{"id":13527,"date":"2021-01-31T22:14:37","date_gmt":"2021-02-01T03:14:37","guid":{"rendered":"https:\/\/nebula.org\/blog\/genetica-de-sars-coronavirus-infeccao-ching-2010\/"},"modified":"2021-02-20T20:46:16","modified_gmt":"2021-02-21T01:46:16","slug":"genetica-de-sars-coronavirus-infeccao-ching-2010","status":"publish","type":"post","link":"https:\/\/nebula.org\/blog\/pt-br\/genetica-de-sars-coronavirus-infeccao-ching-2010\/","title":{"rendered":"Infec\u00e7\u00e3o por coronav\u00edrus SARS (Ching, 2010)"},"content":{"rendered":"\n

T\u00cdTULO DO ESTUDO:<\/strong> Significado do Gene de Resist\u00eancia A Myxovirus A (MxA) – 123C> Um Polimorfismo de Nucleot\u00eddeo \u00danico na Indu\u00e7\u00e3o de Interferon \u03b2 Suprimido de Infec\u00e7\u00e3o por Coronav\u00edrus com S\u00edndrome Respirat\u00f3ria Aguda Grave<\/a><\/p>\n\n

RESUMO:<\/strong> Identifica\u00e7\u00e3o de uma variante gen\u00e9tica associada a um risco reduzido de SARS coronav\u00edrus<\/em> infec\u00e7\u00e3o.<\/p>\n\n

VIS\u00c3O GERAL:<\/strong> A s\u00edndrome respirat\u00f3ria aguda grave (SARS) coronav\u00edrus<\/em> surgiu em 2003 na China. Em pouco mais de um ano, infectou 8.000 pessoas e causou mais de 900 mortes em todo o mundo. Os sintomas t\u00edpicos incluem febre alta, dor de cabe\u00e7a e tosse seca. Estudos anteriores mostraram que interferons<\/em> pode inibir a replica\u00e7\u00e3o do SARS coronav\u00edrus<\/em> induzindo a produ\u00e7\u00e3o de prote\u00ednas antivirais como MxA. Este estudo demonstrou que uma variante gen\u00e9tica (rs17000900) pr\u00f3xima ao gene MxA influencia sua atividade quando as c\u00e9lulas s\u00e3o expostas a interferons<\/em> . O estudo tamb\u00e9m examinou a informa\u00e7\u00e3o gen\u00e9tica de mais de 1200 indiv\u00edduos de ascend\u00eancia chinesa e estabeleceu uma rela\u00e7\u00e3o entre esta variante gen\u00e9tica e o risco de SARS coronav\u00edrus<\/em> infec\u00e7\u00e3o. Os resultados sugerem que o alelo A da variante rs17000900 est\u00e1 ligado a uma diminui\u00e7\u00e3o da suscetibilidade \u00e0 SARS coronav\u00edrus<\/em> infec\u00e7\u00e3o. (Observa\u00e7\u00e3o: este estudo n\u00e3o \u00e9 um estudo de associa\u00e7\u00e3o do genoma. Apenas algumas variantes foram genotipadas seletivamente.)<\/p>\n\n

VOC\u00ca SABIA?<\/strong> Os coronav\u00edrus tamb\u00e9m s\u00e3o respons\u00e1veis pela pandemia MERS (S\u00edndrome Respirat\u00f3ria do Oriente M\u00e9dio) no in\u00edcio dos anos 2010. [SOURCE]<\/a><\/p>\n\n

RESULTADOS DE AMOSTRA:<\/strong> Saiba mais sobre o Nebula Research Library<\/a> . <\/p>\n\n

\"Resultados<\/a><\/figure>\n\n

<\/p>\n\n

SARS CORONAVIRUS ANALYZED VARIANTS:<\/strong> rs17000900<\/p>\n\n

RECURSOS ADICIONAIS:<\/strong>S\u00edndrome respirat\u00f3ria aguda grave (SARS)<\/a>Li\u00e7\u00e3o aprendida com o surto de SARS (v\u00eddeo)<\/a><\/p>\n\n

ATUALIZA\u00c7\u00c3O SEMANAL:<\/strong> 23 de mar\u00e7o de 2020<\/p>\n\n

Para atualiza\u00e7\u00f5es sobre a gen\u00e9tica de COVID-19, visite: https:\/\/nebula.org\/blog\/category\/science\/<\/a><\/p>\n\n

Voc\u00ea pode aprender mais sobre testes caseiros de coronav\u00edrus<\/a> em nossa revis\u00e3o!<\/p>\n","protected":false},"excerpt":{"rendered":"

T\u00cdTULO DO ESTUDO: Significado do Gene de Resist\u00eancia A Myxovirus A (MxA) – 123C> Um Polimorfismo de Nucleot\u00eddeo \u00danico na Indu\u00e7\u00e3o de Interferon \u03b2 Suprimido de Infec\u00e7\u00e3o por Coronav\u00edrus com S\u00edndrome Respirat\u00f3ria Aguda Grave RESUMO: Identifica\u00e7\u00e3o de uma variante gen\u00e9tica …<\/p>\n

Infec\u00e7\u00e3o por coronav\u00edrus SARS (Ching, 2010)<\/span> Leia mais \u00bb<\/a><\/p>\n","protected":false},"author":12,"featured_media":13530,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"site-sidebar-layout":"default","site-content-layout":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_FSMCFIC_featured_image_caption":"","_FSMCFIC_featured_image_nocaption":"","_FSMCFIC_featured_image_hide":"","footnotes":""},"categories":[4999],"tags":[],"class_list":["post-13527","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reports-pt-br"],"yoast_head":"\nA 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