{"id":13122,"date":"2021-01-31T17:17:10","date_gmt":"2021-01-31T22:17:10","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-de-anemia-aplastica-selvagem-2020\/"},"modified":"2021-02-20T20:47:24","modified_gmt":"2021-02-21T01:47:24","slug":"genetica-de-anemia-aplastica-selvagem-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/pt-br\/genetica-de-anemia-aplastica-selvagem-2020\/","title":{"rendered":"Anemia apl\u00e1stica (Savage, 2020)"},"content":{"rendered":"\n

T\u00cdTULO DO ESTUDO:<\/strong> Estudo de associa\u00e7\u00e3o de todo o genoma identifica o HLA-DPB1 como um fator de risco significativo para anemia apl\u00e1stica severa<\/a><\/p>\n\n

RESUMO:<\/strong> Identifica\u00e7\u00e3o de 2 regi\u00f5es gen\u00f4micas associadas ao risco de anemia apl\u00e1stica grave.<\/p>\n\n

VIS\u00c3O GERAL:<\/strong> A anemia apl\u00e1stica (AA) \u00e9 uma doen\u00e7a autoimune na qual a medula \u00f3ssea n\u00e3o produz c\u00e9lulas sangu\u00edneas suficientes. Em casos graves, o AA pode ser fatal. Este estudo de associa\u00e7\u00e3o do genoma procurou identificar variantes associadas ao risco de anemia apl\u00e1stica grave, examinando informa\u00e7\u00f5es gen\u00e9ticas de cerca de 3.000 indiv\u00edduos de ascend\u00eancia europeia. Os resultados indicaram 2 regi\u00f5es gen\u00e9ticas ligadas ao risco de AA grave. Ambas as regi\u00f5es gen\u00e9ticas codificam para prote\u00ednas do sistema do ant\u00edgeno leucocit\u00e1rio humano (HLA) que desempenha um papel na regula\u00e7\u00e3o do sistema imunol\u00f3gico.<\/p>\n\n

VOC\u00ca SABIA?<\/strong> A exposi\u00e7\u00e3o a produtos qu\u00edmicos t\u00f3xicos como pesticidas e inseticidas pode aumentar o risco de anemia apl\u00e1stica. A condi\u00e7\u00e3o tamb\u00e9m pode ser um efeito colateral tempor\u00e1rio da radia\u00e7\u00e3o e quimioterapia usada para o tratamento do c\u00e2ncer. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE AMOSTRA:<\/strong> Saiba mais sobre o Nebula Research Library<\/a> . <\/p>\n\n

\"resultados<\/a><\/figure>\n\n

<\/p>\n\n

VARIANTES ANALISADAS:<\/strong> rs1042151, rs28367832<\/p>\n\n

RECURSOS ADICIONAIS:<\/strong>Anemia apl\u00e1stica<\/a>Anemia apl\u00e1stica (v\u00eddeo)<\/a><\/p>\n\n

ATUALIZA\u00c7\u00c3O SEMANAL:<\/strong> 15 de fevereiro de 2020<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DO ESTUDO: Estudo de associa\u00e7\u00e3o de todo o genoma identifica o HLA-DPB1 como um fator de risco significativo para anemia apl\u00e1stica severa RESUMO: Identifica\u00e7\u00e3o de 2 regi\u00f5es gen\u00f4micas associadas ao risco de anemia apl\u00e1stica grave. VIS\u00c3O GERAL: A anemia …<\/p>\n

Anemia apl\u00e1stica (Savage, 2020)<\/span> Leia mais \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":13125,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4999],"tags":[],"class_list":["post-13122","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports-pt-br"],"yoast_head":"\nA gen\u00e9tica da anemia apl\u00e1stica (Savage, 2020)<\/title>\n<meta name=\"description\" content=\"Fa\u00e7a upload de seus dados de DNA, explore as variantes gen\u00e9ticas ligadas \u00e0 anemia apl\u00e1stica (Savage, 2020) e descubra sua pontua\u00e7\u00e3o polig\u00eanica.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nebula.org\/blog\/pt-br\/genetica-de-anemia-aplastica-selvagem-2020\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A gen\u00e9tica da anemia apl\u00e1stica (Savage, 2020)\" \/>\n<meta property=\"og:description\" content=\"Fa\u00e7a upload de seus dados de DNA, explore as variantes gen\u00e9ticas ligadas \u00e0 anemia apl\u00e1stica (Savage, 2020) e descubra sua pontua\u00e7\u00e3o polig\u00eanica.\" \/>\n<meta property=\"og:url\" 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