{"id":13384,"date":"2021-01-31T22:14:12","date_gmt":"2021-02-01T03:14:12","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-da-acne-navarini-2019\/"},"modified":"2021-02-20T20:48:09","modified_gmt":"2021-02-21T01:48:09","slug":"genetica-da-acne-navarini-2019","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/pt-br\/genetica-da-acne-navarini-2019\/","title":{"rendered":"Acne (Navarini, 2019)"},"content":{"rendered":"\n

T\u00cdTULO DO ESTUDO:<\/strong> Estudo de associa\u00e7\u00e3o do genoma identifica tr\u00eas novos loci de susceptibilidade para Acne vulgaris grave<\/a><\/p>\n\n

RESUMO:<\/strong> A desregula\u00e7\u00e3o da via de sinaliza\u00e7\u00e3o do TGF\u03b2 pode aumentar a suscetibilidade \u00e0 acne.<\/p>\n\n

DESCRI\u00c7\u00c3O:<\/strong> Acne \u00e9 uma doen\u00e7a inflamat\u00f3ria da pele na qual os fol\u00edculos pilosos ficam obstru\u00eddos com \u00f3leo e c\u00e9lulas mortas da pele. \u00c9 cerca de 80% heredit\u00e1rio. Este estudo de associa\u00e7\u00e3o do genoma incluiu 1.893 pacientes com essa doen\u00e7a de pele e 5.132 indiv\u00edduos saud\u00e1veis do Reino Unido. O estudo identificou 3 variantes gen\u00e9ticas que est\u00e3o ligadas aos genes OVOL1, FST e TGF\u03b22, todos associados \u00e0 via de sinaliza\u00e7\u00e3o celular TGF\u03b2. A via de sinaliza\u00e7\u00e3o do TGF\u03b2 (fator de crescimento transformador beta) est\u00e1 envolvida em v\u00e1rios processos em adultos e embri\u00f5es. Alguns desses processos incluem o crescimento celular, a manuten\u00e7\u00e3o de condi\u00e7\u00f5es celulares normais e a apoptose (morte celular programada).<\/p>\n\n

VOC\u00ca SABIA?<\/strong> Al\u00e9m de medicamentos ou produtos para a pele, voc\u00ea pode ajudar a prevenir esse problema de pele lavando o rosto duas vezes ao dia, mantendo o cabelo limpo, sem estourar ou cutucar as espinhas e usar protetor solar ao sair de casa. [ FONTE<\/a> ]<\/p>\n\n

RESULTADOS DE AMOSTRA:<\/strong> Saiba mais sobre o Nebula Research Library<\/a> .<\/p>\n\n

\"Relatório<\/a><\/figure>\n\n

<\/p>\n\n

VARIANTES ASSOCIADOS A ACNE:<\/strong> rs478304, rs38055, rs1159268<\/p>\n\n

RECURSOS ADICIONAIS:<\/strong>Via de sinaliza\u00e7\u00e3o de TGF\u03b2<\/a>Apoptose<\/a>Vis\u00e3o geral da acne<\/a>Acne em movimento<\/a><\/p>\n\n

ATUALIZA\u00c7\u00c3O SEMANAL:<\/strong> 23 de julho de 2019<\/p>\n\n

Al\u00e9m disso, d\u00ea uma olhada em nosso Revis\u00e3o de curologia<\/a> !<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DO ESTUDO: Estudo de associa\u00e7\u00e3o do genoma identifica tr\u00eas novos loci de susceptibilidade para Acne vulgaris grave RESUMO: A desregula\u00e7\u00e3o da via de sinaliza\u00e7\u00e3o do TGF\u03b2 pode aumentar a suscetibilidade \u00e0 acne. DESCRI\u00c7\u00c3O: Acne \u00e9 uma doen\u00e7a inflamat\u00f3ria da …<\/p>\n

Acne (Navarini, 2019)<\/span> Leia mais \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":13387,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4999],"tags":[],"class_list":["post-13384","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports-pt-br"],"yoast_head":"\nA 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