{"id":12987,"date":"2021-01-31T17:16:21","date_gmt":"2021-01-31T22:16:21","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetics-of-telomere-length-codd-2013\/"},"modified":"2021-02-20T20:50:05","modified_gmt":"2021-02-21T01:50:05","slug":"genetics-of-telomere-length-codd-2013","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/pt-br\/genetics-of-telomere-length-codd-2013\/","title":{"rendered":"Comprimento do tel\u00f4mero (Codd, 2013)"},"content":{"rendered":"\n

T\u00cdTULO DO ESTUDO:<\/strong> Identifica\u00e7\u00e3o de sete loci que afetam o comprimento m\u00e9dio dos tel\u00f4meros e sua associa\u00e7\u00e3o com a doen\u00e7a<\/a><\/p>\n\n

RESUMO:<\/strong> Identifica\u00e7\u00e3o de 5 novas regi\u00f5es gen\u00e9ticas ligadas ao comprimento dos tel\u00f4meros.<\/p>\n\n

VIS\u00c3O GERAL:<\/strong> O DNA em nossas c\u00e9lulas \u00e9 compactado em estruturas chamadas cromossomos. As sequ\u00eancias nas extremidades dos cromossomos formam capas conhecidas como tel\u00f4meros. Essas estruturas ajudam a proteger nossos cromossomos da mesma forma que as pontas de pl\u00e1stico dos cadar\u00e7os protegem as pontas do desgaste. Em muitas divis\u00f5es celulares, durante as quais todo o DNA da c\u00e9lula \u00e9 copiado, os tel\u00f4meros ficam progressivamente mais curtos at\u00e9 que o DNA seja danificado e as c\u00e9lulas morram. Estima-se que at\u00e9 80% do comprimento do tel\u00f4mero de um indiv\u00edduo seja heredit\u00e1rio. Tel\u00f4meros curtos t\u00eam sido associados ao aumento do risco de v\u00e1rias doen\u00e7as relacionadas \u00e0 idade. O comprimento dos tel\u00f4meros tamb\u00e9m foi relacionado ao c\u00e2ncer, mas a direcionalidade do efeito dessa associa\u00e7\u00e3o \u00e9 menos clara. Este estudo examinou dados gen\u00e9ticos de quase 50.000 indiv\u00edduos de ascend\u00eancia europeia e identificou 7 regi\u00f5es gen\u00e9ticas associadas ao comprimento dos tel\u00f4meros, 5 das quais s\u00e3o novas. A varia\u00e7\u00e3o gen\u00e9tica nessas regi\u00f5es explica coletivamente mais de 1% da vari\u00e2ncia no comprimento dos tel\u00f4meros.<\/p>\n\n

VOC\u00ca SABIA?<\/strong> Enquanto nossos tel\u00f4meros encurtam naturalmente ao longo de nossas vidas, algumas escolhas de estilo de vida s\u00e3o conhecidas por acelerar esse processo! Em particular, o fumo e a exposi\u00e7\u00e3o aos raios ultravioleta podem acelerar o encurtamento dos tel\u00f4meros e aumentar a suscetibilidade a v\u00e1rias doen\u00e7as. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE AMOSTRA:<\/strong> Saiba mais sobre o Nebula Research Library<\/a> . <\/p>\n\n

\"resultados<\/a><\/figure>\n\n

<\/p>\n\n

VARIANTES ANALISADAS:<\/strong> rs10936599, rs2736100, rs7675998, rs9420907, rs8105767, rs755017, rs11125529<\/p>\n\n

RECURSOS ADICIONAIS:<\/strong>Tel\u00f4meros<\/a>A ci\u00eancia das c\u00e9lulas que nunca envelhecem (v\u00eddeo)<\/a><\/p>\n\n

ATUALIZA\u00c7\u00c3O SEMANAL:<\/strong> 15 de fevereiro de 2020<\/p>\n\n

Interessado em aprender mais sobre o comprimento do tel\u00f4mero? Voc\u00ea pode gostar do nosso TeloYears<\/a> Reveja.<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DO ESTUDO: Identifica\u00e7\u00e3o de sete loci que afetam o comprimento m\u00e9dio dos tel\u00f4meros e sua associa\u00e7\u00e3o com a doen\u00e7a RESUMO: Identifica\u00e7\u00e3o de 5 novas regi\u00f5es gen\u00e9ticas ligadas ao comprimento dos tel\u00f4meros. VIS\u00c3O GERAL: O DNA em nossas c\u00e9lulas \u00e9 …<\/p>\n

Comprimento do tel\u00f4mero (Codd, 2013)<\/span> Leia mais \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":12992,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4999],"tags":[],"class_list":["post-12987","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports-pt-br"],"yoast_head":"\nA gen\u00e9tica do comprimento dos tel\u00f4meros de DNA (Codd, 2013)<\/title>\n<meta name=\"description\" content=\"Carregue seus dados de DNA, explore as variantes gen\u00e9ticas vinculadas ao comprimento dos tel\u00f4meros (Codd, 2013) e descubra sua pontua\u00e7\u00e3o polig\u00eanica.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nebula.org\/blog\/pt-br\/genetics-of-telomere-length-codd-2013\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A gen\u00e9tica do comprimento dos tel\u00f4meros de DNA (Codd, 2013)\" \/>\n<meta property=\"og:description\" content=\"Carregue seus dados de DNA, explore as variantes gen\u00e9ticas vinculadas ao comprimento dos tel\u00f4meros (Codd, 2013) e descubra sua pontua\u00e7\u00e3o polig\u00eanica.\" \/>\n<meta property=\"og:url\" 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