{"id":13130,"date":"2021-01-31T22:13:25","date_gmt":"2021-02-01T03:13:25","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-de-febril-convulsoes-feenstra-2014\/"},"modified":"2021-02-20T20:21:37","modified_gmt":"2021-02-21T01:21:37","slug":"genetica-de-febril-convulsoes-feenstra-2014","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/pt-br\/genetica-de-febril-convulsoes-feenstra-2014\/","title":{"rendered":"Apreens\u00f5es febris (Feenstra, 2014)"},"content":{"rendered":"\n

T\u00cdTULO DO ESTUDO:<\/strong> Variantes comuns associadas a convuls\u00f5es febris gerais e relacionadas \u00e0 vacina MMR<\/a><\/p>\n\n

RESUMO:<\/strong> Identifica\u00e7\u00e3o de 6 variantes gen\u00e9ticas associadas com febril<\/em> convuls\u00f5es. <\/p>\n\n

VIS\u00c3O GERAL:<\/strong> Em crian\u00e7as pequenas, a febre alta pode induzir convuls\u00f5es, causando tremores incontrol\u00e1veis e perda de consci\u00eancia. Esta condi\u00e7\u00e3o \u00e9 conhecida como febril<\/em> convuls\u00f5es e \u00e9 uma experi\u00eancia terr\u00edvel para muitos pais. No entanto, eles s\u00e3o normalmente inofensivos e tamb\u00e9m bastante comuns, afetando 2 – 9% (dependendo da etnia) das crian\u00e7as antes dos 5 anos de idade. Como a condi\u00e7\u00e3o \u00e9 causada por febre, eles podem ocorrer ap\u00f3s a vacina\u00e7\u00e3o. A febre \u00e9 uma resposta relativamente comum \u00e0s vacina\u00e7\u00f5es com a vacina contra sarampo, caxumba e rub\u00e9ola (MMR). Porque pouco se sabe sobre a predisposi\u00e7\u00e3o gen\u00e9tica para febril<\/em> convuls\u00f5es, em particular em resposta \u00e0 vacina MMR, este estudo examinou genomas de quase 9.000 crian\u00e7as descendentes de europeus para identificar fatores gen\u00e9ticos contribuintes. O estudo descobriu 2 variantes gen\u00e9ticas associadas com MMR relacionado febril<\/em> convuls\u00f5es e mais 4 variantes associadas \u00e0 condi\u00e7\u00e3o em geral. Uma das variantes identificadas est\u00e1 perto de um gene que desempenha um papel na resposta imunol\u00f3gica a infec\u00e7\u00f5es virais. Outra variante est\u00e1 perto de um gene que codifica para um receptor<\/em> que \u00e9 usado pelo v\u00edrus do sarampo para entrar nas c\u00e9lulas. <\/p>\n\n

VOC\u00ca SABIA?<\/strong> A maioria das crian\u00e7as que tem convuls\u00f5es febris n\u00e3o precisa de tratamento com medicamentos contra convuls\u00f5es. A melhor maneira de responder \u00e0s crises febris \u00e9 colocar a crian\u00e7a deitada de lado em uma superf\u00edcie protegida e observ\u00e1-la cuidadosamente. No entanto, \u00e9 importante entender o motivo da febre e trat\u00e1-la adequadamente. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE AMOSTRA:<\/strong> Saiba mais sobre o Nebula Research Library<\/a> . <\/p>\n\n

\"resultados<\/a><\/figure>\n\n

VARIANTES ASSOCIADOS \u00c0 APREENS\u00c3O DE FEBRILE:<\/strong> rs114444506, rs6432860, rs273259, rs11105468, rs1318653, rs3769955<\/p>\n\n

RECURSOS ADICIONAIS:<\/strong>Ficha informativa sobre apreens\u00f5es febris<\/a>Apreens\u00f5es febris (v\u00eddeo)<\/a><\/p>\n\n

ATUALIZA\u00c7\u00c3O SEMANAL:<\/strong> 21 de abril de 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DO ESTUDO: Variantes comuns associadas a convuls\u00f5es febris gerais e relacionadas \u00e0 vacina MMR RESUMO: Identifica\u00e7\u00e3o de 6 variantes gen\u00e9ticas associadas com febril convuls\u00f5es. VIS\u00c3O GERAL: Em crian\u00e7as pequenas, a febre alta pode induzir convuls\u00f5es, causando tremores incontrol\u00e1veis e …<\/p>\n

Apreens\u00f5es febris (Feenstra, 2014)<\/span> Leia mais \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":13132,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4999],"tags":[],"class_list":["post-13130","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports-pt-br"],"yoast_head":"\nA 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