{"id":13170,"date":"2021-01-31T22:13:45","date_gmt":"2021-02-01T03:13:45","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-de-calculo-biliar-ferkingstad-2018\/"},"modified":"2021-02-20T20:26:55","modified_gmt":"2021-02-21T01:26:55","slug":"genetica-de-calculo-biliar-ferkingstad-2018","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/pt-br\/genetica-de-calculo-biliar-ferkingstad-2018\/","title":{"rendered":"C\u00e1lculos biliares (Ferkingstad, 2018)"},"content":{"rendered":"\n

T\u00cdTULO DO ESTUDO:<\/strong> Meta-an\u00e1lise de associa\u00e7\u00e3o de todo o genoma produz 20 loci associados \u00e0 doen\u00e7a do c\u00e1lculo biliar<\/a><\/p>\n\n

RESUMO:<\/strong> Descoberta de 21 regi\u00f5es gen\u00f4micas associadas \u00e0 forma\u00e7\u00e3o de c\u00e1lculos biliares. <\/p>\n\n

VIS\u00c3O GERAL:<\/strong> A ves\u00edcula biliar armazena um fluido chamado bile. Ele libera bile nos intestinos, onde ajuda na digest\u00e3o. A bile cont\u00e9m \u00e1cidos biliares que s\u00e3o produzidos no corpo a partir do colesterol. Os c\u00e1lculos biliares s\u00e3o c\u00e1lculos que podem se formar na ves\u00edcula biliar quando h\u00e1 muito colesterol e \u00e1cidos biliares insuficientes. As pedras podem causar dor no abdome superior direito e podem exigir cirurgia. Para identificar as variantes gen\u00e9ticas associadas \u00e0 forma\u00e7\u00e3o de c\u00e1lculos biliares, este estudo de associa\u00e7\u00e3o do genoma examinou os genomas de mais de 750.000 indiv\u00edduos de ascend\u00eancia europeia. O estudo identificou 28 regi\u00f5es gen\u00f4micas associadas \u00e0 doen\u00e7a do c\u00e1lculo biliar, 21 das quais s\u00e3o novas. Algumas dessas variantes gen\u00e9ticas j\u00e1 foram associadas ao diabetes e ao metabolismo da gordura. <\/p>\n\n

VOC\u00ca SABIA?<\/strong> De acordo com o Guinness World Records, a maioria dos c\u00e1lculos biliares removidos de um paciente foi de aproximadamente 24.000. Em contraste, a maioria dos pacientes que se submetem \u00e0 cirurgia para a doen\u00e7a do c\u00e1lculo biliar tem, em m\u00e9dia, 2 a 20. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE AMOSTRA:<\/strong> Saiba mais sobre o Nebula Research Library<\/a> . <\/p>\n\n

\"resultados<\/a><\/figure>\n\n

VARIANTES ASSOCIADOS A GALLSTONE:<\/strong> rs11887534, rs212100, rs12633863, rs4148808, rs2291428, rs2290846, rs1800961, rs6471717, rs601338, rs686030, rs756082276, rs28929474, rs1260326, rs34851490, rs1169288, rs756935975, rs13280055, rs56398830, rs174567, rs708686, rs11012737, rs1935, rs2469991, rs17240268, rs2070959, rs12004, rs55971546, rs11641445, rs17138478, rs45575636, rs2292553, rs12968116<\/p>\n\n

RECURSOS ADICIONAIS:<\/strong>C\u00e1lculos biliares (v\u00eddeo)<\/a> Doen\u00e7a do c\u00e1lculo biliar<\/a><\/p>\n\n

ATUALIZA\u00c7\u00c3O SEMANAL:<\/strong> 28 de abril de 2020<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DO ESTUDO: Meta-an\u00e1lise de associa\u00e7\u00e3o de todo o genoma produz 20 loci associados \u00e0 doen\u00e7a do c\u00e1lculo biliar RESUMO: Descoberta de 21 regi\u00f5es gen\u00f4micas associadas \u00e0 forma\u00e7\u00e3o de c\u00e1lculos biliares. VIS\u00c3O GERAL: A ves\u00edcula biliar armazena um fluido chamado …<\/p>\n

C\u00e1lculos biliares (Ferkingstad, 2018)<\/span> Leia mais \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":13175,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4999],"tags":[],"class_list":["post-13170","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports-pt-br"],"yoast_head":"\nA 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