{"id":13108,"date":"2021-01-31T17:17:05","date_gmt":"2021-01-31T22:17:05","guid":{"rendered":"https:\/\/nebula.org\/blog\/podoconiose-ayele-2012\/"},"modified":"2021-02-20T20:48:14","modified_gmt":"2021-02-21T01:48:14","slug":"podoconiose-ayele-2012","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/pt-br\/podoconiose-ayele-2012\/","title":{"rendered":"Podoconiose (Ayele, 2012)"},"content":{"rendered":"\n

T\u00cdTULO DO ESTUDO:<\/strong> Locus HLA Classe II e susceptibilidade \u00e0 podoconiose<\/a><\/p>\n\n

RESUMO:<\/strong> Identifica\u00e7\u00e3o de uma regi\u00e3o gen\u00f4mica associada \u00e0 suscetibilidade ao desenvolvimento de podoconiose.<\/p>\n\n

VIS\u00c3O GERAL:<\/strong> A podoconiose \u00e9 uma doen\u00e7a da qual muitas pessoas podem nunca ter ouvido falar, mas em algumas comunidades em todo o mundo, quase 1 em cada 20 indiv\u00edduos \u00e9 afetado. A doen\u00e7a afeta predominantemente fazendeiros e pessoas que andam descal\u00e7os em solo argiloso formado de rocha vulc\u00e2nica que \u00e9 encontrada na \u00c1frica tropical, Am\u00e9rica Central e do Sul e norte da \u00cdndia. Os cientistas acreditam que o solo de argila vermelha cont\u00e9m grandes quantidades de minerais que s\u00e3o absorvidos pela pele dos p\u00e9s. Isso induz uma rea\u00e7\u00e3o do sistema imunol\u00f3gico que leva ao incha\u00e7o caracter\u00edstico dos p\u00e9s. Acredita-se que a gen\u00e9tica contribua com mais de 60% para o risco de uma pessoa desenvolver podoconiose. Este estudo de todo o genoma examinou quase 400 indiv\u00edduos do sul da Eti\u00f3pia para identificar variantes gen\u00e9ticas associadas \u00e0 podoconiose e encontrou uma associa\u00e7\u00e3o significativa com a regi\u00e3o HLA-DQA1, que tem uma fun\u00e7\u00e3o importante no sistema imunol\u00f3gico.<\/p>\n\n

VOC\u00ca SABIA?<\/strong> A Organiza\u00e7\u00e3o Mundial da Sa\u00fade acredita que \u00e9 poss\u00edvel erradicar a podoconiose. Os esfor\u00e7os para aumentar a disponibilidade de cal\u00e7ados e o desenvolvimento de estradas s\u00e3o vistos como estrat\u00e9gias-chave para controlar a doen\u00e7a. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE AMOSTRA:<\/strong> Saiba mais sobre o Nebula Research Library<\/a> . <\/p>\n\n

\"resultados<\/a><\/figure>\n\n

<\/p>\n\n

VARIANTES ASSOCIADOS \u00c0 PODOCONIOSE:<\/strong> rs17612858<\/p>\n\n

RECURSOS ADICIONAIS:<\/strong>Mais informa\u00e7\u00f5es sobre esta condi\u00e7\u00e3o<\/a><\/p>\n\n

ATUALIZA\u00c7\u00c3O SEMANAL:<\/strong> 8 de fevereiro de 2020<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DO ESTUDO: Locus HLA Classe II e susceptibilidade \u00e0 podoconiose RESUMO: Identifica\u00e7\u00e3o de uma regi\u00e3o gen\u00f4mica associada \u00e0 suscetibilidade ao desenvolvimento de podoconiose. VIS\u00c3O GERAL: A podoconiose \u00e9 uma doen\u00e7a da qual muitas pessoas podem nunca ter ouvido falar, …<\/p>\n

Podoconiose (Ayele, 2012)<\/span> Leia mais \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":13111,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4999],"tags":[],"class_list":["post-13108","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports-pt-br"],"yoast_head":"\nA 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