u00f4micas associadas a hiperintensidades da subst\u00e2ncia branca periventricular. A presen\u00e7a dessas les\u00f5es foi associada a um risco aumentado de acidente vascular cerebral, mas n\u00e3o foi associada a um risco aumentado de dem\u00eancia.<\/p>\n\n

VOC\u00ca SABIA?<\/strong> H\u00e1 algumas evid\u00eancias de que as les\u00f5es de subst\u00e2ncia branca podem ser evitadas por n\u00e3o fumar e prevenir hipertens\u00e3o, diabetes tipo 2 e obesidade. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE AMOSTRA:<\/strong> Saiba mais sobre o Nebula Research Library<\/a> . <\/p>\n\n

\"resultados<\/a><\/figure>\n\n

VARIANTES ASSOCIADOS \u00c0 LES\u00c3O CEREBRAL:<\/strong> rs3744020, rs3758575, rs12928520, rs275350, rs7596872, rs72934583, rs57242328, rs7213273, rs1993484, rs11838776, rs1799983 <\/p>\n\n

RECURSOS ADICIONAIS:<\/strong>O que \u00e9 doen\u00e7a da subst\u00e2ncia branca? (V\u00eddeo)<\/a>Doen\u00e7a da subst\u00e2ncia branca<\/a><\/p>\n\n

VOC\u00ca TAMB\u00c9M PODE ESTAR INTERESSADO EM:<\/strong> Stroke (Malik, 2018)<\/a>Espessura do c\u00f3rtex cerebral (Grasby, 2020)<\/a>Volume total do c\u00e9rebro (Zhao, 2019)<\/a><\/p>\n\n

ATUALIZA\u00c7\u00c3O SEMANAL:<\/strong> 25 de junho de 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DO ESTUDO: Varia\u00e7\u00e3o gen\u00e9tica comum indica causas distintas para hiperintensidades periventricular e de subst\u00e2ncia branca profunda RESUMO: Descoberta de 11 regi\u00f5es gen\u00f4micas associadas a hiperintensidades da subst\u00e2ncia branca periventricular que indicam les\u00f5es cerebrais. VIS\u00c3O GERAL: O c\u00e9rebro \u00e9 um …<\/p>\n

Les\u00f5es cerebrais (Armstrong, 2020)<\/span> Leia mais 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