{"id":12839,"date":"2021-01-31T13:19:45","date_gmt":"2021-01-31T18:19:45","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetics-of-longevity-timmers-2020\/"},"modified":"2021-02-20T20:26:05","modified_gmt":"2021-02-21T01:26:05","slug":"genetics-of-longevity-timmers-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/pt-br\/genetics-of-longevity-timmers-2020\/","title":{"rendered":"Longevidade (Timmers, 2020)"},"content":{"rendered":"\n

T\u00cdTULO DO ESTUDO:<\/strong> Varredura gen\u00f4mica multivariada implica novos loci e metabolismo heme no envelhecimento humano<\/a><\/p>\n\n

RESUMO:<\/strong> Identifica\u00e7\u00e3o de 10 variantes gen\u00e9ticas associadas \u00e0 longevidade.<\/p>\n\n

VIS\u00c3O GERAL:<\/strong> Longevidade \u00e9 uma caracter\u00edstica definida como tendo uma vida \u00fatil mais longa do que a maioria das pessoas. Este estudo definiu especificamente a longevidade como viver mais de 90% das pessoas. Embora fatores como dieta e acesso a cuidados de sa\u00fade influenciem quanto tempo um indiv\u00edduo pode viver, a gen\u00e9tica tamb\u00e9m desempenha um papel importante na longevidade. Este estudo de associa\u00e7\u00e3o do genoma examinou mais de 36.000 indiv\u00edduos de ascend\u00eancia europeia para determinar os fatores gen\u00e9ticos associados \u00e0 longevidade. O estudo encontrou 10 variantes gen\u00e9ticas que est\u00e3o ligadas \u00e0 caracter\u00edstica, mas tamb\u00e9m ao tempo de vida dos pais e \u00e0 expectativa de sa\u00fade. A variante com a associa\u00e7\u00e3o mais forte (rs429358) est\u00e1 no gene APOE e est\u00e1 ligada \u00e0 doen\u00e7a de Alzheimer. Esta variante por si s\u00f3 d\u00e1 uma probabilidade ~ 1,7 maior de viver mais do que 90% das pessoas.<\/p>\n\n

VOC\u00ca SABIA?<\/strong> \u201cZonas azuis\u201d s\u00e3o locais em todo o mundo onde os indiv\u00edduos tendem a viver muito mais tempo do que a m\u00e9dia. Okinawa (Jap\u00e3o) e Ikaria (Gr\u00e9cia) s\u00e3o dois desses locais, onde uma alta porcentagem de habitantes vive at\u00e9 os 90 anos. Dietas ricas em vegetais e fortes conex\u00f5es familiares s\u00e3o caracter\u00edsticas comuns em muitas \u201czonas azuis\u201d. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE AMOSTRA:<\/strong> Saiba mais sobre o Nebula Research Library<\/a> . <\/p>\n\n

\"resultados<\/a><\/figure>\n\n

VARIANTES ASSOCIADAS \u00c0 LONGEVIDADE:<\/strong> rs429358, rs10455872, rs7859727, rs61905747, rs6511720, rs12830425, rs1159806, rs4783780, rs2643826, rs17499404<\/p>\n\n

RECURSOS ADICIONAIS:<\/strong><\/a>A ci\u00eancia do envelhecimento (V\u00eddeo)<\/a>A longevidade \u00e9 determinada pela gen\u00e9tica?<\/a><\/p>\n\n

VOC\u00ca TAMB\u00c9M PODE ESTAR INTERESSADO EM:<\/strong> Longevidade (Deelen, 2019)<\/a><\/p>\n\n

ATUALIZA\u00c7\u00c3O SEMANAL:<\/strong> 28 de julho de 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DO ESTUDO: Varredura gen\u00f4mica multivariada implica novos loci e metabolismo heme no envelhecimento humano RESUMO: Identifica\u00e7\u00e3o de 10 variantes gen\u00e9ticas associadas \u00e0 longevidade. VIS\u00c3O GERAL: Longevidade \u00e9 uma caracter\u00edstica definida como tendo uma vida \u00fatil mais longa do que …<\/p>\n

Longevidade (Timmers, 2020)<\/span> Leia mais 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