{"id":13417,"date":"2021-01-31T22:14:20","date_gmt":"2021-02-01T03:14:20","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-de-cancer-pancreatico-infantil-2015\/"},"modified":"2021-02-20T20:45:17","modified_gmt":"2021-02-21T01:45:17","slug":"genetica-de-cancer-pancreatico-infantil-2015","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/pt-br\/genetica-de-cancer-pancreatico-infantil-2015\/","title":{"rendered":"C\u00e2ncer de p\u00e2ncreas (Childs, 2015)"},"content":{"rendered":"\n

T\u00cdTULO DO ESTUDO:<\/strong> Varia\u00e7\u00e3o comum em 2p13.3, 3q29, 7p13 e 7q25.1 associada \u00e0 suscetibilidade ao c\u00e2ncer pancre\u00e1tico<\/a><\/p>\n\n

RESUMO:<\/strong> O c\u00e2ncer de p\u00e2ncreas pode ser influenciado por variantes nos genes LINC00673, SUGCT e TP63.<\/p>\n\n

DESCRI\u00c7\u00c3O:<\/strong> O p\u00e2ncreas \u00e9 um \u00f3rg\u00e3o atr\u00e1s do est\u00f4mago que ajuda na digest\u00e3o e no controle dos n\u00edveis de a\u00e7\u00facar no sangue. Para entender melhor a gen\u00e9tica que ajuda a determinar o risco de c\u00e2ncer pancre\u00e1tico, este estudo examinou 21.494 indiv\u00edduos de ascend\u00eancia europeia e asi\u00e1tica. Ele identificou tr\u00eas novas variantes gen\u00e9ticas associadas a um risco aumentado de desenvolver esta condi\u00e7\u00e3o. Uma dessas variantes estava no gene LINC00673, que anteriormente havia desempenhado um papel no c\u00e2ncer. Outra variante significativa foi localizada no gene SUGCT. A prote\u00edna SUGCT est\u00e1 envolvida no metabolismo do amino\u00e1cido glutarato. Finalmente, descobriu-se que uma variante do gene TP63 estava associada. TP63 tamb\u00e9m \u00e9 conhecido como p63 e desempenha um papel na regula\u00e7\u00e3o do ciclo celular e na progress\u00e3o dos tumores. Coletivamente, as variantes identificadas foram respons\u00e1veis por cerca de 2% da herdabilidade desta doen\u00e7a.<\/p>\n\n

VOC\u00ca SABIA?<\/strong> N\u00e3o fumar, manter um peso saud\u00e1vel, limitar o consumo de \u00e1lcool e evitar a exposi\u00e7\u00e3o a certos produtos qu\u00edmicos no local de trabalho s\u00e3o maneiras de reduzir o risco de c\u00e2ncer pancre\u00e1tico. [ FONTE<\/a> ]<\/p>\n\n

RESULTADOS DE AMOSTRA:<\/strong> Saiba mais sobre o Nebula Research Library<\/a> .<\/p>\n\n

\"Resultados<\/a><\/figure>\n\n

<\/p>\n\n

VARIANTES ASSOCIADOS AO C\u00c2NCER DO P\u00c2NCREAS:<\/strong> rs11655237, rs1486134, rs17688601, rs9854771<\/p>\n\n

RECURSOS ADICIONAIS:<\/strong> Supressor de tumor<\/a>\u00c1cido glut\u00e1rico<\/a>Vis\u00e3o geral do c\u00e2ncer de p\u00e2ncreas<\/a>Ciclo celular (v\u00eddeo)<\/a><\/p>\n\n

ATUALIZA\u00c7\u00c3O SEMANAL:<\/strong> 23 de julho de 2019<\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DO ESTUDO: Varia\u00e7\u00e3o comum em 2p13.3, 3q29, 7p13 e 7q25.1 associada \u00e0 suscetibilidade ao c\u00e2ncer pancre\u00e1tico RESUMO: O c\u00e2ncer de p\u00e2ncreas pode ser influenciado por variantes nos genes LINC00673, SUGCT e TP63. DESCRI\u00c7\u00c3O: O p\u00e2ncreas \u00e9 um \u00f3rg\u00e3o atr\u00e1s …<\/p>\n

C\u00e2ncer de p\u00e2ncreas (Childs, 2015)<\/span> Leia mais \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":13419,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4999],"tags":[],"class_list":["post-13417","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports-pt-br"],"yoast_head":"\nA gen\u00e9tica do c\u00e2ncer pancre\u00e1tico (Childs, 2015)<\/title>\n<meta name=\"description\" content=\"O p\u00e2ncreas \u00e9 um \u00f3rg\u00e3o atr\u00e1s do est\u00f4mago. 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