{"id":13141,"date":"2021-01-31T22:13:34","date_gmt":"2021-02-01T03:13:34","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-de-nefropatia-membranosa-xie-2020\/"},"modified":"2021-02-20T20:30:02","modified_gmt":"2021-02-21T01:30:02","slug":"genetica-de-nefropatia-membranosa-xie-2020","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/pt-br\/genetica-de-nefropatia-membranosa-xie-2020\/","title":{"rendered":"Nefropatia membranosa (Xie, 2020)"},"content":{"rendered":"\n

T\u00cdTULO DO ESTUDO:<\/strong> A arquitetura gen\u00e9tica da nefropatia membranosa e seu potencial para melhorar o diagn\u00f3stico n\u00e3o invasivo<\/a><\/p>\n\n

RESUMO:<\/strong> Identifica\u00e7\u00e3o de 4 regi\u00f5es gen\u00f4micas associadas \u00e0 nefropatia membranosa, um autoimune<\/em> doen\u00e7a dos rins. <\/p>\n\n

VIS\u00c3O GERAL:<\/strong> Os rins s\u00e3o \u00f3rg\u00e3os que removem os res\u00edduos e o excesso de \u00e1gua do sangue, que eventualmente termina em urina. A nefropatia membranosa (NM) \u00e9 uma autoimune<\/em> doen\u00e7a que leva \u00e0 insufici\u00eancia renal. Este estudo de associa\u00e7\u00e3o do genoma tentou identificar variantes gen\u00e9ticas associadas a um risco aumentado de nefropatia membranosa. Ao examinar os dados gen\u00e9ticos de mais de 12.000 indiv\u00edduos de ancestrais do Leste Asi\u00e1tico e europeus, 4 regi\u00f5es do genoma se correlacionaram com um risco aumentado de MN. Todas as variantes identificadas est\u00e3o pr\u00f3ximas de genes relacionados \u00e0 fun\u00e7\u00e3o do sistema imunol\u00f3gico, ressaltando que a nefropatia membranosa \u00e9 uma autoimune<\/em> doen\u00e7a. Al\u00e9m disso, as variantes j\u00e1 foram associadas a doen\u00e7as inflamat\u00f3rias intestinais, outro autoimune<\/em> doen\u00e7a. <\/p>\n\n

VOC\u00ca SABIA?<\/strong> Os tratamentos para a nefropatia membranosa incluem medicamentos que fazem com que os pacientes urinem mais e uma dieta pobre em sal. Tamb\u00e9m s\u00e3o usados medicamentos que ajudam a manter o sistema imunol\u00f3gico sob controle. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE AMOSTRA:<\/strong> Saiba mais sobre o Nebula Research Library<\/a> . <\/p>\n\n

\"resultados<\/a><\/figure>\n\n

VARIANTES ASSOCIADOS MN:<\/strong> rs9271573, rs17831251, rs9405192, rs230540 <\/p>\n\n

RECURSOS ADICIONAIS:<\/strong>Seus rins e como eles funcionam<\/a> Neuropatia membranosa (v\u00eddeo)<\/a><\/p>\n\n

ATUALIZA\u00c7\u00c3O SEMANAL:<\/strong> 21 de abril de 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DO ESTUDO: A arquitetura gen\u00e9tica da nefropatia membranosa e seu potencial para melhorar o diagn\u00f3stico n\u00e3o invasivo RESUMO: Identifica\u00e7\u00e3o de 4 regi\u00f5es gen\u00f4micas associadas \u00e0 nefropatia membranosa, um autoimune doen\u00e7a dos rins. VIS\u00c3O GERAL: Os rins s\u00e3o \u00f3rg\u00e3os que …<\/p>\n

Nefropatia membranosa (Xie, 2020)<\/span> Leia mais \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":13144,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4999],"tags":[],"class_list":["post-13141","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports-pt-br"],"yoast_head":"\nA 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