{"id":13389,"date":"2021-01-31T22:14:13","date_gmt":"2021-02-01T03:14:13","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-da-doenca-de-alzheimer-wang-2019\/"},"modified":"2021-02-20T20:54:13","modified_gmt":"2021-02-21T01:54:13","slug":"genetica-da-doenca-de-alzheimer-wang-2019","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/pt-br\/genetica-da-doenca-de-alzheimer-wang-2019\/","title":{"rendered":"Doen\u00e7a de Alzheimer (Wang, 2019)"},"content":{"rendered":"\n

T\u00cdTULO DO ESTUDO:<\/strong> Estudo de associa\u00e7\u00e3o do genoma identifica CD1A associado \u00e0 taxa de aumento da luz do neurofilamento do plasma em idosos n\u00e3o demenciados<\/a><\/p>\n\n

RESUMO:<\/strong> Variantes gen\u00e9ticas no gene CD1A est\u00e3o associadas a um aumento das prote\u00ednas NFL no sangue e a um maior risco de doen\u00e7a de Alzheimer.<\/p>\n\n

DESCRI\u00c7\u00c3O:<\/strong> A doen\u00e7a de Alzheimer causa um decl\u00ednio gradual nas habilidades de mem\u00f3ria e pensamento, danificando as c\u00e9lulas nervosas do c\u00e9rebro. As prote\u00ednas leves do neurofilamento (NFL) s\u00e3o frequentemente usadas para testar a presen\u00e7a ou o progresso da doen\u00e7a de Alzheimer e outras doen\u00e7as neurodegenerativas. A contribui\u00e7\u00e3o gen\u00e9tica que leva ao aumento dos n\u00edveis de NFL no sangue n\u00e3o \u00e9 bem compreendida. Este estudo examinou 545 participantes brancos n\u00e3o hisp\u00e2nicos, a fim de encontrar variantes gen\u00e9ticas ligadas a n\u00edveis elevados de NFL no sangue e, portanto, a um risco aumentado de Alzheimer. As variantes gen\u00e9ticas identificadas estavam localizadas no gene CD1A – um gene que desempenha um papel no sistema imunol\u00f3gico.<\/p>\n\n

VOC\u00ca SABIA?<\/strong> Controlar a hipertens\u00e3o ou os n\u00edveis elevados de colesterol pode reduzir o risco de doen\u00e7a de Alzheimer. Al\u00e9m disso, ser f\u00edsica e socialmente ativo pode ajudar a prevenir esta doen\u00e7a. [ FONTE<\/a> ]<\/p>\n\n

RESULTADOS DE AMOSTRA:<\/strong> Saiba mais sobre o Nebula Research Library<\/a> .<\/p>\n\n

\"Relatório<\/a><\/figure>\n\n

<\/p>\n\n

VARIANTES ASSOCIADAS A ALZHEIMER:<\/strong> rs16840041<\/p>\n\n

RECURSOS ADICIONAIS:<\/strong> Polipept\u00eddeo Neurofilament Light<\/a>Vis\u00e3o geral da doen\u00e7a de Alzheimer<\/a><\/p>\n\n

ATUALIZA\u00c7\u00c3O SEMANAL:<\/strong> 26 de julho de 2019<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DO ESTUDO: Estudo de associa\u00e7\u00e3o do genoma identifica CD1A associado \u00e0 taxa de aumento da luz do neurofilamento do plasma em idosos n\u00e3o demenciados RESUMO: Variantes gen\u00e9ticas no gene CD1A est\u00e3o associadas a um aumento das prote\u00ednas NFL no …<\/p>\n

Doen\u00e7a de Alzheimer (Wang, 2019)<\/span> Leia mais 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