{"id":13109,"date":"2021-01-31T17:17:05","date_gmt":"2021-01-31T22:17:05","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-de-hiv-samson-1996\/"},"modified":"2021-02-20T20:32:18","modified_gmt":"2021-02-21T01:32:18","slug":"genetica-de-hiv-samson-1996","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/pt-br\/genetica-de-hiv-samson-1996\/","title":{"rendered":"Resist\u00eancia ao HIV (Samson, 1996)"},"content":{"rendered":"\n

T\u00cdTULO DO ESTUDO:<\/strong> Resist\u00eancia \u00e0 infec\u00e7\u00e3o por HIV-1 em indiv\u00edduos caucasianos com alelos mutantes do gene do receptor de quimiocina CCR-5<\/a><\/p>\n\n

RESUMO:<\/strong> Identifica\u00e7\u00e3o de uma variante gen\u00e9tica comum que confere resist\u00eancia ao v\u00edrus da imunodefici\u00eancia humana (HIV).<\/p>\n\n

VIS\u00c3O GERAL:<\/strong> O v\u00edrus da imunodefici\u00eancia humana (HIV) destr\u00f3i o sistema imunol\u00f3gico ao matar os gl\u00f3bulos brancos necess\u00e1rios para combater a infec\u00e7\u00e3o. Essa doen\u00e7a \u00e9 chamada de s\u00edndrome da imunodefici\u00eancia adquirida (AIDS). O CCR5 \u00e9 uma prote\u00edna na superf\u00edcie das c\u00e9lulas brancas do sangue, que \u00e9 ligada pelo HIV e usada para entrar nas c\u00e9lulas. Este estudo analisou o gene CCR5 em mais de 1400 indiv\u00edduos de ascend\u00eancia europeia para encontrar variantes gen\u00e9ticas que podem estar ligadas ao risco de infec\u00e7\u00e3o pelo HIV. O estudo descobriu que uma variante relativamente comum (uma dele\u00e7\u00e3o de 32 bases) confere resist\u00eancia quase total \u00e0 infec\u00e7\u00e3o pelo HIV se presente em ambas as c\u00f3pias do gene CCR5. Uma prote\u00edna CCR5 que abriga essa variante aparentemente n\u00e3o pode ser usada com efici\u00eancia pelo HIV para entrar nas c\u00e9lulas brancas do sangue.<\/p>\n\n

VOC\u00ca SABIA?<\/strong> Embora a variante gen\u00e9tica no gene CCR5 que confere resist\u00eancia ao HIV seja relativamente comum em indiv\u00edduos de ascend\u00eancia europeia, n\u00e3o \u00e9 encontrada em indiv\u00edduos de ascend\u00eancia africana. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE AMOSTRA:<\/strong> Saiba mais sobre o Nebula Research Library<\/a> . <\/p>\n\n

\"Resultados<\/a><\/figure>\n\n

<\/p>\n\n

VARIANTES ANALISADAS:<\/strong> rs333<\/p>\n\n

RECURSOS ADICIONAIS:<\/strong>O que s\u00e3o HIV e AIDS?<\/a>HIV e AIDS (v\u00eddeo)<\/a><\/p>\n\n

ATUALIZA\u00c7\u00c3O SEMANAL:<\/strong> 15 de fevereiro de 2020<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DO ESTUDO: Resist\u00eancia \u00e0 infec\u00e7\u00e3o por HIV-1 em indiv\u00edduos caucasianos com alelos mutantes do gene do receptor de quimiocina CCR-5 RESUMO: Identifica\u00e7\u00e3o de uma variante gen\u00e9tica comum que confere resist\u00eancia ao v\u00edrus da imunodefici\u00eancia humana (HIV). VIS\u00c3O GERAL: O …<\/p>\n

Resist\u00eancia ao HIV (Samson, 1996)<\/span> Leia mais 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